
Chemical Equations
... Chemical equations show a number of important features of a reaction. The formulas of the reactants and products are given, and through the use of coefficients in front of the formulas, the relative amounts of the substances that react and form are given. It is important to realize that the amounts ...
... Chemical equations show a number of important features of a reaction. The formulas of the reactants and products are given, and through the use of coefficients in front of the formulas, the relative amounts of the substances that react and form are given. It is important to realize that the amounts ...
Structural Biochemistry/Enzyme
... enhances the binding of substrates as well as catalysis. Nevertheless, the cleft may also contain polar residues. Certain of these polar residues acquire special properties essential for substrate bidning or catalyis. 4. Substrates are bound to enzymes by multiple weak interations. Stated above 5. T ...
... enhances the binding of substrates as well as catalysis. Nevertheless, the cleft may also contain polar residues. Certain of these polar residues acquire special properties essential for substrate bidning or catalyis. 4. Substrates are bound to enzymes by multiple weak interations. Stated above 5. T ...
Paper - Revision Science
... Name the bases in your strand, indicating clearly which base bonds to each base in the strand shown. phosphate ...
... Name the bases in your strand, indicating clearly which base bonds to each base in the strand shown. phosphate ...
Lecture # 7 Pentose Phosphate Pathway
... • The pathway yields ribose 5-phosphate. – Nucleotide biosynthesis leading to: •DNA •RNA •Various cofactors (CoA, FAD, SAM, NAD+/NADP+). ...
... • The pathway yields ribose 5-phosphate. – Nucleotide biosynthesis leading to: •DNA •RNA •Various cofactors (CoA, FAD, SAM, NAD+/NADP+). ...
... Choice A: The South Beach diet suggests that the dieter completely eliminate carbohydrates from their diet. Should athletes with high energy demands, such a sprinters, go on this diet? Why or why not? Sprinters need a fast source of energy. This can only be provided from glucose in glycolysis. The g ...
Introduction
... Actuality of the theme. Amino acids are organic low-molecular compounds, which are included into the structure of proteins and peptides, and also are in the cells of organism in the free state and take part in metabolism. Physical and chemical properties of amino acids are predetermined by features ...
... Actuality of the theme. Amino acids are organic low-molecular compounds, which are included into the structure of proteins and peptides, and also are in the cells of organism in the free state and take part in metabolism. Physical and chemical properties of amino acids are predetermined by features ...
Acid – base balance
... Intracellular pH is maintained at about the pH of neutrality (6.8 at 37˚C) because this is the pH at which metabolite intermediates are all charged and trapped inside the cell ...
... Intracellular pH is maintained at about the pH of neutrality (6.8 at 37˚C) because this is the pH at which metabolite intermediates are all charged and trapped inside the cell ...
Interpretation of Arterial Blood Gas
... in the force of cardiac contractions, a decrease in the vascular response to catecholamines, and a diminished response to the effects and actions of certain medications. When the pH is above 7.45, the blood is said to be alkalotic. An alkalotic state interferes with tissue oxygenation and normal neu ...
... in the force of cardiac contractions, a decrease in the vascular response to catecholamines, and a diminished response to the effects and actions of certain medications. When the pH is above 7.45, the blood is said to be alkalotic. An alkalotic state interferes with tissue oxygenation and normal neu ...
Supporting material
... and varying substrate (up to 5 Km) in 0.1 mL of assay buffer. For the E. coli PaaI, the buffer and assay method were the same as used with A. evansii PaaI. Reactions were carried out in 0.2 mL assay buffer containing PaaI (7 nM for pH 6.0, 6.5 and 10.0, 4 nM for pH 7.0, and 3 nM for pH 7.5 to 9.5) a ...
... and varying substrate (up to 5 Km) in 0.1 mL of assay buffer. For the E. coli PaaI, the buffer and assay method were the same as used with A. evansii PaaI. Reactions were carried out in 0.2 mL assay buffer containing PaaI (7 nM for pH 6.0, 6.5 and 10.0, 4 nM for pH 7.0, and 3 nM for pH 7.5 to 9.5) a ...
Medical Endocrine Course
... Be able to explain how and why the level of key enzymes in glycolysis would be different between normal and diabetic patients Lecture 4 a. Know the 5 general mechanisms for controlling enzyme activity in a metabolic pathway b. Be able to explain the concept of Dynamic State (macromolecular turnover) ...
... Be able to explain how and why the level of key enzymes in glycolysis would be different between normal and diabetic patients Lecture 4 a. Know the 5 general mechanisms for controlling enzyme activity in a metabolic pathway b. Be able to explain the concept of Dynamic State (macromolecular turnover) ...
ppt - Tripod
... immediate postictal state after a generalized seizure coma may develop when multiple generalized seizures occur in succession and there is not enough time between seizures to allow patients to recover ...
... immediate postictal state after a generalized seizure coma may develop when multiple generalized seizures occur in succession and there is not enough time between seizures to allow patients to recover ...
B-Metabolism of Sulphur containing amino acids
... - Both methionine and cysteine can undergo transamination reaction. - Methionine is an essential amino acid and has to be supplied in the diet. Cysteine is not essential and can be synthesized in the body from methionine. - The presence of cysteine and cysteine in the diet reduces the requirement of ...
... - Both methionine and cysteine can undergo transamination reaction. - Methionine is an essential amino acid and has to be supplied in the diet. Cysteine is not essential and can be synthesized in the body from methionine. - The presence of cysteine and cysteine in the diet reduces the requirement of ...
General Chemistry 110 Quiz 1
... Discuss a topic of your choice from metabolism that is unrelated to your previous answers. Give at least three main points. Don’t make your answer too general. (15 points) ...
... Discuss a topic of your choice from metabolism that is unrelated to your previous answers. Give at least three main points. Don’t make your answer too general. (15 points) ...
Glycolysis
... D-Glucose is a major fuel for most organisms. D-Glucose metabolism occupies the center position for all metabolic pathways. Glucose contains a great deal of potential energy. The complete oxidation of glucose yields −2,840 kJ/mol of energy. ...
... D-Glucose is a major fuel for most organisms. D-Glucose metabolism occupies the center position for all metabolic pathways. Glucose contains a great deal of potential energy. The complete oxidation of glucose yields −2,840 kJ/mol of energy. ...
The TCA Cycle
... g. The overall outcome of the cycle will be the carboxylation of pyruvate, producing acetyl CoA and one molecule of reduced electron carrier NADH. h. **NOTE: “important for later consideration.” This reaction is irreversible, which creates many problems studying metabolism and its regulation in huma ...
... g. The overall outcome of the cycle will be the carboxylation of pyruvate, producing acetyl CoA and one molecule of reduced electron carrier NADH. h. **NOTE: “important for later consideration.” This reaction is irreversible, which creates many problems studying metabolism and its regulation in huma ...
Flux analysis in central carbon metabolism in plants
... experiments that employ U-13C (uniformly 13C-labeled) substrates. It was shown that the enumeration of feasible bondomers in a metabolic network reduced the number of bondomer balances 3-fold. This resulted in a simplified system that offers the advantages of faster computation, and easier flux iden ...
... experiments that employ U-13C (uniformly 13C-labeled) substrates. It was shown that the enumeration of feasible bondomers in a metabolic network reduced the number of bondomer balances 3-fold. This resulted in a simplified system that offers the advantages of faster computation, and easier flux iden ...
SURVEY AND SUMMARY Regulation of mammalian nucleotide
... synthesis for cell viability is discussed and how this may lead to potential new approaches to drug development in diseases such as cancer. INTRODUCTION A large fraction of the genome is now known to be transcribed into a wide range of RNAs whose functions are still being ascertained (1–4). Even in ...
... synthesis for cell viability is discussed and how this may lead to potential new approaches to drug development in diseases such as cancer. INTRODUCTION A large fraction of the genome is now known to be transcribed into a wide range of RNAs whose functions are still being ascertained (1–4). Even in ...
Divergent Evolution of ( )8-Barrel Enzymes
... Evolution of the Enolase Superfamily The sequence similarities between the members of the enolase superfamily are often low and their substrates are chemically quite diverse. However, their similar three-dimensional structures and catalytic mechanisms indicate a common evolutionary origin (Babbitt a ...
... Evolution of the Enolase Superfamily The sequence similarities between the members of the enolase superfamily are often low and their substrates are chemically quite diverse. However, their similar three-dimensional structures and catalytic mechanisms indicate a common evolutionary origin (Babbitt a ...
P3- Biochemical Processes
... The nature of biochemical processes within cells Catabolic and anabolic reactions – reactions releasing or requiring energy Role of enzymes as protein catalysts The role of ATP and ADP in energy ...
... The nature of biochemical processes within cells Catabolic and anabolic reactions – reactions releasing or requiring energy Role of enzymes as protein catalysts The role of ATP and ADP in energy ...
Metabolic network modelling

Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑