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Host microbe interactions BIO475 Dr. Dieter M. Schifferli
Host microbe interactions BIO475 Dr. Dieter M. Schifferli

... • Invasion of subepithelial tissue/inflammatory response – Polar movements and exit at the baso(lateral) epithelial surface – Adaptation to environment ( Fe2+) – Extracellular resistance to complement and PMN degranulation products ...
Immunogenetics: changing the face of immunodeficiency
Immunogenetics: changing the face of immunodeficiency

... with congenital agammaglobulinaemia and absent B cells3 and boys with a similar immunological profile but from an autosomal pedigree have also been reported, suggesting that the same immunophenotype can arise from a number of molecular defects. In 1993, two groups identified the gene defective in XL ...
Word File - University of Georgia College of Veterinary Medicine
Word File - University of Georgia College of Veterinary Medicine

... circulation of maternal cells between 12 and 30 hours after receiving colostrum. Immunology of the pig One of the most striking features of the immune system of the pig is the low ratio of CD4:CD8 T cells, generally less than 1:1 in adult. Mature pigs also have a large population of CD4, CD8 double ...
(SLE).
(SLE).

... - increased levels of type I IFN–induced genes in lupus PBMCs (MX1, the OAS family, and IFIT1) - both type I IFNs and type II IFN (IFN-γ) • fluctuation of IFN levels in individual patients - ELISA platforms for measuring IFN-α have not been useful - fluctuations in IFN-inducible gene expression in P ...
Microbiology
Microbiology

... thymus  Are activated by macrophages that have engulfed a bacteria and presented its antigen on its cell ...
Regents Exam Review Guide
Regents Exam Review Guide

... Enzymes and catalysts (proteins)- reaction rates (temperature and pH affect ...
Mader/Biology, 11/e – Chapter Outline
Mader/Biology, 11/e – Chapter Outline

... Like B cells, T cells have unique antigen receptors, called the T cell receptor, or TCR. However, the receptors of cytotoxic and helper T cells cannot recognize antigen present in the tissues, lymph, or blood. Instead, antigen must be presented to them by an antigen-presenting cell (APC). When an AP ...
Immune response to multiple stimuli
Immune response to multiple stimuli

Discovery of Viruses Near the end of the nineteenth century
Discovery of Viruses Near the end of the nineteenth century

... • For years after the initial infection, HIV continues to replicate (and mutate). Eventually and by chance, HIV’s surface glycoproteins change to the point that they now recognize a new cell surface receptor. This receptor is found on the subset of lymphocytes called T cells. • Unlike its activity i ...
Chapter 10 Classification
Chapter 10 Classification

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Information Packet

... ...
Intracellular Vesicular Traffic
Intracellular Vesicular Traffic

... Epithelial cells have two distinct early endosomal compartments but a common late endosomal compartment ...
Chapter 43: Immune System
Chapter 43: Immune System

... peptides to enter the tissue. Signals released by immune cells attract neutrophils. Neutrophils digest pathogens and cell debris at the site, and the tissue heals. 10. What role do natural killer cells play in the immune system? Cellular innate defenses in vertebrates involve natural killer cells, w ...
New cell for asthma: enter the myeloid
New cell for asthma: enter the myeloid

... eosinophils from the bone marrow and prolongs their survival once in the lung tissue. These mechanisms are used to explain the basics of asthma characterised by Th2 lymphocyte activation and the appearance of large numbers of eosinophils in the lung. However, it is clear from clinical practice that ...
target cells
target cells

... The adaptive immune response counters specific invaders  Our immune system responds to foreign molecules called antigens, which elicit the adaptive immune response.  The adaptive immune system – is found only in the vertebrates, – reacts to specific pathogens, and – “remembers” an invader. ...
T cell receptors, T cell function and signaling
T cell receptors, T cell function and signaling

... into effector cytolytic T cells (CTLs) that can kill infected target cells • Helper T cells: naïve CD4+ T cells differentiate into one of two types of effector cells – TH1 cells that activate macrophages – TH2 cells that help B cells produce antibodies ...
Echinococcus granulosus
Echinococcus granulosus

... Immunity in intermediate hosts Immune response against Oncosphere The earliest IgG response to oncospheral antigens appears after 11 weeks in mice and sheep challenged with eggs or oncospheres of E. granulosus Experiments in vitro have shown also that neutrophils, in association with antibody are d ...
AP Biology Cancer Webquest - Kallin-APBIO
AP Biology Cancer Webquest - Kallin-APBIO

... 1. What is Apoptosis? 2. How do normal cells and cancer cells differ? D. Processing Nutrients: 1. What is angiogenesis? 2. What role does is play in the development of tumors? E. Becoming Immortal: 1. How are telomeres related to cell aging? 2. What do cancer cells do that makes them immortal? F. In ...
Respiratory tract
Respiratory tract

... • stem cell – any type of leucocytes, erytrocytes or trombocytes can develop from them ...
Talk Title: Regulation of dendritic cell development at steady
Talk Title: Regulation of dendritic cell development at steady

... viruses,  it  triggers  signal  to  activate  antiviral  genes  including  those  of  type  I  and  III  IFN.     Activation  of   IFN   system   is   critical   as   antiviral   innate   immunity   and   promotes   activation   of   acq ...
Chap 43 Immune Syst
Chap 43 Immune Syst

... • Antigens are large molecules displayed on surfaces of cells/organisms; have unique molecular shapes; are proteins or polysaccharides • Antigen receptor = lymphocyte membrane protein which binds an Ag to the cell – In B cells the antibodies migrate in a transmembrane fashion and are secreted from ...
White Blood Cells (WBCs) or Leukocytes Types of WBCs:
White Blood Cells (WBCs) or Leukocytes Types of WBCs:

... the tissues. In times of serious tissue infection, this total life span is often shortened to only a few hours because the granulocytes then proceed rapidly to the infected area, perform their functions, and in the process are themselves destroyed. The monocytes also have a short transit time, 10 to ...
ABTIBODY SCREENING5
ABTIBODY SCREENING5

... cell, or when the patient’s serum contains an autoantibody, more than one screening cell will be positive.  A single Ab specificity should be suspected when all cells react at the same phase and strength.  Multiple Abs are most likely when cells react at different phases and strengths and auto-ant ...
Powerpoint - UCSF Immunology Program
Powerpoint - UCSF Immunology Program

... Shin H, Iwasaki A. A vaccine strategy that protects against genital herpes by establishing local memory T cells. 2012 Nature 491(7424):463-7 Braun A, Worbs T, Moschovakis GL, Halle S, Hoffmann K, Bölter J, Münk A, Förster R. Afferent lymph-derived T cells and DCs use different chemokine receptor CCR ...
2016 department of medicine research day
2016 department of medicine research day

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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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