Sperm-based contraceptive vaccine for wild rabbit
... World-wide there is considerable interest in the development of contraceptive vaccines for the control of wild animal pests. Oral vaccination is often the only practical route and an optimal formulation that stimulates an effective immune response is pivotal to development of this technology. Delive ...
... World-wide there is considerable interest in the development of contraceptive vaccines for the control of wild animal pests. Oral vaccination is often the only practical route and an optimal formulation that stimulates an effective immune response is pivotal to development of this technology. Delive ...
Immune mechanisms in Borrelia burgdorferi sensu lato
... persistent infection, but could instead be affected by the host’s ability to mount an optimal immune response to the spirochaete. The hypothesis of this thesis was that a strong inflammatory Th1-like immune response is required in the early stage of infection in order to achieve both an optimal erad ...
... persistent infection, but could instead be affected by the host’s ability to mount an optimal immune response to the spirochaete. The hypothesis of this thesis was that a strong inflammatory Th1-like immune response is required in the early stage of infection in order to achieve both an optimal erad ...
PDF
... the airways. Neutrophils contribute to the pathology of these diseases. To date, NETs have been identified in the lungs of cystic fibrosis (CF), acute lung injury (ALI), allergic asthma, and lungs infected with bacteria, virus, or fungi. These microbes and several host factors can stimulate NET form ...
... the airways. Neutrophils contribute to the pathology of these diseases. To date, NETs have been identified in the lungs of cystic fibrosis (CF), acute lung injury (ALI), allergic asthma, and lungs infected with bacteria, virus, or fungi. These microbes and several host factors can stimulate NET form ...
Probiotics and phytogenics for poultry
... of the strains tested. A major point for developing new strategies is to better understand the mechanisms through which the probiotic organisms could protect the intestinal environment from damage induced by pathogens. The intestine is a complex system in which a continuous dialog between the mucosa ...
... of the strains tested. A major point for developing new strategies is to better understand the mechanisms through which the probiotic organisms could protect the intestinal environment from damage induced by pathogens. The intestine is a complex system in which a continuous dialog between the mucosa ...
Angioimmunoblastic T-cell lymphoma
... (TFH) (review in 4). These normal TFH cells with a CD4+/CD57+/CXCR5+/CCR7– immuno-phenotype are distributed in the light zone of germinal centers where they provide functional help to B-cells by inducing expression of the activation-induced cytidine deaminase (AID) critical to the follicular B-cell ...
... (TFH) (review in 4). These normal TFH cells with a CD4+/CD57+/CXCR5+/CCR7– immuno-phenotype are distributed in the light zone of germinal centers where they provide functional help to B-cells by inducing expression of the activation-induced cytidine deaminase (AID) critical to the follicular B-cell ...
Ataxia..Telangiectasia and Cellular Responses
... strand breaks, shortened telomeres, and other DNA damage that occurs spontaneously during the course of normal DNA metabolism (e.g. , site-specific gene rearrangements, genetic recombination, and repair of replication errors). Given the viability of yeast and mamma han mutants that lack functional d ...
... strand breaks, shortened telomeres, and other DNA damage that occurs spontaneously during the course of normal DNA metabolism (e.g. , site-specific gene rearrangements, genetic recombination, and repair of replication errors). Given the viability of yeast and mamma han mutants that lack functional d ...
Characterization of CD56 CD16 natural killer (NK) cells: A highly
... into two different groups: (i) killer immunoglobulin-like receptors (KIRs); (ii) LIR1兾ILT2 and NKG2A兾CD94, which belong to the family of the C-type lectin proteins. Diminution or absence of expression of HLA-I molecules on the cell surface because of viral infection or tumor transformation results i ...
... into two different groups: (i) killer immunoglobulin-like receptors (KIRs); (ii) LIR1兾ILT2 and NKG2A兾CD94, which belong to the family of the C-type lectin proteins. Diminution or absence of expression of HLA-I molecules on the cell surface because of viral infection or tumor transformation results i ...
Myelin Recovery in Multiple Sclerosis: The Challenge of
... neurons—are terminally differentiated cells with a limited capacity to respond to injury. They depend for renewal on the availability of their precursors—the oligodendrocyte progenitor cells (OPCs) and neuronal progenitor cells (NPCs), that undergo proliferation, migration and differentiation into d ...
... neurons—are terminally differentiated cells with a limited capacity to respond to injury. They depend for renewal on the availability of their precursors—the oligodendrocyte progenitor cells (OPCs) and neuronal progenitor cells (NPCs), that undergo proliferation, migration and differentiation into d ...
Review Chronic Intestinal Inflammation and Intestinal Disease in Dogs
... in human ulcerative colitis.64–66 T cells, MHC class II⫹ cells, macrophages, and granulocytes are all increased within the lamina propria. There is also increased expression of MHC class II molecules by the intestinal epithelium, which is again similar to findings in human IBD.67 The function of MHC ...
... in human ulcerative colitis.64–66 T cells, MHC class II⫹ cells, macrophages, and granulocytes are all increased within the lamina propria. There is also increased expression of MHC class II molecules by the intestinal epithelium, which is again similar to findings in human IBD.67 The function of MHC ...
Atopy and HIV. Do Basophils Play a Role in Both?
... Results: No significant difference was found between the absolute basophil count in patients with asthma (p=0.402) and eczema (p=0.947) compared to the healthy volunteers. HIV positive patients (p=0.007) and allergic patients (p=0.022) had statistically significant lower basophil counts compared to hea ...
... Results: No significant difference was found between the absolute basophil count in patients with asthma (p=0.402) and eczema (p=0.947) compared to the healthy volunteers. HIV positive patients (p=0.007) and allergic patients (p=0.022) had statistically significant lower basophil counts compared to hea ...
Feline infectious peritonitis
... antibodies are not protective, development of cell-mediated immunity is the most crucial factor in determining the outcome of this viral infection. Cats that produce humoral antibodies but fail to generate an effective cell-mediated immune response develop effusive FIP. In this effusive form, immune ...
... antibodies are not protective, development of cell-mediated immunity is the most crucial factor in determining the outcome of this viral infection. Cats that produce humoral antibodies but fail to generate an effective cell-mediated immune response develop effusive FIP. In this effusive form, immune ...
B cells - Cloudfront.net
... interfere with PG production Fever is thought to increase immune function and inhibit pathogens Mosby items and derived items © 2013, 2010, 2007, 2003 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... interfere with PG production Fever is thought to increase immune function and inhibit pathogens Mosby items and derived items © 2013, 2010, 2007, 2003 by Mosby, Inc., an affiliate of Elsevier Inc. ...
daniela tesi on line 3 - Padis
... Matsuzaki et al., 1989). The use of convenient assay bacteria or common animal pathogens have defined the spectra of action, while experiments on artificial membranes, lipid vesicles and different spectroscopic methods, as well as the use of synthetic peptides, have been applied to understand the ly ...
... Matsuzaki et al., 1989). The use of convenient assay bacteria or common animal pathogens have defined the spectra of action, while experiments on artificial membranes, lipid vesicles and different spectroscopic methods, as well as the use of synthetic peptides, have been applied to understand the ly ...
Introduction Multiple Sclerosis (MS) is a highly degenerative, auto
... indicators of injury or invasion (Wake et al, 2014). When microglia detect a potential insult, they become activated and respond in a number of ways including the release of pro-inflammatory molecules including reactive oxygen species. The release of these molecules is believed to be designed to tar ...
... indicators of injury or invasion (Wake et al, 2014). When microglia detect a potential insult, they become activated and respond in a number of ways including the release of pro-inflammatory molecules including reactive oxygen species. The release of these molecules is believed to be designed to tar ...
Wetting: Unobtrusive graphene coatings
... and the substrate it rests on. When the attractive interactions among the molecules in the liquid outweigh those between the liquid and the solid, a macroscopic drop at equilibrium displays an almost spherical shape with a large contact angle. Conversely, the more strongly the liquid is attracted by ...
... and the substrate it rests on. When the attractive interactions among the molecules in the liquid outweigh those between the liquid and the solid, a macroscopic drop at equilibrium displays an almost spherical shape with a large contact angle. Conversely, the more strongly the liquid is attracted by ...
Corps Member - TFA
... following occurs to create immunity: (HOW) 1) White blood cells produce antibodies in response to the pathogen (the vaccine) 2) Building up these antibodies helps the body “remember” the specific pathogen so that the body’s immune system can more easily destroy such pathogens in the future. KP4: Exa ...
... following occurs to create immunity: (HOW) 1) White blood cells produce antibodies in response to the pathogen (the vaccine) 2) Building up these antibodies helps the body “remember” the specific pathogen so that the body’s immune system can more easily destroy such pathogens in the future. KP4: Exa ...
Novel pebbles in the mosaic of autoimmunity Open Access Carlo Perricone
... via several adaptor molecules, such as MyD88, TLRs lead to the activation of NFκB [12]. By contrast, self-reactive antibodies against self-reactive or cross-reactive DNA coengage antigen receptors and TLRs, leading to a continuous activation of these auto-reactive B cells and the development of auto ...
... via several adaptor molecules, such as MyD88, TLRs lead to the activation of NFκB [12]. By contrast, self-reactive antibodies against self-reactive or cross-reactive DNA coengage antigen receptors and TLRs, leading to a continuous activation of these auto-reactive B cells and the development of auto ...
Assessment of Cytokine mRNA Expression Profiles in Tumor
... ovarian conditions and controls with normal ovaries. Cytokine assessment was done by real-time quantitative RT-PCR and specific primers and probes for 12 cytokines-IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-15, TNF-α, TNF-β/LTA, TGF-β1, and GM-CSF chosen to distinguish between cytotoxic Th1, hu ...
... ovarian conditions and controls with normal ovaries. Cytokine assessment was done by real-time quantitative RT-PCR and specific primers and probes for 12 cytokines-IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-15, TNF-α, TNF-β/LTA, TGF-β1, and GM-CSF chosen to distinguish between cytotoxic Th1, hu ...
B cell sub-types following acute malaria and associations with
... (MBCs) non-class switched ‘innate-like’ MBCs and antibody-secreting plasmablasts/plasma cells [18]; these cells can be detected in blood as they migrate to other secondary lymphoid organs and tissues. Exposure to Plasmodium alters the distribution of these B cell sub-sets, and has been associated wi ...
... (MBCs) non-class switched ‘innate-like’ MBCs and antibody-secreting plasmablasts/plasma cells [18]; these cells can be detected in blood as they migrate to other secondary lymphoid organs and tissues. Exposure to Plasmodium alters the distribution of these B cell sub-sets, and has been associated wi ...
Peer-reviewed Article PDF
... The IgE antibody binds to the epitope (known as the B-cell epitope) that is mainly present on the surface of the allergen. Since B-cell epitopes are dependent on the tertiary structure of allergen proteins, changing the tertiary structure through allergen modification, such as in peptide allergens, ...
... The IgE antibody binds to the epitope (known as the B-cell epitope) that is mainly present on the surface of the allergen. Since B-cell epitopes are dependent on the tertiary structure of allergen proteins, changing the tertiary structure through allergen modification, such as in peptide allergens, ...
Mouse and human FcR effector functions
... internalization: when mFccRIIB is involved a restricted set of T-cell epitopes is presented compared to when mFccRIII is involved after immune complex internalization, probably due to cell activation concomitantly triggered by the latter receptor through the FcRc chain (28) and the SYK kinase (29). ...
... internalization: when mFccRIIB is involved a restricted set of T-cell epitopes is presented compared to when mFccRIII is involved after immune complex internalization, probably due to cell activation concomitantly triggered by the latter receptor through the FcRc chain (28) and the SYK kinase (29). ...
Immunocompatibility of Bacteriophages as Nanomedicines
... delivery of the genome in a form required to confer an immune response. As such, phage particles have been applied in DNA vaccine technology as a safe container for DNA delivery. The vaccine gene and its expression cassette are cloned into phage genome, and purified phage lysate can be directly inje ...
... delivery of the genome in a form required to confer an immune response. As such, phage particles have been applied in DNA vaccine technology as a safe container for DNA delivery. The vaccine gene and its expression cassette are cloned into phage genome, and purified phage lysate can be directly inje ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑