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BIOL 495: Introduction to Immunology
BIOL 495: Introduction to Immunology

... • 1930’s – early techniques made it easier to study humoral elements [than cellular ones]. -discovery of active component of blood – gamma globulin “protein” • 1950’s – discovery of T and B cells Later discoveries linked lymphocytes to both cellular and humoral immunity ...
Cell Communication
Cell Communication

... • Play a key role in cell-cell recognition – ability of a cell to distinguish one cell from another • antigens – important in organ & tissue development – basis for rejection of foreign cells by immune system ...
35-2 Reading Guide
35-2 Reading Guide

... Specific Defenses: The Immune System The function of the immune system is to fight infection by inactivating foreign substances or cells that have entered the body. The specific immune response works in several ways, including: recognizing “self,” including cells and proteins that belong to the body ...
Science Translational Medicine
Science Translational Medicine

... Critical Unmet Needs of Human Disease ...
Structure of an IgG Antibody
Structure of an IgG Antibody

... • Functional genes for antigen receptors do not exist until they are generated during the development of lymphocytes • Variable region exons are formed by splicing together segments of genes inherited through the germline • The process is called Ig or TCR gene rearrangement, and generates tremendous ...
Review Words for Immune System Test
Review Words for Immune System Test

1. dia
1. dia

... Normal tissue cells do not express MHC class II NO SIGNAL 1. for CD4+ Th activation Normal tissue cells do not express co-stimulatory molecules and do not produce T cell differentiating cytokines NO SIGNAL 2. for CD4+ Th activation Migration of naive T lymphocytes to normal tissues is limited Antige ...
Chapter 43 Immune System
Chapter 43 Immune System

... attachment to microbes and increase phagocytosis 3. Agglutination – clumping of bacteria or viruses forms aggregates that can be readily phagocytosed by macrophages 4. Precipitation – antibodies cross link soluble antigen molecules dissolved in body fluids making them immobile and easily targeted by ...
中文題目:微核糖核酸-17透過標的物Eos調整調節性T細胞的活性 英文
中文題目:微核糖核酸-17透過標的物Eos調整調節性T細胞的活性 英文

... sequential prcessing of primary RNA polymerase II transcripts mediated by two RNase III enzymes. We were interested in determining whether Treg differentiation and/or suppressive activity are regulated by microRNAs (miRNAs). the inflammatory cytokine IL-6 has been shown to induce miR-17-92 expressio ...
chulalongkorn university-naist joint symposium on biological sciences
chulalongkorn university-naist joint symposium on biological sciences

... more salt-tolerant plants, it is crucial to identify the key components of the salt-response network. Here, two omics approaches have been employed to identify genes responsible for salt tolerance in rice (Oryza sativa L.). In the first approach, we used genome-wide association mapping based on SNPs ...
Type IV hypersensitivity
Type IV hypersensitivity

... Insulin resistant diabetes Pernicious anemia others ...
Immunology 03 MED
Immunology 03 MED

... Cooperation of specific humoral and cellular response: immunophagocytosis, antibody dependent cellular cytoxicity (ADCC) – NK CD16, macrophages, neutrophils Appropriate (defense against infections, pre-cancer growth control) and inappropriate (allergy, autoimmunity, transplant rejection) specific re ...
345.1 Salcedo - Advances in Neuroblastoma Research
345.1 Salcedo - Advances in Neuroblastoma Research

The Immune System
The Immune System

... modifying their surface to prevent recognition or by resisting breakdown following phagocytosis ...
Slide - Smith Lab
Slide - Smith Lab

... [mouse models via immunization with IRBP, Retinal S-ag] Disease Associations made with particular MHC molecules HLA-B27 : Reiter’s syndrome HLA-B5: Behcet’s Disease HLA-29: Birdshot Choroidopathy How could an immune response to an ocular antigen develop to Cause autoimmune uveitis? Retention of T ce ...
MICR 201 Microbiology for Health Related Sciences
MICR 201 Microbiology for Health Related Sciences

... is phagocytosed by macrophages ...
The_Specific_Immune_Response
The_Specific_Immune_Response

... shaped antigen on its cell surface membrane. Your lymphocytes with the complementary antibody may come into contact with this antigen in one of three ways: - By encountering the pathogen itself - By your macrophages engulfing the pathogen, then presenting the antigen on their surface - By the pathog ...
Lecture 29-30
Lecture 29-30

... TIFF (Uncompressed) decompressor are needed to see this picture. ...
European Research Council (ERC) funded programme of work
European Research Council (ERC) funded programme of work

... of genetic variation in the MHC, how it may modulate gene expression and the consequences of this for disease. We demonstrated the importance of context-specificity in the action of regulatory genetic variants and produced route maps of putative functional variants and their modulated genes for diff ...
Immunity
Immunity

... The Clonal Selection Theory of Antibody Formation: • Great number of antigens can be fought (mouse can form antibodies against 10 million different antigens!). • Each person has a large # of B lymphocytes, each only able to synthesize one type of antibody (on its surface). • When an antigen is intr ...
The Immune Response - Point Pleasant Beach School District
The Immune Response - Point Pleasant Beach School District

... The Clonal Selection Theory of Antibody Formation: • Great number of antigens can be fought (mouse can form antibodies against 10 million different antigens!). • Each person has a large # of B lymphocytes, each only able to synthesize one type of antibody (on its surface). • When an antigen is intr ...
Immune System Worksheet
Immune System Worksheet

... 15. Humoral immunity is a response to pathogens in blood and lymph. 16. The first response of humoral immunity to infection is much faster than the second response. 17. Plasma cells are specialized B cells. 18. Cell-mediated immunity involves antibodies. 19. Cell-mediated immunity causes infected bo ...
prrs_3_pathogenesis
prrs_3_pathogenesis

... The target cells in which PRRSV replicates are subsets of macrophages that have specific glycoprotein receptors for the virus. These include pulmonary alveolar and interstitial macrophages and macrophages in lymphoid tissues. In order for replication to take place maturity and/or activation are requ ...
Specific Responses
Specific Responses

... • There exist specific B and T cells for any possible antigen we are likely to encounter during our lifetime! ...
Hamel, Misse et al, J Virol 2015
Hamel, Misse et al, J Virol 2015

... After initial inoculation of the virus three groups of cells are targeted by ZIKV ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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