TAM receptors and the clearance of apoptotic cells
... cells by macrophages has been found to be ProS,33 and this ProS stimulation requires Mer binding and activation.34 These effects of the loss of TAM signaling on phagocytosis do not reflect any deficiency in the ability of Mer −/– phagocytes to bind apoptotic cells, which they do just as well as wild ...
... cells by macrophages has been found to be ProS,33 and this ProS stimulation requires Mer binding and activation.34 These effects of the loss of TAM signaling on phagocytosis do not reflect any deficiency in the ability of Mer −/– phagocytes to bind apoptotic cells, which they do just as well as wild ...
The B7 Family and Cancer Therapy: Costimulation and Coinhibition
... objective tumor responses and durations seen in those studies seem to be similar to anti – CTLA-4 monotherapy studies (60). GVAX elicits a dense local infiltrate of dendritic cells, granulocytes, and macrophages, which promotes the crosspriming process (76). A phase I trial studying the combination ...
... objective tumor responses and durations seen in those studies seem to be similar to anti – CTLA-4 monotherapy studies (60). GVAX elicits a dense local infiltrate of dendritic cells, granulocytes, and macrophages, which promotes the crosspriming process (76). A phase I trial studying the combination ...
Slide 1
... • Median Peak CD4 was progressively higher for specific CD4 strata (p<0.001) • Multivariate analysis: Increased mortality with CD4 < 50 (HR=4.6) and CD4 50-199 (HR=2.6) compared to 350 cells/mm3 • Lower baseline CD4 at initiation also associated with increased risk of death from non-AIDSrelated caus ...
... • Median Peak CD4 was progressively higher for specific CD4 strata (p<0.001) • Multivariate analysis: Increased mortality with CD4 < 50 (HR=4.6) and CD4 50-199 (HR=2.6) compared to 350 cells/mm3 • Lower baseline CD4 at initiation also associated with increased risk of death from non-AIDSrelated caus ...
Toll-like receptors as therapeutic targets in cystic fibrosis.
... IKKs, TANK-binding kinase 1 (TBK1) and IKKε/IKKi and culminates in activation of the transcription factors IRF 3 and 7 (Figure 2B) [50,56,57] which regulate IFN-β and IFN-α expression, respectively. TLRs expressed by immune and epithelial cells in the CF lung contribute to the pulmonary immune respo ...
... IKKs, TANK-binding kinase 1 (TBK1) and IKKε/IKKi and culminates in activation of the transcription factors IRF 3 and 7 (Figure 2B) [50,56,57] which regulate IFN-β and IFN-α expression, respectively. TLRs expressed by immune and epithelial cells in the CF lung contribute to the pulmonary immune respo ...
(From the Department of Pathology, New York University School of
... About 30-40% of random-bred Hartley (I) and all strain 2 (2) guinea pigs recognize poly-L-lysine (PLL) I and hapten-PLL conjugates as antigens. These "responder" animals develop delayed hypersensitivity to the conjugated polymer and produce specific antihapten antibodies when immunized with hapten-P ...
... About 30-40% of random-bred Hartley (I) and all strain 2 (2) guinea pigs recognize poly-L-lysine (PLL) I and hapten-PLL conjugates as antigens. These "responder" animals develop delayed hypersensitivity to the conjugated polymer and produce specific antihapten antibodies when immunized with hapten-P ...
Two different lateral amygdala cell populations contribute to the
... approaches1,4,5. However, LA is composed of several subdivisions. We focused on LAd because tract tracing and physiological studies show that this region is the primary target of pathways that transmit the auditory CS to the amygdala25–27 and is a site of CS and US convergence28, and because previou ...
... approaches1,4,5. However, LA is composed of several subdivisions. We focused on LAd because tract tracing and physiological studies show that this region is the primary target of pathways that transmit the auditory CS to the amygdala25–27 and is a site of CS and US convergence28, and because previou ...
Current progress in beta-amyloid immunotherapy
... transgenic mice, including neuritic dystrophy and synaptic density [2,23,24]. These findings are difficult to reconcile with the observation that antibodies (such as m266), which only bind to soluble forms of Ab, are also effective acutely in behavioral models of AD [19]. The simplest explanation fo ...
... transgenic mice, including neuritic dystrophy and synaptic density [2,23,24]. These findings are difficult to reconcile with the observation that antibodies (such as m266), which only bind to soluble forms of Ab, are also effective acutely in behavioral models of AD [19]. The simplest explanation fo ...
Antibody responses of variable lymphocyte receptors in the lamprey
... lymphocytes are composed of leucine-rich-repeat (LRR) protein segments and an invariant stalk region that is tethered to the lymphocyte surface by glycosylphosphatidylinositol linkage. The LRR segments in VLRs vary in number and amino acid sequence. The sequence variations are concentrated in the b- ...
... lymphocytes are composed of leucine-rich-repeat (LRR) protein segments and an invariant stalk region that is tethered to the lymphocyte surface by glycosylphosphatidylinositol linkage. The LRR segments in VLRs vary in number and amino acid sequence. The sequence variations are concentrated in the b- ...
Associations between Cellular Immune Effector Function, Iron
... Hepatitis C virus (HCV) infection is responsible for the majority of cases of parenterally acquired non-A, non-B hepatitis. This virus has a high propensity to cause chronic infection, and a substantial proportion of patients progress to cirrhosis, liver failure, and hepatocellular carcinoma [1]. No ...
... Hepatitis C virus (HCV) infection is responsible for the majority of cases of parenterally acquired non-A, non-B hepatitis. This virus has a high propensity to cause chronic infection, and a substantial proportion of patients progress to cirrhosis, liver failure, and hepatocellular carcinoma [1]. No ...
Vaccinia-Expressed Human Papillomavirus 16 and 18 E6 and E7 as
... SCC.2 Both intraepithelial neoplasia and SCC are commonly associated with HR-HPVs. Indeed, for cervical disease, the development of sensitive PCR methodology has demonstrated HR-HPV to be present in almost all cases of SCC (1), and HR-HPV infection is now widely accepted as a necessary cause for cer ...
... SCC.2 Both intraepithelial neoplasia and SCC are commonly associated with HR-HPVs. Indeed, for cervical disease, the development of sensitive PCR methodology has demonstrated HR-HPV to be present in almost all cases of SCC (1), and HR-HPV infection is now widely accepted as a necessary cause for cer ...
5211: Session 1 Hypothalamus and its regulation of anterior and
... thyroid stimulating hormone, adrenocorticotropic hormone. Infundibulum contains axons from hypothalamic neurons that project into the posterior pituitary where they terminate near capillaries. These terminals contain hormones oxytocin and vasopressin. ...
... thyroid stimulating hormone, adrenocorticotropic hormone. Infundibulum contains axons from hypothalamic neurons that project into the posterior pituitary where they terminate near capillaries. These terminals contain hormones oxytocin and vasopressin. ...
Ws_ch20e_Ts
... British doctor, noticed that milkmaids never came down with smallpox but a similar disease called cowpox (天花). This inspired him to put some pus collected from the boils (皮下膿腫) of a cowpox patient into the wound of a healthy boy. The boy did catch cowpox but it was only a mild disease. When the boy ...
... British doctor, noticed that milkmaids never came down with smallpox but a similar disease called cowpox (天花). This inspired him to put some pus collected from the boils (皮下膿腫) of a cowpox patient into the wound of a healthy boy. The boy did catch cowpox but it was only a mild disease. When the boy ...
Sheet 1
... Transport of substances to tissues: many substances are transported by hormones or increased or decreased its concentration in the blood. Defense against pathogens: immune system responses are regulated by hormones, such as inflammation, antibody production and fever. Growth: it is does not oc ...
... Transport of substances to tissues: many substances are transported by hormones or increased or decreased its concentration in the blood. Defense against pathogens: immune system responses are regulated by hormones, such as inflammation, antibody production and fever. Growth: it is does not oc ...
The relationship between allergic rhinitis and viral infections
... consequences, especially secondary bacterial infection. Viral infection can also lead to lower respiratory traction conditions such as bronchitis, bronchiolitis, pneumonia and, especially, asthma. This article will review the existing scientific literature examining the linkage and relationship betw ...
... consequences, especially secondary bacterial infection. Viral infection can also lead to lower respiratory traction conditions such as bronchitis, bronchiolitis, pneumonia and, especially, asthma. This article will review the existing scientific literature examining the linkage and relationship betw ...
Hepatocytes: a key cell type for innate immunity
... of its opsonic activity as a pro-inflammatory factor. To date, a specific receptor for SAA has not been found. SAA is thought to react with several important inflammation-related receptors to exert its function, including Toll-like receptor 2 (TLR2), TLR4, formyl peptide receptor-like 1, receptor fo ...
... of its opsonic activity as a pro-inflammatory factor. To date, a specific receptor for SAA has not been found. SAA is thought to react with several important inflammation-related receptors to exert its function, including Toll-like receptor 2 (TLR2), TLR4, formyl peptide receptor-like 1, receptor fo ...
Media release - Peter MacCallum Cancer Centre
... The biogenesis of cytotoxic granules Cytotoxic lymphocytes are immune cells responsible for killing infected or cancerous cells. How cytotoxic lymphocytes mature from a naïve inactive to a fully activated state as they encounter infected or malignant cells is poorly understood, and will be investiga ...
... The biogenesis of cytotoxic granules Cytotoxic lymphocytes are immune cells responsible for killing infected or cancerous cells. How cytotoxic lymphocytes mature from a naïve inactive to a fully activated state as they encounter infected or malignant cells is poorly understood, and will be investiga ...
Lund_Apr04
... genome/proteome information and guide vaccine development. The causative virus, the SARS corona virus (SARS CoV), has been isolated and full-length sequenced. ...
... genome/proteome information and guide vaccine development. The causative virus, the SARS corona virus (SARS CoV), has been isolated and full-length sequenced. ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.