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Primary Sjo¨gren`s syndrome: current and emergent
Primary Sjo¨gren`s syndrome: current and emergent

... the immune system, and should subsequently not give rise to abnormal B-cell responses. However, stresses, such as ultraviolet radiation, viral infections and apoptosis, have been suggested to lead to undesirable cell surface exposure of autoantigens to the immune system [51]. Ro/SSA and La/SSB have ...
Chapter 8
Chapter 8

LACTOBACILLUS ACIDOPHILUS = Not good, and for - Nutri-Spec
LACTOBACILLUS ACIDOPHILUS = Not good, and for - Nutri-Spec

... health food industry fanatics, are not a significant component of the human microbiota. Lactobacilli are now known to not be the numerically dominant organisms of the human gut even though they are still listed as such in many microbiology textbooks. Lactobacilli form a very small proportion of the ...
EFFECT OF EXERCISE-INDUCED PHYSIOLOGICAL STRAIN ON
EFFECT OF EXERCISE-INDUCED PHYSIOLOGICAL STRAIN ON

... hormone (GH), cortisol, β-endorphin and adrenocorticotropic hormone (ACTH), [4]. Several of these stress-induced hormones elicit substantial changes in total number and relative proportions of blood leukocytes [2]. Cortisol exerts on circulation leukocytes with a time lag and do not play a major rol ...
Major Functions of the Lymphatic System
Major Functions of the Lymphatic System

... 2. To absorb fats and other substances from the digestive tract (this topic will be discussed in the Digestive System Unit), and 3. To initiate and coordinate an immune response to remove cellular debris, bacteria, toxins, fungi, parasites, and viruses that accumulate in our bodies. Because this sys ...
Vitamin D deficiency(common) - Rajiv Gandhi University of Health
Vitamin D deficiency(common) - Rajiv Gandhi University of Health

... actions on the cells of immune system (8). Vitamin D has an important role as an immunomodulator (9). Vitamin D mediates its effect through binding to vitamin D receptor (VDR) and activation of VDR responsive genes. The VDR protein has been found to be expressed in most of the lymphocytic cells invo ...
Normocytic Anemia
Normocytic Anemia

Distinct and Separable Roles of the Complement System in Factor H
Distinct and Separable Roles of the Complement System in Factor H

... platelets are endowed with Cfh upon exit from the bone marrow. To investigate this, we cultured megakaryocytes from normal C57BL/6 mice. These had the expected arborizing processes that released into the culture supernatant a continuous supply of platelets with features that were comparable to those ...
The correct answer is d
The correct answer is d

... pores. Which of the following would provide these plants immunity from fungal infection? a. Removing all of the stomata from the plant b. Changing the spacing of stomatal pores in these plants c. Reinforcing the cell wall in the guard cells of stomatal pores d. Increasing the number of trichomes on ...
Hemophagocytosis in adults (Hemophagocytic Syndrome) Brady Miller Hematology Oncology Fellow
Hemophagocytosis in adults (Hemophagocytic Syndrome) Brady Miller Hematology Oncology Fellow

... - Fulfill 5 of 8 above clinical/laboratory criteria (do not need to fulfill this if have a family history or molecular diagnosis that is consistent with HLH). Note that these current diagnostic criteria from the Histiocyte Society do not differentiate between “major” and “minor” criteria that are di ...
EGFR Kinase Mutations Are Not Affected by Lung Cancer
EGFR Kinase Mutations Are Not Affected by Lung Cancer

... while wt EGFR-transgenic animals remained tumor free (20, 21). Furthermore, mutated EGFR selectively activated Akt and STAT signaling pathways, which promoted cell survival, but had no effect on proliferation (22). Importantly, EGFR-mutated NSCLC cell lines demonstrated markedly increased resistance ...
Unit F222 - Growth, development and disease - High band
Unit F222 - Growth, development and disease - High band

... oncogenes and this makes the cells keep dividing by mitosis. Instead of stopping the cells keep making new cells which are also affected by the mutation and this makes a ball of cells which forms a tumour. This tumour can then break away from its original place and spread through the body to start c ...
High acid phosphatase level in the gingival tissues of periodontitis
High acid phosphatase level in the gingival tissues of periodontitis

Prevalence of Serum IgG and Neutralizing Factors Against
Prevalence of Serum IgG and Neutralizing Factors Against

... Adeno-associated viruses (AAVs) are small, nonenveloped single-stranded DNA viruses that require helper viruses to facilitate efficient replication. Despite the presence of humoral responses to the wild-type AAV in humans, AAV remains one of the most promising candidates for therapeutic gene transfe ...
clinical features of leprosy
clinical features of leprosy

... IMMUNOLOGY OF LEPROSY LEPROMIN TEST –INTRADERMAL INJECTION OF LEPROMIN , AN ANTIGENIC EXTRACT OF M.LEPRAE. NOT A DIAGNOSTIC TEST BUT USED FOR CLASSIFYING LEPROSY ON THE BASIS OF IMMUNE RESPONSE ...
Macrophage Cell Surface CD4 Type 1 HIV gp120 Induced Loss of A
Macrophage Cell Surface CD4 Type 1 HIV gp120 Induced Loss of A

Carbohydrate profiling reveals a distinctive role for
Carbohydrate profiling reveals a distinctive role for

Granulocyte Macrophage Colony-Stimulating Factor
Granulocyte Macrophage Colony-Stimulating Factor

Vaccinia virus protein A46R targets multiple Toll-like
Vaccinia virus protein A46R targets multiple Toll-like

... mice (2–5). Many but not all of these receptors have been assigned a role in the initial detection of, and response to, specific pathogen-associated molecules (PAMs). In macrophages and neutrophils, this drives innate immune responses, such as inflammation and induction of microbicidal activity, whe ...
The source of fatty acids incorporated into proliferating lymphoid
The source of fatty acids incorporated into proliferating lymphoid

... composition, as well as the abundance, of fatty acids available to growing or proliferating lymphoid cells are important, since those incorporated into membranes can modulate cell mobility, cell signalling and tolerance for oxidative stress (Calder, 2001). Immune activation increases energy utilisat ...
A human SARS-CoV neutralizing antibody against epitope on S2
A human SARS-CoV neutralizing antibody against epitope on S2

... Preparation of Luc/SARS S pseudovirus. The Luc/SARS S pseudovirus system was prepared based on the method described in [26]. Briefly, mammalian cell 293T was cotransfected by using three vectors that are mammalian expression vector pMT 21-S coding SARS-CoV S protein, pCMVR 8.2 coding for MuLV Gag and ...
Analysis of the roles of Interleukin 15 and CD4+ T cells specific of a
Analysis of the roles of Interleukin 15 and CD4+ T cells specific of a

... availability in spite of your tight schedule, for all regular meetings and discussions that we had. Thank you for having given me a large autonomy and your precious advice at moments when I particularly needed it. Thanks for the time you devoted for improving of our manuscripts and correction of thi ...
TLR2 and TLR4 expression on CD14++ and CD14+ monocyte
TLR2 and TLR4 expression on CD14++ and CD14+ monocyte

... and the metabolic syndrome17,18. The TLR up-regulation observed in T1DM patients is hypothesized to be induced by hyperglycaemia19. Upon stimuli, monocytes are capable of producing ...
Parasitism, predation and the evolution of animal personalities
Parasitism, predation and the evolution of animal personalities

Introduction to Immunoassays
Introduction to Immunoassays

... is a test that utilizes immunocomplexing when antibodies and antigens are brought together ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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