Development and application of a positive
... such as complementation of function through restoration of the disrupted gene or by the introduction of transgenes that complement the loss of gene function are not common practice in Plasmodium (7,8). The availability of a negative selectable marker, in combination with a small number of positive s ...
... such as complementation of function through restoration of the disrupted gene or by the introduction of transgenes that complement the loss of gene function are not common practice in Plasmodium (7,8). The availability of a negative selectable marker, in combination with a small number of positive s ...
Whole Exome Re-Sequencing Implicates CCDC38 and
... of exomes, where all of the variation in the protein-coding portion of the genome can be measured, is a recent approach for the study of low frequency and rare variants. We undertook re-sequencing of the exomes of ‘‘resistant smokers’’ and used publicly available exome data for comparisons. Our find ...
... of exomes, where all of the variation in the protein-coding portion of the genome can be measured, is a recent approach for the study of low frequency and rare variants. We undertook re-sequencing of the exomes of ‘‘resistant smokers’’ and used publicly available exome data for comparisons. Our find ...
Subsystem: Transport of Nickel and Cobalt
... • Secondary transporters from the UreH family are Ni-specific and are often clustered with either urease or [Ni] supeoxide dismutase. • Secondary transporters from the HupE/UreJ family are widespread among bacteria and encoded within certain [NiFe] hydrogenase and urease gene clusters. M ost of them ...
... • Secondary transporters from the UreH family are Ni-specific and are often clustered with either urease or [Ni] supeoxide dismutase. • Secondary transporters from the HupE/UreJ family are widespread among bacteria and encoded within certain [NiFe] hydrogenase and urease gene clusters. M ost of them ...
Polymorphism of Insulin-Like Growth Factor I Gene among Chicken
... of gel mobility. Using SSCP analysis, three nonoverlapping SSCP patterns were found indicating the successful development of breed-diagnostic markers across the studied breeds (Fig. 3). The Cobb 500 breed showed a unique SSCP pattern with four bands. As mentioned in several studies (Bodenes et al., ...
... of gel mobility. Using SSCP analysis, three nonoverlapping SSCP patterns were found indicating the successful development of breed-diagnostic markers across the studied breeds (Fig. 3). The Cobb 500 breed showed a unique SSCP pattern with four bands. As mentioned in several studies (Bodenes et al., ...
Association of MMP-3 (-1612 5A/6A) polymorphism with knee
... psoriasis, hemochromatosis, previous knee injury, or previous joint infection. The patients with any systemic inflammatory or autoimmune disorders, or any type of malignant or chronic illness were not included in this study. Genotyping of MMP-3 gene Peripheral venous blood samples of 3 ml were drawn ...
... psoriasis, hemochromatosis, previous knee injury, or previous joint infection. The patients with any systemic inflammatory or autoimmune disorders, or any type of malignant or chronic illness were not included in this study. Genotyping of MMP-3 gene Peripheral venous blood samples of 3 ml were drawn ...
An Introduction to Streptomyces
... applications in human medicine as antibacterial, antitumour and antifungal agents. Also, in agriculture these compounds act as growth promoters, agents for plant protection, antiparasitic agents and herbicides (Hopwood, 1995). The onset of antibiotic production of Streptomyces cultures grown on agar ...
... applications in human medicine as antibacterial, antitumour and antifungal agents. Also, in agriculture these compounds act as growth promoters, agents for plant protection, antiparasitic agents and herbicides (Hopwood, 1995). The onset of antibiotic production of Streptomyces cultures grown on agar ...
Increased transversions in a novel mutator colon cancer cell line
... to known mismatch repair defective colon cancer mutators, the distribution of mutations in Vaco411 is signi®cantly dierent. Consistent with this dierence, Vaco411 extracts are pro®cient in assays of mismatch repair. The Vaco411 mutator appears to be novel, and is not an obvious human homologue of ...
... to known mismatch repair defective colon cancer mutators, the distribution of mutations in Vaco411 is signi®cantly dierent. Consistent with this dierence, Vaco411 extracts are pro®cient in assays of mismatch repair. The Vaco411 mutator appears to be novel, and is not an obvious human homologue of ...
Lecture 15 Notes CH.14
... The relationship between genotype and phenotype is rarely as simple as in the pea plant characters Mendel studied Many heritable characters are not determined by only one gene with two alleles However, the basic principles of segregation and independent assortment apply even to more complex patterns ...
... The relationship between genotype and phenotype is rarely as simple as in the pea plant characters Mendel studied Many heritable characters are not determined by only one gene with two alleles However, the basic principles of segregation and independent assortment apply even to more complex patterns ...
Somatic Cell Gene Mutations in Humans
... because they measure this common functional pathway. When these mutations occur in critical regions, they produce genotoxic disease. Most studies of human genotoxic diseases are concerned with genes involved in the disorder. Cancer research has become highly focused on the critical genes involved in ...
... because they measure this common functional pathway. When these mutations occur in critical regions, they produce genotoxic disease. Most studies of human genotoxic diseases are concerned with genes involved in the disorder. Cancer research has become highly focused on the critical genes involved in ...
Genetic Traits
... the mother and the father. Introduction Traits are passed down from parent to offspring through genetic material in cells called deoxyribonucleic acid (DNA). Therefore, the DNA that an individual inherits determines his or her characteristics. Within cells, molecules of DNA form structures called ch ...
... the mother and the father. Introduction Traits are passed down from parent to offspring through genetic material in cells called deoxyribonucleic acid (DNA). Therefore, the DNA that an individual inherits determines his or her characteristics. Within cells, molecules of DNA form structures called ch ...
Complete genome sequence of the thermophilic Thermus sp
... size that is below 2.5 Mb. They also display a high G + C content that may correlate with their thermophilic lifestyle. CCB_US3_UF1 has a higher number of predicted protein coding sequences (2279) than HB27 (2210) and HB8 (2173), but lower than that of T. scotoductus SA-01 (2458). They also share a ...
... size that is below 2.5 Mb. They also display a high G + C content that may correlate with their thermophilic lifestyle. CCB_US3_UF1 has a higher number of predicted protein coding sequences (2279) than HB27 (2210) and HB8 (2173), but lower than that of T. scotoductus SA-01 (2458). They also share a ...
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
... covers only viruses and bacteria; you are not responsible for text material on eukaryotic microbes). Note that problems on previous exams which require you to integrate material from two or more lectures are not included in the examples given above. However, you can be certain that some such problem ...
... covers only viruses and bacteria; you are not responsible for text material on eukaryotic microbes). Note that problems on previous exams which require you to integrate material from two or more lectures are not included in the examples given above. However, you can be certain that some such problem ...
cbb752-mg-spr10-bioinfo-intro
... Information: Whole Genomes • The Revolution Driving Everything Kerlavage, A. R., Bult, C. J., Tomb, J. F., Dougherty, B. A., Merrick, J. M., McKenney, K., Sutton, G., Fitzhugh, W., Fields, C., Gocayne, J. D., Scott, J., Shirley, R., Liu, L. I., Glodek, A., Kelley, J. M., Weidman, J. F., Phillips, C. ...
... Information: Whole Genomes • The Revolution Driving Everything Kerlavage, A. R., Bult, C. J., Tomb, J. F., Dougherty, B. A., Merrick, J. M., McKenney, K., Sutton, G., Fitzhugh, W., Fields, C., Gocayne, J. D., Scott, J., Shirley, R., Liu, L. I., Glodek, A., Kelley, J. M., Weidman, J. F., Phillips, C. ...
fulltext
... Positional cloning and identification of the causative mutation After linking the phenotype of interest to a chromosomal region the next step is to narrow down the region and identify candidate genes and the causative mutation. In fine-mapping experiments, more genetic markers are added in the regio ...
... Positional cloning and identification of the causative mutation After linking the phenotype of interest to a chromosomal region the next step is to narrow down the region and identify candidate genes and the causative mutation. In fine-mapping experiments, more genetic markers are added in the regio ...
PopGen 6: Brief Introduction to Evolution by Natural Selection
... evolutionary fitness into an ecological context. Ecological resources such as food, water, and habitat are finite, whereas the reproductive capacity is potentially limitless. From this observation comes the premise “life is a struggle for existence”. This premise leads both Darwin and Wallace to the ...
... evolutionary fitness into an ecological context. Ecological resources such as food, water, and habitat are finite, whereas the reproductive capacity is potentially limitless. From this observation comes the premise “life is a struggle for existence”. This premise leads both Darwin and Wallace to the ...
Lesson 1.1: Mutation
... Cancer is a disease in which cells grow out of control and form abnormal masses of cells. It is generally caused by mutations in genes that regulate the cell cycle. Because of the mutations, cells with damaged DNA are allowed to divide without limits. Cancer genes can be inherited. ...
... Cancer is a disease in which cells grow out of control and form abnormal masses of cells. It is generally caused by mutations in genes that regulate the cell cycle. Because of the mutations, cells with damaged DNA are allowed to divide without limits. Cancer genes can be inherited. ...
Tumour necrosis factor α -308G/A gene polymorphism
... and percentages) in tables. Multiple logistic regression models were used to compare the distribution of genotypes between cases and controls and to determine the association between TNFα308 G/A polymorphism and knee OA. To adjust differences in age, BMI, and gender between the groups, these three v ...
... and percentages) in tables. Multiple logistic regression models were used to compare the distribution of genotypes between cases and controls and to determine the association between TNFα308 G/A polymorphism and knee OA. To adjust differences in age, BMI, and gender between the groups, these three v ...
Genetic Causes of Infertility: Chromosomal Abnormalities in Couples
... missing DNA in the sons, therefore, no evidence that the abnormality is getting worse with a subsequent generation. The Y chromosome is not essential for life and until recently most regions of it were assumed to be functionally inert. Sex determination (controlled by the SRY gene) has long been vie ...
... missing DNA in the sons, therefore, no evidence that the abnormality is getting worse with a subsequent generation. The Y chromosome is not essential for life and until recently most regions of it were assumed to be functionally inert. Sex determination (controlled by the SRY gene) has long been vie ...
Consulta: subjectFacets:"Phenotype" Registros recuperados: 25
... Significant advances recently occurred in Coffea canephora research, such as the completion of its full genome sequencing. The information generated can be used in advanced molecular approaches for genetic improvement, like genome-wide selection programs (GWS). The purpose of this study was the phen ...
... Significant advances recently occurred in Coffea canephora research, such as the completion of its full genome sequencing. The information generated can be used in advanced molecular approaches for genetic improvement, like genome-wide selection programs (GWS). The purpose of this study was the phen ...
Alterations to the remote control of Shh gene expression cause
... (fusion of the digits) of the hands and feet. An intrachromosomal inversion was identified which interrupts the normal regulatory landscape of the SHH gene [13]. However, the limb defects were not owing to the loss of SHH regulatory information, but rather the influence of newly juxtaposed enhancers ...
... (fusion of the digits) of the hands and feet. An intrachromosomal inversion was identified which interrupts the normal regulatory landscape of the SHH gene [13]. However, the limb defects were not owing to the loss of SHH regulatory information, but rather the influence of newly juxtaposed enhancers ...
fulltext
... Tardigrades are known for being resistant to extreme conditions, including tolerance to ionising and UV radiation in both the hydrated and the dehydrated state. It is known that these factors may cause damage to DNA. It has recently been shown that single and double DNA strand breaks occur when tard ...
... Tardigrades are known for being resistant to extreme conditions, including tolerance to ionising and UV radiation in both the hydrated and the dehydrated state. It is known that these factors may cause damage to DNA. It has recently been shown that single and double DNA strand breaks occur when tard ...
Monoallelic Expression and Dominance
... in heterozygotes relative to Sb homozygotes. Importantly, comparison of eight SaSa and eight SaSb plants generated by forced selfing of an SaSb plant in which SCRa was “silent” showed that SCRa was expressed in SaSa progeny and “silenced” in their SaSb sibs. Thus, the low-expression state of SCRa is ...
... in heterozygotes relative to Sb homozygotes. Importantly, comparison of eight SaSa and eight SaSb plants generated by forced selfing of an SaSb plant in which SCRa was “silent” showed that SCRa was expressed in SaSa progeny and “silenced” in their SaSb sibs. Thus, the low-expression state of SCRa is ...
About the origins of Molecular Biology and of our Department at UTD
... the development of blood vessel patterns in chick embryos by means of measuring redox (reduction-oxidation) potentials and pH gradients that might precede the differentiation of blood vessels. To do so, I needed micro redox and pH electrodes. To learn how to make them and measure those parameters, ...
... the development of blood vessel patterns in chick embryos by means of measuring redox (reduction-oxidation) potentials and pH gradients that might precede the differentiation of blood vessels. To do so, I needed micro redox and pH electrodes. To learn how to make them and measure those parameters, ...
The universal reagent for genome tailoring
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...