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12.3 and12.4 notes CD
12.3 and12.4 notes CD

... determined by heredity, such as height, are also affected by the environment. ...
GeneticsPt1.ppt
GeneticsPt1.ppt

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... used to amplify the portion of the gene corresponding to the disease mutation. Write out the first 5 bases of each of the primers. PGPN5b: 5’ AGCAG 3’ PGPN5b: 5’GATGG 3’ 2. (1 pt.) Why is some of the sequence given in lowercase letters and some uppercase? One explicit sentence. Uppercase = exon sequ ...
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... then be wider, for it will intervene between man in a more civilized state, as we may hope, even than the Caucasion, and some ape as low as a baboon, instead of as now between the negro or Australian [aborigine] and the gorilla.” • Charles Darwin, The Descent of Man (New York: A.L. Burt, 1874, 2nd e ...
HbVar_PhenCode - Center for Comparative Genomics and
HbVar_PhenCode - Center for Comparative Genomics and

... • MANY more people go to genome browsers than to locus specific databases • Data on variants and mutations can be easily displayed as a track on the browser • Information from other resources can be readily be integrated with variation information – E.g. ENCODE data on transcription, factor binding ...
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... – Changes in population due to chance, because traits not selected for/against (i.e., neutral) – Generally only significant in small populations; each mating act has larger influence on gene frequencies of population ...
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Epistasis



Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.
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