Raulet, D. H. and N. Guerra. 2009. Oncogenic stress sensed by the immune system: role of natural killer cell receptors. Nat Rev Immunol 9:568-580.
... perforin in immune surveillance of cancer was shown by the deletion of the gene encoding perforin in two mouse strains11,12,14. TNF-related apoptosis-inducing ligand (TRAIl; also known as TNFRSF10), another mediator of cytolysis, has also been implicated in responses against cancer13. These studies ...
... perforin in immune surveillance of cancer was shown by the deletion of the gene encoding perforin in two mouse strains11,12,14. TNF-related apoptosis-inducing ligand (TRAIl; also known as TNFRSF10), another mediator of cytolysis, has also been implicated in responses against cancer13. These studies ...
Immunotherapy of Breast Cancer
... 1x108 CFU administered i.p. in C57BL/6 and IFN-γ knock out (GKO) mice. (Limit of detection is 100 CFU) ...
... 1x108 CFU administered i.p. in C57BL/6 and IFN-γ knock out (GKO) mice. (Limit of detection is 100 CFU) ...
Immunotherapy for prostate cancer: the next step?
... and injection site reactions.14 It is not yet clear at which stage of disease PROSTVAC-VF will be most effective; the results of studies evaluating its use in non-metastatic hormone-sensitive prostate cancer are awaited. Another viral vaccine in early development uses adenovirus type 5 vectors to de ...
... and injection site reactions.14 It is not yet clear at which stage of disease PROSTVAC-VF will be most effective; the results of studies evaluating its use in non-metastatic hormone-sensitive prostate cancer are awaited. Another viral vaccine in early development uses adenovirus type 5 vectors to de ...
Stem cell biology is population biology: differentiation of
... Recent whole organism manipulations have demonstrated the veracity of this proposition (see [10] for myeloid cells; [11] for lymphoid cells). At the same time, when the organism is in a steady state (homeostasis) the HSC system and its products are relatively stable [12]. In addition, the demand is ...
... Recent whole organism manipulations have demonstrated the veracity of this proposition (see [10] for myeloid cells; [11] for lymphoid cells). At the same time, when the organism is in a steady state (homeostasis) the HSC system and its products are relatively stable [12]. In addition, the demand is ...
Difference in cytokine production and cell cycle
... (TNFR). LMP1 activates the transcription factor nuclear factor-κB (NF-κB) by promoting turnover of IκBα, an important inhibitor of NF-κB, conferring the cells a protection against apoptosis. A direct link between LMP1 and cell cycle progression has also been shown in several studies although they we ...
... (TNFR). LMP1 activates the transcription factor nuclear factor-κB (NF-κB) by promoting turnover of IκBα, an important inhibitor of NF-κB, conferring the cells a protection against apoptosis. A direct link between LMP1 and cell cycle progression has also been shown in several studies although they we ...
Rheumatoid arthritis is an autoimmune disease in which the target
... are initially monocytes that squeeze through gaps in capillary walls to reach an infection site where they then expand and become able to engulf and break down pathogens using lysozyme. The more important of the two phagocytes are the neutrophils that not only engulf and break down pathogens, but al ...
... are initially monocytes that squeeze through gaps in capillary walls to reach an infection site where they then expand and become able to engulf and break down pathogens using lysozyme. The more important of the two phagocytes are the neutrophils that not only engulf and break down pathogens, but al ...
T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel
... 1F). The results of flow cytometry were reproducible in a profile that positively correlated with our LNLV density measurements, verifying the reliability of our immunohistochemical data. The LNLVs of athymic mice densely covered the entire T cell-absent LN paracortex, a corresponding region where L ...
... 1F). The results of flow cytometry were reproducible in a profile that positively correlated with our LNLV density measurements, verifying the reliability of our immunohistochemical data. The LNLVs of athymic mice densely covered the entire T cell-absent LN paracortex, a corresponding region where L ...
Immune Abnormalities in Patients Meeting New Diagnostic Criteria
... Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria. Significant developments have been made to diagnostic criteria, but potential immunological markers have no ...
... Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria. Significant developments have been made to diagnostic criteria, but potential immunological markers have no ...
Aberrant DNA Methylation in Cholangiocarcinoma
... inhibitor 5-Aza-CdR, which is an analog of cytidine, has been widely studied and was recently approved for the treatment of myelodysplastic syndrome (MDS). However the effect of DNA methylation inhibitors on patients with cholangiocarcinoma remains to be elucidated. In this review, we summarize the ...
... inhibitor 5-Aza-CdR, which is an analog of cytidine, has been widely studied and was recently approved for the treatment of myelodysplastic syndrome (MDS). However the effect of DNA methylation inhibitors on patients with cholangiocarcinoma remains to be elucidated. In this review, we summarize the ...
Cytokines in anaesthesia - Oxford Academic
... adequate numbers to analyse their response patterns and functions. Consequently, even basic questions remain unresolved. It seems the inhibitory effects of these suppressor lymphocytes may be mediated by suppressor proteins which are soluble receptors belonging to this lymphocyte subset, hence their ...
... adequate numbers to analyse their response patterns and functions. Consequently, even basic questions remain unresolved. It seems the inhibitory effects of these suppressor lymphocytes may be mediated by suppressor proteins which are soluble receptors belonging to this lymphocyte subset, hence their ...
roles in innate immune receptors: host - pathogen
... The CLRs consist of around one thousand members although all of them are not involved in recognition of PAMPs. These receptors typically recognize carbohydrates that are rich in mannose, fucose and glycan. The downstream result of binding to CLRs is often classified as activation of adaptive Th17 or ...
... The CLRs consist of around one thousand members although all of them are not involved in recognition of PAMPs. These receptors typically recognize carbohydrates that are rich in mannose, fucose and glycan. The downstream result of binding to CLRs is often classified as activation of adaptive Th17 or ...
Maternal Recognition of Pregnancy
... avoidance of direct immune confrontation. Finally, we close the review by describing some work from this laboratory on an unusual group of molecules, the pregnancy-associated glycoproteins, that are released at the trophoblast-uterine interface in a surprisingly broad collection of mammals. Their fu ...
... avoidance of direct immune confrontation. Finally, we close the review by describing some work from this laboratory on an unusual group of molecules, the pregnancy-associated glycoproteins, that are released at the trophoblast-uterine interface in a surprisingly broad collection of mammals. Their fu ...
Antiviral activity of Engystol® and Gripp-Heel®: an in
... defence mechanism in the early stage of viral infection. Interferon (IFN) release, triggered by virus infection, is an important factor in establishing an antiviral state, where IFN activation occurs prior to the onset of the adaptive immune response. The two ultra-low-dose combination medications, ...
... defence mechanism in the early stage of viral infection. Interferon (IFN) release, triggered by virus infection, is an important factor in establishing an antiviral state, where IFN activation occurs prior to the onset of the adaptive immune response. The two ultra-low-dose combination medications, ...
Immunology
... In some biological reactions high affinity is superior to low affinity like in haemagglutination, haemolysis, complement fixation and enzyme inactivation. ...
... In some biological reactions high affinity is superior to low affinity like in haemagglutination, haemolysis, complement fixation and enzyme inactivation. ...
Review Article: Human Gut Flora
... The intestinal microflora is a complex ecosystem. An improved understanding of this hidden organ will reveal secrets that are relevant to human health and to several infectious, inflammatory and neoplastic disease processes. Given the ability of the immune response to rapidly counter infectious agen ...
... The intestinal microflora is a complex ecosystem. An improved understanding of this hidden organ will reveal secrets that are relevant to human health and to several infectious, inflammatory and neoplastic disease processes. Given the ability of the immune response to rapidly counter infectious agen ...
Distinct lines of chickens express different splenic cytokine profiles
... Figure 1. Mean IL-18 and IL-6 mRNA expression levels by genetic line, in the spleen of hens either nonchallenged or challenged with Salmonella Enteritidis. a,bBars not sharing a letter indicate a suggestive difference shown by Tukey’s test (P < 0.1). A,BBars not sharing a letter are shown to be sign ...
... Figure 1. Mean IL-18 and IL-6 mRNA expression levels by genetic line, in the spleen of hens either nonchallenged or challenged with Salmonella Enteritidis. a,bBars not sharing a letter indicate a suggestive difference shown by Tukey’s test (P < 0.1). A,BBars not sharing a letter are shown to be sign ...
written report
... lasts from 2-14 days and a rash that may be seen from 3-8 days (“Detailed Guide,” 2005). Diagnosis is typically done through blood testing, but even after a diagnosis is made, treatment is still experimental. It is important for patients to understand that although both KS and HHV-8 can be treated, ...
... lasts from 2-14 days and a rash that may be seen from 3-8 days (“Detailed Guide,” 2005). Diagnosis is typically done through blood testing, but even after a diagnosis is made, treatment is still experimental. It is important for patients to understand that although both KS and HHV-8 can be treated, ...
Here - Vanderbilt University
... must survive digestive enzymes and invade the midgut epithelium by either digesting a thick acellular chitinaceous peritrophic matrix formed in response to blood feeding or by initiating epithelium invasion prior to the formation of this matrix.28‑30 The mechanisms leading to midgut penetration are ...
... must survive digestive enzymes and invade the midgut epithelium by either digesting a thick acellular chitinaceous peritrophic matrix formed in response to blood feeding or by initiating epithelium invasion prior to the formation of this matrix.28‑30 The mechanisms leading to midgut penetration are ...
Evidence-based guidelines for the investigation of recurrent
... • Diagnosis: Traditionally, laparoscopy, HSG and/or hysteroscopy have been used to these uterine malformations in women with RM. • Ultrasound, and in particular 3D ultrasound, has become an accurate, reproducible, non-invasive, out-patient method for the diagnosis of congenital uterine anomalies (Sa ...
... • Diagnosis: Traditionally, laparoscopy, HSG and/or hysteroscopy have been used to these uterine malformations in women with RM. • Ultrasound, and in particular 3D ultrasound, has become an accurate, reproducible, non-invasive, out-patient method for the diagnosis of congenital uterine anomalies (Sa ...
Dendritic Cell-Based Immunotherapy
... immune resistance to tumors. CD8 + cytolytic T cells (CTLs) directly kill tumor cells expressing the appropriate MHC-peptide complexes, whereas NK and NKT cells eliminate targets that downregulate MHC class I expression to escape a CTL attack. CD4 + helper T cells assist in inducing and maintaining ...
... immune resistance to tumors. CD8 + cytolytic T cells (CTLs) directly kill tumor cells expressing the appropriate MHC-peptide complexes, whereas NK and NKT cells eliminate targets that downregulate MHC class I expression to escape a CTL attack. CD4 + helper T cells assist in inducing and maintaining ...