ducing antibodies with a slightly different configuration at the antigen-
... Proteolytic fragments can be helpful in analyzing how antibodies bind in vitro. For example, to test whether the Fc piece is important for a particular function, you can compare intact antibody with F(ab )2 fragments of the same antibody. When using antibodies to stain cells in immunohistochemical o ...
... Proteolytic fragments can be helpful in analyzing how antibodies bind in vitro. For example, to test whether the Fc piece is important for a particular function, you can compare intact antibody with F(ab )2 fragments of the same antibody. When using antibodies to stain cells in immunohistochemical o ...
Testosterone and sexual selection
... Sperm cells are non-self to die male and therefore targets of immunological attacks in the reproductive tract Consequently, sperm cells, and eventually ejaculate quality, are influenced by a male's ability to down-regulate immune responses during the production df ejaculates, a process potentially r ...
... Sperm cells are non-self to die male and therefore targets of immunological attacks in the reproductive tract Consequently, sperm cells, and eventually ejaculate quality, are influenced by a male's ability to down-regulate immune responses during the production df ejaculates, a process potentially r ...
Gene-set - Bader Lab
... How do pathways and processes differ? – In a purely biological perspective, the question is philosophical (still worth speculating…) – In a bioinformatics perspective: • A gene is annotated for a GO Biological Processes if the curators deem it (significantly) contributes to the process (which is at ...
... How do pathways and processes differ? – In a purely biological perspective, the question is philosophical (still worth speculating…) – In a bioinformatics perspective: • A gene is annotated for a GO Biological Processes if the curators deem it (significantly) contributes to the process (which is at ...
Definition of a Conserved Immunodominant Domain on Hepatitis C
... epitopes that are conserved among different HCV genotypes. Five human monoclonal antibodies (HMAbs) are described that cross-compete with other antibodies to a cluster of overlapping epitopes, previously designated domain B. Each HMAb broadly neutralizes retroviral pseudotype particles expressing HC ...
... epitopes that are conserved among different HCV genotypes. Five human monoclonal antibodies (HMAbs) are described that cross-compete with other antibodies to a cluster of overlapping epitopes, previously designated domain B. Each HMAb broadly neutralizes retroviral pseudotype particles expressing HC ...
Susceptibility to tuberculosis is associated with variants in
... the MHC region, none of those loci was significantly associated with TB after Bonferroni correction (Supplementary Tables 3 and 4). Our only genome-wide significant TB-associated locus was on chromosome 8q24, where 11 SNPs located in introns of the ASAP1 gene had P < 5 × 10−8 (Fig. 1); the strongest ...
... the MHC region, none of those loci was significantly associated with TB after Bonferroni correction (Supplementary Tables 3 and 4). Our only genome-wide significant TB-associated locus was on chromosome 8q24, where 11 SNPs located in introns of the ASAP1 gene had P < 5 × 10−8 (Fig. 1); the strongest ...
Complexity in cancer stem cells and tumor evolution: towards
... seems plausible that both factors contribute to metastasis. The possibility that cancer cells can switch into CSCs under specific conditions dictated by a depletion in the number of CSCs or by the environments, opens a new perspective on the metastatic process. The metastatic process is usually intr ...
... seems plausible that both factors contribute to metastasis. The possibility that cancer cells can switch into CSCs under specific conditions dictated by a depletion in the number of CSCs or by the environments, opens a new perspective on the metastatic process. The metastatic process is usually intr ...
Suppression of adaptive immunity to heterologous antigens during
... after LPS stimulation (Figure 2e,f), suggesting that the presence of parasites does not result in DC activation. The viability of treated DCs and control cells was quantified after 24 hours of culture by trypan blue exclusion (Figure 2g) and propidium iodide (PI) and annexin V staining (data not sho ...
... after LPS stimulation (Figure 2e,f), suggesting that the presence of parasites does not result in DC activation. The viability of treated DCs and control cells was quantified after 24 hours of culture by trypan blue exclusion (Figure 2g) and propidium iodide (PI) and annexin V staining (data not sho ...
Probing Cell Wall Structure and Development by
... antibody to bind. Specific epitopes may be structurally altered or masked by other components in the system, and thus inaccessible to the antibody (Knox, 2008). For example, the pre-treatment of sections of plant material with pectate lyase [in N-cyclohexyl3-aminopropanesulfonic acid (CAPS) buffer] ...
... antibody to bind. Specific epitopes may be structurally altered or masked by other components in the system, and thus inaccessible to the antibody (Knox, 2008). For example, the pre-treatment of sections of plant material with pectate lyase [in N-cyclohexyl3-aminopropanesulfonic acid (CAPS) buffer] ...
CONNECTIVE TISSUE
... - fibrous tissue with fewer cells (cells are mostly fibroblasts) - collagen fibers are bundles, without definite orientation - found in dermis, prostate, mammary glands, outer capsule of many organs 2. dense regularly arranged connective tissue (DRACT) - made of many fibers that run in the same dire ...
... - fibrous tissue with fewer cells (cells are mostly fibroblasts) - collagen fibers are bundles, without definite orientation - found in dermis, prostate, mammary glands, outer capsule of many organs 2. dense regularly arranged connective tissue (DRACT) - made of many fibers that run in the same dire ...
Aplastic anemia (AA) is a bone marrow failure disease, which mainly
... be that the generation of CD4+ cells depend mainly on the thymus, while the formation and maturation of CD8+ cells are not completely dependent on the thymus[10]. Related research[11] showed that, lymphocyte subsets especially the dynamic balance of T lymphocyte subsets was related to immune functio ...
... be that the generation of CD4+ cells depend mainly on the thymus, while the formation and maturation of CD8+ cells are not completely dependent on the thymus[10]. Related research[11] showed that, lymphocyte subsets especially the dynamic balance of T lymphocyte subsets was related to immune functio ...
Successful Plating Strategies
... yielded a strong response, the fusion should be repeated, but the choice of screening method should be re-evaluated. If the immune response was weak, new approaches to the immunization should be tried. If only a few positive clones were identified, these should be tested as early as possible to dete ...
... yielded a strong response, the fusion should be repeated, but the choice of screening method should be re-evaluated. If the immune response was weak, new approaches to the immunization should be tried. If only a few positive clones were identified, these should be tested as early as possible to dete ...
Characterization of immune cells in psoriatic adipose tissue
... Immunophenotyping studies of human adipose have generally assumed that characteristic markers of immune cells described in animal models or in other human tissues can be applied similarly to adipose tissue. A major limitation of prior studies has been a paucity of data confirming flow cytometric ana ...
... Immunophenotyping studies of human adipose have generally assumed that characteristic markers of immune cells described in animal models or in other human tissues can be applied similarly to adipose tissue. A major limitation of prior studies has been a paucity of data confirming flow cytometric ana ...
The Antinociceptive Effect of Dexmedetomidine Modulates Spleen
... injury through nociceptor-induced sympathetic activation, because immune cells of lymphoid organs express adrenorecptors [1]. Generally, pain enhances the cytotoxic activity of natural killer (NK) cells, the lymphoproliferative response of lymphoid tissue, and cytokine production by immune cells [2, ...
... injury through nociceptor-induced sympathetic activation, because immune cells of lymphoid organs express adrenorecptors [1]. Generally, pain enhances the cytotoxic activity of natural killer (NK) cells, the lymphoproliferative response of lymphoid tissue, and cytokine production by immune cells [2, ...
Postprint
... was detectable both for the number of lesional parasites in infected skin (left panel) or the degree of parasite dissemination into spleen, which is a prominent feature of visceral leishmaniasis (right panel). Even though IL-22 does not directly signal to immune cells, it can initiate skin inflammat ...
... was detectable both for the number of lesional parasites in infected skin (left panel) or the degree of parasite dissemination into spleen, which is a prominent feature of visceral leishmaniasis (right panel). Even though IL-22 does not directly signal to immune cells, it can initiate skin inflammat ...
Human Leukocyte Antigen-Class II-Positive
... In the cornea, it is thought that Langerhans cells, which exist in limbal and peripheral cornea, can be potent APCs. It has been shown that rabbit corneal endothelium, expressing class II antigen after treatment with IFN-y, could stimulate fresh allogenic lymphocytes.25 On the other hand, human corn ...
... In the cornea, it is thought that Langerhans cells, which exist in limbal and peripheral cornea, can be potent APCs. It has been shown that rabbit corneal endothelium, expressing class II antigen after treatment with IFN-y, could stimulate fresh allogenic lymphocytes.25 On the other hand, human corn ...
innate immunity in c. elegans
... are absent from the C. elegans genome. One prominent class of PRRs, in vertebrates the TLRs, can sense outer membrane components of the bacteria, RNA or DNA.22 As mentioned above, the single worm TLR, TOL‑1, is involved in behavioural avoidance of some pathogenic bacteria,4,5 but does not seem to pl ...
... are absent from the C. elegans genome. One prominent class of PRRs, in vertebrates the TLRs, can sense outer membrane components of the bacteria, RNA or DNA.22 As mentioned above, the single worm TLR, TOL‑1, is involved in behavioural avoidance of some pathogenic bacteria,4,5 but does not seem to pl ...
Surface Protein-1 Carboxyl-Terminal Fragment of Merozoite
... passively protected by adoptively transferred Abs. B10.BR mice are not protected following vaccination with GST-MSP119 (6). The reasons for this are not clear, but may relate to the titer of Ab induced by vaccination or to other factors such as the fine specificity of the Ab response. However, these ...
... passively protected by adoptively transferred Abs. B10.BR mice are not protected following vaccination with GST-MSP119 (6). The reasons for this are not clear, but may relate to the titer of Ab induced by vaccination or to other factors such as the fine specificity of the Ab response. However, these ...
Airway smooth muscle cells respond directly to inhaled
... Asthma was first described as a pathology of the airway smooth muscle since all asthma cases examined presented one unique pathology, an increased mass of airway smooth muscle bundles [23]. Today an increasing number of publications have provided evidence on both the clinical and experimental level ...
... Asthma was first described as a pathology of the airway smooth muscle since all asthma cases examined presented one unique pathology, an increased mass of airway smooth muscle bundles [23]. Today an increasing number of publications have provided evidence on both the clinical and experimental level ...
Chapter 5 Protein Function
... surface of the killer T cells called T-cell receptors • The TH cells produce soluble signaling proteins called cytokines that interact with other proteins and cells of the immune system Chapter 5 ...
... surface of the killer T cells called T-cell receptors • The TH cells produce soluble signaling proteins called cytokines that interact with other proteins and cells of the immune system Chapter 5 ...