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An Interaction-Dependent Model for Transcription Factor Binding
An Interaction-Dependent Model for Transcription Factor Binding

... footprinting assay [4] to determine binding sites followed by specific mutagenesis of the binding site to determine the acceptable bases. Either of these technologies result in short sequences, which can be aligned to derive the binding specificity as a positional weight matrix (PWM) [5]. A recent h ...
FEBS Letters
FEBS Letters

... 2 H + + 2 e - = H2 have been demonstrated for the heterocystous, N2-fixing cyanobacteria A. variabilis and Anabaena sp. PCC 7120 [1,2]. One of these enzymes, the so-called bidirectional or reversible hydrogenase, catalyzes both the Na2S204and methyl viologen-dependent H2 evolution and the uptake of ...
Exploring Human Traits - University of Hawaii at Hilo
Exploring Human Traits - University of Hawaii at Hilo

... smooth seed) of pea plants Mendel discovered the basic principles of heredity. Over many generations of breeding pea plants, Mendel discovered that certain traits show up in offspring without any blending of parent characteristics. For example, when pollen from tall plants was used to pollinate the ...
Genetics Quiz Wiz
Genetics Quiz Wiz

... length of fins, and color of skin can be observed on catfish. It is possible to see any combination of these traits in individual catfish. Which of Mendel’s Laws best explains this? The Law of Independent Assortment- if genes are located on separate chromosomes they are inherited independently. ...
Inheritance genetics
Inheritance genetics

... inherited as a unit. Chiasma formation (crossing over) during prophase I of meiosis can result in swapping of genes from one homologous chromosome to another. Consider the example of inheritance of body colour and wing length in the fruit fly, Drosophila melanogaster. Pure breeding grey-bodied and l ...
snpGalaxyEx.new
snpGalaxyEx.new

... Finding SNPs that fall in suspected functional regions a. Filter our input dataset (from part 1) to keep rows only whose intervals intersect (i.e. overlap) those in the library dataset of predicted regulatory regions. b. Filter our input dataset (from part 1) to keep only rows whose intervals inters ...
Bis2A 12.2 Eukaryotic Transcription
Bis2A 12.2 Eukaryotic Transcription

... features. However, eukaryotic promoters and other gene regulatory sequences may evolve as well. For instance, consider a gene that, over many generations, becomes more valuable to the cell. Maybe the gene encodes a structural protein that the cell needs to synthesize in abundance for a certain funct ...
Identify differential APA usage from RNA-seq
Identify differential APA usage from RNA-seq

... ”treatmentValue” and ”controlValue” representing the level of expression of the relative gene in the two conditions, while countResults puts in that columns the number of reads that were counted on the PRE portion of genes. standardFilter get a parameter with a cutoff for the FPKM value and selects ...
Genomic overview of serine proteases
Genomic overview of serine proteases

... presented here agrees with a previous attempt to segregate proteases into functional groups based on phylogenetic analysis [18]. The tight clustering, size homogeneity, sequence similarity, and uniform direction of transcription support the idea that genes of each cluster arose from a common ancesto ...
Name______KEY Genetics C3032 - Examination #2
Name______KEY Genetics C3032 - Examination #2

... Conversion from an F- to F+ is rare because the F factor enters the F- cell late; recombination occurs much more frequently because the host chromosome is transferred first (hence the name Hfr). ...
Identification of Full and Partial Class Relevant Genes
Identification of Full and Partial Class Relevant Genes

... [7], genetic algorithm (GA) with maximum likelihood [8] or SVM hybridization [9], degree of differential prioritization [10], shrunken centroid [11], [12] and Bayesian model averaging [13], represent some of the core approaches that have emerged recently. For detailed comparative studies on multicla ...
Bacterial Genetics
Bacterial Genetics

Downloaded - Cornell University
Downloaded - Cornell University

... the formation of multiple, nondormant intracellular offspring (39, 40, 45), which will be described below. Some of the smaller epulo morphotypes undergo binary fission, and many have the ability to produce phasebright endospores (34, 36, 39, 40, 45). The generation of intracellular offspring in Epulo ...
DNA Chips: Genes to Disease
DNA Chips: Genes to Disease

... • Genes that are expressed at low levels may still play an important role in the cell; their mRNA and protein may be needed only at low levels (e.g., P450 oxidases). • Housekeeping genes are those that are important for basic cellular functioning and are expressed in both types of cells. These genes ...
Looping versus linking: toward a model for long
Looping versus linking: toward a model for long

Introduction
Introduction

... KBase has a suite of apps and data that support the reconstruction, optimization, and analysis of metabolic models for microbes and plants (see Figure 2 and http://kbase.us/metabolic-modeling-inkbase/). In KBase, genome-scale metabolic models are primarily reconstructed from functional annotations p ...
Ch. 15 power point
Ch. 15 power point

... • Alterations of chromosome number and structure are associated with some serious disorders • Some types of aneuploidy appear to upset the genetic balance less than others, resulting in individuals surviving to birth and beyond • These surviving individuals have a set of symptoms, or syndrome, chara ...
PART II Introducció 53
PART II Introducció 53

... cromosoma 15 extranumerari (Blennow et al., 1995; Huang et al., 1997). S’han identificat duplicacions proximals de 15q en casos d’autisme i individus amb graus variables de retard mental (Cook et al., 1997). A la regió més proximal de 15q, s’han observat triplicacions intersticials en fenotips carac ...
Playing by pair-rules?
Playing by pair-rules?

... Pair-rule genes in non-insect arthropods? Among non-insect arthropods, divergent expression of pairrule orthologues appears to be more prevalent. ftz expression has thus far been examined in the barnacle crustacean Sacculina carcini,(22) the centipede Lithobius atkinsoni,(23) and the mite Archegozet ...
Candidate gene resequencing to identify rare, pedigree
Candidate gene resequencing to identify rare, pedigree

... The lifespan in LLFS was estimated as the duration of survival free of death from any cause or from any one of a specified list of diseases including cardiovascular disease, congestive heart failure, cancer, stroke, and Type 2 diabetes. The LLFS proband generation, including probands and full and ha ...
Detection of Mosaicism by Augmented Exome
Detection of Mosaicism by Augmented Exome

... sequencing is hampered by multiple factors. Assumptions inherent to genotyping and filtration strategies utilized by both genome and exome analysis often result in the dismissal or outright failure to call variants at allelic representations consistent with mosaicism. For those variants that are cal ...
Evolutionary relationships and diversification of barhl genes within
Evolutionary relationships and diversification of barhl genes within

... mutations and are functionally lost (non-functionalization [3,4]) or acquire a new function (neo-functionalization), or split the ancestral function between the paralogs (sub-functionalization) [2]), therefore adding complexity to the developmental gene network that shapes organ formation. The genes ...
An Introduction to the Genetics and Molecular Biology of the F S
An Introduction to the Genetics and Molecular Biology of the F S

... Approximately 30% of the genes already have been characterized experimentally. Of the remaining 70% with unknown function, approximately one half either contain a motif of a characterized class of proteins or correspond to genes encoding proteins that are structurally related to functionally charact ...
(a) (b)
(a) (b)

...  The inactive X condenses into a Barr body, and its genetic instructions are not used in that cell  If a female is heterozygous for a particular gene located on the X chromosome, she will be a mosaic for that character (some cells will express the allele from one X, some cells will express the all ...
Characterization of PIR1, a GATA family transcription factor involved
Characterization of PIR1, a GATA family transcription factor involved

... metabolism and the putative functional coupling between these two enzymes remains uncertain. Notably, iron is particularly important for wood-degrading fungi. This metal not only plays a key role in the central metabolism, but also serves as critical cofactor of several of the enzymes that are invol ...
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Minimal genome

The concept of minimal genome assumes that genomes can be reduced to a bare minimum, given that they contain many non-essential genes of limited or situational importance to the organism. Therefore, if a collection of all the essential genes were put together, a minimum genome could be created artificially in a stable environment. By adding more genes, the creation of an organism of desired properties is possible. The concept of minimal genome arose from the observations that many genes do not appear to be necessary for survival. In order to create a new organism a scientist must determine the minimal set of genes required for metabolism and replication. This can be achieved by experimental and computational analysis of the biochemical pathways needed to carry out basic metabolism and reproduction. A good model for a minimal genome is Mycoplasma genitalium, the organism with the smallest known genome. Most genes that are used by this organism are usually considered essential for survival; based on this concept a minimal set of 256 genes has been proposed.
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