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1 A multi-platform metabolomics approach identifies novel
1 A multi-platform metabolomics approach identifies novel

... associated with high bacterial diversity could accurately identify clinical BV as defined by Nugent scoring. Metabolites significantly elevated in Nugent BV (unpaired t-test, Benjamini-Hochberg p < 0.01) with OR > 1 are shown in Fig. 3A. Succinate was included as a comparator, although it did not re ...
Sodium Bicarbonate
Sodium Bicarbonate

... laboratory determinations, and the patient's age, weight and clinical condition. Sodium Bicarbonate Injection is administered by the intravenous route preferably via a central line. Extravasation must be avoided; the solution is hypertonic and irritant to veins resulting in extensive skin necrosis i ...
26. oxidation of amino acids
26. oxidation of amino acids

... The first step in the catabolism of most of the L-amino acids is the removal of the α-amino group (i.e., transamination) by a group of enzymes called aminotransferases (= transaminases). In these reactions, the α-amino group is transferred to the α-carbon atom of α-ketoglutarate, leaving behind the ...
Nicotinamide adenine dinucleotide, a metabolic regulator of
Nicotinamide adenine dinucleotide, a metabolic regulator of

... components of the de novo pathway reside evenly throughout the cell and have no effect on silencing [14,15]. NAD also regulates gene expression at other genomic loci. Clock/BMAL1 and NPAS2/BMAL1 are heterodimeric transcription factors that regulate the expression of genes controlling the circadian ...
Treating individuals with severe anaphylactic type allergic reactions
Treating individuals with severe anaphylactic type allergic reactions

... This document was put together with the assistance of numerous contributors in the fields of first aid, allergies, and pre-hospital emergency services (EMS). Given the need to rapidly treat victims of serious allergic reactions, other groups of emergency responders, including first aiders, must be a ...
k 1 - College of Arts and Sciences
k 1 - College of Arts and Sciences

... d: dissolved; sp, lp: small and large particles, respectively; l: decay constant; k1, k-1: second order adsorption and first order desorption rate constants, respecitvely; b2, b-2: first order aggregation and disaggragation rate constants, respectively; b-1: first order remineralization rate constan ...
Open the publication - UEF Electronic Publications
Open the publication - UEF Electronic Publications

... Pgc-1α, peroxisome proliferator-activated receptor gamma co-activator-1 alpha, is a coactivator involved in variety of regulatory functions in cellular metabolism and energy homeostasis. Due to its nature as co-activator, Pgc-1α regulates gene expression through protein-protein interactions with tra ...
Title of Document: HIGH-THROUGHPUT TIME-SERIES
Title of Document: HIGH-THROUGHPUT TIME-SERIES

... Woodard of University of Maryland-Bio Scale-Up facility for allowing us to have access to their lab, house our GC-MS during the intermediate period of time and use some of the equipments required for our research. I would also like to thank my advisor Dr. Maria Klapa and National Science Foundation ...
Ethanol-soluble Intermediates and Products of
Ethanol-soluble Intermediates and Products of

... Whatman no. I filter paper, using ethyl acetate acetic acid + water (9 :2 :2 , by vol.) as a descending solvent. The paper was cut in the form of a symmetrical trapezoid, with solvent applied to the shorter of the two parallel edges. This geometry gave more compact spots, with less 'tailing', than t ...
Chapter 8
Chapter 8

... respiration of pigeon flight muscle. As you might expect, this very active tissue is highly enriched in energy producing enzymes. Furthermore a freshly prepared mince contains a sufficient quantity of endogenous substrates (probably from the metabolism of glycogen which functions as a source of pyru ...
Enzymes at work
Enzymes at work

... Enzymes in this class catalyze the transfer of groups of atoms from one molecule to another or from one position in a molecule to other positions in the same molecule. Common types are acyltransferases and glycosyltransferases. CGTase (cyclodextrin glycosyltransferase) is one such enzyme type, which ...
Flux limitations in the ortho pathway of benzoate
Flux limitations in the ortho pathway of benzoate

University of Groningen Lactococcus lactis systems biology Eckhardt
University of Groningen Lactococcus lactis systems biology Eckhardt

... decades 19,20. The main components of the protein degradation machinery were characterized at the biochemical and genetic level, describing its functions and activities, the interactions between the enzymes and the regulation of the genes encoding the major players in proteolysis in L. lactis. The L ...
Biomarker discovery for psychiatric disorders
Biomarker discovery for psychiatric disorders

... metabolomes of HAB/NAB/LAB mice were quantified, and altered protein and metabolite networks were identified by in silico pathway analysis. Differential expression of sideroflexin-5 (Sfxn5), carbonic anhydrase 2 (Car2), myosin, heavy polypeptide 10 (Myh10) and succinate dehydrogenase, subunit b (Sdh ...
- Journal of Hepatology
- Journal of Hepatology

this document - Publications du ministère de la Santé et
this document - Publications du ministère de la Santé et

... epinephrine so that it can be used even more quickly when required. For nearly ten years now, ambulance paramedics, and more recently first responders, have been administering epinephrine in the course of pre-hospital care. Under regional EMS quality improvement programs, hundreds of cases of epinep ...
ATP regulation in bioproduction
ATP regulation in bioproduction

... is a critical factor in bioproduction by cell factories. Recent studies have shown that changing the ATP supply is critical for improving product yields. In this review, we summarize the recent challenges faced by researchers engaged in the development of engineered cell factories, including the mai ...
ATP regulation in bioproduction
ATP regulation in bioproduction

... is a critical factor in bioproduction by cell factories. Recent studies have shown that changing the ATP supply is critical for improving product yields. In this review, we summarize the recent challenges faced by researchers engaged in the development of engineered cell factories, including the mai ...
AMINO ACID OXIDATION AND THE PRODUCTION OF UREA
AMINO ACID OXIDATION AND THE PRODUCTION OF UREA

The Regulation of Energy Metabolism Pathways
The Regulation of Energy Metabolism Pathways

... level that is able to induce changes in the homeostasis of L-carnitine. However, it must be noted that to our knowledge, an acute mildronate treatment does not induce any metabolic or gene expression changes, and therefore, long-term treatment (at least 10-14 days) is necessary to achieve regulatory ...
Microbial degradation of chloroaromatics Mars, Astrid E.
Microbial degradation of chloroaromatics Mars, Astrid E.

microbial metabolism of oxalate and one
microbial metabolism of oxalate and one

Type B Lactic Acidosis Secondary to Thiamine
Type B Lactic Acidosis Secondary to Thiamine

No Slide Title
No Slide Title

... the absence of renal dysfunction AA with lytes is usually appropriate. ...
Engineering Acetyl Coenzyme A Supply: Functional Expression of a
Engineering Acetyl Coenzyme A Supply: Functional Expression of a

... In this yeast, synthesis of cytosolic acetyl-CoA via acetyl-CoA synthetase (ACS) involves hydrolysis of ATP to AMP and pyrophosphate. Here, we demonstrate that expression and assembly in the yeast cytosol of an ATP-independent pyruvate dehydrogenase complex (PDH) from Enterococcus faecalis can fully ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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