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Immunology at a Glance. 10th Edition. At a Glance Brochure
Immunology at a Glance. 10th Edition. At a Glance Brochure

... day one of a medical, biomedical or life science course, the text begins with a basic overview of both adaptive and innate immunity, before progressing to applied immunological concepts, which look at what happens when things go wrong, and how, in clinical medicine, each body system can be affected ...
Tried and tested: From smallpox to measles
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... helper T cell, which determines whether it is necessary to take action. If the answer is positive, B lymphocytes are activated to produce large quantities of specific antibodies, which will eventually destroy the invading bacteria. ...
Factors affecting blood gene expression
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... cells in blood (lymphocytes and monocytes), with very few other cell types. Therefore, the gene expression pattern from fractionated blood will be different from whole blood. This is not only because of differences in blood cell composition, but also because fractionation can reportedly alter the ex ...
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... 34. What must a virus do to infect a host? Describe the process. What is the receptor for HIV? Which cells express this receptor? Describe how poliovirus can cause brain and spinal cord infection when it initially infects the digestive tract. 35. How can viruses avoid the effects of interferons? 36. ...
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Adaptive Immunity

... Where all lymphocytes arise (two words) Two _____ polypeptide chains form part of an antibody molecule The type of immune response to pathogens in fluids The class of proteins to which antibodies belong The smaller polypeptide chains of an antibody T-_____ cells bind to antigen-presenting cells Cell ...
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Gap junction-mediated antigen transport in immune responses

... increased GMAT could lead to a reduced viral load, ultimately reducing the number of dead cells. The optimal GMAT rate will be at a level at which the firebreak mechanism is strong enough to reduce viral load significantly and thereby reduce virus-induced cell death, while at the same time keeping G ...
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Lecture Note VII

... large occupying most of the cellular space. With respect to the amount of cytoplasm, lymphocytes are divided into small, medium and large. The lymphocytes are the main constituents of the immune system which is a defense against the attack of pathogenic micro-organisms such as viruses, bacteria, fun ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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