Immunological aspects of liver disease
... significant recent development has been the finding by Li Wen that HLA restricted helper T cell clones recognising the asialoglycoprotein receptor can cooperate with B cells from the same patient in vitro to produce auto-antibodies reacting with this liver membrane antigen.'3 This coupled with work ...
... significant recent development has been the finding by Li Wen that HLA restricted helper T cell clones recognising the asialoglycoprotein receptor can cooperate with B cells from the same patient in vitro to produce auto-antibodies reacting with this liver membrane antigen.'3 This coupled with work ...
PATHOGENESIS OF AN EMERGING PATHOGEN – CRIMEAN
... transepithelial electrical resistance (TER) over infected epithelial cells, and showed that CCHFV replication has no direct effect on epithelial permeability. Furthermore, we observed no effect of CCHFV on the localization of the TJ proteins occludin and ZO-1 in epithelial cells. Interestingly, CCHF ...
... transepithelial electrical resistance (TER) over infected epithelial cells, and showed that CCHFV replication has no direct effect on epithelial permeability. Furthermore, we observed no effect of CCHFV on the localization of the TJ proteins occludin and ZO-1 in epithelial cells. Interestingly, CCHF ...
Gene expression analyses in Atlantic salmon challenged with
... protection against ISAV are unknown. Association between specific MHCI alleles and survival has been shown [7], which imply that a collection of multiple host factors may explain disease resistance. Although far from completely resolved, it seems that type 1 interferon (IFN) does not confer antivira ...
... protection against ISAV are unknown. Association between specific MHCI alleles and survival has been shown [7], which imply that a collection of multiple host factors may explain disease resistance. Although far from completely resolved, it seems that type 1 interferon (IFN) does not confer antivira ...
Superantigens and Their Role in Autoimmune Disorders
... may be the products of either viruses or bacteria, this discussion will focus on bacterial superantigens. This is not to say that viral superantigens cannot be involved in autoimmune disorders. However, most of the work examining the relationship of superantigens to autoimmunity involves the study o ...
... may be the products of either viruses or bacteria, this discussion will focus on bacterial superantigens. This is not to say that viral superantigens cannot be involved in autoimmune disorders. However, most of the work examining the relationship of superantigens to autoimmunity involves the study o ...
Mast Cells in Autoimmune Disease - Direct-MS
... pathway41 and the accumulation of neutrophils42. Recently, it has been also shown to depend critically on mast cells43. Mast cell degranulation was one of the first responses detected after the injection of antibodies against BP180, occurring only 1 h after administration and preceding neutrophil ac ...
... pathway41 and the accumulation of neutrophils42. Recently, it has been also shown to depend critically on mast cells43. Mast cell degranulation was one of the first responses detected after the injection of antibodies against BP180, occurring only 1 h after administration and preceding neutrophil ac ...
Raulet, D.H. 2004. Interplay of natural killer cells and their receptors with the adaptive immune response. Nat Rev Immunol 5:996-1002.
... Inhibitory recognition of classical MHC class I molecules (class Ia) is mediated mainly by KIR in humans and Ly49 receptors in mice48. Despite the differences in structure and genetic origin, KIR and Ly49 receptors are very similar in their pattern of expression and function. Each family consists of ...
... Inhibitory recognition of classical MHC class I molecules (class Ia) is mediated mainly by KIR in humans and Ly49 receptors in mice48. Despite the differences in structure and genetic origin, KIR and Ly49 receptors are very similar in their pattern of expression and function. Each family consists of ...
Cytokine responses in human Lyme borreliosis
... Although Lyme borreliosis is treatable with antibiotics and the causative spirochete has not been shown to be resistant to drugs, some patients do not recover completely. They have persistent symptoms and are diagnosed with chronic or persistent Lyme borreliosis. The mechanism behind the lingering s ...
... Although Lyme borreliosis is treatable with antibiotics and the causative spirochete has not been shown to be resistant to drugs, some patients do not recover completely. They have persistent symptoms and are diagnosed with chronic or persistent Lyme borreliosis. The mechanism behind the lingering s ...
Recombinant core proteins of Japanese encephalitis virus as
... [1, 2]. During JEV infection, there is no established antiviral treatment for JEV, and the recovery from viral infection mainly depends upon host immunity. The antiJEV effect of nitric oxide (NO) has been suggested to be one of the important factors of innate immunity in controlling the initial stag ...
... [1, 2]. During JEV infection, there is no established antiviral treatment for JEV, and the recovery from viral infection mainly depends upon host immunity. The antiJEV effect of nitric oxide (NO) has been suggested to be one of the important factors of innate immunity in controlling the initial stag ...
د. غسان The Autonomic Nervous System (ANS): The ANS coordinates
... ganglia found in the sympathetic ganglion chains. These ganglion chains, which run parallel immediately along either side of the spinal cord, each consist of 22 ganglia. The preganglionic neuron may exit the spinal cord and synapse with a postganglionic neuron in a ganglion at the same spinal cord ...
... ganglia found in the sympathetic ganglion chains. These ganglion chains, which run parallel immediately along either side of the spinal cord, each consist of 22 ganglia. The preganglionic neuron may exit the spinal cord and synapse with a postganglionic neuron in a ganglion at the same spinal cord ...
CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2
... CD4+ T cells are at the nexus of the innate and adaptive arms of the immune system. However, little is known about the evolutionary history of CD4+ T cells, and it is unclear whether their differentiation into specialized subsets is conserved in early vertebrates. In this study, we have created tran ...
... CD4+ T cells are at the nexus of the innate and adaptive arms of the immune system. However, little is known about the evolutionary history of CD4+ T cells, and it is unclear whether their differentiation into specialized subsets is conserved in early vertebrates. In this study, we have created tran ...
Methylation - The Hoffman Centre for Integrative Medicine
... optimally, then tissues function properly. When tissues function optimally, then organs and glands function properly, and when that occurs, the body can live in excellent health. Seems simple enough. ...
... optimally, then tissues function properly. When tissues function optimally, then organs and glands function properly, and when that occurs, the body can live in excellent health. Seems simple enough. ...
Rachel M. Dudek - Leonard Lab
... permissive to their growth that entails heterotypic signaling from the tumor-associated stroma and a complicated relationship with both tumor-antagonizing and tumor-promoting immune cells. [1] Tumor-associated immune cells secrete cytokines such as interleukin 10 (IL-10) that are involved in the wou ...
... permissive to their growth that entails heterotypic signaling from the tumor-associated stroma and a complicated relationship with both tumor-antagonizing and tumor-promoting immune cells. [1] Tumor-associated immune cells secrete cytokines such as interleukin 10 (IL-10) that are involved in the wou ...
Lymphoma - Starpace
... -Large B-cell lymphomas (DLBCL, FLL, BL) have been shown to express Ig molecules on their surface, which bear the scars of affinity maturation; an antigen-driven process (Klein et al, 1995, Chapman et al, 1995, Kuppers et al, 1997) -The gene expression profiles of DLBCL cells resemble those of B-cel ...
... -Large B-cell lymphomas (DLBCL, FLL, BL) have been shown to express Ig molecules on their surface, which bear the scars of affinity maturation; an antigen-driven process (Klein et al, 1995, Chapman et al, 1995, Kuppers et al, 1997) -The gene expression profiles of DLBCL cells resemble those of B-cel ...
The properties and functions of effector T cells
... the T cell and the target cell. The migration of effector T cells from the circulation to peripheral sites of infection is largely independent of antigen, ensuring that the maximum possible number of previously activated T cells have the opportunity to locate pathogens and to eradicate the infection ...
... the T cell and the target cell. The migration of effector T cells from the circulation to peripheral sites of infection is largely independent of antigen, ensuring that the maximum possible number of previously activated T cells have the opportunity to locate pathogens and to eradicate the infection ...
“No donor”? Consider a haploidentical transplant ⁎ Stefan O. Ciurea ,
... N90% patients with a low GVHD rate [8]. Subsequently, we have shown that not only T cells can mediate rejection of donor cells, but also B cells via anti-HLA antibodies against donor's HLA antigens, now acknowledged as playing a major role in the development of primary graft failure in these patient ...
... N90% patients with a low GVHD rate [8]. Subsequently, we have shown that not only T cells can mediate rejection of donor cells, but also B cells via anti-HLA antibodies against donor's HLA antigens, now acknowledged as playing a major role in the development of primary graft failure in these patient ...
The Complement system
... • The complement works as a cascade system. – Cascade is when one reaction triggers another reaction which trigger others and so on. These types of systems can grow exponentially very fast. ...
... • The complement works as a cascade system. – Cascade is when one reaction triggers another reaction which trigger others and so on. These types of systems can grow exponentially very fast. ...
Modulation of cellular innate immune responses by lactobacilli
... what they claim of course. In real life, many of these products don’t even contain microorganisms with documented health benefits or in some cases – they don’t have any bacteria at all in them! Luckily, there is ample evidence for using probiotics, in cases where such an epithet is justified. During ...
... what they claim of course. In real life, many of these products don’t even contain microorganisms with documented health benefits or in some cases – they don’t have any bacteria at all in them! Luckily, there is ample evidence for using probiotics, in cases where such an epithet is justified. During ...
The Nervous System
... Composed of Telencephalon (Cerebral Cortex) and Diencephalon Cerebral Cortex is gray matter because nerve fibers lack white myelin coating ...
... Composed of Telencephalon (Cerebral Cortex) and Diencephalon Cerebral Cortex is gray matter because nerve fibers lack white myelin coating ...
Contributions of the immune system to the
... and play a role in remodeling neuronal circuits. In both studies several different models of cerebral ischemia were investigated, such as photo-thrombotic stroke and global ischemia. CBF in the region of interest was assessed and directly compared and matched with alterations observed in microglia. ...
... and play a role in remodeling neuronal circuits. In both studies several different models of cerebral ischemia were investigated, such as photo-thrombotic stroke and global ischemia. CBF in the region of interest was assessed and directly compared and matched with alterations observed in microglia. ...
View - Dr Falk
... that AIH is an aggressive disease. Without treatment, AIH can result in extensive damage to liver cells making it impossible for your liver to function adequately. With treatment, most people with AIH have a normal life expectancy and feel well most of the time. That’s why it is also very important ...
... that AIH is an aggressive disease. Without treatment, AIH can result in extensive damage to liver cells making it impossible for your liver to function adequately. With treatment, most people with AIH have a normal life expectancy and feel well most of the time. That’s why it is also very important ...
Mesenchymal stem cells in immunoregulation
... of DC.61 Finally, MSC caused mature DC1 to decrease TNF-a secretion and mature DC2 to increase IL-10 secretion, leading to a state of immunotolerance. IL-10 tends to have a significant inhibitory effect on several aspects of APC function, such as downregulating the expression of surface markers (CD4 ...
... of DC.61 Finally, MSC caused mature DC1 to decrease TNF-a secretion and mature DC2 to increase IL-10 secretion, leading to a state of immunotolerance. IL-10 tends to have a significant inhibitory effect on several aspects of APC function, such as downregulating the expression of surface markers (CD4 ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.