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Autoimmunity
Autoimmunity

... Autoimmune disease occurs when an immune response attacks our own tissues. Like all adaptive immune responses, it is focused on specific antigens by T-cell receptors and B cell receptors. In contrast to infection, the antigens that these cells recognise are processed from proteins within the target ...
Document
Document

... Autoimmune disease occurs when an immune response attacks our own tissues. Like all adaptive immune responses, it is focused on specific antigens by T-cell receptors and B cell receptors. In contrast to infection, the antigens that these cells recognise are processed from proteins within the target ...
No Slide Title
No Slide Title

... Age-related changes in the immune system All lymphoid tissues decreases in mass and efficiency with age ...
IMMUNOLOGY AND THE IMMUNE SYSTEM
IMMUNOLOGY AND THE IMMUNE SYSTEM

... against infection through studying the components and function of the immune system. Lectures : - General information in immunology (immunology and the immune system) - general introduction in immunology ( innate and adaptive immunity - Antigen characteristic - Antibody characteristic - B and T cell ...
Natural Defense Mechanisms
Natural Defense Mechanisms

...  Consist of a group of small proteins serum proteins (proteins + glycoprotoens) circulate in inactive form. (Once they become activated, they produce important biological effects that start inflammation).  This system plays an important role in both Innate & Adaptive immunity.  There are three ty ...
Document
Document

... leukocytes that stimulate or inhibit the proliferation or function of immune cells. – Interleukin – cytokines that only affect leukocytes. • Lymphocyte – A type of leukocyte (white blood cell) of the immune system. – T-Regulatory Cell – slows down and stops immune response – T-Helper Cell – has anti ...
File - Classes with Mrs. Sheetz
File - Classes with Mrs. Sheetz

... • Histamine: a chemical which initiates the inflammatory response; causes blood vessels to dilate, increases blood flow to area • Phagocytes (macrophages & neutrophils): engulf and remove pathogens ...
Department of Microbiology, Immunology and Tropical Medicine
Department of Microbiology, Immunology and Tropical Medicine

... initiation of CD8+ T cell response in the gut • Is NK-DC interaction critical for induction of robust CD8+ T cell immunity • Can long term central memory CD8+ T cell response be generated • What is the role of cytokines like IL-7 and IL-15 in the generation and maintenance of CD8+ T cell immunity in ...
Immune Disorders and Imbalances
Immune Disorders and Imbalances

... Auto immune diseases • The reason why the immune system looses the ability to recognize it’s self is dependent upon a variety of factors. – Lymphocyte programming is ineffective – New proteins appear that the immune system has not had a chance to become acquainted with. – Self antigens look very si ...
Immunity L.Saba Abood
Immunity L.Saba Abood

... when the injury is not serious the inflammatory response is short-lived and healing process will quickly return the affected area to normal state. If the neutrophils are overwhelmed, they call for reinforcements by secreting chemical mediators called cytokines which attract more WBCs to the area inc ...
At the heart of the immune response is the ability to distinguish
At the heart of the immune response is the ability to distinguish

Chapter 43 Power Point notes
Chapter 43 Power Point notes

...  Antigen – any foreign molecule that is specifically recognized by lymphocytes and elicits a response from them  2 main types of lymphocytes  B lymphocytes (B cells)  T lymphocytes (T cells)  Both circulate through the blood and lymph and are concentrated in the spleen, lymph nodes, and other l ...
ELISA Pre and Post Test
ELISA Pre and Post Test

Pejman Soroosh
Pejman Soroosh

... airway tolerance and development of asthma. In 2010 he joined the Immunology Department at Janssen R&D where he was involved in the drug discovery efforts as a project leader and responsible for direct scientific management of internal and external projects. In 215 he co-founded Immunology Expletory ...
Slide 1
Slide 1

... • Follicular involution & lymphocyte depletion-burnt out lymph nodes • Opportunistic infections • lymphomas ...
REGULATION OF THE IMMUNE RESPONSE
REGULATION OF THE IMMUNE RESPONSE

... the most polymorphic residues in MHC molecules (encoded by different alleles) • Thus, MHC dependent aminoacid sequences of the groove determine the accuracy of peptide binding and in turn, antigen ...
Exam Key 1 2008
Exam Key 1 2008

... infection and destruction of pathogens. The MAP kinase pathway is also activated and are translocated to the nucleus where they also act as transcription factors producing cytokines (some students may include NFkB causing cells to proliferate and MAPK to cause cells to undergo apoptosis) 2. Describe ...
the immune system phagocytosis antibody function
the immune system phagocytosis antibody function

... Some hypothesize that immune cells function more effectively at that temperature Invaders/pathogens are not so equipped with dealing with heat (High temp. denatures their proteins) ...
Introduction to Immuno-Oncology
Introduction to Immuno-Oncology

... Mechanisms promoting cancer development: (1) Inflammation => Angiogenesis & Tissue remodeling (2) Enhance survival pathways (NF-kB activation) (3) Suppression of anti-tumor immune responses ...
30_Extracellular bact BA
30_Extracellular bact BA

... Degradation of IgA antibodies Neisseria, H. influenzae ...
here - Molecular Medicine Ireland
here - Molecular Medicine Ireland

... immune responses, and the provision of the concept of the “licensing” of professional antigen presenting cell functions by CD4+ T helper cells, required for the optimized induction of CTL responses. This concept has modified not only our knowledge of the fundamental mechanisms regulating the generat ...
Immune System Disorders
Immune System Disorders

... Allograft: Use of tissue from another person Xenotransplantation product: Use of nonhuman tissue Graft-versus-host disease can result from transplanted bone marrow that contains immunocompetent cells ...
THE IMMUNE SYSTEM
THE IMMUNE SYSTEM

... Humoral Immunity produces antibodies ...
Immunity and Infection Sexually Transmitted Diseases`
Immunity and Infection Sexually Transmitted Diseases`

... helper cells release cytokines to trigger production of T killers & B lymphocytes ...
Chapter One Concept Checks
Chapter One Concept Checks

... system with their function in the body: (a) macrophages, (b) B cells, (c) immunoglobins, (d) killer T cells, (e) suppressor T cells, (f) memory cells. 1. This subgroup targets viral infections within the cells by directly destroying the antigens. ____________ 2. A type of leukocyte that surrounds id ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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