Current and novel therapeutics in the treatment of systemic lupus erythematosus
... treatment modalities are effective in lupus-prone mice, the situation is more complex in human subjects. This article reviews the general approach to the therapy of SLE, focusing on current approved therapies and novel approaches that might be used in the future. (J Allergy Clin Immunol 2011;127:303 ...
... treatment modalities are effective in lupus-prone mice, the situation is more complex in human subjects. This article reviews the general approach to the therapy of SLE, focusing on current approved therapies and novel approaches that might be used in the future. (J Allergy Clin Immunol 2011;127:303 ...
COMPLETE AMINO ACID SEQUENCE OF HEAVY CHAIN
... suggest that the BALB/c proteins derive from germline VH gene(s) that are clearly different from the germline VH segment that gives rise to the Ars-A family. On the other hand, the homology between the VR segments of these two molecules is substantial, with only 16 differences in 98 residues (84% ho ...
... suggest that the BALB/c proteins derive from germline VH gene(s) that are clearly different from the germline VH segment that gives rise to the Ars-A family. On the other hand, the homology between the VR segments of these two molecules is substantial, with only 16 differences in 98 residues (84% ho ...
Toward a Universal Influenza Vaccine
... an inactivated influenza vaccine or infection with influenza virus resulted in increased cytotoxicity from PBMCs within 7 d. Hashimoto et al. (34) performed follow-up studies showing that ADCC-mediating Abs were found in serum from children recently vaccinated with either inactivated or live-attenua ...
... an inactivated influenza vaccine or infection with influenza virus resulted in increased cytotoxicity from PBMCs within 7 d. Hashimoto et al. (34) performed follow-up studies showing that ADCC-mediating Abs were found in serum from children recently vaccinated with either inactivated or live-attenua ...
Single-nucleotide polymorphisms of toll
... elements, including viral and bacterial DNA, lipopolysaccharides, and proteoglycans. The TLR ability to recognize microbial components and to trigger activation of innate immunity and/or adaptive immunity in human body makes them excellent candidate genes to be investigated for its association with ...
... elements, including viral and bacterial DNA, lipopolysaccharides, and proteoglycans. The TLR ability to recognize microbial components and to trigger activation of innate immunity and/or adaptive immunity in human body makes them excellent candidate genes to be investigated for its association with ...
PDF - Journal of Neuroinflammation
... cells into secondary lymphatic organs [1,20,21]. Additionally, CCL19 levels have been shown to be increased in the CSF of patients with inflammatory neurological diseases and MS [1,22]. CCL19 mRNA was shown to be overexpressed in MS lesions [4,22]. The cytokines BAFF (B cell activating factor) and A ...
... cells into secondary lymphatic organs [1,20,21]. Additionally, CCL19 levels have been shown to be increased in the CSF of patients with inflammatory neurological diseases and MS [1,22]. CCL19 mRNA was shown to be overexpressed in MS lesions [4,22]. The cytokines BAFF (B cell activating factor) and A ...
Acute-on-chronic liver failure: an update
... ▸ Patients with cirrhosis and known prior decompensation ( jaundice, encephalopathy or ascites) who develop acute deterioration of their clinical status that is either related or unrelated to precipitating events are considered to have acute decompensation ...
... ▸ Patients with cirrhosis and known prior decompensation ( jaundice, encephalopathy or ascites) who develop acute deterioration of their clinical status that is either related or unrelated to precipitating events are considered to have acute decompensation ...
General Food Panel: IgA/IgG/IgE
... US BioTek Laboratories' proprietary ELISA analyses are designed to assay specific total IgG (subclasses 1, 2, 3, 4), total IgA (subclasses 1, 2), and IgE antibodies. The classification of 0 to VI denotes the level of IgG, IgA, and/or IgE antibodies detected through spectrophotometric analysis. ...
... US BioTek Laboratories' proprietary ELISA analyses are designed to assay specific total IgG (subclasses 1, 2, 3, 4), total IgA (subclasses 1, 2), and IgE antibodies. The classification of 0 to VI denotes the level of IgG, IgA, and/or IgE antibodies detected through spectrophotometric analysis. ...
MYOCARDITIS - cardiologycmc.in - The department of cardiology
... DR JULIAN JOHNY THOTTIAN DM CARDIO RESIDENT CALICUT MEDICAL COLLEGE ...
... DR JULIAN JOHNY THOTTIAN DM CARDIO RESIDENT CALICUT MEDICAL COLLEGE ...
Hyper-Reactive Malarial Splenomegaly Syndrome (HMSS)
... 1) HMSS results from abnormal immunological response due to repeated attacks of malaria and is usually seen in those who live in malaria endemic areas. 2) The main features of this syndrome are hepato-splenomegaly, high IGM levels, and hepatic lymphocytosis on liver biopsy, in addition to features o ...
... 1) HMSS results from abnormal immunological response due to repeated attacks of malaria and is usually seen in those who live in malaria endemic areas. 2) The main features of this syndrome are hepato-splenomegaly, high IGM levels, and hepatic lymphocytosis on liver biopsy, in addition to features o ...
A Introduction
... high MBL serum levels and high MBL activity have been associated with inflammatory autoimmune diseases like Systemic Lupus Erythematosus (SLE) that in turn results in to tissue damage and finally leads to organ damage. Serum MBL levels fluctuate during the course of SLE disease activity and MBL geno ...
... high MBL serum levels and high MBL activity have been associated with inflammatory autoimmune diseases like Systemic Lupus Erythematosus (SLE) that in turn results in to tissue damage and finally leads to organ damage. Serum MBL levels fluctuate during the course of SLE disease activity and MBL geno ...
The role of Fc–Fc R interactions in IgG-mediated microbial
... FcR engagement by sialylated IgG Fcs results in active suppression of antibody-mediated and T cell–mediated inflammation (Anthony and Ravetch, 2010; Anthony et al., 2012; Schwab and Nimmerjahn, 2013; Fiebiger et al., 2015). In contrast, engagement of type I FcRs results in an array of pleiotropic ...
... FcR engagement by sialylated IgG Fcs results in active suppression of antibody-mediated and T cell–mediated inflammation (Anthony and Ravetch, 2010; Anthony et al., 2012; Schwab and Nimmerjahn, 2013; Fiebiger et al., 2015). In contrast, engagement of type I FcRs results in an array of pleiotropic ...
Slide 1
... • Chronic GVHD • SOT • Multiple myeloma • Solid tumours / lymphoma • SLE / Wegener disease • AIDS Nedel WL, Kontoyiannis DP, Pasqualotto AC. Rev Iberoamer Micol 2009; 26: 175-83 ...
... • Chronic GVHD • SOT • Multiple myeloma • Solid tumours / lymphoma • SLE / Wegener disease • AIDS Nedel WL, Kontoyiannis DP, Pasqualotto AC. Rev Iberoamer Micol 2009; 26: 175-83 ...
Pathogenic antibodies to coagulation factors. Part one: Factor VIII
... within a few days unless they find antigen using the BCR. B cells encounter antigen-specific T cells in extrafollicular areas of secondary lymphoid organs and a B cell–T cell–DC triad forms. During the primary humoral response, recognition of antigen by the BCR leads to a signaling pathway that turns ...
... within a few days unless they find antigen using the BCR. B cells encounter antigen-specific T cells in extrafollicular areas of secondary lymphoid organs and a B cell–T cell–DC triad forms. During the primary humoral response, recognition of antigen by the BCR leads to a signaling pathway that turns ...
Identification of Klebsiella Pneumoniae by Capsular Polysaccharide
... Klebsiella is an important opportunistic pathogen, which was reported worldwide. It can causes infections of respiratory tract, nasal mucosa, pharynx and generally results in primary pneumonia. Pneumonia is the most frequent nosocomial infection (30 to 33% of cases) among combined medical-surgical i ...
... Klebsiella is an important opportunistic pathogen, which was reported worldwide. It can causes infections of respiratory tract, nasal mucosa, pharynx and generally results in primary pneumonia. Pneumonia is the most frequent nosocomial infection (30 to 33% of cases) among combined medical-surgical i ...
Absence of cellular responses to a putative autoantigen in
... Absence of Cellular Responses to a Putative Autoantigen in Onchocercal Chorioretinopathy Cellular Autoimmunity in Onchocercal Chorioretinopathy Philip]. Cooper *-\ Ronald H. Guderian* Roberto Proano* and David W. Taylorf ...
... Absence of Cellular Responses to a Putative Autoantigen in Onchocercal Chorioretinopathy Cellular Autoimmunity in Onchocercal Chorioretinopathy Philip]. Cooper *-\ Ronald H. Guderian* Roberto Proano* and David W. Taylorf ...
Somatostatin, octreotide and gabexate mesilate in the therapy of
... PPI have shown ↓rebleeding, ↓need for surgery compared with H2 blocker or placebo – Meta-analyses: high dose PPI after successful endoscopic therapy ↓rebleeding – RUGBE: PPI ↓rebleeding, mortality in high-risk patient, trend toward ↓rebleeding in patient with low-risk. ...
... PPI have shown ↓rebleeding, ↓need for surgery compared with H2 blocker or placebo – Meta-analyses: high dose PPI after successful endoscopic therapy ↓rebleeding – RUGBE: PPI ↓rebleeding, mortality in high-risk patient, trend toward ↓rebleeding in patient with low-risk. ...
Introduction to Immunoassays
... • An advantage of monoclonal antibodies is that the hybridoma cell line that produces them is potentially “immortal” and can produce the same antibodies consistently and indefinitely. • A polyclonal antisera produced by immunization of animals can vary from animal to animal, and a useful antiserum m ...
... • An advantage of monoclonal antibodies is that the hybridoma cell line that produces them is potentially “immortal” and can produce the same antibodies consistently and indefinitely. • A polyclonal antisera produced by immunization of animals can vary from animal to animal, and a useful antiserum m ...
Zhang Study
... One study showed that the FcγR of effector cells is important for effectiveness of antibody treatments against tumors in mice. They tested the efficacy of trastuzumab and rituxan on eradicating human tumor xenographs in mice lacking various FcγRs. They found that the mechanism of efficacy of the mAb ...
... One study showed that the FcγR of effector cells is important for effectiveness of antibody treatments against tumors in mice. They tested the efficacy of trastuzumab and rituxan on eradicating human tumor xenographs in mice lacking various FcγRs. They found that the mechanism of efficacy of the mAb ...
Prognostic and Predictive Markers for the New
... autoimmunity predicts for antitumor activity remains to be established. Studies are actively investigating not only predictive biomarkers for efficacy but also for toxicity. Moving forward, a patient’s germline genetics also may play a critical role in predicting the clinical effects of various immu ...
... autoimmunity predicts for antitumor activity remains to be established. Studies are actively investigating not only predictive biomarkers for efficacy but also for toxicity. Moving forward, a patient’s germline genetics also may play a critical role in predicting the clinical effects of various immu ...
Chikungunya fever, IgM positivity, Srikakulam district.
... and 2014. The percentage of IgM positivity recorded was found to be variable, high during the months of September in 2013 and May in 2014. (Table 1 & 2).The number of seropositive cases referred from tribal area was more 18(78.26%). DISCUSSION: Chikungunya fever is caused by alpha virus of the famil ...
... and 2014. The percentage of IgM positivity recorded was found to be variable, high during the months of September in 2013 and May in 2014. (Table 1 & 2).The number of seropositive cases referred from tribal area was more 18(78.26%). DISCUSSION: Chikungunya fever is caused by alpha virus of the famil ...
Systemic Lupus Erythematosus - UC Irvine`s Department of Medicine
... 10th century- case reports appeared in writings Late 1800s- Sir William Osler initially described the systemic nature and linked rashes to organ involvement 1949- LE cell described by Malcolm Hargraves at Mayo Clinic 1954- ANA described 1971- First set of classification criteria proposed f ...
... 10th century- case reports appeared in writings Late 1800s- Sir William Osler initially described the systemic nature and linked rashes to organ involvement 1949- LE cell described by Malcolm Hargraves at Mayo Clinic 1954- ANA described 1971- First set of classification criteria proposed f ...
Periodontal disease associated to systemic genetic disorders
... disease may differ in each of the syndromes. In the case of Marfan syndrome, periodontitis manifests in a chronic and severe form with patterns of both horizontal and vertical bone resorption, and in accordance to the presence of bacterial plaque. Dental mobility has been shown to be due to periodon ...
... disease may differ in each of the syndromes. In the case of Marfan syndrome, periodontitis manifests in a chronic and severe form with patterns of both horizontal and vertical bone resorption, and in accordance to the presence of bacterial plaque. Dental mobility has been shown to be due to periodon ...
Persistent burnout theory of chronic fatigue syndrome
... Hypothalamic–pituitary–adrenal axis There are many different CFS symptoms, and no two patients have exactly the same set of symptoms. However there are certain abnormalities that appear to be present in the majority of patients. One common finding is a dysfunction in the hypothalamic–pituitary–adren ...
... Hypothalamic–pituitary–adrenal axis There are many different CFS symptoms, and no two patients have exactly the same set of symptoms. However there are certain abnormalities that appear to be present in the majority of patients. One common finding is a dysfunction in the hypothalamic–pituitary–adren ...
Oxidative Stress in Cardiovascular Inflammation: Its Involvement in
... Hb preparation enhanced phenotypic maturation of LPSstimulated DCs, as demonstrated by the appearance of the DC maturation marker CD83 and by the upregulation of the costimulatory molecules CD80, CD40, HLA-DR, and CD86, and significantly increased the production of the proinflammatory cytokines inte ...
... Hb preparation enhanced phenotypic maturation of LPSstimulated DCs, as demonstrated by the appearance of the DC maturation marker CD83 and by the upregulation of the costimulatory molecules CD80, CD40, HLA-DR, and CD86, and significantly increased the production of the proinflammatory cytokines inte ...