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Cytokine hypothesis of overtraining: a physiological adaptation to
Cytokine hypothesis of overtraining: a physiological adaptation to

... represent a “. . .musculoskeletal manifestation of the overtraining syndrome” (39). This implies first the development of OTS and then the inception of injury. However, it is proposed here, that the injury may be both the initiating and perpetuating cause of OTS. Many reports suggest the presence of ...
D. Vertebrate Nervous Systems
D. Vertebrate Nervous Systems

...  Receives input from brain centers involved in the regulation of emotion and arousal.  Hypothalamus.  Regulates autonomic activity.  Contains nuclei involved in thermoregulation, hunger, thirst, sexual and mating behavior, etc.  Regulates the pituitary gland.  The Hypothalamus and Circadian Rh ...
No Slide Title
No Slide Title

... nearly 180 patients may have been exposed to the CRE superbug that was linked to two deaths in one of its hospitals. Today, 30 percent of severe strep pneumonia infections are resistant to multiple drugs and 30 percent of gonorrhea infections are resistant to all antibiotics. And drug-resistant ente ...
PowerPoint Chapter 29
PowerPoint Chapter 29

... a. Increased levels of neurotransmitters cause brain cells to become desensitized and can lead to building up a tolerance to drug (need larger doses to create same effect) b. Sensitization can occur when low amounts of neurotransmitters are in synapses ...
Document
Document

... In humans, following antigen presentation to T helper cells (Th), and differentiation of Th to Th2, the cytokines interleukin (IL)-10, IL-4 and transforming growth factor beta (TGF)- are involved in causing the preferential maturation of B cells (B-cell Ab class-switching and differentiation) into ...
Reprint - Immune Tolerance Network
Reprint - Immune Tolerance Network

... might be beneficial in maintaining tolerance and preventing autoimmunity (Surh and Sprent, 2012; Ng et al., 2013). IL-6 is a key cytokine that has been implicated in autoimmune disease; it supports the development of IL-17-producing T effector cells (Th17) and antagonizes the development of Tregs. T ...
Prevention and treatment of chlamydiosis and cryptococcosis in koalas
Prevention and treatment of chlamydiosis and cryptococcosis in koalas

... marsupial cytokine importance in relation to the fundamental humoral and cellular immune responses which will have important implications for understanding and controlling a wide range of infectious diseases not only in koalas but in evaluating infectious diseases in other marsupial species. Cryptoc ...
Antitumor Immunity and Dietary Compounds
Antitumor Immunity and Dietary Compounds

... did not prevent the outgrowth of continuously arising cancer cells [1]. This idea became the basis for the field of tumor immunology and the generation of the cancer immunosurveillance hypothesis by Burnet and Thomas. The cancer immunosurveillance hypothesis suggests that constant occurrence of canc ...
Neurons, Synapses, & Signaling
Neurons, Synapses, & Signaling

... defense by attacking pathogens or impeding their reproduction Interferon proteins provide innate defense, interfering with viruses and helping activate macrophages About 30 proteins make up the complement system, which causes lysis of invading cells and helps trigger inflammation ...
module b6: brain and mind – overview
module b6: brain and mind – overview

... understand that humans are more likely to remember information if they can see a pattern in it (or impose a pattern on it), if there is repetition of the information, especially over an extended period of time, or if there is a strong stimulus associated with it, including colour, light, smell, soun ...
A1981MQ75900001
A1981MQ75900001

... delayed type intracutaneous reaction to the same antigen. These results initially attracted only limited interest, since it was generally assumed that the system could only work with guinea pig macrophages. Søborg continued to explore the mechanism of the reaction, using Brucella hypersensitivity as ...
B cells take their time: sequential IgG class switching over
B cells take their time: sequential IgG class switching over

... Immunology and Cell Biology (2014) 92, 645–646; doi:10.1038/icb.2014.48; published online 17 June 2014 ...
Neurons, Synapses, the Nervous System
Neurons, Synapses, the Nervous System

... Contains centers for visual and auditory reflexes Acts as a “bridge” for messages passing to and from the cerebrum; also relays messages to the cerebellum. It also contains centers involved in respiration. This is the part of the brain that is continuous with the spinal cord. It contains a cardiac c ...
The role of autoantibodies in health and disease
The role of autoantibodies in health and disease

... systemic sclerosis, Sjögren’s syndrome) [37]. In organ-specific autoimmune diseases (such as myasthenia gravis or pemphigus), autoantibodies directly bind to and injure target organs. In some diseases, the autoimmune aggression results in the complete and irreversible loss of function of the targete ...
Immunity and Health - PubContent test page
Immunity and Health - PubContent test page

... B cells and T cells are responsible for the specific immunity response. They are named for the location in the body where they mature (the bone marrow and thymus). B CELLS • Develop and mature in bone marrow • Lymphocytes that combat pathogens by releasing antibodies into body fluids when antigens a ...
Correction - The Journal of Immunology
Correction - The Journal of Immunology

Basic Immunology Prof : Wafaa Saad Zaghloul
Basic Immunology Prof : Wafaa Saad Zaghloul

... Heavy chain class (isotype) switching: is the switch from one Ig isotype to another. After activation of B lymphocytes, the antigen-specific clone of B cells proliferate and differentiate into progeny that secrete antibodies; some of the progeny secrete IgM, and other progeny of the same B cells pr ...
PDF Links - J Korean Med
PDF Links - J Korean Med

... gene expression. Responses to cytokines include increasing or decreasing expression of membrane proteins, proliferation, and secretion of effector molecules. It is common for different cell types to secrete the same cytokine or for a single cytokine to act on several different cell types. Cytokines ...
New cell for asthma: enter the myeloid
New cell for asthma: enter the myeloid

... their survival once in the lung tissue. These mechanisms are used to explain the basics of asthma characterised by Th2 lymphocyte activation and the appearance of large numbers of eosinophils in the lung. However, it is clear from clinical practice that there are several subtypes of asthma, although ...
Chap 21 The Immune System V10
Chap 21 The Immune System V10

... • Summary of antibody actions – Antigen-antibody complexes do not destroy antigens; they prepare them for destruction by innate defenses – Antibodies go after extracellular pathogens; they do not invade solid tissue unless lesion is present • Recent exception found: antibodies can act intracellularl ...
Nervous System Study Guide 1
Nervous System Study Guide 1

... 38. What must take place in order for the neuron to trigger? (Explain this in terms of the difference in charge between the inside and outside of the cell.) ...
The Immune System Chapter 10 (10-2)
The Immune System Chapter 10 (10-2)

Dousing the Flames of Allergic Eye Disease
Dousing the Flames of Allergic Eye Disease

Gene Therapy for Primary Immunodeficiency Diseases: Should we do it?
Gene Therapy for Primary Immunodeficiency Diseases: Should we do it?

... •Typical SCID, due to defects that include IL2RG (X-linked), ADA, IL7R, JAK3, RAG1, RAG2, DCLRE1C (Artemis), TCRD, TCRE, TCRZ, and CD45 • Leaky SCID or Omenn syndrome • Variant SCID, with low T-cells but no defect in a known SCID gene • Syndromes with variably affected cellular immunity that may be ...
dynamics of cell populations in lymph node during primary immune
dynamics of cell populations in lymph node during primary immune

... The morphological responses to various antigenic stimuli have been extensively studied in lymph nodes of various experimental aninals 1>-?>. These works established that the germinal center development in the cortex and plasma cell proliferation in medullary cords were the main features of humoral a ...
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Psychoneuroimmunology



Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.
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