NCC Collaborator - New England Genetics Collaborative
... system evaluation framework established in the current funding cycle with the same evaluation measures through 2017. – NCC will bridge between public health long-term follow-up and the NBSTRN LTFU work through facilitating pilots of the public health common data elements (CDEs) in the longitudinal p ...
... system evaluation framework established in the current funding cycle with the same evaluation measures through 2017. – NCC will bridge between public health long-term follow-up and the NBSTRN LTFU work through facilitating pilots of the public health common data elements (CDEs) in the longitudinal p ...
Genomic imprinting in the development and evolution of
... ‘autistic spectrum’ used for Kanner (infantile) autism, Asperger syndrome, Rett syndrome, and some other conditions (Table 1). I thus refer to ‘psychosis’ throughout this paper in a general sense as disordered cognition, emotionality, or both, commonly involving some component of positive symptoms s ...
... ‘autistic spectrum’ used for Kanner (infantile) autism, Asperger syndrome, Rett syndrome, and some other conditions (Table 1). I thus refer to ‘psychosis’ throughout this paper in a general sense as disordered cognition, emotionality, or both, commonly involving some component of positive symptoms s ...
PDF - NIMH Genetics
... no assumptions about mode of inheritance, disease allele frequencies, and penetrance. However, even without specifying models correctly, parametric analyses can be a more powerful test given the type of pedigree collection. In this study, many pedigrees included multiple generations and were, theref ...
... no assumptions about mode of inheritance, disease allele frequencies, and penetrance. However, even without specifying models correctly, parametric analyses can be a more powerful test given the type of pedigree collection. In this study, many pedigrees included multiple generations and were, theref ...
zChap07_140901 - Online Open Genetics
... a recombinant genotype. On the other hand, if no recombination occurs during meiosis, the products have their original combinations and are said to have a nonrecombinant, or parental genotype. Recombination is important because it contributes to the genetic variation that may be observed between ind ...
... a recombinant genotype. On the other hand, if no recombination occurs during meiosis, the products have their original combinations and are said to have a nonrecombinant, or parental genotype. Recombination is important because it contributes to the genetic variation that may be observed between ind ...
VCR 221 - Potato - UC Davis Plant Sciences
... homologs of Arabidopsis thaliana genes functional in defense signaling Identification, genetic mapping, and molecular cloning Molecular Plant-Microbe Interactions 18 : 1107-1119 Park, TH et al 2007. Genetic positioning of centromeres using half-tetrad analysis in a 4x-2x cross population of potato. ...
... homologs of Arabidopsis thaliana genes functional in defense signaling Identification, genetic mapping, and molecular cloning Molecular Plant-Microbe Interactions 18 : 1107-1119 Park, TH et al 2007. Genetic positioning of centromeres using half-tetrad analysis in a 4x-2x cross population of potato. ...
The effect of inbreeding rate on fitness, inbreeding depression and
... due to multilocus interactions should develop slowly in the beginning, but at accelerated speed as populations become increasingly differentiated (Orr and Turelli 2001). Consistent with the expectation, many empirical studies have found an intermediate optimum or a negative relationship between pare ...
... due to multilocus interactions should develop slowly in the beginning, but at accelerated speed as populations become increasingly differentiated (Orr and Turelli 2001). Consistent with the expectation, many empirical studies have found an intermediate optimum or a negative relationship between pare ...
Lesson Overview
... Mendel’s second conclusion is called the principle of dominance. This principle states that some alleles are dominant and others are recessive. An organism with at least one dominant allele for a particular form of a trait will exhibit that form of the trait. An organism with a recessive allele for ...
... Mendel’s second conclusion is called the principle of dominance. This principle states that some alleles are dominant and others are recessive. An organism with at least one dominant allele for a particular form of a trait will exhibit that form of the trait. An organism with a recessive allele for ...
Conserved syntenic clusters of protein coding genes are missing in
... Results: Using comparative genomics based on extensive searches of 60 avian genomes, we have found that birds lack approximately 274 protein coding genes that are present in the genomes of most vertebrate lineages and are for the most part organized in conserved syntenic clusters in non-avian saurop ...
... Results: Using comparative genomics based on extensive searches of 60 avian genomes, we have found that birds lack approximately 274 protein coding genes that are present in the genomes of most vertebrate lineages and are for the most part organized in conserved syntenic clusters in non-avian saurop ...
Effects of the Ordering of Natural Selection and Population
... We explore the effect of different mechanisms of natural selection on the evolution of populations for one- and two-locus systems. We compare the effect of viability and fecundity selection in the context of the Wright-Fisher model with selection under the assumption of multiplicative fitness. We sh ...
... We explore the effect of different mechanisms of natural selection on the evolution of populations for one- and two-locus systems. We compare the effect of viability and fecundity selection in the context of the Wright-Fisher model with selection under the assumption of multiplicative fitness. We sh ...
factor occupancy and gene expression Effects of sequence variation
... Table 1). Whole genome sequencing has been performed on this cell line and on LCLs derived from both of her parents (The 1000 Genomes Project Consortium 2010), and we aligned sequence reads to both the maternal and paternal versions of the genome (see Methods; Figure 1A). We identified 157,586 high- ...
... Table 1). Whole genome sequencing has been performed on this cell line and on LCLs derived from both of her parents (The 1000 Genomes Project Consortium 2010), and we aligned sequence reads to both the maternal and paternal versions of the genome (see Methods; Figure 1A). We identified 157,586 high- ...
factor occupancy and gene expression Effects of sequence variation
... Table 1). Whole genome sequencing has been performed on this cell line and on LCLs derived from both of her parents (The 1000 Genomes Project Consortium 2010), and we aligned sequence reads to both the maternal and paternal versions of the genome (see Methods; Figure 1A). We identified 157,586 high- ...
... Table 1). Whole genome sequencing has been performed on this cell line and on LCLs derived from both of her parents (The 1000 Genomes Project Consortium 2010), and we aligned sequence reads to both the maternal and paternal versions of the genome (see Methods; Figure 1A). We identified 157,586 high- ...
factor occupancy and gene expression Effects of
... Table 1). Whole genome sequencing has been performed on this cell line and on LCLs derived from both of her parents (The 1000 Genomes Project Consortium 2010), and we aligned sequence reads to both the maternal and paternal versions of the genome (see Methods; Figure 1A). We identified 157,586 high- ...
... Table 1). Whole genome sequencing has been performed on this cell line and on LCLs derived from both of her parents (The 1000 Genomes Project Consortium 2010), and we aligned sequence reads to both the maternal and paternal versions of the genome (see Methods; Figure 1A). We identified 157,586 high- ...
Genetic balancers
... heterozygotes that carry them. Maintenance of the heterozygous genotype from one generation to the next requires selection of heterozygous individuals, a task that becomes burdensome if more than a few strains must be maintained. For example, the self progeny of an unmarked recessive lethal heterozy ...
... heterozygotes that carry them. Maintenance of the heterozygous genotype from one generation to the next requires selection of heterozygous individuals, a task that becomes burdensome if more than a few strains must be maintained. For example, the self progeny of an unmarked recessive lethal heterozy ...
Conserved syntenic clusters of protein coding genes are missing in birds
... many conserved genes that could not be found in the previous assembly (for example, [20]), and yielded significant BLAT-alignments for approximately 96% of genes from a positive control search set consisting of randomly selected lizard gene models with known orthologs in birds). Lastly, this subset ...
... many conserved genes that could not be found in the previous assembly (for example, [20]), and yielded significant BLAT-alignments for approximately 96% of genes from a positive control search set consisting of randomly selected lizard gene models with known orthologs in birds). Lastly, this subset ...
journals - the biopsychology research group
... provide more precise evidence that there is no demonstrable threshold effect demarcating extreme groups. Differences between Clinical Samples and Twin Data: Clinical samples used in most molecular ...
... provide more precise evidence that there is no demonstrable threshold effect demarcating extreme groups. Differences between Clinical Samples and Twin Data: Clinical samples used in most molecular ...
Introduction of the AmpliChip CYP450 Test to a prospective cohort study
... was to compare the AmpliChip CYP450 TestW (AmpliChip) to alternative genotyping platforms for phenotype prediction of CYP2C19 and CYP2D6 in a representative cohort of the South African population. Methods: AmpliChip was used to screen for thirty-three CYP2D6 and three CYP2C19 alleles in two differen ...
... was to compare the AmpliChip CYP450 TestW (AmpliChip) to alternative genotyping platforms for phenotype prediction of CYP2C19 and CYP2D6 in a representative cohort of the South African population. Methods: AmpliChip was used to screen for thirty-three CYP2D6 and three CYP2C19 alleles in two differen ...
Do universal codon-usage patterns minimize the effects of mutation
... each other codon that can be reached by a single-base substitution (see Materials and methods). The standard genetic code and all known variants resist error better (have a lower error value) than do random codes for a wide range of different amino-acid properties and models of random code generatio ...
... each other codon that can be reached by a single-base substitution (see Materials and methods). The standard genetic code and all known variants resist error better (have a lower error value) than do random codes for a wide range of different amino-acid properties and models of random code generatio ...
THE GENETICS AND REPRODUCTIVE ISOLATING MECHANISMS
... ink in arguments among taxonomists as to whether bryonia: is a distinct species or only a subspecies of napi, without having brought about a satisfactory explanation. Even after the extensive work of MULLER and KAUTZ (1938), a turning-point in the opinions on this problem, the situation remained rat ...
... ink in arguments among taxonomists as to whether bryonia: is a distinct species or only a subspecies of napi, without having brought about a satisfactory explanation. Even after the extensive work of MULLER and KAUTZ (1938), a turning-point in the opinions on this problem, the situation remained rat ...
2013 - Allied Academies
... increase pregnancy loss in early stage Figure. 1. Pedigree of the family transmitting Robertsonian translocation chromosome t(14; 15)(q10;q10). Open hexagon designates a presumed carrier of t(14; 15)(q10;q10). Filled hexagon designates a known carrier of t(14;15)(q10;q10). The proband, IV-1 (arrow), ...
... increase pregnancy loss in early stage Figure. 1. Pedigree of the family transmitting Robertsonian translocation chromosome t(14; 15)(q10;q10). Open hexagon designates a presumed carrier of t(14; 15)(q10;q10). Filled hexagon designates a known carrier of t(14;15)(q10;q10). The proband, IV-1 (arrow), ...
Limb Girdle Muscular Dystrophy - Muscular Dystrophy Foundation of
... a. Some individuals earlier diagnosed as having LGMD did not have muscular dystrophy at all, but one of several clinically similar disorders such as spinal muscular atrophy (an inherited disorder of spinal nerve cells) or polymyositis (an inflammation of muscles which is not inherited). b. There are ...
... a. Some individuals earlier diagnosed as having LGMD did not have muscular dystrophy at all, but one of several clinically similar disorders such as spinal muscular atrophy (an inherited disorder of spinal nerve cells) or polymyositis (an inflammation of muscles which is not inherited). b. There are ...
Construction of a linkage map based on a Lathyrus sativus
... were used to detect QTLs for stem resistance to ascochyta blight at the seedling stage using three methods: single-point analysis, simple interval mapping and composite interval mapping. Each method was performed using MapManager QTX. The significance of each potential association between a marker an ...
... were used to detect QTLs for stem resistance to ascochyta blight at the seedling stage using three methods: single-point analysis, simple interval mapping and composite interval mapping. Each method was performed using MapManager QTX. The significance of each potential association between a marker an ...
selection for recombination in small populations
... on the stochastic nature of evolution in small populations. In infinitely large populations, every genotype already exists; thus, as long as there is no epistasis and no initial linkage disequilibrium, genes that modify recombination rates experience no selection (Maynard Smith 1968). Intuitively, o ...
... on the stochastic nature of evolution in small populations. In infinitely large populations, every genotype already exists; thus, as long as there is no epistasis and no initial linkage disequilibrium, genes that modify recombination rates experience no selection (Maynard Smith 1968). Intuitively, o ...
Fine mapping of Noonan/cardio-facio cutaneous syndrome
... the same yeast artificial chromosome (YAC) (920g2).12 The exact position of D12S129 in relation to D12S809 is not known.11 No other markers were available for a more precise mapping of the crossover. Another crossover was observed in an unaffected individual (III1) between the NS/CFC locus and marke ...
... the same yeast artificial chromosome (YAC) (920g2).12 The exact position of D12S129 in relation to D12S809 is not known.11 No other markers were available for a more precise mapping of the crossover. Another crossover was observed in an unaffected individual (III1) between the NS/CFC locus and marke ...
Population Differences in the Polyalanine Domain and 6
... and Japanese populations. (GCC)9 was almost as common as (GCC)11 in Chinese and Japanese populations, whereas its frequency was <10% in Yoruba and CEPH populations. The Yoruba population had the highest frequency of the largest alleles [(GCC)12 and (GCC)13], which were almost absent in the other gro ...
... and Japanese populations. (GCC)9 was almost as common as (GCC)11 in Chinese and Japanese populations, whereas its frequency was <10% in Yoruba and CEPH populations. The Yoruba population had the highest frequency of the largest alleles [(GCC)12 and (GCC)13], which were almost absent in the other gro ...
Human genetic variation
Human genetic variation is the genetic differences both within and among populations. There may be multiple variants of any given gene in the human population (genes), leading to polymorphism. Many genes are not polymorphic, meaning that only a single allele is present in the population: the gene is then said to be fixed. On average, in terms of DNA sequence all humans are 99.9% similar to any other humans.No two humans are genetically identical. Even monozygotic twins, who develop from one zygote, have infrequent genetic differences due to mutations occurring during development and gene copy-number variation. Differences between individuals, even closely related individuals, are the key to techniques such as genetic fingerprinting. Alleles occur at different frequencies in different human populations, with populations that are more geographically and ancestrally remote tending to differ more.Causes of differences between individuals include the exchange of genes during meiosis and various mutational events. There are at least two reasons why genetic variation exists between populations. Natural selection may confer an adaptive advantage to individuals in a specific environment if an allele provides a competitive advantage. Alleles under selection are likely to occur only in those geographic regions where they confer an advantage. The second main cause of genetic variation is due to the high degree of neutrality of most mutations. Most mutations do not appear to have any selective effect one way or the other on the organism. The main cause is genetic drift, this is the effect of random changes in the gene pool. In humans, founder effect and past small population size (increasing the likelihood of genetic drift) may have had an important influence in neutral differences between populations. The theory that humans recently migrated out of Africa supports this.The study of human genetic variation has both evolutionary significance and medical applications. It can help scientists understand ancient human population migrations as well as how different human groups are biologically related to one another. For medicine, study of human genetic variation may be important because some disease-causing alleles occur more often in people from specific geographic regions. New findings show that each human has on average 60 new mutations compared to their parents.Apart from mutations, many genes that may have aided humans in ancient times plague humans today. For example, it is suspected that genes that allow humans to more efficiently process food are those that make people susceptible to obesity and diabetes today.