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Genes and Medical Genetics
Genes and Medical Genetics

... • If know genotype of parents, can predict chances of having a child with certain genotypes (and thus certain phenotypes). – Ex. If one parent is homozygous dominant (EE) the chance of having a child with ...
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... Model to generate a wild-type BLM locus via somatic intragenic recombination: I, The two pairs of sister chromatids of the homologous chromosome Nos. 15 in a G2 somatic cell of a BS genetic compound (blm1 /blm2 ) are numbered 1-1 to 4-4. Each of the two mutations in BLM (the hatched rectangle), repr ...
Chapter 8: Microbial Genetics
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Workshop II Fungal-Plant Interactions Chair: Henriette Giese 55
Workshop II Fungal-Plant Interactions Chair: Henriette Giese 55

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DNA Replication

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... presence in the human genetics arena. In its 98-year history GENETICS has featured many articles in which the subject species was Homo sapiens, but until recently those were largely in the realm of population genetics. We intend to maintain the journal as a high status, high visibility venue for com ...
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... • depend directly on computation or automated transfer of annotations from a database – Hits from BLAST searches – InterPro2GO mappings ...
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... reviewed evidence on the putative detrimental effects of cousin marriages on offspring health, something of personal interest to him as he was the product of such a union (G.H. Darwin, 1875). He concluded by reviewing the most comprehensive studies of the issue and described what maybe the first pre ...
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... database sequence. Hence, it is important to extend the analysis by searching the predicted protein sequence for characteristic domains (conserved amino acid patterns that can be aligned) that serve as a signature of a protein family or of a biochemical or structural feature. A further extension is ...
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m5zn_2ab2252f39932cd

... C) Ammonia excretion conserves energy. 13) The land animals that evolved from earlier aquatic forms had to change their mechanisms for excreting nitrogenous wastes because D) land animals had a more difficult time with water balance than aquatic species since water was not always available on land. ...
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Status of Indian and global developments in Genetically Modified

... To feed the ever increasing population more and more food has to be produced from less and less land water and other natural resources ...
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Genetic engineering



Genetic engineering, also called genetic modification, is the direct manipulation of an organism's genome using biotechnology. It is therefore a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA may be inserted in the host genome by first isolating and copying the genetic material of interest using molecular cloning methods to generate a DNA sequence, or by synthesizing the DNA, and then inserting this construct into the host organism. Genes may be removed, or ""knocked out"", using a nuclease. Gene targeting is a different technique that uses homologous recombination to change an endogenous gene, and can be used to delete a gene, remove exons, add a gene, or introduce point mutations.An organism that is generated through genetic engineering is considered to be a genetically modified organism (GMO). The first GMOs were bacteria generated in 1973 and GM mice in 1974. Insulin-producing bacteria were commercialized in 1982 and genetically modified food has been sold since 1994. Glofish, the first GMO designed as a pet, was first sold in the United States December in 2003.Genetic engineering techniques have been applied in numerous fields including research, agriculture, industrial biotechnology, and medicine. Enzymes used in laundry detergent and medicines such as insulin and human growth hormone are now manufactured in GM cells, experimental GM cell lines and GM animals such as mice or zebrafish are being used for research purposes, and genetically modified crops have been commercialized.
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