Clever tricks EBV employed to modulate innate immunity during
... are naïve B cells and epithelial cells, but EBV can also infect or can be taken up by other cell types, including monocytes and plasmacytoid dendritic cells (pDCs)9. EBV tethers to B cells by binding of the viral glycoprotein gp350 to complement receptor CR2 (CD21), a receptor expressed by B cells9. ...
... are naïve B cells and epithelial cells, but EBV can also infect or can be taken up by other cell types, including monocytes and plasmacytoid dendritic cells (pDCs)9. EBV tethers to B cells by binding of the viral glycoprotein gp350 to complement receptor CR2 (CD21), a receptor expressed by B cells9. ...
The Development and Survival of Lymphocytes
... Chapter 4 described the structure of the antigen receptor genes expressed by B and T cells, introduced the mechanisms controlling the DNA rearrangements needed to assemble a complete antigen receptor, and explained how these processes can generate an antigen receptor repertoire of high diversity. Th ...
... Chapter 4 described the structure of the antigen receptor genes expressed by B and T cells, introduced the mechanisms controlling the DNA rearrangements needed to assemble a complete antigen receptor, and explained how these processes can generate an antigen receptor repertoire of high diversity. Th ...
03 PACE Inflammatory process and CV - pace
... Conclusions: Tocilizumab was efficacious in severe, persistent systemic JIA. Adverse events were common and included infection, neutropenia, and increased aminotransferase levels. ...
... Conclusions: Tocilizumab was efficacious in severe, persistent systemic JIA. Adverse events were common and included infection, neutropenia, and increased aminotransferase levels. ...
White blood cells, C-reactive protein and erythrocyte sedi
... The method by which PNC infection was diagnosed (by antigen, antibody or immune complex assays) had no significant influence on the results. In clinical practice, an alveolar-type infiltration is used to indicate bacterial pneumonia, and an interstitial-type to indicate viral pneumonia, though this ...
... The method by which PNC infection was diagnosed (by antigen, antibody or immune complex assays) had no significant influence on the results. In clinical practice, an alveolar-type infiltration is used to indicate bacterial pneumonia, and an interstitial-type to indicate viral pneumonia, though this ...
Dissertation LeWi Fakultät Humboldt-Universität zu Berlin
... to their multifunctional capacities, are involved in a variety of reactions in the muscle, and it has been shown in many studies, that during muscle injury, macrophages are involved in clearing pathogens and perform a switch from pro-inflammatory to alternatively activated macrophage phenotypes. Mor ...
... to their multifunctional capacities, are involved in a variety of reactions in the muscle, and it has been shown in many studies, that during muscle injury, macrophages are involved in clearing pathogens and perform a switch from pro-inflammatory to alternatively activated macrophage phenotypes. Mor ...
The dynamics of acute inflammation
... lead to recurrent infection as we see in the next section). In this case, low levels of infection persist indefinitely. This could be likened to infection with tuberculosis, yeast infections or low-grade bacterial infections that persist for long periods of time (Beatty et al., 1994). Although, an or ...
... lead to recurrent infection as we see in the next section). In this case, low levels of infection persist indefinitely. This could be likened to infection with tuberculosis, yeast infections or low-grade bacterial infections that persist for long periods of time (Beatty et al., 1994). Although, an or ...
Transient Reversions in MHC
... Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants Barouch et al.,2005 Nat. Imm. 6(3): 247-252 ...
... Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants Barouch et al.,2005 Nat. Imm. 6(3): 247-252 ...
C YTOKINES AND IMMUNE BALANCE IN PREECLAMPSIA
... Activated macrophages and NK cells secrete cytokines and chemokines, which initiate the inflammatory response and aid the destruction of phagocytosed particles (Abbas and Lichtman 2005, Janeway 2005). Furthermore, the macrophages have the capacity to present antigens from phagocytosed particles. The ...
... Activated macrophages and NK cells secrete cytokines and chemokines, which initiate the inflammatory response and aid the destruction of phagocytosed particles (Abbas and Lichtman 2005, Janeway 2005). Furthermore, the macrophages have the capacity to present antigens from phagocytosed particles. The ...
Cytokines That Promote Periodontal Tissue Destruction
... Although periodontal diseases are initiated by bacteria that colonize the tooth surface and gingival sulcus, the host response is believed to play an essential role in the breakdown of connective tissue and bone, key features of the disease process. An intermediate mechanism that lies between bacter ...
... Although periodontal diseases are initiated by bacteria that colonize the tooth surface and gingival sulcus, the host response is believed to play an essential role in the breakdown of connective tissue and bone, key features of the disease process. An intermediate mechanism that lies between bacter ...
Plasma IL-25 is elevated in a subgroup of patients Open Access
... allergen itself but represents a risk factor for the development or persistence of clinical reactivity to peanut. Recently it was suggested that IL-25 secretion is induced during disruption of epithelial barriers. Our data are insufficient to make a conclusion on the nature of a IL-25 subgroup, but ...
... allergen itself but represents a risk factor for the development or persistence of clinical reactivity to peanut. Recently it was suggested that IL-25 secretion is induced during disruption of epithelial barriers. Our data are insufficient to make a conclusion on the nature of a IL-25 subgroup, but ...
... mesothelial cell collagen production [21]. Finally, macrophages obtained from patients with malignant effusion expressed the human leucocyte antigen (HLA)-DR antigen, released interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) and stimulated allogeneic T-lymphocyte proliferation [22]. Pleur ...
Complement in skin diseases
... normal control, the system has been activated. If there is almost no destruction in vitro, the system is either over-activated or defective. Demonstration of split products of central components such as C3, C4, and C5 now leads to consideration of whether complement is really activated. If complemen ...
... normal control, the system has been activated. If there is almost no destruction in vitro, the system is either over-activated or defective. Demonstration of split products of central components such as C3, C4, and C5 now leads to consideration of whether complement is really activated. If complemen ...
Preclinical models of acute and chronic graft-versus
... Besides cytokines that promote the activation of T cells, chemokines that guide the migration of T cells toward GVHD target organs were identified as a pharmacologic target in mouse models of aGVHD.48,49 However, this strategy is seen controversial as high radiation can break the principles of chemok ...
... Besides cytokines that promote the activation of T cells, chemokines that guide the migration of T cells toward GVHD target organs were identified as a pharmacologic target in mouse models of aGVHD.48,49 However, this strategy is seen controversial as high radiation can break the principles of chemok ...
j.The Lymphatic System
... since lymphatic capillaries are so permeable, cancer cells can easily enter and travel in the lymph tend to lodge in 1st node they enter and enlarge and destroy the node = lymphoma once lymphoma is established cells travel from their to other nodes ...
... since lymphatic capillaries are so permeable, cancer cells can easily enter and travel in the lymph tend to lodge in 1st node they enter and enlarge and destroy the node = lymphoma once lymphoma is established cells travel from their to other nodes ...
Emerging Concepts in the Management of Skin Cancer
... PD-1 Inhibitors: NIVO and PEMBRO • PD-1 is an inhibitory receptor expressed on T cells after activation • Binding of PD-1 to its ligands PD-L1 and PD-L2 on APCs and tumor cells downregulates T-cell activity • Plays a role in peripheral tolerance and protection from autoimmune damage • Anti-PD-1 res ...
... PD-1 Inhibitors: NIVO and PEMBRO • PD-1 is an inhibitory receptor expressed on T cells after activation • Binding of PD-1 to its ligands PD-L1 and PD-L2 on APCs and tumor cells downregulates T-cell activity • Plays a role in peripheral tolerance and protection from autoimmune damage • Anti-PD-1 res ...
Mast cell-orchestrated immunity to pathogens
... antibodies) and receptors for inflammatory factors produced at the site of infection. Direct pathogen recognition by mast cells occurs both in response to factors that are common to classes of pathogens (such as through TlRs) and those that are specific to only a certain infectious challenge (such a ...
... antibodies) and receptors for inflammatory factors produced at the site of infection. Direct pathogen recognition by mast cells occurs both in response to factors that are common to classes of pathogens (such as through TlRs) and those that are specific to only a certain infectious challenge (such a ...
Proliferation T Cell + Nonredundantly Stimulates CD8
... Recent studies demonstrate that injection of mice with IL-4, in the form of IL-4/anti-IL-4 mAb complexes, can stimulate CD8⫹ T cells in unimmunized mice to proliferate (12). To determine whether IL-4 generated during a Th2 immune response is sufficient to stimulate CD8⫹ T cell proliferation, we firs ...
... Recent studies demonstrate that injection of mice with IL-4, in the form of IL-4/anti-IL-4 mAb complexes, can stimulate CD8⫹ T cells in unimmunized mice to proliferate (12). To determine whether IL-4 generated during a Th2 immune response is sufficient to stimulate CD8⫹ T cell proliferation, we firs ...
From carbohydrate leads to glycomimetic drugs
... as the hepatitis C virus54, Dengue virus55, Ebola virus56, Marburg virus57, coronavirus (which causes severe acute respiratory syndrome)58 and cytomegalovirus59, as well as bacteria such as Mycobacterium tuberculosis 60 and Helicobacter pylori 52 and yeast (Candida albicans) — exploit DCSIGn to inf ...
... as the hepatitis C virus54, Dengue virus55, Ebola virus56, Marburg virus57, coronavirus (which causes severe acute respiratory syndrome)58 and cytomegalovirus59, as well as bacteria such as Mycobacterium tuberculosis 60 and Helicobacter pylori 52 and yeast (Candida albicans) — exploit DCSIGn to inf ...
aplastic anemia - MEDICINE DEPARTMENT of MMC
... Corticosteroids, such as methylprednisolone (Medrol, Solu-Medrol), are often given at the same time as these drugs. Immune-suppressing drugs can be very effective at treating aplastic anemia. The downside is that these drugs further weaken your immune system. It’s also possible that after you stop t ...
... Corticosteroids, such as methylprednisolone (Medrol, Solu-Medrol), are often given at the same time as these drugs. Immune-suppressing drugs can be very effective at treating aplastic anemia. The downside is that these drugs further weaken your immune system. It’s also possible that after you stop t ...
Clinical Microbiology
... By the end of this lecture the Student should be able to understand Streptococci Types ,Shape Characteristics, pathology and Diagnosis. ...
... By the end of this lecture the Student should be able to understand Streptococci Types ,Shape Characteristics, pathology and Diagnosis. ...
Carbohydrate profiling reveals a distinctive role for
... Ninety-six-well plates (NUNC maxisorb) were coated overnight at room temperature with biotinylated PAA-glycoconjugates (5 lg mlÿ1) or SEA (2 lg mlÿ1) and afterwards blocked with 1% BSA. Calceine AM-labeled DCs (Molecular Probes) were added for 1.5 h at 37C in the presence or absence of 10 mM EGTA o ...
... Ninety-six-well plates (NUNC maxisorb) were coated overnight at room temperature with biotinylated PAA-glycoconjugates (5 lg mlÿ1) or SEA (2 lg mlÿ1) and afterwards blocked with 1% BSA. Calceine AM-labeled DCs (Molecular Probes) were added for 1.5 h at 37C in the presence or absence of 10 mM EGTA o ...
Cytokines in the management of rotavirus infection
... secondary metabolites on rotavirus infectivity. Neonatal gnotobiotic pigs have been used widely as a model of human rotavirus diarrhoea and exhibits a similar intestinal epithelial structure to humans [16]. This model is preferred in experimental studies, since it furnishes significant details of th ...
... secondary metabolites on rotavirus infectivity. Neonatal gnotobiotic pigs have been used widely as a model of human rotavirus diarrhoea and exhibits a similar intestinal epithelial structure to humans [16]. This model is preferred in experimental studies, since it furnishes significant details of th ...
Full Text - Statistics
... feeding, they should also be free from taking antibiotics in the last 2 months; hormonal factors during last one year, drugs strengthening immunity system in the last two months and drugs inhibiting immune system during the last year. Based on diameter of chronic periapical lesions, the samples were ...
... feeding, they should also be free from taking antibiotics in the last 2 months; hormonal factors during last one year, drugs strengthening immunity system in the last two months and drugs inhibiting immune system during the last year. Based on diameter of chronic periapical lesions, the samples were ...
Claire Baldock
... NGF, named TrkA and act as antagonist for the binding of NGF to TrkA, and which prevents the functional activation of TrkA by NGF, in the manufacture of a pharmacological composition for treatment of neurological pathologies comprised within the following group: chronic pain and acute pain.” ...
... NGF, named TrkA and act as antagonist for the binding of NGF to TrkA, and which prevents the functional activation of TrkA by NGF, in the manufacture of a pharmacological composition for treatment of neurological pathologies comprised within the following group: chronic pain and acute pain.” ...