Introduction to Genomics, Bioinformatics - UNC
... • Retrieve/compare gene sequences • Predict function of unknown genes/proteins • Search for previously known functions of a gene ...
... • Retrieve/compare gene sequences • Predict function of unknown genes/proteins • Search for previously known functions of a gene ...
Species Editor
... Tools in Molecular Genetics eXplorer Genetics-explains biological phenomena in terms of genes. (e.g. how a flower color is inherited). Biochemistry- explains biological phenomena in terms of proteins. (e.g. how protein sequence in a flower determine protein structure and color). Molecular Bio ...
... Tools in Molecular Genetics eXplorer Genetics-explains biological phenomena in terms of genes. (e.g. how a flower color is inherited). Biochemistry- explains biological phenomena in terms of proteins. (e.g. how protein sequence in a flower determine protein structure and color). Molecular Bio ...
3.1.1.4 Proteins
... muscle proteins that work together to cause a muscle to contract. There are proteins in cell membranes that help identify a cell or serve as a receptor. Adrenalin and insulin are two examples of hormones that are made of protein. All proteins have a special shape that is the result of the interactio ...
... muscle proteins that work together to cause a muscle to contract. There are proteins in cell membranes that help identify a cell or serve as a receptor. Adrenalin and insulin are two examples of hormones that are made of protein. All proteins have a special shape that is the result of the interactio ...
Interactive Software for the study of membrane biology: lipid
... **Depto Bioquímica, Instituto de Biologia – UNICAMP, Campinas, SP. - E-mail: [email protected] Biological membranes define cellular boundaries, divide cells into discrete compartments, organize complex reaction sequences, and act in signal reception and energy transformations. This topic is studi ...
... **Depto Bioquímica, Instituto de Biologia – UNICAMP, Campinas, SP. - E-mail: [email protected] Biological membranes define cellular boundaries, divide cells into discrete compartments, organize complex reaction sequences, and act in signal reception and energy transformations. This topic is studi ...
Gene Expression
... an increased cellular demand for protein synthesis increasing the number of ribosomes cells must coordinate the synthesis of ribosomal proteins (r-proteins) and rRNA ...
... an increased cellular demand for protein synthesis increasing the number of ribosomes cells must coordinate the synthesis of ribosomal proteins (r-proteins) and rRNA ...
Protein Evolution and Sequence Analysis
... on properties of known proteins and is a direct consequence of evolutionary relationships. Speciation- Evolution of a new gene/protein that is genetically independent of the ancestral gene from which it arose. Homolog- A gene/protein related to a second gene/protein by descent from a common ancestra ...
... on properties of known proteins and is a direct consequence of evolutionary relationships. Speciation- Evolution of a new gene/protein that is genetically independent of the ancestral gene from which it arose. Homolog- A gene/protein related to a second gene/protein by descent from a common ancestra ...
ciliate genomics consortium - Tetrahymena Genome Database
... construct. Transformation of the construct and selection of the transformants is performed outside of this module. Once transformants are obtained they can be analyzed for phenotypes by future students in other classes such as cell biology. IV. GENE EXPRESSION ANALYSIS (GE) – A 3-lab module in which ...
... construct. Transformation of the construct and selection of the transformants is performed outside of this module. Once transformants are obtained they can be analyzed for phenotypes by future students in other classes such as cell biology. IV. GENE EXPRESSION ANALYSIS (GE) – A 3-lab module in which ...
Researchers use neutron scattering and supercomputing
... The data from the neutron experiments will then be analyzed using the supercomputing capabilities at DOE's Oak Ridge Leadership Computing Facility at ORNL. Additionally, the researchers will run simulations and model the protein while looking at other proteins to detect and characterize the protein' ...
... The data from the neutron experiments will then be analyzed using the supercomputing capabilities at DOE's Oak Ridge Leadership Computing Facility at ORNL. Additionally, the researchers will run simulations and model the protein while looking at other proteins to detect and characterize the protein' ...
AB094Sufia_abstract_30-09-2016
... shoot. Among them 45 proteins were common to all the 3 samples. The uncharacterized proteins were maximum for shoot tissues. Interestingly Dof family of proteins were significantly observed for all the samples. There are 38 Dof proteins are present in pigeonpea genome, among them 13 were reported fo ...
... shoot. Among them 45 proteins were common to all the 3 samples. The uncharacterized proteins were maximum for shoot tissues. Interestingly Dof family of proteins were significantly observed for all the samples. There are 38 Dof proteins are present in pigeonpea genome, among them 13 were reported fo ...
How do we determine a genes function?
... For Example:the NEW protein is a kinase (based on sequence) but without showing that the kinase domain is necessary for function this is not confirmed. How would this be possible using the techniques we have available? ...
... For Example:the NEW protein is a kinase (based on sequence) but without showing that the kinase domain is necessary for function this is not confirmed. How would this be possible using the techniques we have available? ...
Macromolecules
... You need hemoglobin to help transport oxygen to these muscles via your red blood cells! Specialized proteins hurry to your DNA and help ‘transcribe’ the hemoglobin gene to take it to another location outside the nucleus The result is a messenger RNA that provides instructions straight from the DNA o ...
... You need hemoglobin to help transport oxygen to these muscles via your red blood cells! Specialized proteins hurry to your DNA and help ‘transcribe’ the hemoglobin gene to take it to another location outside the nucleus The result is a messenger RNA that provides instructions straight from the DNA o ...
Proteins
... Factors that must be supplied in the diet for the body to be able to synthesis PROTEİN include : 1 . all E.a.a consume simultaneously and in proper amount 2 . an adequate total amount of protein to supply amine groups to synthesis non – E.a.a 3 . adequate of CHO & FAT to spare protein being used to ...
... Factors that must be supplied in the diet for the body to be able to synthesis PROTEİN include : 1 . all E.a.a consume simultaneously and in proper amount 2 . an adequate total amount of protein to supply amine groups to synthesis non – E.a.a 3 . adequate of CHO & FAT to spare protein being used to ...
Proteins
... • Compact, roughly spherical, water soluble and comprise all other types of protein as albumins and globulins. ...
... • Compact, roughly spherical, water soluble and comprise all other types of protein as albumins and globulins. ...
The UL21 gene of herpes simplex virus 1
... The UL21 gene of herpes simplex virus (HSV) encodes a 535-amino-acid tegument protein that is located throughout the cytoplasm and nuclei of infected cells. Little is known of the function of this protein, but studies of pseudorabies virus (PRV) suggest a role in viral DNA processing in the nucleus ...
... The UL21 gene of herpes simplex virus (HSV) encodes a 535-amino-acid tegument protein that is located throughout the cytoplasm and nuclei of infected cells. Little is known of the function of this protein, but studies of pseudorabies virus (PRV) suggest a role in viral DNA processing in the nucleus ...
Protein Synthesis (Gene Expression) Notes
... made, but proteins are made by the ribosomes—ribosomes are outside the nucleus in the cytoplasm. DNA is too large to leave the nucleus (double stranded), but RNA can leave the nucleus (single stranded) ...
... made, but proteins are made by the ribosomes—ribosomes are outside the nucleus in the cytoplasm. DNA is too large to leave the nucleus (double stranded), but RNA can leave the nucleus (single stranded) ...
Biosynthesis and degradation of proteins
... A large conformational change in the serpin accompanies cleavage of its substrate loop. This leads to disordering of the protease active site, preventing completion of the reaction. The serpin remains covalently linked to the protease as an acylenzyme intermediate. ...
... A large conformational change in the serpin accompanies cleavage of its substrate loop. This leads to disordering of the protease active site, preventing completion of the reaction. The serpin remains covalently linked to the protease as an acylenzyme intermediate. ...
Biological Molecules
... The major classes of organic compounds are Proteins, Carbohydrates, Lipids and Nucleic acids. •All of these organic molecules always contain the elements Carbon (C), Hydrogen (H) and Oxygen (O). Proteins contain Nitrogen as well, and sometimes sulfur. Nucleic acids have C, H, O, N and phosphorus (P ...
... The major classes of organic compounds are Proteins, Carbohydrates, Lipids and Nucleic acids. •All of these organic molecules always contain the elements Carbon (C), Hydrogen (H) and Oxygen (O). Proteins contain Nitrogen as well, and sometimes sulfur. Nucleic acids have C, H, O, N and phosphorus (P ...
Different Mechanisms for Turning On Viral Protein Production in
... the L1 protein prior to infection, the body will be better equipped at destroying the virus if viral invasion does occur. In my research I have looked at different ways to produce the L1 protein in human cells grown in the laboratory. Different forms of the L1 gene (encoding the L1 protein) were ins ...
... the L1 protein prior to infection, the body will be better equipped at destroying the virus if viral invasion does occur. In my research I have looked at different ways to produce the L1 protein in human cells grown in the laboratory. Different forms of the L1 gene (encoding the L1 protein) were ins ...
Biochemical studies on animal models of ceroid
... c. Quantitation of the sequence data showed that subunit c accounted for at least 50% of the lipopigment mass. No other mitochondrial protein was detected. Analyses of isolated mitochondria showed that they were functionally normal and did not contain excess amounts of subunit c. Subunit c is classi ...
... c. Quantitation of the sequence data showed that subunit c accounted for at least 50% of the lipopigment mass. No other mitochondrial protein was detected. Analyses of isolated mitochondria showed that they were functionally normal and did not contain excess amounts of subunit c. Subunit c is classi ...
Proteins Behaving badly - The University of Oklahoma
... fibrillar morphology and a regular cross-b sheet structure is linked to a number of neurodegenerative diseases. These aggregates, called amyloid, are believed to be the root cause of disease pathology. Although it was once believed that the insoluble aggregates were the biologically active species, ...
... fibrillar morphology and a regular cross-b sheet structure is linked to a number of neurodegenerative diseases. These aggregates, called amyloid, are believed to be the root cause of disease pathology. Although it was once believed that the insoluble aggregates were the biologically active species, ...
Bi190 Advanced Genetics 2011 Lecture 11/ho10 Genome to Function
... There are several high throughput methods for examining protein-protein interactions. Tandem affinity tagged pulldown of a protein complex, and its analysis by liquid chromatography and mass spectrometry (LC-MS-MS) has proven to be powerful and reasonably accurate. The yeast two-hybrid assay (Stan F ...
... There are several high throughput methods for examining protein-protein interactions. Tandem affinity tagged pulldown of a protein complex, and its analysis by liquid chromatography and mass spectrometry (LC-MS-MS) has proven to be powerful and reasonably accurate. The yeast two-hybrid assay (Stan F ...
powerpoint slides - Central Web Server 2
... For comparison the universe contains only about 1089 protons and has an age of about 5*1017 seconds or 5*1029 picoseconds. If every proton in the universe were a super computer that explored one possible protein sequence per picosecond, we only would have explored 5*10118 sequences, i.e. a negligibl ...
... For comparison the universe contains only about 1089 protons and has an age of about 5*1017 seconds or 5*1029 picoseconds. If every proton in the universe were a super computer that explored one possible protein sequence per picosecond, we only would have explored 5*10118 sequences, i.e. a negligibl ...
2 Answer all the questions. 1 Knowledge of the nitrogen cycle can
... Knowledge of the nitrogen cycle can be used to make decisions about management of farmland. A farmer uses her grass meadow to raise sheep. In a separate field she grows cabbages. (a) Fig. 1.1 shows part of the nitrogen cycle. The four boxes on the bottom line of the diagram refer to substances in th ...
... Knowledge of the nitrogen cycle can be used to make decisions about management of farmland. A farmer uses her grass meadow to raise sheep. In a separate field she grows cabbages. (a) Fig. 1.1 shows part of the nitrogen cycle. The four boxes on the bottom line of the diagram refer to substances in th ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.