B-cell receptor signal strength and zinc signaling: unraveling the
... primary arms of the adaptive immune system. Resting mature follicular (FO) B cells in the spleen are essential for antibody-mediated immune responses. They recirculate through the blood, and are activated upon the binding of various diverse cognate antigens to the specific B cell antigen receptor (B ...
... primary arms of the adaptive immune system. Resting mature follicular (FO) B cells in the spleen are essential for antibody-mediated immune responses. They recirculate through the blood, and are activated upon the binding of various diverse cognate antigens to the specific B cell antigen receptor (B ...
Stress: The Constant Challenge
... * Past Experiences General Adaptation Syndrome (G.A.S.) * Alarm – Fight or Flight * Resistance * Exhaustion * Allostatic load Alarm Phase Psychoneuroimmunology (PNI) * The study of …. * Complex network of nerve and chemical connections between the nervous system, endocrine system and the immune syst ...
... * Past Experiences General Adaptation Syndrome (G.A.S.) * Alarm – Fight or Flight * Resistance * Exhaustion * Allostatic load Alarm Phase Psychoneuroimmunology (PNI) * The study of …. * Complex network of nerve and chemical connections between the nervous system, endocrine system and the immune syst ...
2014 Lifespan Research Day PROGRAM 3 November 2014
... O4: Yvonne Zurynski Growing up with neuromuscular disorders: experiences of transition from paediatric to adult health services O5: Loretta Lau Alternative Lengthening of Telomeres (ALT) predicts poor outcome in neuroblastoma O6: Wendy Gold Microtubule dysfunction can be corrected by HDAC6 inhibitor ...
... O4: Yvonne Zurynski Growing up with neuromuscular disorders: experiences of transition from paediatric to adult health services O5: Loretta Lau Alternative Lengthening of Telomeres (ALT) predicts poor outcome in neuroblastoma O6: Wendy Gold Microtubule dysfunction can be corrected by HDAC6 inhibitor ...
The Immune System Terminology Glossary
... also known as antibodies, produced by B cells. immunosuppressive—capable of reducing immune responses. inflammatory response—redness, warmth, and swelling produced in response to infection, as the result of increased blood flow and an influx of immune cells and secretions. interferons—proteins produ ...
... also known as antibodies, produced by B cells. immunosuppressive—capable of reducing immune responses. inflammatory response—redness, warmth, and swelling produced in response to infection, as the result of increased blood flow and an influx of immune cells and secretions. interferons—proteins produ ...
Autoimmune Diseases
... •Regulatory T cells play a crucial in controlling autoimmune responses: CD25+FoxP3+ CD4+T cells block the effect of autoimmune responses mediated by autoreactive T cells. This blocking may or may not require the secretion of suppressive cytokines such as TGF and IL-10. Some autoimmune diseases appe ...
... •Regulatory T cells play a crucial in controlling autoimmune responses: CD25+FoxP3+ CD4+T cells block the effect of autoimmune responses mediated by autoreactive T cells. This blocking may or may not require the secretion of suppressive cytokines such as TGF and IL-10. Some autoimmune diseases appe ...
T-cell Recognition/Antigen presentation
... (consider attachment of the invariant chain that prevents binding of proteasome derived peptides ) ...
... (consider attachment of the invariant chain that prevents binding of proteasome derived peptides ) ...
Nonspecific vs. Specific Defense Mechanisms
... molecules and cells) b. Antigen specific: responds to particular foreign substances c. Systemic response: body wide response d. Memory: quicker and stronger response to previously encountered pathogens ...
... molecules and cells) b. Antigen specific: responds to particular foreign substances c. Systemic response: body wide response d. Memory: quicker and stronger response to previously encountered pathogens ...
Steven A. Porcelli, M.D.
... residency at Temple University Hospital in 1987. He was a fellow and then a junior faculty member in the Division of Rheumatology, Immunology and Allergy at Brigham and Women’s Hospital in Boston. As a research fellow and assistant professor at Harvard Medical School in the 1990s, he pioneered studi ...
... residency at Temple University Hospital in 1987. He was a fellow and then a junior faculty member in the Division of Rheumatology, Immunology and Allergy at Brigham and Women’s Hospital in Boston. As a research fellow and assistant professor at Harvard Medical School in the 1990s, he pioneered studi ...
Slide 1
... • Lifespan of both CD4+ and CD8+ T cells is shortened to about a third of normal -increase of CD8+ T cells but CD4+ cannot keep up with the pace of destruction • Increase in the amount of terminally differentiated T cellsconsequence of immune activation -leads to immunosenescence, also occurs with C ...
... • Lifespan of both CD4+ and CD8+ T cells is shortened to about a third of normal -increase of CD8+ T cells but CD4+ cannot keep up with the pace of destruction • Increase in the amount of terminally differentiated T cellsconsequence of immune activation -leads to immunosenescence, also occurs with C ...
chapter 14: stress and health
... Prolonged stress and unhealthy behavior contribute to heart disease, cancer, stroke, and chronic lung disease, the four leading causes of death. Stress is not just a stimulus or a response; rather it is the process by which we appraise and cope with environmental events. In response to stress, ...
... Prolonged stress and unhealthy behavior contribute to heart disease, cancer, stroke, and chronic lung disease, the four leading causes of death. Stress is not just a stimulus or a response; rather it is the process by which we appraise and cope with environmental events. In response to stress, ...
cytokines and cytokine receptors
... A. BACKGROUND Cytokines are small proteins. Over 200 different human cytokines have now been identified. Cytokines act in a network. They are part of an extracellular signaling network that controls every function of the innate and specific immune responses. T helper cells can be divided into TH1 an ...
... A. BACKGROUND Cytokines are small proteins. Over 200 different human cytokines have now been identified. Cytokines act in a network. They are part of an extracellular signaling network that controls every function of the innate and specific immune responses. T helper cells can be divided into TH1 an ...
Poster
... Life used to be simple: Celiac Disease (CD) was a rare disease, diagnosed in 1 in 1,000 individuals. Patients were HLA-DQ2+ of HLA-DQ8+ and could be treated effectively with a gluten-free diet. That was about it. Now we know that CD affects ~1% of the population in Western Europe and the USA, most o ...
... Life used to be simple: Celiac Disease (CD) was a rare disease, diagnosed in 1 in 1,000 individuals. Patients were HLA-DQ2+ of HLA-DQ8+ and could be treated effectively with a gluten-free diet. That was about it. Now we know that CD affects ~1% of the population in Western Europe and the USA, most o ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.