JDRF Cure Research – Halting the autoimmune process and
... Targeted T1D vaccines are ones focused on the specific beta cell components to which the immune system mistakenly reacts. A vaccine focused on these beta cell components could stop the autoimmune process before a person becomes insulin dependent. JDRF is supporting this unique nanoparticle-based vac ...
... Targeted T1D vaccines are ones focused on the specific beta cell components to which the immune system mistakenly reacts. A vaccine focused on these beta cell components could stop the autoimmune process before a person becomes insulin dependent. JDRF is supporting this unique nanoparticle-based vac ...
HMGB1 Mediates Endogenous TLR2 Activation and
... conditional cytotoxic gene thymidine kinase (TK) [8]. Cell death can trigger antigen-specific immune responses by releasing tumor antigens and signals that mediate phagocytosis by DCs and also DC maturation. Tumor cell death caused by radiation can induce DC-mediated cytotoxic T-lymphocyte (CTL) res ...
... conditional cytotoxic gene thymidine kinase (TK) [8]. Cell death can trigger antigen-specific immune responses by releasing tumor antigens and signals that mediate phagocytosis by DCs and also DC maturation. Tumor cell death caused by radiation can induce DC-mediated cytotoxic T-lymphocyte (CTL) res ...
JDRF Research Top 10 Advances of FY2012 JDRF Cure Research
... Targeted T1D vaccines are ones focused on the specific beta cell components to which the immune system mistakenly reacts. A vaccine focused on these beta cell components could stop the autoimmune process before a person becomes insulin dependent. JDRF is supporting this unique nanoparticle-based vac ...
... Targeted T1D vaccines are ones focused on the specific beta cell components to which the immune system mistakenly reacts. A vaccine focused on these beta cell components could stop the autoimmune process before a person becomes insulin dependent. JDRF is supporting this unique nanoparticle-based vac ...
(Poly(I:C)) Induces Stable Maturation of Polyriboinosinic
... Stable Maturation of Functionally Active Human Dendritic Cells1 Rob M. Verdijk,2 Tuna Mutis, Ben Esendam, Janine Kamp, Cees J. M. Melief, Anneke Brand, and Els Goulmy ...
... Stable Maturation of Functionally Active Human Dendritic Cells1 Rob M. Verdijk,2 Tuna Mutis, Ben Esendam, Janine Kamp, Cees J. M. Melief, Anneke Brand, and Els Goulmy ...
Section 2 Specific Defense
... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
MB_47_win
... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade
... CD206+, CD64+, CD68+, CD11c+ CD115low, and CD102+, confirming they were macrophages but were different from Kupffer cells (Figure S1). Furthermore, CD102 has been identified as a specific marker for resident peritoneal macrophages and was present on macrophages in injury but not on Kupffer cells (Ok ...
... CD206+, CD64+, CD68+, CD11c+ CD115low, and CD102+, confirming they were macrophages but were different from Kupffer cells (Figure S1). Furthermore, CD102 has been identified as a specific marker for resident peritoneal macrophages and was present on macrophages in injury but not on Kupffer cells (Ok ...
Insurmountable Heat: The Evolution and Persistence of Defensive
... by positing that body temperature, including during fever, was regulated by the central nervous system. Using rabbits, Welch demonstrated that heat itself did not cause the damage observed in autopsied remains of disease victims, and suggested then that fever might be beneficial, outlining the basic ...
... by positing that body temperature, including during fever, was regulated by the central nervous system. Using rabbits, Welch demonstrated that heat itself did not cause the damage observed in autopsied remains of disease victims, and suggested then that fever might be beneficial, outlining the basic ...
The level of monocyte turnover predicts disease progression in the
... Destruction of CD4⫹ T cells is considered to be the main cause of immunodeficiency resulting from HIV infection in humans as well as in the simian immunodeficiency virus (SIV)–infected macaque model of AIDS. However, the degree of CD4⫹ T-cell depletion does not always correlate with AIDS progression ...
... Destruction of CD4⫹ T cells is considered to be the main cause of immunodeficiency resulting from HIV infection in humans as well as in the simian immunodeficiency virus (SIV)–infected macaque model of AIDS. However, the degree of CD4⫹ T-cell depletion does not always correlate with AIDS progression ...
Internalization of the Granulocyte-Macrophage
... have previously shown that internalization of '"I-GM-CSF after binding to neutrophils is temperature-dependent, with no detectable internalization at 4OC." These studies were repeated with the factor-dependent cell line, M 0 7 (Fig 1A). At 37"C, 30% to 40% of total GM-CSF was acid-resistant (interna ...
... have previously shown that internalization of '"I-GM-CSF after binding to neutrophils is temperature-dependent, with no detectable internalization at 4OC." These studies were repeated with the factor-dependent cell line, M 0 7 (Fig 1A). At 37"C, 30% to 40% of total GM-CSF was acid-resistant (interna ...
Thomas Davis, MD Celldex Therapeutics, Inc.
... ◦ Single ligand is CD70 (tightly regulated) ◦ Constitutively expressed on most T cells and a subset of B and NK cells ...
... ◦ Single ligand is CD70 (tightly regulated) ◦ Constitutively expressed on most T cells and a subset of B and NK cells ...
Thymus Gland:
... chemical product for use somewhere in the body. Some types of glands release their secretions in specific areas. For instance, exocrine glands, such as the sweat and salivary glands, release secretions in the skin or inside of the mouth. Endocrine glands, on the other hand, release more than 20 majo ...
... chemical product for use somewhere in the body. Some types of glands release their secretions in specific areas. For instance, exocrine glands, such as the sweat and salivary glands, release secretions in the skin or inside of the mouth. Endocrine glands, on the other hand, release more than 20 majo ...
The Sphingosine-1-Phosphate Analogue FTY720 Reduces
... shown to efficiently inhibit graft rejection in experimental animal models and kidney transplant patients.7 Our finding that FTY720 inhibited atherosclerosis is in line with the important role that immunologic processes in general and T-lymphocytes in particular play in the pathogenesis of atheroscl ...
... shown to efficiently inhibit graft rejection in experimental animal models and kidney transplant patients.7 Our finding that FTY720 inhibited atherosclerosis is in line with the important role that immunologic processes in general and T-lymphocytes in particular play in the pathogenesis of atheroscl ...
Saturated and polyunsaturated fatty acids reciprocally modulate
... immune responses. Results from our previous studies demonstrated that saturated fatty acids activate TLRs, whereas n-3 polyunsaturated fatty acids inhibit agonist-induced TLR activation. These results raise a significant question as to whether fatty acids differentially modulate immune responses med ...
... immune responses. Results from our previous studies demonstrated that saturated fatty acids activate TLRs, whereas n-3 polyunsaturated fatty acids inhibit agonist-induced TLR activation. These results raise a significant question as to whether fatty acids differentially modulate immune responses med ...
and Function by Progesterone TLR4
... http://www.jimmunol.org/content/suppl/2010/09/13/jimmunol.090115 5.DC1 This article cites 56 articles, 13 of which you can access for free at: http://www.jimmunol.org/content/185/8/4525.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subsc ...
... http://www.jimmunol.org/content/suppl/2010/09/13/jimmunol.090115 5.DC1 This article cites 56 articles, 13 of which you can access for free at: http://www.jimmunol.org/content/185/8/4525.full#ref-list-1 Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subsc ...
Palmitic Acid Activation of Dendritic Cells
... love for science. I want to thank them for the incredible support of my “outside-the-box” ideas and for allowing me to chase those ideas uninhibited. Thank you both for all of the time, money, energy, ideas, support, passion, and sacrifice you have invested and poured into me to make me a great scie ...
... love for science. I want to thank them for the incredible support of my “outside-the-box” ideas and for allowing me to chase those ideas uninhibited. Thank you both for all of the time, money, energy, ideas, support, passion, and sacrifice you have invested and poured into me to make me a great scie ...
Identificatio of CT521 as a Frequent Target of Th1 Cells in Patients
... analyzed by measuring the IFN-g response to 30 narrow protein fractions with a minimal overlap between neighboring fractions (figu e 1). PBMCs from a total of 16 patients were stimulated with the panel of protein fractions (data not shown). The immune responses showed a marked heterogeneity, and in ...
... analyzed by measuring the IFN-g response to 30 narrow protein fractions with a minimal overlap between neighboring fractions (figu e 1). PBMCs from a total of 16 patients were stimulated with the panel of protein fractions (data not shown). The immune responses showed a marked heterogeneity, and in ...
Mast cells in human airways: the culprit?
... allergy where cross-linking of surface-bound IgE leads to rapid degranulation, mediator release (e.g. histamine) and manifestation of an acute phase allergic reaction [1, 14]. Apart from the acute airway constriction, one hugely important tissue reaction is plasma extravasation [15, 16]. Within seco ...
... allergy where cross-linking of surface-bound IgE leads to rapid degranulation, mediator release (e.g. histamine) and manifestation of an acute phase allergic reaction [1, 14]. Apart from the acute airway constriction, one hugely important tissue reaction is plasma extravasation [15, 16]. Within seco ...
RNA released from necrotic synovial fluid cells activates rheumatoid
... culture with TLR-2 ligands results in the up-regulation of TLR-2 expression and the production of proinflammatory cytokines (6). Moreover, a variety of chemokines typically found in the synovial fluid of RA patients were found to be secreted by fibroblasts stimulated via TLR-2 (7). While certain TLR ...
... culture with TLR-2 ligands results in the up-regulation of TLR-2 expression and the production of proinflammatory cytokines (6). Moreover, a variety of chemokines typically found in the synovial fluid of RA patients were found to be secreted by fibroblasts stimulated via TLR-2 (7). While certain TLR ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑