PHG 413 lecture
... In some diseases, diphtheria and tetanus are notorious examples, it is not the growth of the bacterium that is dangerous, but the protein toxin that is liberated by it. Treating the toxin with, for example, formaldehyde, denatures the protein so that it is no longer dangerous, but retains some epito ...
... In some diseases, diphtheria and tetanus are notorious examples, it is not the growth of the bacterium that is dangerous, but the protein toxin that is liberated by it. Treating the toxin with, for example, formaldehyde, denatures the protein so that it is no longer dangerous, but retains some epito ...
Complement
... In plasma – the components are in inactive form Once activated, each component splits The smaller “a” fragment serves to stimulate the immune system The larger “b” fragment further activates the cascade The exception to this is C2… C2a is the larger molecule that promotes the cascade Act ...
... In plasma – the components are in inactive form Once activated, each component splits The smaller “a” fragment serves to stimulate the immune system The larger “b” fragment further activates the cascade The exception to this is C2… C2a is the larger molecule that promotes the cascade Act ...
How Microorganisms Cause Disease - Pandem-Sim
... and is not contained, it can cause the host cell to burst and release even more pathogens into the body. These then move to susceptible body cells and continue to multiply. Enzymes help some pathogens invade the cells and help with the spread from the initial site of infection to other areas of the ...
... and is not contained, it can cause the host cell to burst and release even more pathogens into the body. These then move to susceptible body cells and continue to multiply. Enzymes help some pathogens invade the cells and help with the spread from the initial site of infection to other areas of the ...
Appearance of peripheral blood plasma cells and memory B cells in
... persons receiving their third immunization in the naive group, 56 days after the first dose, where a rise was seen as early as day 4. This may reflect faster activation of recently generated memory B cells either in extrafollicular foci or after reentry in GCs23,24; or activity of partially involute ...
... persons receiving their third immunization in the naive group, 56 days after the first dose, where a rise was seen as early as day 4. This may reflect faster activation of recently generated memory B cells either in extrafollicular foci or after reentry in GCs23,24; or activity of partially involute ...
Current Clinical Therapies for HIV Remission
... • Are broad neutralizing antibodies -- bind virions and infected cells: DH542 (V3 glycan bnAb), CH557 (CD4bs bnAb), DH511-K3 (gp41 MPER bnAb) • Are ADCC mediating antibodies -- bind only infected cells: (7B2, gp41 ...
... • Are broad neutralizing antibodies -- bind virions and infected cells: DH542 (V3 glycan bnAb), CH557 (CD4bs bnAb), DH511-K3 (gp41 MPER bnAb) • Are ADCC mediating antibodies -- bind only infected cells: (7B2, gp41 ...
Cortisol (Hydrocortisone)
... hypotension, rapid weight loss and general weakness - tints or shades of deep amber or brown skin (due to the stimulation of melanocytes from high ACTH secretion). This results from inadequate negative feedback from low ...
... hypotension, rapid weight loss and general weakness - tints or shades of deep amber or brown skin (due to the stimulation of melanocytes from high ACTH secretion). This results from inadequate negative feedback from low ...
Tumor Cell Subpopulation Analysis in Immunohistochemistry
... marker was cytoplasmic, and the immune cells were identified as described earlier. Notably, the presence of apoptosis and immune infiltrates correlated well; but were anti-correlated with high expression of the biomarker. Low , but not negative, biomarker expression correlated well with proliferatio ...
... marker was cytoplasmic, and the immune cells were identified as described earlier. Notably, the presence of apoptosis and immune infiltrates correlated well; but were anti-correlated with high expression of the biomarker. Low , but not negative, biomarker expression correlated well with proliferatio ...
Presentazione standard di PowerPoint
... • To produce an AAV vector, the rep and cap genes are replaced with a transgene. • The total length of the insert cannot exceed 4.7 kb, the length of the wild type genome. • Production of the recombinant vector requires that rep and cap are provided in trans along with the helper virus gene product ...
... • To produce an AAV vector, the rep and cap genes are replaced with a transgene. • The total length of the insert cannot exceed 4.7 kb, the length of the wild type genome. • Production of the recombinant vector requires that rep and cap are provided in trans along with the helper virus gene product ...
Chronic recurrent infections and immunopathy
... the release of TNF-a and interleukin-1b from macrophages, which causes vasodilation and extravasation of plasma into the tissues and, as a result, an oedema. Group A streptococci in erysipelas induce a cleavage of bradykinin precursors that cause activation of the epithelial complement system and li ...
... the release of TNF-a and interleukin-1b from macrophages, which causes vasodilation and extravasation of plasma into the tissues and, as a result, an oedema. Group A streptococci in erysipelas induce a cleavage of bradykinin precursors that cause activation of the epithelial complement system and li ...
Immunohistochemical Detection of Macrophages and T
... activate macrophages.26 It also produces lymphotoxin, an analogue of tumor necrosis factor,29 and we24 recently found that this protein modulates -y-interferon-induced gene expression in smooth muscle cells. Finally, it has recently been shown that type I interferon, which is produced by virally inf ...
... activate macrophages.26 It also produces lymphotoxin, an analogue of tumor necrosis factor,29 and we24 recently found that this protein modulates -y-interferon-induced gene expression in smooth muscle cells. Finally, it has recently been shown that type I interferon, which is produced by virally inf ...
Lymphatic System Notes (2 of 3)
... combo (allergen-pollen) are Ag’s •AMI (Humoral) – Antibody Mediated Immune Response carried out primarily by B Cells (and their antibodies) to attack extracellular pathogens (ex. bateria, fungi, viruses) ...
... combo (allergen-pollen) are Ag’s •AMI (Humoral) – Antibody Mediated Immune Response carried out primarily by B Cells (and their antibodies) to attack extracellular pathogens (ex. bateria, fungi, viruses) ...
though its pathogenesis is still unclear, VEGF (an inducer of
... though its pathogenesis is still unclear, VEGF (an inducer of angiogenesis) recently attracted considerable attention as a major contributor to airway remodeling. VEGF was first discovered as a vascular permeability factor ⬎20 years ago. Subsequently, it was revealed to be a potent inducer of endoth ...
... though its pathogenesis is still unclear, VEGF (an inducer of angiogenesis) recently attracted considerable attention as a major contributor to airway remodeling. VEGF was first discovered as a vascular permeability factor ⬎20 years ago. Subsequently, it was revealed to be a potent inducer of endoth ...
Bacteria, Virus and Immune System Objectives
... 4. Describe, in detail, the relationship between an antigen and antibody. 5. Explain why you only get chickenpox once (most people) but can get the flu almost every year. 6. Describe the roles of each type of white blood cell. (macrophages, cytotoxic tcells, helper t cells, plasma cells, phagocytes) ...
... 4. Describe, in detail, the relationship between an antigen and antibody. 5. Explain why you only get chickenpox once (most people) but can get the flu almost every year. 6. Describe the roles of each type of white blood cell. (macrophages, cytotoxic tcells, helper t cells, plasma cells, phagocytes) ...
Major Components of Inflammation
... Express a unique protein group on their surface called CD4. CD stands for “cluster of differentiation” and is a means of specifically identifying different lymphocytes. Helper T cells are activated when they encounter foreign ...
... Express a unique protein group on their surface called CD4. CD stands for “cluster of differentiation” and is a means of specifically identifying different lymphocytes. Helper T cells are activated when they encounter foreign ...
STED microscopy case studies A) Membrane lipid peroxidation in T
... (upon activation and as a result of exposition to external sources of reactive oxygen species, ROS) will be followed by super-resolution microscopy (STED-FCS). B) Unravelling functional protein cluster stoichiometry and dynamics during the early stage of T cell activation Lymphocyte T cells are resp ...
... (upon activation and as a result of exposition to external sources of reactive oxygen species, ROS) will be followed by super-resolution microscopy (STED-FCS). B) Unravelling functional protein cluster stoichiometry and dynamics during the early stage of T cell activation Lymphocyte T cells are resp ...
Elaborate interactions between the immune and nervous systems
... Stimuli such as overeating, sleep and stress, and even operant conditioning in which a positive or negative stimulus is paired with a particular behavioral outcome, can influence the immune response. The well known feeling of sleepiness and the lack of appetite associated with fever is in part a res ...
... Stimuli such as overeating, sleep and stress, and even operant conditioning in which a positive or negative stimulus is paired with a particular behavioral outcome, can influence the immune response. The well known feeling of sleepiness and the lack of appetite associated with fever is in part a res ...
Cells and Tissues of the Immune System
... circulating Ab’s already present, challenge with Ag leads to the formation of Ag-Ab complexes, which bind to surfaces of follicular dendritic cells in germinal centers. The Ag is undegraded and is recognized by memory B cells generated during 1st response • Germinal centers gradually regress after A ...
... circulating Ab’s already present, challenge with Ag leads to the formation of Ag-Ab complexes, which bind to surfaces of follicular dendritic cells in germinal centers. The Ag is undegraded and is recognized by memory B cells generated during 1st response • Germinal centers gradually regress after A ...
Allergy Treatment
... – Increased blood flow – Swelling of the epithelial lining – Contraction of smooth muscle surrounding ...
... – Increased blood flow – Swelling of the epithelial lining – Contraction of smooth muscle surrounding ...
Yukon Immunization Manual: Section 14
... The most abundant class of antibody, constituting approximately 80% of all antibodies in serum Produced slowly upon primary exposure to an antigen Produced rapidly during secondary or subsequent exposure, becoming the major antibody present The principal humoral component of immunological me ...
... The most abundant class of antibody, constituting approximately 80% of all antibodies in serum Produced slowly upon primary exposure to an antigen Produced rapidly during secondary or subsequent exposure, becoming the major antibody present The principal humoral component of immunological me ...
