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ISTOLOGY
ISTOLOGY

... Caries  dentin is demineralized  dentin proteins released  Cytokine expression by pulp cells (odontoblasts, fibroblasts, dendritic cells) – IL-8 for PMNs; those that induce vascular permeability, promote dentinogenesis & repair, arrest caries progression (TNF, GFs) Barkhorder, et.al, 1999; Tyler ...
The Lymphatic System and Immunity
The Lymphatic System and Immunity

... the body. This system has three major functions: (1) to protect the body through the immune response; (2) to transport fluid from the interstitial fluid to the bloodstream; and (3) to help distribute hormones and nutrients, and transport waste. The immune response produced by activated lymphocytes i ...
Protective Skin Microbes Help Fight Off Disease
Protective Skin Microbes Help Fight Off Disease

Chapter 21: Blood Vessels and Circulation
Chapter 21: Blood Vessels and Circulation

... • Physical and chemical barriers that prevent or slow entry/progress of infectious organisms • 2 Types of defenses – Nonspecific defenses – Specific defenses ...
Autoimmunity and Autoimmune Diseases
Autoimmunity and Autoimmune Diseases

... Antibodies to citrullinated peptides (anti-CCP antibodies) Antibodies to Fc portion of IgG (rheumatoid factor) Immune complex formation and T-cell infiltration in synovium Leads to activation of innate immune system components through Fc receptors Synovial inflammation, destruction of cartilage and ...
Cell Communication per Parrott
Cell Communication per Parrott

... – Protein Kinase (usually TK) Linked Receptors. These generate cascades of modifications, but do not always use 2nd messengers. – Ion Channels. Receptor is part of an ion channel. (Neurons) ...
Topic: Immunity Aim: Describe how your immune system works to
Topic: Immunity Aim: Describe how your immune system works to

... Sometimes foreign materials manage to get past the first line of defense. When this occurs, the immune system responds in two ways. The white blood cells that first respond to the site of injury or infection attack foreign materials in a nonspecific response. Some of these cells attack foreign mater ...
Section VIII - BC Centre for Disease Control
Section VIII - BC Centre for Disease Control

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Developing Multi‐HIV Antigen Specific T Cells as a Component of a
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... improve the lives of millions of people living with HIV/AIDS.  The latent reservoir is comprised of resting CD4+ T cells (and most  probably other cells). The absence of viral replication means that  these infected cells do not express HIV antigens and are therefore  not killed by immune effectors.  ...
Complement
Complement

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What is the importance of the immunological synapse? Daniel M. Davis
What is the importance of the immunological synapse? Daniel M. Davis

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Correlation between viral load and levels of CD8 T cells
Correlation between viral load and levels of CD8 T cells

... battle HIV, as with other infections • After acute HIV infection, immune system remains persistently activated in most people • The T10 marker is now called CD38 and is used to measure immune activation • Levels of CD38 measured on immune cells called CD8 T cells correlate with pace of disease progr ...
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Cells of the Immune Response

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Human perinatal immunity in physiological conditions and during
Human perinatal immunity in physiological conditions and during

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Parasite Immunology 2015 pre print - T-Stor
Parasite Immunology 2015 pre print - T-Stor

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393 KB - International Medical Press
393 KB - International Medical Press

... The innate immune receptors TLR7 and TLR8 recognize pathogen RNA and are able to induce an antiviral response. They are currently under investigation as targets for new antiviral drugs. TLR stimulatory drugs including CpG ODN or R848 have been shown to induce a robust activation of the innate immune ...
Immunology
Immunology

... PHASES OF HUMORAL IMMUNE RESPONSE The average affinity of the antibodies produced during the course of the humoral response increases remarkably during the process of affinity maturation. Experimentally, the affinity of the serum anti-DNP antibodies produced in response to the antigen was then measu ...
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... Ability to Elicit Strong T-Cell Immune Response Montreal, Canada – November 12, 2014— Caprion announced today that its immune monitoring business unit, ImmuneCarta©, jointly published data with Medicago Inc. on the immune response induced by a Virus-like particles (VLPs) vaccine, targeted at the H5 ...
B10: Functional role of eicosanoids in host
B10: Functional role of eicosanoids in host

... via the lipoxygenase (LOX) and cyclooxygenase (COX) pathways. There is mounting evidence about their role in connecting innate and adaptive immunity. Among these prostanoids, PGE2 modulates immune and inflammatory responses (1, 2). Similarly leukotrienes, contribute directly to airway inflammation ( ...
Human Anatomy & Physiology II
Human Anatomy & Physiology II

... 1. Damage  mast cells, basophils & platelets release histamine  increased permeability & vasodilation in blood vessels 2. Leakage of clotting proteins into tissue ...
Immunology
Immunology

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Mature T cells
Mature T cells

Allergy and Immune Disorders
Allergy and Immune Disorders

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14_Hypersensitivity I - V14-Study

...  In an individual allergic to a particular antigen, a large proportion of IgE molecules bound to mast cells (and other effector cells) are specific for that antigen o Thus, exposure to antigen will cross link enough IgE molecules to illicit mast cell activation  In non-allergic individuals, mast c ...
Age-related autoimmunity Open Access
Age-related autoimmunity Open Access

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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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