Lec.5-426
... Nalorphine acts as antagonist & partial agonist. Nalorphine is used in treatment of morphine addiction and respiratory depression. Nalorphine acts at two opioid receptors, at the mu receptor it has antagonistic effects and at the kappa receptors it exerts agonistic characteristics. It is used to rev ...
... Nalorphine acts as antagonist & partial agonist. Nalorphine is used in treatment of morphine addiction and respiratory depression. Nalorphine acts at two opioid receptors, at the mu receptor it has antagonistic effects and at the kappa receptors it exerts agonistic characteristics. It is used to rev ...
CM 21- Stimulants, Benzo, Barbs, Opiates, Heroin Psychostimulants
... Switch to long acting benzodiazepine (Valium or Librium) and taper very slowly Tapering with clonazepam also very effective Treatment Depakote (valproic acid) mitigates withdrawal symptoms, decreases seizure potential, decreases craving o Loading dose = 10 X body wt BID first 24 hours ...
... Switch to long acting benzodiazepine (Valium or Librium) and taper very slowly Tapering with clonazepam also very effective Treatment Depakote (valproic acid) mitigates withdrawal symptoms, decreases seizure potential, decreases craving o Loading dose = 10 X body wt BID first 24 hours ...
OPIOIDS
... To some degree, drug tolerance is associated with environmental factors. Tolerance may disappear or decrease if a drug is used in an unfamiliar environment. A diagram of Siegel’s rat experiment ...
... To some degree, drug tolerance is associated with environmental factors. Tolerance may disappear or decrease if a drug is used in an unfamiliar environment. A diagram of Siegel’s rat experiment ...
OPIOIDS
... To some degree, drug tolerance is associated with environmental factors. Tolerance may disappear or decrease if a drug is used in an unfamiliar environment. A diagram of Siegel’s rat experiment ...
... To some degree, drug tolerance is associated with environmental factors. Tolerance may disappear or decrease if a drug is used in an unfamiliar environment. A diagram of Siegel’s rat experiment ...
activity 1-071510 - ids
... http://en.wikipedia.org/wiki/Morphine What is heroin? What do you know about it? -Heroin is a semi-synthetic opioid drug synthesized from morphine, a derivative of the opium poppy. It is the 3,6-diacetyl ester of morphine. It gives you a burst or rush of good feelings, and users feel "high" and rela ...
... http://en.wikipedia.org/wiki/Morphine What is heroin? What do you know about it? -Heroin is a semi-synthetic opioid drug synthesized from morphine, a derivative of the opium poppy. It is the 3,6-diacetyl ester of morphine. It gives you a burst or rush of good feelings, and users feel "high" and rela ...
Chemistry of Opioids
... o Metabolism to nor-meperidine via N-demethylation CNS excitation (e.g. tremors, seizures) o Inhibits 5-HT reuptake: potential for serotonin syndrome Absolute contraindication: meperidine + MAOIs Fentanyl o Structural features: Extra nitrogen between ring and phenyl group ↓CNS toxicities com ...
... o Metabolism to nor-meperidine via N-demethylation CNS excitation (e.g. tremors, seizures) o Inhibits 5-HT reuptake: potential for serotonin syndrome Absolute contraindication: meperidine + MAOIs Fentanyl o Structural features: Extra nitrogen between ring and phenyl group ↓CNS toxicities com ...
San Francisco Designer Drug that was supposed to mimic heroin
... all other opioids are either prepared from morphine (semisynthetic opioids like heroin) or synthesized from other precursors (synthetic opioids such as fentanyl) ...
... all other opioids are either prepared from morphine (semisynthetic opioids like heroin) or synthesized from other precursors (synthetic opioids such as fentanyl) ...
Opioids – anal-gesics (lol) ©2010 Mark Tuttle Mechanism of action
... - Hyperactivity of autonomic nervous system analgesia from the adverse effects ↓potency, ↓ abuse - GU Tract: ↓renal function, uterus: ↑ labor - Intense craving (Psychological withdrawl) - Low PC no BBB o Can be worse than physical withdrawal Tolerance is functional not metabolic o Diphenoxylate ...
... - Hyperactivity of autonomic nervous system analgesia from the adverse effects ↓potency, ↓ abuse - GU Tract: ↓renal function, uterus: ↑ labor - Intense craving (Psychological withdrawl) - Low PC no BBB o Can be worse than physical withdrawal Tolerance is functional not metabolic o Diphenoxylate ...
Morphine
Morphine, sold under many trade names, is a pain medication of the opiate type. It acts directly on the central nervous system (CNS) to decrease the feeling of pain. It can be used for both acute pain and chronic pain. Morphine is also frequently used for pain from myocardial infarction and during labour. It can be administered orally, intramuscularly, subcutaneously, intravenously, into the space around the spinal cord, or rectally. Maximum effect is around 20 min when given intravenously and 60 min when given by mouth while duration of effect is between three and seven hours. Long acting formulations also exist.Potentially serious side effects include a decreased respiratory effort and low blood pressure. Morphine has a high potential for addiction and abuse. If the dose is reduced after long term use withdrawal may occur. Common side effects include drowsiness, vomiting, and constipation. Caution is advised when used during pregnancy or breast feeding as morphine will affect the infant.Morphine was first isolated between 1803 and 1805 by Friedrich Sertürner. This is generally believed to be the first isolation of an active ingredient from a plant. Merck began marketing it commercially in 1827. Morphine was more widely used after the invention of the hypodermic syringe in 1853–1855. Sertürner originally named the substance morphium after the Greek god of dreams, Morpheus, for its tendency to cause sleep.The primary source of morphine is isolation from poppy straw of the opium poppy. In 2013 an estimated 523,000 kilograms of morphine were produced. About 45,000 kilograms were used directly for pain, an increase over the last twenty years of four times. Most use for this purpose was in the developed world. About 70% of morphine is used to make other opioids such as hydromorphone, oxycodone, heroin, and methadone. It is a Schedule II drug in the United States, Class A in the United Kingdom, and Schedule I in Canada. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.