1 Modulation of HLA-G and HLA-E expression in - HAL
... production of immunosubversive molecules in the tissues they infect, resulting in the inactivation of T cells expressing receptors for these molecules. One such molecule, the Ligand of Fas, FasL, has been shown to be involved in the killing of migratory T cells into the nervous system (NS) in rabies ...
... production of immunosubversive molecules in the tissues they infect, resulting in the inactivation of T cells expressing receptors for these molecules. One such molecule, the Ligand of Fas, FasL, has been shown to be involved in the killing of migratory T cells into the nervous system (NS) in rabies ...
Very Diverse CD8 T Cell Clonotypic Responses after Virus
... (strain JHM) (7). Intranasal infection with this virus causes acute encephalitis with a robust T cell response (8). The CD8 T cell response in B6 mice is directed against an immunodominant and a subdominant epitope, encompassing residues 510 –518 (epitope S510, H-2Db restricted) and residues 598 – 6 ...
... (strain JHM) (7). Intranasal infection with this virus causes acute encephalitis with a robust T cell response (8). The CD8 T cell response in B6 mice is directed against an immunodominant and a subdominant epitope, encompassing residues 510 –518 (epitope S510, H-2Db restricted) and residues 598 – 6 ...
슬라이드 1 - Hanyang
... - graft rejection, host-versus-graft disease, and infection during the period before HSCs have engrafted and resumed full blood cell production - Knowledge of the key cellular actors in autoimmune disease, immune grafting, and graft rejection could also permit scientists to design gentler “minitrans ...
... - graft rejection, host-versus-graft disease, and infection during the period before HSCs have engrafted and resumed full blood cell production - Knowledge of the key cellular actors in autoimmune disease, immune grafting, and graft rejection could also permit scientists to design gentler “minitrans ...
Tumor Immunology and Immunotherapy
... tumors and may be expressed in fetal and adult tissues-similar to oncofetal antigens • Nonmutated HER-2/neu, ...
... tumors and may be expressed in fetal and adult tissues-similar to oncofetal antigens • Nonmutated HER-2/neu, ...
Experimental Biology and Medicine
... stimulate cell division and result in the formation of small, benign tumors. A similar promotion phase is thought to exist in naturally occurring cancers, but the actual events are still only poorly understood. Progression to malignancy occurs when the tight controls that normally govern cell cycle ...
... stimulate cell division and result in the formation of small, benign tumors. A similar promotion phase is thought to exist in naturally occurring cancers, but the actual events are still only poorly understood. Progression to malignancy occurs when the tight controls that normally govern cell cycle ...
Basic and Clinical Immunology
... • The spleen is located in the left upper quadrant of the abdomen. • Blood supply arrives via the splenic artery which divides into progressively smaller branches, then into arterioles which drain into vascular sinusoids which drain into the venous system. • It contains two types of tissues: red pul ...
... • The spleen is located in the left upper quadrant of the abdomen. • Blood supply arrives via the splenic artery which divides into progressively smaller branches, then into arterioles which drain into vascular sinusoids which drain into the venous system. • It contains two types of tissues: red pul ...
“Lymphocytes”. In: Encyclopedia of Life Sciences (ELS)
... with little cytoplasm and a dense nucleus (Kumar et al., 2007). They are relatively quiet in that they do not synthesise deoxyribonucleic acid (DNA), and transcribe limited amounts of ribonucleic acid (RNA). Under conventional light microscopy, lymphocytes have no distinguishable features, but sophi ...
... with little cytoplasm and a dense nucleus (Kumar et al., 2007). They are relatively quiet in that they do not synthesise deoxyribonucleic acid (DNA), and transcribe limited amounts of ribonucleic acid (RNA). Under conventional light microscopy, lymphocytes have no distinguishable features, but sophi ...
TRACE MINERALS ON THE IMMUNE RESPONSE FOLLOWING
... The adaptive or acquired immunity has the capacity to recognize specific antigens and has memory. The primary components of the adaptive immune system involve humoral (antibody production by B lymphocytes) and cell mediated immunity (developed mainly by CD4+ helper T cells, CD8+ cytotoxic T cells an ...
... The adaptive or acquired immunity has the capacity to recognize specific antigens and has memory. The primary components of the adaptive immune system involve humoral (antibody production by B lymphocytes) and cell mediated immunity (developed mainly by CD4+ helper T cells, CD8+ cytotoxic T cells an ...
Orthosteric, allosteric and metabotropic activity of alpha7 nAChR
... and expressed in many non-neuronal cells. These receptors function as homopentamers, with five binding sites for orthosteric agonists. Although activatible by acetylcholine (ACh) and the precursor molecule choline, orthosteric agonists produce relatively little channel activation compared to that ...
... and expressed in many non-neuronal cells. These receptors function as homopentamers, with five binding sites for orthosteric agonists. Although activatible by acetylcholine (ACh) and the precursor molecule choline, orthosteric agonists produce relatively little channel activation compared to that ...
Almanac, Vol. 47, No. 26 March 20, 2001
... Compstatin owes its effectiveness -- and potential use as a therapeutic -- to its small size. Compstatin's ring structure makes it resistant to proteases, enzymes that destroy proteins, so it is less likely to be broken down before it meets its target. Smaller molecules like Compstatin are also more ...
... Compstatin owes its effectiveness -- and potential use as a therapeutic -- to its small size. Compstatin's ring structure makes it resistant to proteases, enzymes that destroy proteins, so it is less likely to be broken down before it meets its target. Smaller molecules like Compstatin are also more ...
the emergence of immuno-oncology in clinical cancer research
... system to attack and destroy tumor cells, potentially transforming the treatment landscape. Additional important advantages beyond enhanced efficacy include reduced toxicity and an increased tolerability, which can further improve the chances of therapeutic success across a broad range of potential ...
... system to attack and destroy tumor cells, potentially transforming the treatment landscape. Additional important advantages beyond enhanced efficacy include reduced toxicity and an increased tolerability, which can further improve the chances of therapeutic success across a broad range of potential ...
The role of Th1/Th2 polarization in mucosal immunity
... regulate T-helper cell polarizatients with ulcerative colitis, an IBD thought to be mediated by tion are known, the original sources of these cytokines in vivo have been a matter of debate41. Recent evidence suggests a key T cells producing IL-5 rather than IFN-γ (ref. 28). role for DCs in orchestra ...
... regulate T-helper cell polarizatients with ulcerative colitis, an IBD thought to be mediated by tion are known, the original sources of these cytokines in vivo have been a matter of debate41. Recent evidence suggests a key T cells producing IL-5 rather than IFN-γ (ref. 28). role for DCs in orchestra ...
Supplemental Information Supplementary Materials and Methods
... MFI value of the relevant isotype control from the raw MFI value for each sample. Briefly, BM was isolated, depleted of Lineage positive cells using biotinylated antibodies against Gr-1, NK1.1, CD3, CD8, Ter119 and IgM and immunomagnetic negative selection (StemCell Technologies) (similar to protoco ...
... MFI value of the relevant isotype control from the raw MFI value for each sample. Briefly, BM was isolated, depleted of Lineage positive cells using biotinylated antibodies against Gr-1, NK1.1, CD3, CD8, Ter119 and IgM and immunomagnetic negative selection (StemCell Technologies) (similar to protoco ...
Lect 03 - Connective Tissue
... B-cells (adaptive immune system) Activation of B-cells ─ 1. B cells produce ‘immunoglobulin-receptors’ that are inserted on surface membrane ─ 2. antigens bind to receptors & induce B-cell differentiation into plasma and memory cells ─ 3. memory cells are long lived and allow quick attack against sa ...
... B-cells (adaptive immune system) Activation of B-cells ─ 1. B cells produce ‘immunoglobulin-receptors’ that are inserted on surface membrane ─ 2. antigens bind to receptors & induce B-cell differentiation into plasma and memory cells ─ 3. memory cells are long lived and allow quick attack against sa ...
Training load and URTI - ACCEPTED MS Text 01-11
... 2.2 vs 1.0 ± 1.6, respectively: P < 0.05). The HIGH group had ~3-fold higher IL-2, IL-4 and ...
... 2.2 vs 1.0 ± 1.6, respectively: P < 0.05). The HIGH group had ~3-fold higher IL-2, IL-4 and ...
Human IL-23-producing type 1 macrophages promote but IL
... Macrophages (M) play a central role as effector cells in immunity to intracellular pathogens such as Mycobacterium. Paradoxically, they also provide a habitat for intracellular bacterial survival. This paradoxical role of M remains poorly understood. Here we report that this dual role may emanate ...
... Macrophages (M) play a central role as effector cells in immunity to intracellular pathogens such as Mycobacterium. Paradoxically, they also provide a habitat for intracellular bacterial survival. This paradoxical role of M remains poorly understood. Here we report that this dual role may emanate ...
The interplay of infection, stress and the immune response
... MMP-9 during labor, delivery, and 1 to 2 days after calving. In addition, there was inhibited expression of TIMP genes and genes that normally keep TIMP expression at normal levels during this period. • HIgh MMP activity in the blood serum of these cows, suggesting that neutrophils become activated ...
... MMP-9 during labor, delivery, and 1 to 2 days after calving. In addition, there was inhibited expression of TIMP genes and genes that normally keep TIMP expression at normal levels during this period. • HIgh MMP activity in the blood serum of these cows, suggesting that neutrophils become activated ...
Chapter 19
... inflammatory chemicals like histamine. Release chemicals that help destroy tapeworms, flukes, pinworms, and hookworms. Account for 2-4% of the WBC. ...
... inflammatory chemicals like histamine. Release chemicals that help destroy tapeworms, flukes, pinworms, and hookworms. Account for 2-4% of the WBC. ...
Cancer Immunotherapy - British Society for Immunology
... Cancer immunotherapy is portrayed in the media as providing hope for the long sought after “cure for cancer”. However, this is an emerging field and there are a number of challenges yet to be overcome before the full potential of cancer immunotherapy can be realised. Cancer immunotherapy is not a “o ...
... Cancer immunotherapy is portrayed in the media as providing hope for the long sought after “cure for cancer”. However, this is an emerging field and there are a number of challenges yet to be overcome before the full potential of cancer immunotherapy can be realised. Cancer immunotherapy is not a “o ...
Blood and the circulatory system
... Function #3- Facilitating immune responses by recognizing microbes or abnormal cells and killing them directly or by antibodies. ...
... Function #3- Facilitating immune responses by recognizing microbes or abnormal cells and killing them directly or by antibodies. ...
Immunomodulatory effects of Lactobacillus casei Shirota
... associated with spleen, lung and peritoneal macrophages were activated by L. casei administration. The secretion of lysosomal enzymes from macrophages in mice fed fermented milk containing L. casei was found to be more effective compared with feeding the mice fermented milk containing other probioti ...
... associated with spleen, lung and peritoneal macrophages were activated by L. casei administration. The secretion of lysosomal enzymes from macrophages in mice fed fermented milk containing L. casei was found to be more effective compared with feeding the mice fermented milk containing other probioti ...
Thioaptamer decoy targeting of AP-1 proteins influences cytokine
... The P388D1 macrophage-like cell line contains members of the AP-1 family which may act as negative regulators of AP-1-controlled transcription. XBY-S2 was found to bind to Fra-2 and JunB, and enhance the induction of cytokines IL-6, IL-8 and TNF-a, while reducing the binding to AP-1 promoter element ...
... The P388D1 macrophage-like cell line contains members of the AP-1 family which may act as negative regulators of AP-1-controlled transcription. XBY-S2 was found to bind to Fra-2 and JunB, and enhance the induction of cytokines IL-6, IL-8 and TNF-a, while reducing the binding to AP-1 promoter element ...
No Slide Title
... The stress-illness correlation. One or more aspects of personality, physiology, or memory could play the role of a postulated third variable in the relationship between high stress and high incidence of illness. For example, neuroticism may lead some subjects to view more events as stressful and to ...
... The stress-illness correlation. One or more aspects of personality, physiology, or memory could play the role of a postulated third variable in the relationship between high stress and high incidence of illness. For example, neuroticism may lead some subjects to view more events as stressful and to ...
