Evasion of innate immunity by parasitic protozoa
... David Sacks and Alan Sher Parasitic protozoa are a major cause of global infectious disease. These eukaryotic pathogens have evolved with the vertebrate immune system and typically produce long-lasting chronic infections. A critical step in their host interaction is the evasion of innate immune defe ...
... David Sacks and Alan Sher Parasitic protozoa are a major cause of global infectious disease. These eukaryotic pathogens have evolved with the vertebrate immune system and typically produce long-lasting chronic infections. A critical step in their host interaction is the evasion of innate immune defe ...
Cellular characterization of the gouty tophus: A quantitative analysis
... minutes. Negative-staining control experiments were performed by using an isotype-matched polyclonal antibody. Sections were incubated for 30 minutes with a biotinylated secondary antibody and then with AB enzyme reagent for 30 minutes prior to application of DAB⫹ chromogen, counterstaining, and mou ...
... minutes. Negative-staining control experiments were performed by using an isotype-matched polyclonal antibody. Sections were incubated for 30 minutes with a biotinylated secondary antibody and then with AB enzyme reagent for 30 minutes prior to application of DAB⫹ chromogen, counterstaining, and mou ...
Cardiovascular diseases
... oxygen and nutrients to all of the cells in the body. It also picks up carbon dioxide and other waste products that the body produces so that they can be disposed of. The main components of this system are the heart, blood vessels, and blood. When a problem arises within the system, it is know ...
... oxygen and nutrients to all of the cells in the body. It also picks up carbon dioxide and other waste products that the body produces so that they can be disposed of. The main components of this system are the heart, blood vessels, and blood. When a problem arises within the system, it is know ...
The Immune System
... Antimicrobial Peptides and Proteins • Peptides and proteins function in innate defense by attacking microbes directly or impeding their reproduction • Interferon proteins provide innate defense against viruses and help activate macrophages • About 30 proteins make up the complement system, which ca ...
... Antimicrobial Peptides and Proteins • Peptides and proteins function in innate defense by attacking microbes directly or impeding their reproduction • Interferon proteins provide innate defense against viruses and help activate macrophages • About 30 proteins make up the complement system, which ca ...
Lymphatic System
... clustered along lymphatic vessels Aggregations of these nodes occur near the body surface in inguinal, axillary, and cervical regions of the body ...
... clustered along lymphatic vessels Aggregations of these nodes occur near the body surface in inguinal, axillary, and cervical regions of the body ...
슬라이드 1 - Hanyang
... - If excess stem cells were injected into an animal, they simply wouldn’t divide or would undergo apoptosis and be eliminated - The particular signals that trigger apoptosis in HSCs are as yet unknown. - when used antibodies to disrupt the adhesion of HSCs to the stroma via VLA-4/VCAM-1, the cells w ...
... - If excess stem cells were injected into an animal, they simply wouldn’t divide or would undergo apoptosis and be eliminated - The particular signals that trigger apoptosis in HSCs are as yet unknown. - when used antibodies to disrupt the adhesion of HSCs to the stroma via VLA-4/VCAM-1, the cells w ...
Microbial Pathogenesis-CCMD 793 I Nyles Charon
... Binding of Yersinia to host-cell receptors triggers phagocytic pathways that result in bacterial uptake. The rapid translocation of several effectors by Yersinia disarms these pathways, facilitating bacterial avoidance of phagocytosis. YopH dephosphorylates a number of tyrosine-phosphorylated signal ...
... Binding of Yersinia to host-cell receptors triggers phagocytic pathways that result in bacterial uptake. The rapid translocation of several effectors by Yersinia disarms these pathways, facilitating bacterial avoidance of phagocytosis. YopH dephosphorylates a number of tyrosine-phosphorylated signal ...
Document
... – Second - antimicrobial proteins, phagocytes, and other cells • Inhibit spread of invaders • Inflammation most important mechanism ...
... – Second - antimicrobial proteins, phagocytes, and other cells • Inhibit spread of invaders • Inflammation most important mechanism ...
immunology and medical microbiology
... Penicillin is a small molecule and by itself is not immunogenic. Once degraded in body it forms very reactive “penicilloyl” group which can react with proteins (albumin) to form a penicilloyl-protein conjugate (hapten-carrier conjugate). This is recognized as foreign and provokes an immune response. ...
... Penicillin is a small molecule and by itself is not immunogenic. Once degraded in body it forms very reactive “penicilloyl” group which can react with proteins (albumin) to form a penicilloyl-protein conjugate (hapten-carrier conjugate). This is recognized as foreign and provokes an immune response. ...
lectures
... • Kill by secreting toxic agents – TNF, a cytokine, binds to TNF receptor on the target cell, inducing caspase activation and apoptosis – Perforin, a pore-forming protein, related to complement C9 is inserted into the target cell membrane causing lysis – Granzymes, serine esterases that activate apo ...
... • Kill by secreting toxic agents – TNF, a cytokine, binds to TNF receptor on the target cell, inducing caspase activation and apoptosis – Perforin, a pore-forming protein, related to complement C9 is inserted into the target cell membrane causing lysis – Granzymes, serine esterases that activate apo ...
Page - Legionnaires` disease outbreak investigation
... Infectiousness of aerosolised organisms The locations of infection for cases of Legionnaires' disease have occasionally been epidemiologically-linked to sources up to several kilometres from the point of presumptive release of aerosolised organisms. An expected reduction in aerosol concentration awa ...
... Infectiousness of aerosolised organisms The locations of infection for cases of Legionnaires' disease have occasionally been epidemiologically-linked to sources up to several kilometres from the point of presumptive release of aerosolised organisms. An expected reduction in aerosol concentration awa ...
Understanding the Science behind Immuno
... ability to recognize foreign threats (nonself) as distinct from normal cells (self), is an essential feature of the immune system.2-4 Despite originating from normal cells, tumor cells can be recognized as nonself through production of tumor antigens.5 ...
... ability to recognize foreign threats (nonself) as distinct from normal cells (self), is an essential feature of the immune system.2-4 Despite originating from normal cells, tumor cells can be recognized as nonself through production of tumor antigens.5 ...
plasma cells
... Interleukins are cytokines that signal between immune cells and can also serve as growth factors for specific cell types. ...
... Interleukins are cytokines that signal between immune cells and can also serve as growth factors for specific cell types. ...
Supplementary Data (doc 82K)
... postvaccine (post-V) or post-SCT serum samples from the indicated time points in the donors (A, B, E) and recipients (C, D, F) were tested in parallel for KLH (A-D) and Id- (E, F) specific antibody responses by ELISA as described in the Materials and Methods. Post-SCT samples at 4 mo, 6 mo, 7 mo and ...
... postvaccine (post-V) or post-SCT serum samples from the indicated time points in the donors (A, B, E) and recipients (C, D, F) were tested in parallel for KLH (A-D) and Id- (E, F) specific antibody responses by ELISA as described in the Materials and Methods. Post-SCT samples at 4 mo, 6 mo, 7 mo and ...
Document
... How do T lymphocytes meet their challenges? • Very few lymphocytes in the body are specific for any one microbe (or antigen) • Lymphocytes must be able to locate and respond to microbes that enter anywhere in the body – Antigens are transported to and concentrated in the lymphoid organs through whi ...
... How do T lymphocytes meet their challenges? • Very few lymphocytes in the body are specific for any one microbe (or antigen) • Lymphocytes must be able to locate and respond to microbes that enter anywhere in the body – Antigens are transported to and concentrated in the lymphoid organs through whi ...
幻灯片 1 - Shandong University
... induced by physiochemical factors, such as X-ray Tumor low-specific antigens TSA---expressed on more than one kind of tumor, induced by virus ...
... induced by physiochemical factors, such as X-ray Tumor low-specific antigens TSA---expressed on more than one kind of tumor, induced by virus ...
PHG 413 lecture
... foreign, destroys them, and 'remembers' them. When the virulent version of an agent comes along the body recognizes the protein coat on the virus, and thus is prepared to respond, by (1) neutralizing the target agent before it can enter cells, and (2) by recognizing and destroying infected cells bef ...
... foreign, destroys them, and 'remembers' them. When the virulent version of an agent comes along the body recognizes the protein coat on the virus, and thus is prepared to respond, by (1) neutralizing the target agent before it can enter cells, and (2) by recognizing and destroying infected cells bef ...
M-cells: origin, morphology and role in mucosal immunity and
... and there are two distinct axes of migration and differentiation (Heath, 1996). Cells located on the villous side of the crypt differentiate into absorptive enterocytes, goblet cells and endocrine cells as they migrate upwards in columns along the villous (Sierro et al., 2000). Cells enter programme ...
... and there are two distinct axes of migration and differentiation (Heath, 1996). Cells located on the villous side of the crypt differentiate into absorptive enterocytes, goblet cells and endocrine cells as they migrate upwards in columns along the villous (Sierro et al., 2000). Cells enter programme ...
PS - Immune Checkpoint Inhibitors
... cells as in Fig. 1. The survival in the RT + 2aG4 group was significantly longer than in all other groups (P < 0.001). Thirteen percent of rats treated with RT + 2aG4 were rendered disease free. After 230 d, the disease-free rats were rechallenged by intracerebral injection of 5 î 104 into the contr ...
... cells as in Fig. 1. The survival in the RT + 2aG4 group was significantly longer than in all other groups (P < 0.001). Thirteen percent of rats treated with RT + 2aG4 were rendered disease free. After 230 d, the disease-free rats were rechallenged by intracerebral injection of 5 î 104 into the contr ...
coppin chapter 13
... Some states are accepting, meaning the FSA is saying “Yes”. Other states are rejecting. In this example there are two possible input characters – a and b, and two states, 1 and 2. It will finish in state 1 (the accepting state) if ...
... Some states are accepting, meaning the FSA is saying “Yes”. Other states are rejecting. In this example there are two possible input characters – a and b, and two states, 1 and 2. It will finish in state 1 (the accepting state) if ...
Lycera and Celgene Announce an Exclusive
... Transformational collaboration will focus on the advancement of Lycera's innovative pipeline, including Lycera's first-in-class RORgamma agonists for cancer immunotherapy, and clinicalstage candidate, LYC-30937, being studied for inflammatory bowel disease (IBD) NEW YORK and ANN ARBOR, Mich., June 9 ...
... Transformational collaboration will focus on the advancement of Lycera's innovative pipeline, including Lycera's first-in-class RORgamma agonists for cancer immunotherapy, and clinicalstage candidate, LYC-30937, being studied for inflammatory bowel disease (IBD) NEW YORK and ANN ARBOR, Mich., June 9 ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑