![Acute Management of Atrial Fibrillation](http://s1.studyres.com/store/data/002199083_1-e358185a32cc82a956fcab492974d8fb-300x300.png)
Acute Management of Atrial Fibrillation
... instability were excluded from the trials. With the evidence of increased mortality from the Cardiac Arrhythmia Suppression Trial (CAST) study, flecainide with its increased proarrhythmia risk is contraindicated in patients with a history of acute coronary ischemia.25 Furthermore, its use is contrai ...
... instability were excluded from the trials. With the evidence of increased mortality from the Cardiac Arrhythmia Suppression Trial (CAST) study, flecainide with its increased proarrhythmia risk is contraindicated in patients with a history of acute coronary ischemia.25 Furthermore, its use is contrai ...
Seborrheic Dermatitis: An Update
... of corticosteroids. In a randomized, double blind, vehicle-controlled 4-week efficacy trial of twice daily pimecrolimus 1% cream in 96 patients, topical calcineurin inhibitor therapy was effective and well tolerated in the treatment of SD (37). In two randomized clinical trials, pimecrolimus 1% prov ...
... of corticosteroids. In a randomized, double blind, vehicle-controlled 4-week efficacy trial of twice daily pimecrolimus 1% cream in 96 patients, topical calcineurin inhibitor therapy was effective and well tolerated in the treatment of SD (37). In two randomized clinical trials, pimecrolimus 1% prov ...
SMART
... Interventions for treating and preventing SUDs must therefore be approached as a chronic health condition, such as diabetes or heart disease, and less like acute conditions such as bacterial infections or broken bones.5 SUDs occur along a continuum – people don’t suddenly ‘catch’ substance dependenc ...
... Interventions for treating and preventing SUDs must therefore be approached as a chronic health condition, such as diabetes or heart disease, and less like acute conditions such as bacterial infections or broken bones.5 SUDs occur along a continuum – people don’t suddenly ‘catch’ substance dependenc ...
Training on HIV/AIDS & STI
... burning sensation in cases (20%) as compared to none in the control group (p<0.05). Increased localized pruritus, however, was not found to be significantly associated with either case or control group (p>0.05). ...
... burning sensation in cases (20%) as compared to none in the control group (p<0.05). Increased localized pruritus, however, was not found to be significantly associated with either case or control group (p>0.05). ...
Product Information for Canagliflozin
... A total of 10,285 patients with type 2 diabetes who received medicinal product participated in nine double-blind, controlled clinical efficacy and safety studies conducted to evaluate the effects of INVOKANA on glycaemic control. Approximately 58% of patients were male. Patients had an overall mean ...
... A total of 10,285 patients with type 2 diabetes who received medicinal product participated in nine double-blind, controlled clinical efficacy and safety studies conducted to evaluate the effects of INVOKANA on glycaemic control. Approximately 58% of patients were male. Patients had an overall mean ...
Clinical Trials in Bulgaria Key Challenges
... standard in WE can turn out to be very costly or even unavailable in Bulgaria during standard treatment procedures. Participation in clinical trial would make it accessible. ...
... standard in WE can turn out to be very costly or even unavailable in Bulgaria during standard treatment procedures. Participation in clinical trial would make it accessible. ...
product information - Aspen Pharmacare Australia
... to 100mm scale) after 10 day’s treatment. The primary long term efficacy endpoint was the patient global assessment (PG) of study medicine after 13 week’s treatment. The secondary endpoints analysed were the change in physical function from baseline, change in stiffness from baseline, change in comp ...
... to 100mm scale) after 10 day’s treatment. The primary long term efficacy endpoint was the patient global assessment (PG) of study medicine after 13 week’s treatment. The secondary endpoints analysed were the change in physical function from baseline, change in stiffness from baseline, change in comp ...
(PSD) November 2016 PBAC Meeting - (Word 134KB)
... and replaced with a requirement for evidence that a HRCT scan has been performed. ...
... and replaced with a requirement for evidence that a HRCT scan has been performed. ...
Characterization of and Risk Factors for the Acute
... Inflammatory changes in the eyes have been associated previously with bisphosphonate use, particularly with iv infusions of pamidronate. They have not usually been considered to be part of the APR, but their occurrence (albeit rare) within the same time frame as the other inflammatory symptoms, sugg ...
... Inflammatory changes in the eyes have been associated previously with bisphosphonate use, particularly with iv infusions of pamidronate. They have not usually been considered to be part of the APR, but their occurrence (albeit rare) within the same time frame as the other inflammatory symptoms, sugg ...
Practice Parameter: Pharmacological treatment of migraine
... Diagnosis of primary headache disorders of children rests principally on clinical criteria as set forth by the International Headache Society (IHS, 1988).10 In 2004, the IHS published a modified International Classification of Headache Disorders (ICHD) for primary (e.g., including migraine, with and ...
... Diagnosis of primary headache disorders of children rests principally on clinical criteria as set forth by the International Headache Society (IHS, 1988).10 In 2004, the IHS published a modified International Classification of Headache Disorders (ICHD) for primary (e.g., including migraine, with and ...
Methods
... Pre-exercise spirometry was performed 5 minutes before the challenge. exercise challenge was performed on a treadmill. Workload was increased until 80–90% of the maximum heart rate (220 minus age) was achieved in the first 2 minutes, and exercise was sustained for 6 minutes. Spirometry was performed ...
... Pre-exercise spirometry was performed 5 minutes before the challenge. exercise challenge was performed on a treadmill. Workload was increased until 80–90% of the maximum heart rate (220 minus age) was achieved in the first 2 minutes, and exercise was sustained for 6 minutes. Spirometry was performed ...
Chapter 116: Psychopharmacology Of Eating Disorders
... Few studies of medication using rigorous double-blind placebo-controlled trials have been reported in patients with AN. In contrast to the positive claims from open trials, results from double-blind trials have been limited, for the most part. Double-blind studies, at most, report marginal success i ...
... Few studies of medication using rigorous double-blind placebo-controlled trials have been reported in patients with AN. In contrast to the positive claims from open trials, results from double-blind trials have been limited, for the most part. Double-blind studies, at most, report marginal success i ...
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2
... available at NEJM.org. Members of the University of Freiburg conducted an independent statistical analysis of cardiovascular outcomes (Section B in the Supplementary Appendix). The manuscript was drafted by the first and last authors and revised by all the authors. Medical writing assistance, which ...
... available at NEJM.org. Members of the University of Freiburg conducted an independent statistical analysis of cardiovascular outcomes (Section B in the Supplementary Appendix). The manuscript was drafted by the first and last authors and revised by all the authors. Medical writing assistance, which ...
Clinical effectiveness of cognitive therapy v. interpersonal
... out, so far the data collected in randomized comparisons of CT and IPT are insufficient to reliably decide whether the two therapies have differential effects on the BDI. More specifically, trial sequential analysis on the three existing studies examining the effects of individual CT and IPT for depre ...
... out, so far the data collected in randomized comparisons of CT and IPT are insufficient to reliably decide whether the two therapies have differential effects on the BDI. More specifically, trial sequential analysis on the three existing studies examining the effects of individual CT and IPT for depre ...
AusPAR: Umeclidinium bromide - Therapeutic Goods Administration
... use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as per ...
... use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction for any commercial purpose and retain this copyright notice and all disclaimer notices as part of that reproduction. Apart from rights to use as per ...
Extract from the Clinical Evaluation Report for loteprednol etabonate
... effect, LE is inactivated rapidly by circulating esterases to PJ-91 (∆1-cortienic acid etabonate) and subsequently to PJ-90 (Δ1-cortienic acid), both of these being inactive metabolites. Inactivation of LE takes place at the site of application, before the substance reaches the general circulation. ...
... effect, LE is inactivated rapidly by circulating esterases to PJ-91 (∆1-cortienic acid etabonate) and subsequently to PJ-90 (Δ1-cortienic acid), both of these being inactive metabolites. Inactivation of LE takes place at the site of application, before the substance reaches the general circulation. ...
PERFORMANCE IN INITIATING CLINICAL RESEARCH (Q3, 2014/15)
... Patients now being identified but few consented. Difficulty lies in getting patients diagnosed and into within the 48-hour recruitment window. Considering alternative recruitment options with Sponsor. Study team actively screening for patients. No patients recruited yet. ...
... Patients now being identified but few consented. Difficulty lies in getting patients diagnosed and into within the 48-hour recruitment window. Considering alternative recruitment options with Sponsor. Study team actively screening for patients. No patients recruited yet. ...
Treatment of diabetic neuropathy
... I) Compared with placebo, pregabalin treatment at total daily doses of 150, 300, and 600 mg : statistically significant reduction in the mean pain score, the primary end point of all included studies. The median time to a sustained one point improvement in pain score for pregabalin (at 150 mg, 300 m ...
... I) Compared with placebo, pregabalin treatment at total daily doses of 150, 300, and 600 mg : statistically significant reduction in the mean pain score, the primary end point of all included studies. The median time to a sustained one point improvement in pain score for pregabalin (at 150 mg, 300 m ...
Ethical considerations regarding access to experimental treatment
... of services in many areas, and sometimes to patients’ ignorance. It is a tragedy nonetheless when someone dies for want of medical attention that could easily save him or her. Whether this failure violates international human rights obligations is a topic with its own huge literature. A large number ...
... of services in many areas, and sometimes to patients’ ignorance. It is a tragedy nonetheless when someone dies for want of medical attention that could easily save him or her. Whether this failure violates international human rights obligations is a topic with its own huge literature. A large number ...
- Osteoarthritis and Cartilage
... were identical for each group and were performed without any concurrent medication or use of local anesthesia. For technical reasons (e.g., differences in viscosity, color) blinding of the doctor administering the medication was not possible. To evaluate pain severity, analgesic and anti-inflammator ...
... were identical for each group and were performed without any concurrent medication or use of local anesthesia. For technical reasons (e.g., differences in viscosity, color) blinding of the doctor administering the medication was not possible. To evaluate pain severity, analgesic and anti-inflammator ...
Protocol S1.
... All patients taking part in the study must provide their oral and written informed consent before they are included in the study. It is the investigator's duty to inform patients so that they are fully aware of all aspects of the survey. Patients may at any time withdraw their consent to participati ...
... All patients taking part in the study must provide their oral and written informed consent before they are included in the study. It is the investigator's duty to inform patients so that they are fully aware of all aspects of the survey. Patients may at any time withdraw their consent to participati ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... people, an alternative treatment should be tried, which should be cost effective and easily performed even at primary health centre. Many authors have focused their attention on the bacterial flora of chronic suppurative otitis media, but very little is known about the mycological aspects of these, ...
... people, an alternative treatment should be tried, which should be cost effective and easily performed even at primary health centre. Many authors have focused their attention on the bacterial flora of chronic suppurative otitis media, but very little is known about the mycological aspects of these, ...
Thought Field Therapy Background/Definition Thought Field
... Carbonell (1996) tested TFT’s effectiveness in reducing anxiety levels of individuals with acrophobia (fear of heights). Participants rated their SUD level near to or on a ladder and were randomly placed in a treatment or a placebo group. Both groups received treatment for reversal. TFT was administ ...
... Carbonell (1996) tested TFT’s effectiveness in reducing anxiety levels of individuals with acrophobia (fear of heights). Participants rated their SUD level near to or on a ladder and were randomly placed in a treatment or a placebo group. Both groups received treatment for reversal. TFT was administ ...
A prospective, randomised clinical trial comparing oral diclofenac
... Objectives: To compare the efficacy of oral (PO) diclofenac potassium (Cataflam®) and intramuscular (IM) diclofenac sodium (Voltaren ®) in acute pain relief, with a hypothesis of equivalence between the two. Patients and methods: In this prospective randomised single center clinical study, adult Chi ...
... Objectives: To compare the efficacy of oral (PO) diclofenac potassium (Cataflam®) and intramuscular (IM) diclofenac sodium (Voltaren ®) in acute pain relief, with a hypothesis of equivalence between the two. Patients and methods: In this prospective randomised single center clinical study, adult Chi ...
Distribution of therapeutic response in asthma control between oral
... ABSTRACT: The distribution of responses in study populations provides a novel method of comparing the benefit of two treatments. This 6-week, randomised, placebocontrolled, double-blind study compared the effectiveness of oral montelukast with inhaled beclomethasone in chronic asthma by assessing th ...
... ABSTRACT: The distribution of responses in study populations provides a novel method of comparing the benefit of two treatments. This 6-week, randomised, placebocontrolled, double-blind study compared the effectiveness of oral montelukast with inhaled beclomethasone in chronic asthma by assessing th ...
Placebo-controlled study
![](https://commons.wikimedia.org/wiki/Special:FilePath/Cebocap.jpg?width=300)
Placebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham ""placebo"" treatment which is specifically designed to have no real effect. Placebos are most commonly used in blinded trials, where subjects do not know whether they are receiving real or placebo treatment. Often, there is also a further ""natural history"" group that does not receive any treatment at all.The purpose of the placebo group is to account for the placebo effect, that is, effects from treatment that do not depend on the treatment itself. Such factors include knowing one is receiving a treatment, attention from health care professionals, and the expectations of a treatment's effectiveness by those running the research study. Without a placebo group to compare against, it is not possible to know whether the treatment itself had any effect.Patients frequently show improvement even when given a sham or ""fake"" treatment. Such intentionally inert placebo treatments can take many forms, such as a pill containing only sugar, a surgery where nothing efficacious is actually done (just an incision and sometimes some minor touching or handling of the underlying structures), or a medical device (such as an ultrasound machine) that is not actually turned on. Also, due to the body's natural healing ability and statistical effects such as regression to the mean, many patients will get better even when given no treatment at all. Thus, the relevant question when assessing a treatment is not ""does the treatment work?"" but ""does the treatment work better than a placebo treatment, or no treatment at all?"" As one early clinical trial researcher wrote, ""the first object of a therapeutic trial is to discover whether the patients who receive the treatment under investigation are cured more rapidly, more completely or more frequently, than they would have been without it.""p.195 More broadly, the aim of a clinical trial is to determine what treatments, delivered in what circumstances, to which patients, in what conditions, are the most effective.Therefore, the use of placebos is a standard control component of most clinical trials, which attempt to make some sort of quantitative assessment of the efficacy of medicinal drugs or treatments. Such a test or clinical trial is called a placebo-controlled study, and its control is of the negative type. A study whose control is a previously tested treatment, rather than no treatment, is called a positive-control study, because its control is of the positive type.Government regulatory agencies approve new drugs only after tests establish not only that patients respond to them, but also that their effect is greater than that of a placebo (by way of affecting more patients, by affecting responders more strongly, or both). As a result, ""placebo-controlled studies often are designed in such a way that disadvantages the placebo condition"".