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... (L1425). The detectable phenotype in heterozygous embryos (not reported in human patients or the mouse model) suggests L1429R to be highly deleterious. Importantly, the phenotype was considerably variable from clutch to clutch, indicating that external factors can influence the extent of ectopic min ...
... (L1425). The detectable phenotype in heterozygous embryos (not reported in human patients or the mouse model) suggests L1429R to be highly deleterious. Importantly, the phenotype was considerably variable from clutch to clutch, indicating that external factors can influence the extent of ectopic min ...
Kuijper et al JEB
... the overall frequency of Cm mitochondria does not exceed our threshold of P = 0.05 that demarcates the zone of polymorphism (Fig. S2). The scope for higher frequencies of Cm alleles is enhanced with reverse dominance (Fig. 6b). The selection pressure when the Cm allele is dominant in males and hence ...
... the overall frequency of Cm mitochondria does not exceed our threshold of P = 0.05 that demarcates the zone of polymorphism (Fig. S2). The scope for higher frequencies of Cm alleles is enhanced with reverse dominance (Fig. 6b). The selection pressure when the Cm allele is dominant in males and hence ...
An Update on the Hereditary Spastic Paraplegias: New Genes and
... label the new genes as “candidates” only, and the results need to be interpreted with a degree of caution until mutations in these genes are identified in unrelated families. Notably, several candidate genes have been subsequently confirmed in independent studies, including REEP2,33 DDHD2,34,35 and ...
... label the new genes as “candidates” only, and the results need to be interpreted with a degree of caution until mutations in these genes are identified in unrelated families. Notably, several candidate genes have been subsequently confirmed in independent studies, including REEP2,33 DDHD2,34,35 and ...
The Structural, Biochemical, and Genetic Characterization of a New
... A variegated leaf mutant in soybean [Glycine max (L.) Merr.] has been identified and characterized. E25-10 was derived by exposure of seeds of the “Williams’ 82” cultivar to γ-radiation. In this mutant, yellow leaf sectors contain defective chloroplasts, in which the thylakoid membranes are presente ...
... A variegated leaf mutant in soybean [Glycine max (L.) Merr.] has been identified and characterized. E25-10 was derived by exposure of seeds of the “Williams’ 82” cultivar to γ-radiation. In this mutant, yellow leaf sectors contain defective chloroplasts, in which the thylakoid membranes are presente ...
The causal meaning of Fisher`s average effect
... mating scheme that determines how different alleles combine to form whole-genome genotypes. Later he acknowledged that other factors also influence the departure of genotype frequencies from random combination of genes, explicitly mentioning ‘the partial isolation of sections of the population ’ (Fish ...
... mating scheme that determines how different alleles combine to form whole-genome genotypes. Later he acknowledged that other factors also influence the departure of genotype frequencies from random combination of genes, explicitly mentioning ‘the partial isolation of sections of the population ’ (Fish ...
Characteristics of a Laboratory Strain of Coleomegilla maculata with
... and eggs were collected and counted on a daily basis over ten consecutive days. Eggs were observed daily and the number of hatched neonates was counted. Pupae were weighed individually using a Sartorius CP2P-F analytical balance. Data were analyzed by one way analysis of variance using SigmaPlot, ve ...
... and eggs were collected and counted on a daily basis over ten consecutive days. Eggs were observed daily and the number of hatched neonates was counted. Pupae were weighed individually using a Sartorius CP2P-F analytical balance. Data were analyzed by one way analysis of variance using SigmaPlot, ve ...
Diploid versus Haploid Organisms
... references [3, 4], although they used a completely different model, with conversions (haploid → diploid and asexual → sexual) happening only for individuals with many deleterious mutations. In this case, sexual diploids finally dominate the system with a small fraction of asexual diploids and haplo ...
... references [3, 4], although they used a completely different model, with conversions (haploid → diploid and asexual → sexual) happening only for individuals with many deleterious mutations. In this case, sexual diploids finally dominate the system with a small fraction of asexual diploids and haplo ...
Rare and common variants: twenty arguments
... Infinitesimal model: many variants of small effect. By ‘infinitesimal model’, I mean the proposition that common variants are among the major source of genetic variance for disease susceptibility and continuous traits, where hundreds or thousands of loci contribute in each case. The loci detected by ...
... Infinitesimal model: many variants of small effect. By ‘infinitesimal model’, I mean the proposition that common variants are among the major source of genetic variance for disease susceptibility and continuous traits, where hundreds or thousands of loci contribute in each case. The loci detected by ...
Differences in the diagnostic value of various criteria of negative T
... waves assessed by Criterion 3 was similar between prehypertrophic carriers and non-carriers (n = 64) (12.9 % compared with 4.7 % respectively; P = not significant). In contrast, the frequency of abnormal Q waves was significantly higher in pre-hypertrophic carriers than in non-carriers (22.6 % compa ...
... waves assessed by Criterion 3 was similar between prehypertrophic carriers and non-carriers (n = 64) (12.9 % compared with 4.7 % respectively; P = not significant). In contrast, the frequency of abnormal Q waves was significantly higher in pre-hypertrophic carriers than in non-carriers (22.6 % compa ...
Turning Meiosis into Mitosis - IJPB
... gametophytes, which generate, after fecundation, viable tetraploid plants. However, this phenomenon differs from apomeiosis in that the produced gametes are genetically different from the mother plant. Previously, we reported that in double Atspo11-1/Atrec8 mutants, the first meiotic division is rep ...
... gametophytes, which generate, after fecundation, viable tetraploid plants. However, this phenomenon differs from apomeiosis in that the produced gametes are genetically different from the mother plant. Previously, we reported that in double Atspo11-1/Atrec8 mutants, the first meiotic division is rep ...
Review Article
... infant mouse model of infection. Aside from establishing the importance of certain individual virulence factors in pathogenicity, this work identified a pleiotropically negative avirulent phenotype, designated Vir-, where a single Tn5 insertion prevented the expression of multiple virulence factors, ...
... infant mouse model of infection. Aside from establishing the importance of certain individual virulence factors in pathogenicity, this work identified a pleiotropically negative avirulent phenotype, designated Vir-, where a single Tn5 insertion prevented the expression of multiple virulence factors, ...
Klotho interferes with a novel FGF-signalling pathway and
... primarily expressed in the kidney, acts as an obligate co‐receptor of FGF23 to regulate phosphate homeostasis, secreted Klotho, resulting from the shedding of the KL1‐KL2 ectodomain into the bloodstream, inhibits Insulin/IGF1 signalling. However, the underlying molecular mechanisms ...
... primarily expressed in the kidney, acts as an obligate co‐receptor of FGF23 to regulate phosphate homeostasis, secreted Klotho, resulting from the shedding of the KL1‐KL2 ectodomain into the bloodstream, inhibits Insulin/IGF1 signalling. However, the underlying molecular mechanisms ...
Speciation - Bakersfield College
... when hereditary, meaning in DNA of germ cells) – Have little or no immediate effect on allele frequency, but are available to be selected for by natural selection ...
... when hereditary, meaning in DNA of germ cells) – Have little or no immediate effect on allele frequency, but are available to be selected for by natural selection ...
The genetics of deafness - Archives of Disease in Childhood
... deafness have yet been cloned but there has been some progress in mapping the X chromosomal genes which may cause non-syndromic deafness. Linkage studies in two separate families had indicated that a locus for deafness could be 'mapped' to the qI3-q21 region of the long arm of the X chromosome.12 13 ...
... deafness have yet been cloned but there has been some progress in mapping the X chromosomal genes which may cause non-syndromic deafness. Linkage studies in two separate families had indicated that a locus for deafness could be 'mapped' to the qI3-q21 region of the long arm of the X chromosome.12 13 ...
Phenylketonuria
... chance of decreasing their IQ levels. This is compared to others with above 25% enzyme activity that also went off the diet. This second group maintained or increased their IQ levels 5. The restricted phenylalanine diet needs to be adjusted in order to suit the individual needs for each patient. Th ...
... chance of decreasing their IQ levels. This is compared to others with above 25% enzyme activity that also went off the diet. This second group maintained or increased their IQ levels 5. The restricted phenylalanine diet needs to be adjusted in order to suit the individual needs for each patient. Th ...
Genetic Polymorphism of Human CYP2E1
... cells transfected with CYP2E1*1 cDNA (Fig. 4C). When 6-hydroxylation of chlorzoxazone was measured in the cell homogenates, a similar decrease was seen in activities as monitored on the protein level. By contrast, cells transfected with CYP2E1*3 cDNA had apoprotein levels and rates of chlorzoxazone ...
... cells transfected with CYP2E1*1 cDNA (Fig. 4C). When 6-hydroxylation of chlorzoxazone was measured in the cell homogenates, a similar decrease was seen in activities as monitored on the protein level. By contrast, cells transfected with CYP2E1*3 cDNA had apoprotein levels and rates of chlorzoxazone ...
Article Why There Are No Essential Genes on
... are differences between functions coded for by mobile genes and those in the “core” genome and that these differences can be seen between plasmids and chromosomes. In particular, it has been suggested that essential genes, such as those involved in the formation of structural proteins or in basic me ...
... are differences between functions coded for by mobile genes and those in the “core” genome and that these differences can be seen between plasmids and chromosomes. In particular, it has been suggested that essential genes, such as those involved in the formation of structural proteins or in basic me ...
Epistasis
Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.