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... undergoes a conformational change where helix 7 slides down the protein, switching it into an active open form. This open form is competent for cell surface binding. If we can stop this switch, we may have an anti-inflammatory ...
Chemical Reactions
Chemical Reactions

... matter, the making of new materials with new properties, and energy changes. – Symbols represent elements, formulas describe compounds, chemical equations describe a chemical reaction ...
August 7-10: 5th International Symposium on Diffraction Structural Biology
August 7-10: 5th International Symposium on Diffraction Structural Biology

... This symposium will report on the latest discoveries in structural biology using X-ray, neutron, and electron diffraction, and complementary techniques such as small-angle scattering, nuclear magnetic resonance spectroscopy, electron microscopy, and advanced computational approaches. Scientific insi ...
HS-LS1-6 Evidence Statements
HS-LS1-6 Evidence Statements

... obtained from a variety of sources (including students’ own investigations, models, theories, simulations, peer review) and the assumption that theories and laws that describe the natural world operate today as they did in the past and will continue to do so in the future. ...
HS-LS1-6
HS-LS1-6

... obtained from a variety of sources (including students’ own investigations, models, theories, simulations, peer review) and the assumption that theories and laws that describe the natural world operate today as they did in the past and will continue to do so in the future. ...
Preferentially biotinylate N-terminal α
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Lecture 5 – Chemical Reactions

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... https://phet.colorado.edu/en/simulation/reactants-products-and-leftovers The following questions are based on the material covered so far. I will post full answers on my website (https://blogs.ubc.ca/rchatrath/) halfway through spring break to give you time to do the questions on your own. Please at ...
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... EQUATIONS q  A balanced equation contains the same number of atoms on each side of the equation, and therefore obeys the law of conservation of mass. q  Many equations are balanced by trial and error; but it must be remembered that coefficients can be changed in order to balance an equation, bu ...
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... Organic macromolecules called _______ are insoluble in water, are often found in biological membranes and other waterproof coverings, and have the ability to store energy for extended periods of time. A. lipids B. nucleic acids C. carbohydrates D. proteins Use this information for questions 8 & 9: A ...
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... active particles [30–33]. Or non-activated diffusion of the reactants from particle to particle. In the latter case, the particles do not behave like isolated reactors any more. It is noteworthy that, even where adsorption of the reactants to the support is weak, an additional flux can come from mol ...
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No Slide Title

... • In order to understand the phenomena of the recognition and cleavage of the DNA substrate by the PvuII enzyme, the conformation of the PvuII enzyme as obtained from the complex crystal structure was docked to various frames of the DNA from the MD trajectory. • The structure at the 1230 ps gave goo ...
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... 4. Enzymes catalyze exergonic (exothermic)/ spontaneous reactions. 5. Enzymes are unused and unchanged by the chemical reaction they catalyze. 6. Enzymes catalyze one specific chemical reaction. 7. An increase in the concentration of enzyme will result in an increase in the rate of reaction. 8. An i ...
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Multi-state modeling of biomolecules

Multi-state modeling of biomolecules refers to a series of techniques used to represent and compute the behaviour of biological molecules or complexes that can adopt a large number of possible functional states.Biological signaling systems often rely on complexes of biological macromolecules that can undergo several functionally significant modifications that are mutually compatible. Thus, they can exist in a very large number of functionally different states. Modeling such multi-state systems poses two problems: The problem of how to describe and specify a multi-state system (the ""specification problem"") and the problem of how to use a computer to simulate the progress of the system over time (the ""computation problem""). To address the specification problem, modelers have in recent years moved away from explicit specification of all possible states, and towards rule-based formalisms that allow for implicit model specification, including the κ-calculus, BioNetGen, the Allosteric Network Compiler and others. To tackle the computation problem, they have turned to particle-based methods that have in many cases proved more computationally efficient than population-based methods based on ordinary differential equations, partial differential equations, or the Gillespie stochastic simulation algorithm. Given current computing technology, particle-based methods are sometimes the only possible option. Particle-based simulators further fall into two categories: Non-spatial simulators such as StochSim, DYNSTOC, RuleMonkey, and NFSim and spatial simulators, including Meredys, SRSim and MCell. Modelers can thus choose from a variety of tools; the best choice depending on the particular problem. Development of faster and more powerful methods is ongoing, promising the ability to simulate ever more complex signaling processes in the future.
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