Lymphocyte Populations Within the Lamina Propria
... In animals, where it is possible to experimentally control the gut flora, remarkable progress has been made on the texture of cytokine responses and their regulation by specific members of the microbiota (Figure 7.2). Germ-free mice monocolonized with the human gut bacterium, Bacteroides fragilis, s ...
... In animals, where it is possible to experimentally control the gut flora, remarkable progress has been made on the texture of cytokine responses and their regulation by specific members of the microbiota (Figure 7.2). Germ-free mice monocolonized with the human gut bacterium, Bacteroides fragilis, s ...
Chemical Signals in Animals: Endocrine System and Hormonal
... Hormones are secreted into the bloodstream and regulate whole body processes like growth, reproduction, complex behaviors including courtship and migration. Hormones influence the metabolism of their target cells by binding to receptor proteins within the cell or on the surface of the cell. ...
... Hormones are secreted into the bloodstream and regulate whole body processes like growth, reproduction, complex behaviors including courtship and migration. Hormones influence the metabolism of their target cells by binding to receptor proteins within the cell or on the surface of the cell. ...
REVIEW Human gene therapy - American University of Ras Al
... in order to prevent them from replicating in host cells.41 Gene delivery by means of replicationincompetent viral vectors has been demonstrated to be more efficient and less demanding in terms of dose number because of the presence of strong promoters in viral vectors.42 The genetic material of each ...
... in order to prevent them from replicating in host cells.41 Gene delivery by means of replicationincompetent viral vectors has been demonstrated to be more efficient and less demanding in terms of dose number because of the presence of strong promoters in viral vectors.42 The genetic material of each ...
Gene Therapy in Lung Transplantation
... excessive inflammation but also regulation of adaptive immune response (Figure 2). IL-10 downregulates the expression of class II MHC and co-stimulatory molecules on professional antigen presenting cells such as dendritic cells and macrophages [16]. It has been recognized that the regulatory role of ...
... excessive inflammation but also regulation of adaptive immune response (Figure 2). IL-10 downregulates the expression of class II MHC and co-stimulatory molecules on professional antigen presenting cells such as dendritic cells and macrophages [16]. It has been recognized that the regulatory role of ...
Palmitic Acid Activation of Dendritic Cells
... time, money, energy, ideas, support, passion, and sacrifice you have invested and poured into me to make me a great scientist. I will continually work to make you, my mentors proud, and to strive to attain the potential that you see in me. I would also like to thank my committee members for their gu ...
... time, money, energy, ideas, support, passion, and sacrifice you have invested and poured into me to make me a great scientist. I will continually work to make you, my mentors proud, and to strive to attain the potential that you see in me. I would also like to thank my committee members for their gu ...
T-Cell Subset Analysis of Lewis Lung Carcinoma
... H-2K restriction elements (H-2K bin1, H-2K a, and H-2K k) dem- mean expression of V~33 TCR on CD4- and CD8-positive Tonstrated a similar pattern of the T-cell heterogeneity induced lymphocytes in normal PBL of C57BL/6J mice averages 3% by the 3LL A9 tumor clone expressing the normal syngeneic (38), ...
... H-2K restriction elements (H-2K bin1, H-2K a, and H-2K k) dem- mean expression of V~33 TCR on CD4- and CD8-positive Tonstrated a similar pattern of the T-cell heterogeneity induced lymphocytes in normal PBL of C57BL/6J mice averages 3% by the 3LL A9 tumor clone expressing the normal syngeneic (38), ...
Macrophages and Dendritic Cells
... lesion formation is profoundly influenced by innate and adaptive immunity, which can be regulated locally within atherosclerotic lesions, as well as in secondary lymphoid organs, the bone marrow and the blood. DCs are important modulators of immunity. Advances in the past decade have cemented our un ...
... lesion formation is profoundly influenced by innate and adaptive immunity, which can be regulated locally within atherosclerotic lesions, as well as in secondary lymphoid organs, the bone marrow and the blood. DCs are important modulators of immunity. Advances in the past decade have cemented our un ...
Primary B-Cell Deficiencies Reveal a Link between Human IL
... albicans, which may be related to the preservation of innate sources of IL-17, such as cd T cells, natural killer T cells or myeloid cells. Of note, these individuals featured neither significant naı̈ve Tcell imbalances, nor major alterations in the levels of T-cell activation nor frequencies of IFN ...
... albicans, which may be related to the preservation of innate sources of IL-17, such as cd T cells, natural killer T cells or myeloid cells. Of note, these individuals featured neither significant naı̈ve Tcell imbalances, nor major alterations in the levels of T-cell activation nor frequencies of IFN ...
A robust, high-throughput assay to determine the phagocytic activity
... Antibodies are potent determinants of the humoral immune response. Though generated as a result of the interaction of B and T cells, antibodies trigger their cytotoxic effects by interacting with complement and innate effector cells. Thus they provide a functional link between the adaptive and innat ...
... Antibodies are potent determinants of the humoral immune response. Though generated as a result of the interaction of B and T cells, antibodies trigger their cytotoxic effects by interacting with complement and innate effector cells. Thus they provide a functional link between the adaptive and innat ...
Homeostasis and function of T cells in healthy - UvA-DARE
... CD4+ T cells play a critical role in forming adaptive immune responses against various pathogens 1-3. Furthermore, they are known to be involved in the pathogenesis of autoimmune diseases, asthma and allergic responses 4;5. CD4+ T cells consist of several different T helper (Th) lineages, including ...
... CD4+ T cells play a critical role in forming adaptive immune responses against various pathogens 1-3. Furthermore, they are known to be involved in the pathogenesis of autoimmune diseases, asthma and allergic responses 4;5. CD4+ T cells consist of several different T helper (Th) lineages, including ...
Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme
... arthritis (11,12), suggesting the involvement of mediators different from IFN␥ and interleukin-12 (IL-12) and of other T cell subsets in the pathogenesis of the disease. Th17 cells, a new subset of T helper cells, play a crucial role in the induction of autoimmune tissue injury via the release of IL ...
... arthritis (11,12), suggesting the involvement of mediators different from IFN␥ and interleukin-12 (IL-12) and of other T cell subsets in the pathogenesis of the disease. Th17 cells, a new subset of T helper cells, play a crucial role in the induction of autoimmune tissue injury via the release of IL ...
How might infant and paediatric immune responses influence
... been associated with antibody-dependent cellular inhibition of parasite growth (15) and associated with the acquisition of clinical immunity (16). However, little is known about factors that induce class switching and how the relative proportion of IgG1 ⁄ IgG3 to different malaria antigens is establ ...
... been associated with antibody-dependent cellular inhibition of parasite growth (15) and associated with the acquisition of clinical immunity (16). However, little is known about factors that induce class switching and how the relative proportion of IgG1 ⁄ IgG3 to different malaria antigens is establ ...
Normalizing the environment recapitulates adult human immune
... analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist experiments are neither technically nor ethically possible in humans. However, there is growing concern that laboratory mice do not reflect relevant aspects of the human immu ...
... analyses to be carried out from the onset of disease, and permit the use of tractable disease models. Comparably reductionist experiments are neither technically nor ethically possible in humans. However, there is growing concern that laboratory mice do not reflect relevant aspects of the human immu ...
Pregnancy enhances the innate immune response in experimental cutaneous leishmaniasis through
... adaptive immune responses makes pregnant females more susceptible to a wide variety of pathogens, most notably Plasmodium spp. [3]. This observation extends to laboratory animals infected with Toxoplasma gondii, Listeria monocytogenes, Mycobacterium leprae, and Leishmania major [7, 8]. Pregnant mice ...
... adaptive immune responses makes pregnant females more susceptible to a wide variety of pathogens, most notably Plasmodium spp. [3]. This observation extends to laboratory animals infected with Toxoplasma gondii, Listeria monocytogenes, Mycobacterium leprae, and Leishmania major [7, 8]. Pregnant mice ...
Functional Anatomy of Lymphatic System
... largest lymphatic organ located in upper left abdominal quadrant between fundus of stomach and diaphragm ...
... largest lymphatic organ located in upper left abdominal quadrant between fundus of stomach and diaphragm ...
Diabetes Mellitus
... T1DM…one is autoimmune mediated (Pattern A) & the other (Pattern B) is probably viral mediated Onset of T1DM following initiation of insulitis is variable & spontaneous recovery can occur These patients require life-long ...
... T1DM…one is autoimmune mediated (Pattern A) & the other (Pattern B) is probably viral mediated Onset of T1DM following initiation of insulitis is variable & spontaneous recovery can occur These patients require life-long ...
Enterovirus Infection and Type 1 Diabetes: Closing in on a Link?
... or even different viruses that trigger common pathways might be involved. Furthermore, multiple viral hits might be required before b-cell function is sufficiently impaired, and these could potentially come from different viruses. Last, viral infections can also have protective roles from autoimmunit ...
... or even different viruses that trigger common pathways might be involved. Furthermore, multiple viral hits might be required before b-cell function is sufficiently impaired, and these could potentially come from different viruses. Last, viral infections can also have protective roles from autoimmunit ...
Endometrial Receptivity to Implantation in Humans
... ECC-1 that, like uterine epithelium, expresses MUC-16 and MUC-1 allowed increased adherence of cells of a trophoblast cell line. In parallel experiments, siRNA knockdown of MUC-1 did not affect trophoblast cell adherence. It has been suggested that MUC-1 can play a dual role in relation to cellular ...
... ECC-1 that, like uterine epithelium, expresses MUC-16 and MUC-1 allowed increased adherence of cells of a trophoblast cell line. In parallel experiments, siRNA knockdown of MUC-1 did not affect trophoblast cell adherence. It has been suggested that MUC-1 can play a dual role in relation to cellular ...
Gene Section ELAVL1 (ELAV (embryonic lethal, abnormal vision,
... chronic diseases such as cancer. The bioactive gas nitric oxide has been identified as an important player in cancer-induced cachexia because NO is directly involved in the loss of MyoD mRNA (a key factor needed for the myogenic process, which is destabilized during cachexia) and muscle fiber. These ...
... chronic diseases such as cancer. The bioactive gas nitric oxide has been identified as an important player in cancer-induced cachexia because NO is directly involved in the loss of MyoD mRNA (a key factor needed for the myogenic process, which is destabilized during cachexia) and muscle fiber. These ...
Raulet, D.H. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 3:781-790.
... early transcript 1 (Rae1), a lipid-linked membrane protein, which had previously been cloned based on its rapid induction of expression by F9 embryocarcinoma cells after treatment with retinoic acid16. Rae1β is a member of a subfamily of several closely related (>98% amino-acid identity) proteins, w ...
... early transcript 1 (Rae1), a lipid-linked membrane protein, which had previously been cloned based on its rapid induction of expression by F9 embryocarcinoma cells after treatment with retinoic acid16. Rae1β is a member of a subfamily of several closely related (>98% amino-acid identity) proteins, w ...
Answers
... Autoimmunity: An abnormal condition in which the immune system attacks the body Autoantibodies: Confused antibodies produced to attack the body's own tissues ...
... Autoimmunity: An abnormal condition in which the immune system attacks the body Autoantibodies: Confused antibodies produced to attack the body's own tissues ...
3. Pathogenesis of giant cell arteritis
... component. Genetic studies in GCA clearly pointed to genes located in the MHC region being strongly associated with GCA. Moreover, recent studies have indicated that other key members of the immune and inflammatory response are crucial players in the development and progression of GCA. In particular ...
... component. Genetic studies in GCA clearly pointed to genes located in the MHC region being strongly associated with GCA. Moreover, recent studies have indicated that other key members of the immune and inflammatory response are crucial players in the development and progression of GCA. In particular ...
Cytokine Atlas - Thermo Fisher Scientific
... T cell recruitment to the airways, and alterations in the balance between TH1 and TH2 responses.28 Allergic asthma patients undergoing an asthmatic attack exhibit significantly higher levels of proinflammatory cytokines and chemokines, including Eotaxin, GM-CSF, IFNγ, IL-4, IL-5, IL-8, IL-10, IL-12, ...
... T cell recruitment to the airways, and alterations in the balance between TH1 and TH2 responses.28 Allergic asthma patients undergoing an asthmatic attack exhibit significantly higher levels of proinflammatory cytokines and chemokines, including Eotaxin, GM-CSF, IFNγ, IL-4, IL-5, IL-8, IL-10, IL-12, ...
Full-Text PDF
... animal models of nickel allergy have been widely used to elucidate the molecular mechanisms of metal allergy. Allergic diseases are multifactorial disorders caused by various factors, such as genetics and the environment in addition to exposure to metals. Moreover, little is known regarding the mole ...
... animal models of nickel allergy have been widely used to elucidate the molecular mechanisms of metal allergy. Allergic diseases are multifactorial disorders caused by various factors, such as genetics and the environment in addition to exposure to metals. Moreover, little is known regarding the mole ...