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Opexa Therapeutics, Inc.
Opexa Therapeutics, Inc.

... Damage Myelin Producing Cells • In MS patients, the faulty immune system is not able to prevent the attack of a small subpopulation of myelin reactive T-cells (MRTC) ...
The Blood Brain Barrier
The Blood Brain Barrier

... • formed by an intricate complex of transmembrane proteins (junctional adhesion molecule-1, occludin, and claudins) with cytoplasmic accessory proteins (zonula occludens-1 and -2, cingulin, AF-6, and 7H6). • They are linked to the actin cytoskeleton , thereby forming the most intimate cell to cell c ...
immune status of chronically transfused patients
immune status of chronically transfused patients

... Immunomodulation after blood transfusion has been demonstrated in various studies. Increased risk of post-operative infections favours the deleterious clinical effects of transfusion immunomodulation, but it is debatable NK cell function has been shown but the clinical significance is not certain. W ...
Topic 19 - Roslyn Public Schools
Topic 19 - Roslyn Public Schools

... parasite) – each pathogen triggers a different response – there are millions of different pathogens so there are millions of different B-cells in the blood • (b) T-cells – there are two types of T-cells – 1. Helper T-cells – helps B-cells and other T-cell multiply and coordinate their actions 2. Kil ...
IMMUNO-Immunology Instant
IMMUNO-Immunology Instant

... brought to you by Christine White-Ziegler Name of condition, disease, or immunodeficiency: Atopic dermatitis (AD) Is this a genetic or acquired deficiency? If genetic, is it a dominant or recessive mutation? There is probably a genetic link as patients with AD have increased serum levels of IgE and ...
Serum Sickness
Serum Sickness

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understanding the immune system and laboratory values in multiple
understanding the immune system and laboratory values in multiple

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LSU Neuroscience Center of Excellence Health Sciences
LSU Neuroscience Center of Excellence Health Sciences

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- Medical Journal of Australia
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Fact Sheet
Fact Sheet

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References Costa, Jr. PT et al. Recognition and Initial
References Costa, Jr. PT et al. Recognition and Initial

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Inflammatory Immune Response
Inflammatory Immune Response

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Abstract - luis carrasco
Abstract - luis carrasco

... Among neurogenerative diseases, amyotrophic lateral sclerosis (ALS) is a fatal illness characterized by a progressive motor neuron dysfunction in the motor cortex, brainstem and spinal cord. ALS is the most common form of motor neuron disease; yet, to date, the exact etiology of ALS remains unknown. ...
What Factors Contribute to the Risk for MS?
What Factors Contribute to the Risk for MS?

... • Increased incidence of MS in many regions (especially in women) – When individuals migrate before age 15 from a region of high MS prevalence to one of low prevalence (or vice versa), they seem to adopt a prevalence similar to that of the region to which they moved – When they make the same move af ...
Gary Davis was recently poisoned at an airport. Relatives say he
Gary Davis was recently poisoned at an airport. Relatives say he

... both humeral and cellular response, and this immune response produced an immune modulator. These immune globulins may be transported to a member of a different species by serum transfusion simple administration. Using this approach, Dr. Davis determined that this immune modulation could be produced ...
Role of the innate immune system in the pathogenesis of gluten
Role of the innate immune system in the pathogenesis of gluten

... process whose establishment and maintenance are not completely elucidated. There are cases of gluten reaction defined as gluten sensitivity (GS) in which neither an allergic (wheat allergy) nor an autoimmune [celiac disease (CD)] mechanism can be advocated. Recent evidences suggest that early change ...
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New Oral Treatments for Multiple Sclerosis
New Oral Treatments for Multiple Sclerosis

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Idiopathic intracranial hypertension (pseudotumor cerebri)
Idiopathic intracranial hypertension (pseudotumor cerebri)

...  more common in obese women of childbearing age  usually self limiting, recurrence is common  a preventable cause of blindness from optic atrophy ...
SLE and Cardiovascular Disease
SLE and Cardiovascular Disease

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Non-specific Immunity
Non-specific Immunity

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Cerebrospinal fluid

... moves fluid and solutes from the blood plasma into the ventricles, the choroid plexuses being a specialized part of the blood-brain barrier. • CSF secretion involves the pumping of ions and specialized ion channels, with the energy coming from glucose and oxygen in the blood. • In the adult human CS ...
before movements ceased. The (Swedo SE et al. Sydenham`s dance
before movements ceased. The (Swedo SE et al. Sydenham`s dance

... certain acute-onset cases of OCD acquired during childhood may represent an autoimmune cerebral disorder similar to Sydenham's chorea, and affecting the basal ganglia. A trial of intravenous immunoglobulin in children with Sydenham's chorea is in progress at COMMENT. Of 9 children met DSM-III-R ...
Foundation Testimonials
Foundation Testimonials

... Based on these results I have formed a company, Maji Therapeutics, whose mission is to improve clinical outcomes for patients undergoing cardiovascular surgery by using a novel, ex vivo approach employing therapeutic viruses that prevent pathologic vein graft failure due to restenosis. This pathway ...
ASPERGILLOSIS (BROODER PNEUMONIA)
ASPERGILLOSIS (BROODER PNEUMONIA)

... feed, litter can penetrate broken shells. Large dose to infect Probably not bird to bird. ...
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Pathophysiology of multiple sclerosis

Multiple sclerosis (MS) is a condition where the CNS of a person present a special kind of distributed glial scars (sclerosis) which are a remaining of a previous inflammatory demyelination. MS pathophysiology is complex and still under investigation and there is no agreement about its scope. Some authors consider it a pathological entity, while others consider it a clinical entity. From a pathological point of view, the demyelinating lesions can be classified as encephalomyelitis, and sometimes the disease is known as encephalomyelitis disseminata.There are two phases for how an unknown underlying condition may cause damage in MS: First some MRI-abnormal areas with hidden damage appear in the brain and spine (NAWM, NAGM, DAWM). Second, there are leaks in the blood–brain barrier where immune cells infiltrate causing the known demyelination and axon destruction. Some clusters of activated microglia, transection of axons and myelin degeneration is present before the BBB breaks down and the immune attack beginsPathophysiology is a convergence of pathology with physiology. Pathology is the medical discipline that describes conditions typically observed during a disease state; whereas physiology is the biological discipline that describes processes or mechanisms operating within an organism. Referring to MS, the physiology refers to the different processes that lead to the development of the lesions and the pathology refers to the condition associated with the lesions.
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