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The evolutionary mechanics of bacterial protein toxins
The evolutionary mechanics of bacterial protein toxins

... perform the same pathogenic action through the same receptor.  They have one A subunit that stops protein synthesis inside cells, and 5 identical B subunits that help get the A subunit into the cell. These toxins are similar in structure and function to the plant toxin ricin.  These toxins cause b ...
Characterization of an IS-like element from
Characterization of an IS-like element from

Mendelian inheritance
Mendelian inheritance

... 1. Instead of nearly identical copies of an organism, a broad range of offspring develops, allowing more different abilities and evolutionary strategies. 2. There are usually some errors in every cell nucleus. Copying the genes usually adds more of them. By distributing them randomly over different ...
Ch 23 Evolution of Populations - juan-roldan
Ch 23 Evolution of Populations - juan-roldan

... – Mutations that result in a change in protein production are often harmful. – Mutations that result in a change in protein production can sometimes increase the fitness of the organism in its environment. Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings ...
Genetics Tutorial
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Sex determination in Bombyx mori
Sex determination in Bombyx mori

... behavioural characteristics. It is, however, not well understood which of the target genes of the sex-determining gene products are in Drosophila, C. elegans and mammals. In Drosophila, it is only known that the DSX protein regulates the transcription of yolk protein genes, yp1, yp2 and yp3, directl ...
Characterisation of hexon and fibre genes of a novel strain of
Characterisation of hexon and fibre genes of a novel strain of

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Microsoft Word Document
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Genome-wide DNA replication profile for

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preimplantation genetic diagnosis (pgd): application of the

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A rough guide to Drosophila mating schemes (light version 2.1) 1
A rough guide to Drosophila mating schemes (light version 2.1) 1

... Daily life in a fly laboratory requires performing classical genetic crosses. In these crosses, flies are used that carry gene mutations, chromosomal aberrations or transgenic constructs. These different fly variants are the bread-and-butter of fly research, providing the tools by which genes are ma ...
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... tallness is dominant, and the allele for shortness is recessive. Therefore, the plant’s phenotype is tall and the genotype is either TT or Tt. A short plant can have only one genotype. Both alleles must be for a short stem (tt), because the tall allele (T) is dominant over the short allele (t). Thou ...
A genome-wide scan in affected sibling pairs with
A genome-wide scan in affected sibling pairs with

... abstract: Previously, siblings of patients with idiopathic recurrent miscarriage (IRM) have been shown to have a higher risk of miscarriage. This study comprises two parts: (i) an epidemiological part, in which we introduce data on the frequency of miscarriage among 268 siblings of 244 patients with ...
Mapping Complex Genetic Traits in Humans: New Methods Using A Complete RFLP Linkage Map.
Mapping Complex Genetic Traits in Humans: New Methods Using A Complete RFLP Linkage Map.

... linkage are only about 20:1, corresponding to the 5~ confidence level.) Finding 100:1 odds against linkage is the conventional threshold for rejecting linkage. Once linkage is established, one estimates the recombination fraction as the value 0 at which the likelihood ratio is l a r g e s t - t h e ...
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Genetic engineering



Genetic engineering, also called genetic modification, is the direct manipulation of an organism's genome using biotechnology. It is therefore a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA may be inserted in the host genome by first isolating and copying the genetic material of interest using molecular cloning methods to generate a DNA sequence, or by synthesizing the DNA, and then inserting this construct into the host organism. Genes may be removed, or ""knocked out"", using a nuclease. Gene targeting is a different technique that uses homologous recombination to change an endogenous gene, and can be used to delete a gene, remove exons, add a gene, or introduce point mutations.An organism that is generated through genetic engineering is considered to be a genetically modified organism (GMO). The first GMOs were bacteria generated in 1973 and GM mice in 1974. Insulin-producing bacteria were commercialized in 1982 and genetically modified food has been sold since 1994. Glofish, the first GMO designed as a pet, was first sold in the United States December in 2003.Genetic engineering techniques have been applied in numerous fields including research, agriculture, industrial biotechnology, and medicine. Enzymes used in laundry detergent and medicines such as insulin and human growth hormone are now manufactured in GM cells, experimental GM cell lines and GM animals such as mice or zebrafish are being used for research purposes, and genetically modified crops have been commercialized.
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