Transcription and the Central Dogma
... • 1961: DNA is the molecule which stores genetic information, but – DNA is in nucleus, ribosomes (where protein synthesis takes place) are in the cytoplasm. – RNA, a different nucleic acid, is synthesized in the nucleus, and is similar to DNA. – RNA migrates to cytoplasm (where ribosomes are) – Amou ...
... • 1961: DNA is the molecule which stores genetic information, but – DNA is in nucleus, ribosomes (where protein synthesis takes place) are in the cytoplasm. – RNA, a different nucleic acid, is synthesized in the nucleus, and is similar to DNA. – RNA migrates to cytoplasm (where ribosomes are) – Amou ...
Document
... Tucker KL, Selhub K, et.al. Dietary intake pattern related to plasma folate and HCY concentrations in the Framingham Heart Study. J Nutr ...
... Tucker KL, Selhub K, et.al. Dietary intake pattern related to plasma folate and HCY concentrations in the Framingham Heart Study. J Nutr ...
chapter 23
... CH.6.b The student will investigate and understand how basic chemical properties relate to organic chemistry and biochemistry. Key concepts include: uses in pharmaceuticals and genetics, petrochemicals, plastics, and ...
... CH.6.b The student will investigate and understand how basic chemical properties relate to organic chemistry and biochemistry. Key concepts include: uses in pharmaceuticals and genetics, petrochemicals, plastics, and ...
Lecture 7 DNA REPLICATION
... 102 kDÆKlenow fragment (polymerase activity + 3'Æ5' exonuclease activity) and small domain (5'Æ3' exonuclease activity); all DNA pol have similar shape, thumb, palm and finger. DNA pol I= 1 polypeptide (polymerase, 3’-->5’ exonuclease proofreading, 5’-->3’exonuclease); processivity 20, catalytic rat ...
... 102 kDÆKlenow fragment (polymerase activity + 3'Æ5' exonuclease activity) and small domain (5'Æ3' exonuclease activity); all DNA pol have similar shape, thumb, palm and finger. DNA pol I= 1 polypeptide (polymerase, 3’-->5’ exonuclease proofreading, 5’-->3’exonuclease); processivity 20, catalytic rat ...
Evolution of Metabolic Pathway
... ¾The phyletic pattern for shikimate 5dehydrogenase coincides with the combined pattern of the two forms of 3-dehydroquinate synthase: ...
... ¾The phyletic pattern for shikimate 5dehydrogenase coincides with the combined pattern of the two forms of 3-dehydroquinate synthase: ...
DNA polymerase active site is highly mutable
... stuffer vector (pTaqDUM) was constructed by cloning two hybridized oligonucleotides into pTaq between BisWI and SacII sites; these two restriction sites flank the sequence encoding for motif A. A random library (pTaqLIB) was created by preparing a randomized oligonucleotide with a BisWI site in whic ...
... stuffer vector (pTaqDUM) was constructed by cloning two hybridized oligonucleotides into pTaq between BisWI and SacII sites; these two restriction sites flank the sequence encoding for motif A. A random library (pTaqLIB) was created by preparing a randomized oligonucleotide with a BisWI site in whic ...
Connect the dots…DNA to Disease, Oltmann
... 1.d. Students know the central dogma of molecular biology outlines the flow of information from transcription of ribonucleic acid (RNA) in the nucleus to translation of proteins on ribosomes in the cytoplasm. Genetics 4.b. Students know how mutations in the DNA sequence of a gene may or may not ...
... 1.d. Students know the central dogma of molecular biology outlines the flow of information from transcription of ribonucleic acid (RNA) in the nucleus to translation of proteins on ribosomes in the cytoplasm. Genetics 4.b. Students know how mutations in the DNA sequence of a gene may or may not ...
Connect the dots…DNA to Disease, Oltmann
... 1.d. Students know the central dogma of molecular biology outlines the flow of information from transcription of ribonucleic acid (RNA) in the nucleus to translation of proteins on ribosomes in the cytoplasm. Genetics 4.b. Students know how mutations in the DNA sequence of a gene may or may not ...
... 1.d. Students know the central dogma of molecular biology outlines the flow of information from transcription of ribonucleic acid (RNA) in the nucleus to translation of proteins on ribosomes in the cytoplasm. Genetics 4.b. Students know how mutations in the DNA sequence of a gene may or may not ...
lec 7 Metabolism of purine nucleotides
... Cause: inherited disease resulting from complete deficiency (absesnce) of HGPRTase → block (inhibit) salvage pathway of guanine and hypoxanthine → ↓ use of PRPP in salvage pathway and ↑ its use in purine synthesis leading to overproduction of purine nucleotides which by catabolism, will give increas ...
... Cause: inherited disease resulting from complete deficiency (absesnce) of HGPRTase → block (inhibit) salvage pathway of guanine and hypoxanthine → ↓ use of PRPP in salvage pathway and ↑ its use in purine synthesis leading to overproduction of purine nucleotides which by catabolism, will give increas ...
National Exam
... How might Phe1324 and Ile1270 contribute to the structure and function of the Cas9 protein? (2 pts) These sidechains are hydrophobic in nature – and are closely packed in the inside of a sub-‐domain ...
... How might Phe1324 and Ile1270 contribute to the structure and function of the Cas9 protein? (2 pts) These sidechains are hydrophobic in nature – and are closely packed in the inside of a sub-‐domain ...
103 Lecture Ch21a
... Naming Enzymes • The name of an enzyme identifies the reacting substance - usually ends in –ase • For example, sucrase catalyzes the hydrolysis of sucrose • The name also describes the function of the enzyme • For example, oxidases catalyze oxidation reactions • Sometimes common names are used, par ...
... Naming Enzymes • The name of an enzyme identifies the reacting substance - usually ends in –ase • For example, sucrase catalyzes the hydrolysis of sucrose • The name also describes the function of the enzyme • For example, oxidases catalyze oxidation reactions • Sometimes common names are used, par ...
Document
... What interferes with nitrogen fixation? Oxygen is the major factor. Nitrogen fixation can take place only in the total absence of O2 How does a plant overcome oxygen interference? By synthesizing a heme protein, leghemoglobin, which like other hemoglobins, has a high affinity for binding oxygen….wh ...
... What interferes with nitrogen fixation? Oxygen is the major factor. Nitrogen fixation can take place only in the total absence of O2 How does a plant overcome oxygen interference? By synthesizing a heme protein, leghemoglobin, which like other hemoglobins, has a high affinity for binding oxygen….wh ...
HSC 4572: Selected portions Chapter 6
... It likens the long strand of DNA to a “sentence”, and then considers the smaller gene piece as a “word” in that sentence The blue part is the actual codes that stand for each amino acid The green parts are the all important control areas, where what we eat will have an impact on how often (or ...
... It likens the long strand of DNA to a “sentence”, and then considers the smaller gene piece as a “word” in that sentence The blue part is the actual codes that stand for each amino acid The green parts are the all important control areas, where what we eat will have an impact on how often (or ...
Amino Acid Student Handout 1
... A core idea in the life sciences is that there is a fundamental relationship between a biological structure and the function it must perform. At the macro level, Darwin recognized that the structure of a finch’s beak was related to the food it ate. This fundamental structure-function relationship is ...
... A core idea in the life sciences is that there is a fundamental relationship between a biological structure and the function it must perform. At the macro level, Darwin recognized that the structure of a finch’s beak was related to the food it ate. This fundamental structure-function relationship is ...
Lecture Inhibition of Amino Acid Synthesis
... in translation by polymerizing the amino acids in a precise order as defined by the RNA molecule. In total, there are 20 amino acids with a variety of synthetic pathways in the plant. Herbicides that inhibit one of these metabolic pathways prevent the formation of one or more amino acids that may be ...
... in translation by polymerizing the amino acids in a precise order as defined by the RNA molecule. In total, there are 20 amino acids with a variety of synthetic pathways in the plant. Herbicides that inhibit one of these metabolic pathways prevent the formation of one or more amino acids that may be ...
Presentation (PowerPoint File)
... (N-W)^2 / 2 possible windows per N length protein Look for “minimum density”; scale away from diag ...
... (N-W)^2 / 2 possible windows per N length protein Look for “minimum density”; scale away from diag ...
Biosynthesis
Biosynthesis (also called biogenesis or anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined together to form macromolecules. This process often consists of metabolic pathways. Some of these biosynthetic pathways are located within a single cellular organelle, while others involve enzymes that are located within multiple cellular organelles. Examples of these biosynthetic pathways include the production of lipid membrane components and nucleotides.The prerequisite elements for biosynthesis include: precursor compounds, chemical energy (e.g. ATP), and catalytic enzymes which may require coenzymes (e.g.NADH, NADPH). These elements create monomers, the building blocks for macromolecules. Some important biological macromolecules include: proteins, which are composed of amino acid monomers joined via peptide bonds, and DNA molecules, which are composed of nucleotides joined via phosphodiester bonds.