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Practical Principals of Inpatient Opioid Pain Management
Practical Principals of Inpatient Opioid Pain Management

...  Requires cognitive function and trigger-ability  Parenteral administration only ...
Introduction to Opiates
Introduction to Opiates

... psychological dependence, physical dependence occurs with frequent daily use, which reinforces ant narcotic abuse.  If the user stops taking the drug after physical dependence has occurred severe withdrawal symptoms result. ...
Jeff Barr - USD Biology
Jeff Barr - USD Biology

...  Running rats exhibit withdrawal signs (increased aggression) when access to the running wheel ...
Narcotic analgesics
Narcotic analgesics

... The delta receptors have the greatest binding affinity for enkephalins. They mediate cardiovascular depressant , respiratory depressant and behavioural effects. The enteric neurons contain both µ and delta receptors and if either of this receptor is activated , peristalsis of the GIT is inhibition. ...
Opiates and Opioids
Opiates and Opioids

... injected or taken in pill form, it travels to the brain's opiate receptors and releases endorphins chemicals that produce happy, positive feelings and reduce pain - producing a "reward response” that causes the brain to crave more of the drug. The healthy brain produces natural endorphins on its own ...
opioidnarcotics
opioidnarcotics

...  invariably accompanies severe tolerance  Psychological dependence  common with frequent narcotic use ...
File
File

...  Can be smoked, inhaled or injected ...
Document
Document

... may be affected -The genes trigger production of proteins that wander back to the pre-synaptic neuron and tell it to stop releasing so ...
TOLERANCE
TOLERANCE

... may be affected -The genes trigger production of proteins that wander back to the pre-synaptic neuron and tell it to stop releasing so ...
Opioid Overdose 101 - Harm Reduction Coalition
Opioid Overdose 101 - Harm Reduction Coalition

... Personal embarrassment/shame ...
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... may be affected -The genes trigger production of proteins that wander back to the pre-synaptic neuron and tell it to stop releasing so ...
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... • high doses produce excitation and convulsions • less smooth muscle spasm and miosis,less respiratory depressant effects. little antitussive action than morphine ...
The Major Narcotics
The Major Narcotics

... The nonmedical use of prescription medications is associated with higher rates of tobacco, alcohol and other drug use  5% of 12 to 17 year olds reported nonmedical use of scheduled pain medications*; ...
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Opioid analgesics

... morphine 12–24 hours, e.g. the hot plate test – in mice, after 3 days the dose of morphine required for analgesia increases 5-fold). Important in drug addiction – may need to increase dose 50-fold. ...
analgesics
analgesics

... required to produce the same effect. It occurs rapidly with opioids (with morphine 12–24 hours, e.g. hot plate test – in mice, after 3 days dose of morphine required for analgesia increases 5-fold). Important in drug addiction – may need to increase dose 50-fold. ...
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Basic Neuroanatomy

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Neurotransmitters - UCSD Cognitive Science
Neurotransmitters - UCSD Cognitive Science

... • IV and smoked lead to fast onset and “rush” • 3 times as potent as morphine • Not directly an efficacious mu agonist, but more lipid soluble than morphine • Enters brain quickly, converted into morphine for action ...
File - Riske Science
File - Riske Science

... • We will consider three of these here: codeine, morphine, and diamorphine (known as heroin) and how they are made from morphine ...
Opioid Pharmacology
Opioid Pharmacology

... – Antidiarrheal – Analgesic • e.g., Buprenorphine ...
Morphine
Morphine

... postrema that causes vomiting. g. GI tract: Morphine relieves diarrhea by decreasing the motility and increasing the tone of the intestinal circular smooth muscle. Morphine also increases the tone of the anal sphincter. Overall, morphine and other opioids produce constipation. h. Cardiovascular: Mor ...
Drug Information
Drug Information

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Name  ______________________________  CH 204, Fall 2014 Assignment 8 – Opioids
Name ______________________________ CH 204, Fall 2014 Assignment 8 – Opioids

... NAPQI. Indicate what antidote may be given to a person who has overdosed on acetaminophen. ...
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... During this event, Polymorphonuclear Neutrophil Leukocytes (PMNs) play an important role by producing reactive oxygen species (ROS) and releasing myeloperoxidase (MPO), an oxidant enzyme. The latter one has two main activities: chloration and peroxidation, which participate in the host defence again ...
Presentation Part II
Presentation Part II

... Pain…2002 OK’d for OMT…Suboxone=added Naloxone (4:1)…Butrans for pain only Partial Mu agonist…>Doses Poor GI absorption…SL-Buccal-Nasal-Anal-Vaginal-Tinctures are Best Butrans dose=100-500mcg daily…Bupe pain dose=1-32mg daily OMT Dosing=8-32mg daily ...
Strong Analgesics
Strong Analgesics

... treatment of heroin addicts in some countries /as a legal drug ...
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Morphine



Morphine, sold under many trade names, is a pain medication of the opiate type. It acts directly on the central nervous system (CNS) to decrease the feeling of pain. It can be used for both acute pain and chronic pain. Morphine is also frequently used for pain from myocardial infarction and during labour. It can be administered orally, intramuscularly, subcutaneously, intravenously, into the space around the spinal cord, or rectally. Maximum effect is around 20 min when given intravenously and 60 min when given by mouth while duration of effect is between three and seven hours. Long acting formulations also exist.Potentially serious side effects include a decreased respiratory effort and low blood pressure. Morphine has a high potential for addiction and abuse. If the dose is reduced after long term use withdrawal may occur. Common side effects include drowsiness, vomiting, and constipation. Caution is advised when used during pregnancy or breast feeding as morphine will affect the infant.Morphine was first isolated between 1803 and 1805 by Friedrich Sertürner. This is generally believed to be the first isolation of an active ingredient from a plant. Merck began marketing it commercially in 1827. Morphine was more widely used after the invention of the hypodermic syringe in 1853–1855. Sertürner originally named the substance morphium after the Greek god of dreams, Morpheus, for its tendency to cause sleep.The primary source of morphine is isolation from poppy straw of the opium poppy. In 2013 an estimated 523,000 kilograms of morphine were produced. About 45,000 kilograms were used directly for pain, an increase over the last twenty years of four times. Most use for this purpose was in the developed world. About 70% of morphine is used to make other opioids such as hydromorphone, oxycodone, heroin, and methadone. It is a Schedule II drug in the United States, Class A in the United Kingdom, and Schedule I in Canada. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.
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