Aprotinin Preserves Cellular Junctions and Reduces
... Figure 4. Immunofluorescence demonstrates preservation of adherens junctions in the aprotinin-treated group. Confocal microscopy immunofluorescence images demonstrating the high-intensity and more continuous signals of the -catenin– and ␥-catenin–labeled endothelial cells after aprotinin treatment ...
... Figure 4. Immunofluorescence demonstrates preservation of adherens junctions in the aprotinin-treated group. Confocal microscopy immunofluorescence images demonstrating the high-intensity and more continuous signals of the -catenin– and ␥-catenin–labeled endothelial cells after aprotinin treatment ...
Role of Crosstalk Between Phosphatidylinositol 3
... Many of these have been shown to have pleiotropic effects essential to diverse aspects of vascular development. For example, Shh, which is expressed in the notochord (a dorsal midline structure),11 and VEGF, which is expressed in somites (future trunk muscles just lateral to the notochord), also ser ...
... Many of these have been shown to have pleiotropic effects essential to diverse aspects of vascular development. For example, Shh, which is expressed in the notochord (a dorsal midline structure),11 and VEGF, which is expressed in somites (future trunk muscles just lateral to the notochord), also ser ...
TNF-induced endothelial barrier disruption: beyond actin and Rho
... Upon arrival at the plasma membrane, some of the TNF molecules are shed by the metalloproteinase TNFα-converting enzyme (TACE), also known as a disintegrin and metalloproteinase-17 (ADAM-17), and released as a soluble homotrimer of 17 KD (5, 6). TNF binds to two type I transmembrane receptors, TNFR1 ...
... Upon arrival at the plasma membrane, some of the TNF molecules are shed by the metalloproteinase TNFα-converting enzyme (TACE), also known as a disintegrin and metalloproteinase-17 (ADAM-17), and released as a soluble homotrimer of 17 KD (5, 6). TNF binds to two type I transmembrane receptors, TNFR1 ...
The glycocalyx is present as soon as blood flow is initiated and is
... flow that is present. Since liquids flow in the direction of least resistance, if no barrier to flow into the interstitium is present, the blood plasma will flow into surrounding tissues and reduce the flow in the blood vessels themselves. Therefore, since the glycocalyx is important in the adult both fo ...
... flow that is present. Since liquids flow in the direction of least resistance, if no barrier to flow into the interstitium is present, the blood plasma will flow into surrounding tissues and reduce the flow in the blood vessels themselves. Therefore, since the glycocalyx is important in the adult both fo ...
Developmental Anatomy of the Retinal and Choroidal Vasculature
... During the first gestational month, the posterior compartment of the globe contains the primary vitreous comprised of a fibrillary meshwork of ectodermal origin and vascular structures of mesodermal origin. At the 5-mm stage, the primitive dorsal ophthalmic artery sprouts off the hyaloid artery, whi ...
... During the first gestational month, the posterior compartment of the globe contains the primary vitreous comprised of a fibrillary meshwork of ectodermal origin and vascular structures of mesodermal origin. At the 5-mm stage, the primitive dorsal ophthalmic artery sprouts off the hyaloid artery, whi ...
Chen Tenwek 2015 Bullous Keratopathy
... Lin P et al. Combined phototherapeutic keratectomy and therapeutic contact lens for recurrent erosions in bullous keratopathy. BJO 2001;85:908-11. Maini R et al. A comparison of different depth ablations in the treatment of painful bullous keratopathy with phototherapeutic keratectomy. BJO 2001;85:9 ...
... Lin P et al. Combined phototherapeutic keratectomy and therapeutic contact lens for recurrent erosions in bullous keratopathy. BJO 2001;85:908-11. Maini R et al. A comparison of different depth ablations in the treatment of painful bullous keratopathy with phototherapeutic keratectomy. BJO 2001;85:9 ...
Phospholamban Is Present in Endothelial Cells and Modulates
... sarco(endo)plasmic reticulum Ca21 ATPase (SERCA). Expression of PLB is reportedly limited to cardiac, slow-twitch skeletal and smooth muscle in which PLB is an important regulator of [Ca21]i and contractility in these muscles. In the present study, we report the existence of PLB in the vascular endo ...
... sarco(endo)plasmic reticulum Ca21 ATPase (SERCA). Expression of PLB is reportedly limited to cardiac, slow-twitch skeletal and smooth muscle in which PLB is an important regulator of [Ca21]i and contractility in these muscles. In the present study, we report the existence of PLB in the vascular endo ...
Endothelial Repair and Endothelial Cell-Derived
... Interestingly, circulating number of MPs originated from apoptotic endothelial cells increases in patients with CV risk factors, after newly CV events and in individuals with established CV disease. However, the ability of activated endothelial cells to active secret MPs progressively decreases depe ...
... Interestingly, circulating number of MPs originated from apoptotic endothelial cells increases in patients with CV risk factors, after newly CV events and in individuals with established CV disease. However, the ability of activated endothelial cells to active secret MPs progressively decreases depe ...
Inner Blood-Retinal Barrier Transporters: Relevance to
... the retina (Tout et al., 1993). In experiments with TR-MUL cells, conditionally immortalized rat Müller cells, TR-MUL cells produce transforming growth factor-beta (TGF-) to increase the activity of barrier marker proteins expressed in the TR-iBRB cells, conditionally immortalized rat retinal capil ...
... the retina (Tout et al., 1993). In experiments with TR-MUL cells, conditionally immortalized rat Müller cells, TR-MUL cells produce transforming growth factor-beta (TGF-) to increase the activity of barrier marker proteins expressed in the TR-iBRB cells, conditionally immortalized rat retinal capil ...
Inducibility and Expression of Microvascular
... ELAM-l (0.5% ± 0.5% of vessels) or VCAM-l (0.7% ± 0.7% of vessels) molecules, consistent with previous reports [15,21]. The percentage of CD36+ vessel cross-sections within the SVP ranged from 15% to 25%, which is identical to that seen in normal nonpsoriatic skin specimens [15]. CD36 molecule expre ...
... ELAM-l (0.5% ± 0.5% of vessels) or VCAM-l (0.7% ± 0.7% of vessels) molecules, consistent with previous reports [15,21]. The percentage of CD36+ vessel cross-sections within the SVP ranged from 15% to 25%, which is identical to that seen in normal nonpsoriatic skin specimens [15]. CD36 molecule expre ...
FOXO1 Plays an Essential Role in Apoptosis of Retinal
... Purpose: An early and significant event in diabetic retinopathy is the loss of retinal microvascular pericytes. Studies were performed to investigate pathways through which an advanced glycation endproduct and tumor necrosis factor (TNF)-α stimulate apoptosis in retinal pericytes through the activat ...
... Purpose: An early and significant event in diabetic retinopathy is the loss of retinal microvascular pericytes. Studies were performed to investigate pathways through which an advanced glycation endproduct and tumor necrosis factor (TNF)-α stimulate apoptosis in retinal pericytes through the activat ...
Intracellular pH
... broad variety of intracellular enzymes, and these may involve opposing systems that are activated or inhibited at the same time. This is also evident in the current study, where a lower pHi had presumably beneficial (attenuated blood pressure increase), but also detrimental effects (impairment of en ...
... broad variety of intracellular enzymes, and these may involve opposing systems that are activated or inhibited at the same time. This is also evident in the current study, where a lower pHi had presumably beneficial (attenuated blood pressure increase), but also detrimental effects (impairment of en ...
07 - mesodermal
... endothelial lined channels. These tubes fused to form a primordial heart tube. The tubular heart joins with blood vessels in the embryo; connecting stalk; chorion and yolk sac to form a primordial ...
... endothelial lined channels. These tubes fused to form a primordial heart tube. The tubular heart joins with blood vessels in the embryo; connecting stalk; chorion and yolk sac to form a primordial ...
Ultrastructural Aspects of Human and Canine Diabetic
... preceding changes may be associated with large hemorrhages which extend into the vitreous, and proliferation of new-formed capillaries into the vitreous or on the surface of the retina, so-called "retinitis proliferans."2 This condition almost inevitably leads to blindness if the patient lives long ...
... preceding changes may be associated with large hemorrhages which extend into the vitreous, and proliferation of new-formed capillaries into the vitreous or on the surface of the retina, so-called "retinitis proliferans."2 This condition almost inevitably leads to blindness if the patient lives long ...
Information on casting with Mercox
... vasculature of organs (Figs. 1, 2, 3) including arteries, capillaries, and veins and their valves, and may exhibit details of the endothelium on the cast surfaces including imprints of endothelial nuclei (Figs. 3, 4, 5) and endothelial cell borders. From these imprints one can observe the orienta ...
... vasculature of organs (Figs. 1, 2, 3) including arteries, capillaries, and veins and their valves, and may exhibit details of the endothelium on the cast surfaces including imprints of endothelial nuclei (Figs. 3, 4, 5) and endothelial cell borders. From these imprints one can observe the orienta ...
S1P1 is sufficient to mediate egress (of immature T
... S1P1 is sufficient to mediate egress (of immature T-cells) • Premature egress? • Intercrossed A line with RAG-GFP reporter mice • RAG-1+ (GFP+) during maturation, decay over few days time • S1P1 only KLF2 target? • Bred A line with KLF2f/f-CD4Cre mice (conditional KO) • Selective deletion of KLF2 i ...
... S1P1 is sufficient to mediate egress (of immature T-cells) • Premature egress? • Intercrossed A line with RAG-GFP reporter mice • RAG-1+ (GFP+) during maturation, decay over few days time • S1P1 only KLF2 target? • Bred A line with KLF2f/f-CD4Cre mice (conditional KO) • Selective deletion of KLF2 i ...
New specs for arteriovenous identity
... beds, they first showed that gene expression profiles could not be distinguished based on arterial or venous origin. They then demonstrated that freshly isolated human umbilical vein and arterial endothelial cells yielded an “AV-fresh” gene profile that could be used to reliably separate venous from ar ...
... beds, they first showed that gene expression profiles could not be distinguished based on arterial or venous origin. They then demonstrated that freshly isolated human umbilical vein and arterial endothelial cells yielded an “AV-fresh” gene profile that could be used to reliably separate venous from ar ...
ENGLISH SUMMARY
... vessels to efficiently support the new vascular bed. Third, adult vasculogenesis has been proposed as an additional pathway whereby progenitor cells migrate and differentiate into vascular cells not only supporting resident endothelial cells, put also form new blood vessels de novo. Chapter 2 review ...
... vessels to efficiently support the new vascular bed. Third, adult vasculogenesis has been proposed as an additional pathway whereby progenitor cells migrate and differentiate into vascular cells not only supporting resident endothelial cells, put also form new blood vessels de novo. Chapter 2 review ...
Cardiovascular system
... 20. Why is the internal elastic membrane inconspicuous in elastic arteries? 21. Which is the thickest tunic in an elastic artery? 22. What are the principal cells of the tunica adventitia of elastic arteries? 23. What feature found in muscular arteries helps distinguish them from elastic arteries? 2 ...
... 20. Why is the internal elastic membrane inconspicuous in elastic arteries? 21. Which is the thickest tunic in an elastic artery? 22. What are the principal cells of the tunica adventitia of elastic arteries? 23. What feature found in muscular arteries helps distinguish them from elastic arteries? 2 ...
Harvard-MIT Division of Health Sciences and Technology
... The stimuli that cause cell injury also elicit a complex inflammatory reaction designed to (1) eliminate the cause of injury and (2) clean up the dead and the dying cells and tissues. ...
... The stimuli that cause cell injury also elicit a complex inflammatory reaction designed to (1) eliminate the cause of injury and (2) clean up the dead and the dying cells and tissues. ...
VascDev
... 326-330 (2002)] encodes Frizzled4, a putative Wnt receptor. A second autosomal dominant FEVR locus encodes the Wnt co-receptor Lrp5 [Toomes et al [IOVS 45: 20832090 (2004)]; Jiao et al [Am J Hum Genet 75: 878-884 (2004)]. ...
... 326-330 (2002)] encodes Frizzled4, a putative Wnt receptor. A second autosomal dominant FEVR locus encodes the Wnt co-receptor Lrp5 [Toomes et al [IOVS 45: 20832090 (2004)]; Jiao et al [Am J Hum Genet 75: 878-884 (2004)]. ...
PHENOTYPIC CHANGES IN IRRADIATED ENDOTHELIAL CELLS
... an excessive and uncontrolled synthesis of extracellular matrix by mesenchymal cells. The endothelial to mesenchymal transition (EndoMT) is a process in which endothelial cells transdifferentiate into mesenchymal cells in response to stress. EndoMT was recently described as a possible source of mese ...
... an excessive and uncontrolled synthesis of extracellular matrix by mesenchymal cells. The endothelial to mesenchymal transition (EndoMT) is a process in which endothelial cells transdifferentiate into mesenchymal cells in response to stress. EndoMT was recently described as a possible source of mese ...
Angiogenesis
... and growth factors for metastasis and continued growth. Tumors must stimulate angiogenesis, the growth of new blood vessels from preexisting ones so as to obtain these nutrients. ...
... and growth factors for metastasis and continued growth. Tumors must stimulate angiogenesis, the growth of new blood vessels from preexisting ones so as to obtain these nutrients. ...
Pericyte
Pericytes are contractile cells that wrap around the endothelial cells of capillaries and venules throughout the body. Also known as Rouget cells or mural cells, pericytes are embedded in basement membrane where they communicate with endothelial cells of the body's smallest blood vessels by means of both direct physical contact and paracrine signaling. In the brain, pericytes help sustain the blood–brain barrier as well as several other homeostatic and hemostatic functions of the brain. These cells are also a key component of the neurovascular unit, which includes endothelial cells, astrocytes, and neurons. Pericytes regulate capillary blood flow, the clearance and phagocytosis of cellular debris, and the permeability of the blood–brain barrier. Pericytes stabilize and monitor the maturation of endothelial cells by means of direct communication between the cell membrane as well as through paracrine signaling. A deficiency of pericytes in the central nervous system can cause the blood–brain barrier to break down.