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Passive vs active & vaccines
Passive vs active & vaccines

... Natural immunity: active and passive • An infection is an example of acquiring natural immunity. It is called ACTIVE as your body needs to work to produce the necessary antibodies • When a mother breast feeds her baby she passes antibodies to it. This is a way of acquiring PASSIVE immunity as it is ...
Signaling pathways implicated in the cellular innate immune
Signaling pathways implicated in the cellular innate immune

... importance of phagocytosis and other cell-mediated responses in eliminating various pathogens. Receptorligand binding activates signaling cascades that promote collaborative cellular interactions and the production of pathogen-specific cytotoxic responses. Numerous comparative genetic and molecular ...
T cell
T cell

... • Amplitude and quality of a Tcell response is regulated by a balance of activating and inhibitory signals CTLA-4 = cytotoxic T-lymphocyte antigen-4; LAG-3 = lymphocyte activation gene-3; PD-1 = programmed death-1; PD-L1 = programmed death-ligand 1. ...
Factors Regulating Immunoglobulin Production by Normal and
Factors Regulating Immunoglobulin Production by Normal and

... cell differentiation due to exposure to TI antigen [19,20]. Through the research conducted over the past two decades, a handful of what have been termed master regulators of GC reactions and subsequent PC differentiation have been identified. These transcription factors include B cell lymphoma 6 (BC ...
vaccines
vaccines

... encoding secreted FliC (pFliC(-gly)) and plasmid encoding a model antigen (ovalbumin) by three different immunization routes representative of dermal, systemic, and mucosal tissues. By all three routes we observed increases in antigen-specific antibodies in serum as well as MHC Class I-dependent cel ...
Programme
Programme

A generalized quantitative antibody homeostasis model
A generalized quantitative antibody homeostasis model

... body, reaching various tissues and organs via the blood and the lymphatics. B cells are defined by their  ability to rearrange the genetic loci coding the surface immunoglobulin (Ig) of the B‐cell antigen receptor  (BCR) complex and by their ability to secrete antibodies in later stages of their dev ...
A hypothesis for the initiation of COPD PERSPECTIVE
A hypothesis for the initiation of COPD PERSPECTIVE

... Host immune response to the altered LEBCs Various forms of cell damage lead to DNA fragmentation and destruction of the repair potential that allow its recognition as ‘‘foreign’’ [52, 53]. This hypothesis considers that once the LEBCs suffer oxidative DNA damage, they are detected as ‘‘nonself’’ by ...
Biol 155 Human Physiology - Department of Zoology, UBC
Biol 155 Human Physiology - Department of Zoology, UBC

... Organized in cortex and medulla Substances removed by phagocytosis or stimulate lymphocytes or both Only structures to filter lymph ...
Hooper LV, Macpherson AJ.. Immune adaptations that maintain
Hooper LV, Macpherson AJ.. Immune adaptations that maintain

... the host genome. commensal microorganisms such as Bacteroides thetaiotaomicron are uniquely adapted for harvesting luminal nutrients, as shown by the presence of an unusually large number of genes in these microorganisms that encode carbohydrate-degrading enzymes6. millions of years of co-evolution ...
Phagocytosis and Encapsulation: Cellular Immune Responses in
Phagocytosis and Encapsulation: Cellular Immune Responses in

... but does it contain opsonic factors? The standard test for serum opsonins is (1980) found that a component of Bombyx the addition of serum-treated or untreated mori (L.) serum causes the elongation of test particles (often mammalian erythro- hemocytic filipodia, an action which could cytes) to hemoc ...
Glossary - ASPIRA Association
Glossary - ASPIRA Association

... When a person infected with HIV develops antibodies to the HIV virus. ...
Identification of the yaa lupus as a IIr
Identification of the yaa lupus as a IIr

... (Btk), a molecule known to be critical for marginal zone B-cell formation and B-cell hyperreactivity [11], they would be able to rescue the humoral autoimmune phenotype caused by Yaa. In line with their expectation, they demonstrated that the introduction of Btk deficiency completely rescued both th ...
Defense against the dark arts
Defense against the dark arts

... • All lymphocytes are sensitive to specific chemicals (antigens) – Antigens can be: ...
Increased Generation of HIV-1 gp120-Reactive Encoding the Chemokine CCL3
Increased Generation of HIV-1 gp120-Reactive Encoding the Chemokine CCL3

... expressing the corresponding chemokine receptors to the injection site of the vaccine, and promote cellular uptake of the vaccine antigen into endocytic compartments of APCs. One example is the chemokine CCL3 which is a ligand of the chemokine receptors CCR1 and CCR5 and which production is inducibl ...
on Immune Function
on Immune Function

... and macrophages to phagocytize invading organisms is another type of defense. Cellmediated responses of the T cells and natural killer (NK) cells play a crucial role in controlling invading organisms as do the antibody-producing B cells. Other immune cell products such as cytokines and metalloprotea ...
Innate responses of B cells
Innate responses of B cells

... TLR9. Their response to these stimuli can be to proliferate, to differentiate into antibody secreting cells, to become more efficient antigen-presenting cells (APC), or to secrete cytokines. Clearly, the responses of B cells to antigens in their environment are not solely mediated through the BCR. C ...
STRUCTURE AND FUNCTION OF THE SPLEEN
STRUCTURE AND FUNCTION OF THE SPLEEN

... Recently, various publications have reported that whether marginal-zone B cells or follicular B cells are generated is a cell-fate decision of mature B cells that is controlled by signalling through Notch proteins and by the activity of E proteins90,91. In the absence of Notch-2 or RBP-J (Igκ joinin ...
Chitosan, but not bacterial siderophores, induces a partial
Chitosan, but not bacterial siderophores, induces a partial

... In order to gain further insight into this action, we also used various commercially-available chitin degradation products (chitosans). The results, shown on figure 3 clearly demonstrate that siderophores do not induce any DC activation, while chitin degradation products could induce this activation ...
Pathogenesis of HIV: Pathway to eradication
Pathogenesis of HIV: Pathway to eradication

... control appears to be mediated by a unique CD8+ cell response that identifies an important target for potential HIV vaccines and HIV-specific, immune-based therapies [26]. • Therapeutic vaccines Therapeutic vaccines are immunotherapies aimed at restoring a cellular immunity importantly through the c ...
Post-traumatic stress disorder - Resurrecting Lives Foundation
Post-traumatic stress disorder - Resurrecting Lives Foundation

... produced by T-lymphocytes in response to antigen-presenting cell (APC) stimulation. These cells may have a ‘memory’ of prior exposure to foreign proteins or pathogens, or can be naive (that is, no memory). Those T cells expressing CD4+ surface markers are known as ‘T-helper’ cells, and are further s ...
Exploring Therapeutic Combinations with anti-CTLA
Exploring Therapeutic Combinations with anti-CTLA

... Pre-surgical Phase IIa study with Ipilimumab plus Lupron in patients with localized prostate cancer Phase I study with Ipilimumab plus MDX-1106 (anti-PD-1) in patients with melanoma Phase I/II study with Ipilimumab plus cryoablation in patients with breast cancer Planned study with Ipilimumab plus S ...
Evasive Mechanisms of Oral Microflora - e
Evasive Mechanisms of Oral Microflora - e

... activity, thus, enhancing bone resorption. This activity is enhanced by another bone degrading protein, chaperonin 60. A serotype-specific capsular polysaccharide antigen stimulates osteoclasts formation while at the same time, inducing osteoblastic apoptosis [15]. c) Tissue repair inhibition: A. ac ...
The evolution of natural killer cell receptors
The evolution of natural killer cell receptors

... or lysine) in their transmembrane region, and are associated with signaling adaptor molecules containing immunoreceptor tyrosine-based activating motifs (ITAM), such as DAP10, DAP12, or Fcγ R (Lanier 2005). NK cells integrate signals derived from both types of receptors upon cellular contact, thereb ...
True/False Indicate whether the sentence or statement is true or
True/False Indicate whether the sentence or statement is true or

... Loose connective tissue has fibers that are tightly woven among themselves. ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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