rolduc meeting. feel connected!
... ‘feel connected’. First and foremost it symbolizes our aim to make all participants at the Retreat feel part of the ever expanding human genetics family. This family comprises ‘veterans’, but also many new PhD students from the different centres in the Netherlands and, this year for the first time, ...
... ‘feel connected’. First and foremost it symbolizes our aim to make all participants at the Retreat feel part of the ever expanding human genetics family. This family comprises ‘veterans’, but also many new PhD students from the different centres in the Netherlands and, this year for the first time, ...
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant
... clock mechanism but not in the light input signaling pathway. As a note of caution, one should keep in mind that the phenotypic effect of genetic modifications of genetically altered animals in a nonhomogeneous genetic background are prone to epigenetic effects. However, we tried to minimize this ri ...
... clock mechanism but not in the light input signaling pathway. As a note of caution, one should keep in mind that the phenotypic effect of genetic modifications of genetically altered animals in a nonhomogeneous genetic background are prone to epigenetic effects. However, we tried to minimize this ri ...
Chapter 16: Gene Regulation in Bacteria
... 5. Recognize how feedback inhibition is used in posttranslational regulation. 6. Know how riboswitches can regulate gene expression. 16.1 Overview of Transcriptional Regulation Overview Gene regulation can occur at a number of levels (Figure 16.1), but the most common is at the transcriptional level ...
... 5. Recognize how feedback inhibition is used in posttranslational regulation. 6. Know how riboswitches can regulate gene expression. 16.1 Overview of Transcriptional Regulation Overview Gene regulation can occur at a number of levels (Figure 16.1), but the most common is at the transcriptional level ...
Gene Duplication, Gene Conversion and the Evolution of
... recombination (Clark 1994; Otto and Yong 2002; also see Otto and Goldstein 1992). How does recombination alter the evolutionary dynamics of Y chromosomes? When duplicates do not directly increase fitness (sh ¼ 0), and there is no recombination, selection never favors invasion (Equation 1b above). We ...
... recombination (Clark 1994; Otto and Yong 2002; also see Otto and Goldstein 1992). How does recombination alter the evolutionary dynamics of Y chromosomes? When duplicates do not directly increase fitness (sh ¼ 0), and there is no recombination, selection never favors invasion (Equation 1b above). We ...
PDF
... interference (RNAi) knockdown (van der Zee et al., 2005; Rafiqi et al., 2008; Panfilio et al., 2013). Examining why the endstage phenotypes differ after loss of a conserved gene’s function provides a good example for the integration of the different levels of biological organization. Key to understa ...
... interference (RNAi) knockdown (van der Zee et al., 2005; Rafiqi et al., 2008; Panfilio et al., 2013). Examining why the endstage phenotypes differ after loss of a conserved gene’s function provides a good example for the integration of the different levels of biological organization. Key to understa ...
Excess of Deleterious Mutations around HLA
... also elevate the frequency of deleterious variants (Chun and Fay 2011; Hartfield and Otto 2011; Marsden et al. 2016). Conversely, existing recessive deleterious variation may also slow the fixation of beneficial alleles on the same haplotype (Assaf et al. 2015). However, since hitchhiking eventually ...
... also elevate the frequency of deleterious variants (Chun and Fay 2011; Hartfield and Otto 2011; Marsden et al. 2016). Conversely, existing recessive deleterious variation may also slow the fixation of beneficial alleles on the same haplotype (Assaf et al. 2015). However, since hitchhiking eventually ...
Families of SMA - Children with Spinal Muscular Atrophy
... Two SMN1 copies on one chromosome and none on other Frequency ~8% of people not affected with SMA We have seen 1 case with 2 copies in blood and <2 copies in sperm Resolve new mutation from 2+0 by linkage analysis If new mutation, test father’s sperm for mosaicism ...
... Two SMN1 copies on one chromosome and none on other Frequency ~8% of people not affected with SMA We have seen 1 case with 2 copies in blood and <2 copies in sperm Resolve new mutation from 2+0 by linkage analysis If new mutation, test father’s sperm for mosaicism ...
Recurrent patterns of DNA copy number alterations in tumors reflect
... similarity in their copy-number alteration profiles when evaluated at the level of principal component analysis (PCA), and more specifically that recurrent profiles at the level of PCA correlate with measured glycolytic phenotypes (FDGavidity in the tumor) as well as with increased proliferation. Th ...
... similarity in their copy-number alteration profiles when evaluated at the level of principal component analysis (PCA), and more specifically that recurrent profiles at the level of PCA correlate with measured glycolytic phenotypes (FDGavidity in the tumor) as well as with increased proliferation. Th ...
chapt21_HumanBiology14e_lecture
... • One-trait cross – considers the inheritance of one characteristic e.g. WW x Ww • Two-trait cross – considers the inheritance of two characteristics e.g. WWTT x WwTT • Gametes only carry one allele, so if an individual has the genotype Ww, what are the possible gametes that this individual can pass ...
... • One-trait cross – considers the inheritance of one characteristic e.g. WW x Ww • Two-trait cross – considers the inheritance of two characteristics e.g. WWTT x WwTT • Gametes only carry one allele, so if an individual has the genotype Ww, what are the possible gametes that this individual can pass ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... group compared to healthy control . These results agree with other studies (Abdulhussain et al 2012)(12). In diabetes mellitus, abnormally increased levels of lipids and lipid peroxides in plasma may be due to the abnormal lipid metabolism . Patients with type 2 diabetes frequently have an abnormal ...
... group compared to healthy control . These results agree with other studies (Abdulhussain et al 2012)(12). In diabetes mellitus, abnormally increased levels of lipids and lipid peroxides in plasma may be due to the abnormal lipid metabolism . Patients with type 2 diabetes frequently have an abnormal ...
Genome-Wide Analysis of In Vivo Binding of the Master Regulator
... growth-phase dependent manner [7]. A pivotal question to address is how primary environmental signals are relayed to global carbon and nitrogen control and further to the control of development and antibiotic production. The elucidation of the S. coelicolor genome sequence— the first from an antibio ...
... growth-phase dependent manner [7]. A pivotal question to address is how primary environmental signals are relayed to global carbon and nitrogen control and further to the control of development and antibiotic production. The elucidation of the S. coelicolor genome sequence— the first from an antibio ...
The molecular genetics of head development in Drosophila
... that the peristomium contains pairs of cirri, which are likely the remnants of the parapodia, the appendages present on annelid trunk metameres. Cephalization continued as evolution proceeded and is evident in present-day myriapods (centipedes and millipedes). The insect head, consisting of an asegm ...
... that the peristomium contains pairs of cirri, which are likely the remnants of the parapodia, the appendages present on annelid trunk metameres. Cephalization continued as evolution proceeded and is evident in present-day myriapods (centipedes and millipedes). The insect head, consisting of an asegm ...
A selfish origin for recombination
... population genetics models have emphasized the role of modifier genes (for a review see Feldman et al., 1996) on the evolution of recombination, that is they have considered the evolution of recombination at a certain site as something imposed by another locus at a different position. This is of cour ...
... population genetics models have emphasized the role of modifier genes (for a review see Feldman et al., 1996) on the evolution of recombination, that is they have considered the evolution of recombination at a certain site as something imposed by another locus at a different position. This is of cour ...
poster_CSHL_2007
... • applicable to any type of expression data, • obviates assumptions and parameter tuning often required by existing methods, ...
... • applicable to any type of expression data, • obviates assumptions and parameter tuning often required by existing methods, ...
Supplement Figures
... decreases as sU:U decreases. The correlation decreases from 1 for sU:U=1 (which is as in the original dos Reis tAI values) to 0.61 for sU:U=0, for the bottleneck relative location and 0.51 for the bottleneck relative strength. Next we looked how the modified tAI predicts expression levels of the E. ...
... decreases as sU:U decreases. The correlation decreases from 1 for sU:U=1 (which is as in the original dos Reis tAI values) to 0.61 for sU:U=0, for the bottleneck relative location and 0.51 for the bottleneck relative strength. Next we looked how the modified tAI predicts expression levels of the E. ...
genetics review2
... You are exploring the jungle and find a new species of plant. Some of the plants have red flowers and some have yellow flowers. You cross a red flowering plant with a yellow ...
... You are exploring the jungle and find a new species of plant. Some of the plants have red flowers and some have yellow flowers. You cross a red flowering plant with a yellow ...
A Conserved Molecular Framework for Compound Leaf Development
... structures of selected Eudicots: A. caerulea (A-F), S. lycopersicum (G-J), S. tuberosum (KN), C. hirsuta (O-Q) and P. sativum (R-Y). In A. caerula, AcNAM and AcCUC3 are expressed at the boundaries between leaf primordia (lp) and the meristem (m) during the formation of the rosette leaves (A, B) and ...
... structures of selected Eudicots: A. caerulea (A-F), S. lycopersicum (G-J), S. tuberosum (KN), C. hirsuta (O-Q) and P. sativum (R-Y). In A. caerula, AcNAM and AcCUC3 are expressed at the boundaries between leaf primordia (lp) and the meristem (m) during the formation of the rosette leaves (A, B) and ...
Cytoplasmic male sterility
... Bet Shean Valley, the Upper Jordan Valley, and Golan are interesting, because they are geographically distinct from the Southern Coastal Plain populations in the spontaneum material previously tested in msml cytoplasm. The distribution of restoration in the Southern Coastal Plain sample taken as a s ...
... Bet Shean Valley, the Upper Jordan Valley, and Golan are interesting, because they are geographically distinct from the Southern Coastal Plain populations in the spontaneum material previously tested in msml cytoplasm. The distribution of restoration in the Southern Coastal Plain sample taken as a s ...
REVIEW ARTICLE Gene cassettes
... fication and the cassettes are identified by these names (see Hall e t al., 1991). Table 1 lists the boundaries of the cassettes, many of which were not identified or were incorrectly identified in the primary publication of the sequence. The extent of each gene, assuming that the first in-frame ini ...
... fication and the cassettes are identified by these names (see Hall e t al., 1991). Table 1 lists the boundaries of the cassettes, many of which were not identified or were incorrectly identified in the primary publication of the sequence. The extent of each gene, assuming that the first in-frame ini ...
Chapter 26 Lecture Notes: Population Genetics I. Introduction A
... 1. Variation: Among individuals in a population there is phenotypic and genotypic variation 2. Heredity: Offspring are more similar to their parents than to unrelated individuals 3. Selection: Individuals having some phenotypes are more successful at surviving and reproducing than others B. Populati ...
... 1. Variation: Among individuals in a population there is phenotypic and genotypic variation 2. Heredity: Offspring are more similar to their parents than to unrelated individuals 3. Selection: Individuals having some phenotypes are more successful at surviving and reproducing than others B. Populati ...
The hidden complexity of Mendelian traits across yeast
... landscape of natural genetic variants leading to Mendelian traits has never been thoroughly explored in any species, and their phenotypic effects and inheritance patterns within natural populations are largely unknown. Here, we carried out a first species-wide identification of causal variants of Me ...
... landscape of natural genetic variants leading to Mendelian traits has never been thoroughly explored in any species, and their phenotypic effects and inheritance patterns within natural populations are largely unknown. Here, we carried out a first species-wide identification of causal variants of Me ...
Genetic Algorithms
... Selection mechanism sensitive for converging populations with close fitness values Generational population model (step 5 in SGA repr. cycle) can be improved with explicit survivor selection ...
... Selection mechanism sensitive for converging populations with close fitness values Generational population model (step 5 in SGA repr. cycle) can be improved with explicit survivor selection ...
Pathway/Genome Navigator - Bioinformatics Research Group at SRI
... Genes are boxes on the right Proteins are circles in the middle – numbers show complexes Reactions in box on left, with E.C. number if available Allows navigation between genes, proteins, rxns Links proteins with shared reactions ...
... Genes are boxes on the right Proteins are circles in the middle – numbers show complexes Reactions in box on left, with E.C. number if available Allows navigation between genes, proteins, rxns Links proteins with shared reactions ...
Practice Questions, Lectures 6-13 (259 KB pdf file)
... An RFLP probe shows four different morphs (alleles) in a population of three-spined sticklebacks (a fish Gasterosteus aculeatus). How many different heterozygous genotypes will there be in this population with regard to this RFLP? Question 4 Suppose that you are a genetic counselor, and a couple see ...
... An RFLP probe shows four different morphs (alleles) in a population of three-spined sticklebacks (a fish Gasterosteus aculeatus). How many different heterozygous genotypes will there be in this population with regard to this RFLP? Question 4 Suppose that you are a genetic counselor, and a couple see ...