Independent of IL-4 Development of Lupus in BXSB Mice Is
... body-mediated diseases like SLE might involve Th2-type responses, whereas cell-mediated responses in organ-specific autoimmune diseases might be mediated by Th1-type responses. This attractive but simplistic model, however, has not been supported by studies of humoral autoimmune diseases, such as lu ...
... body-mediated diseases like SLE might involve Th2-type responses, whereas cell-mediated responses in organ-specific autoimmune diseases might be mediated by Th1-type responses. This attractive but simplistic model, however, has not been supported by studies of humoral autoimmune diseases, such as lu ...
UV Irradiation of Skin Regulates a Murine Model of Multiple Sclerosis
... our previous studies, neither acute erythemal (8 kJ/m2) or chronic suberythemal (8 exposures of 2 kJ/m2) UVR significantly altered 25(OH) D levels. Furthermore, Becklund et al. [22] reported an insignificant elevation in 25(OH)D levels for groups of mice that received pretreatment with daily doses o ...
... our previous studies, neither acute erythemal (8 kJ/m2) or chronic suberythemal (8 exposures of 2 kJ/m2) UVR significantly altered 25(OH) D levels. Furthermore, Becklund et al. [22] reported an insignificant elevation in 25(OH)D levels for groups of mice that received pretreatment with daily doses o ...
Analysis of MHC Class II Genes in the Susceptibility to Lupus in New
... Parental NZB/BINJ, C57BL/10 (B10), and C57BL/6J (B6) mice were obtained from The Jackson Laboratory (Bar Harbor, ME) and were maintained in the animal care facility at the National Jewish Medical and Research Center (Denver, CO). All congenic, transgenic, F1, and backcross mice were bred and maintai ...
... Parental NZB/BINJ, C57BL/10 (B10), and C57BL/6J (B6) mice were obtained from The Jackson Laboratory (Bar Harbor, ME) and were maintained in the animal care facility at the National Jewish Medical and Research Center (Denver, CO). All congenic, transgenic, F1, and backcross mice were bred and maintai ...
Card9 Mediates Intestinal Epithelial Cell Restitution, T
... Card9-null (KO) mice as quantified by qRT-PCR. Data are shown as fold changes relative to WT mice without DSS for each time point. (B) Cytokine expression by qRT-PCR (left) and secretion by ELISA (right) in MLN cells after DSS administration and after stimulation with anti-CD3/anti-CD28 antibodies. D ...
... Card9-null (KO) mice as quantified by qRT-PCR. Data are shown as fold changes relative to WT mice without DSS for each time point. (B) Cytokine expression by qRT-PCR (left) and secretion by ELISA (right) in MLN cells after DSS administration and after stimulation with anti-CD3/anti-CD28 antibodies. D ...
Development of a non-invasive murine infection model for acute
... Otitis media (OM) is one of the most frequent diseases in childhood, and Streptococcus pneumoniae is among the main causative bacterial agents. Since current experimental models used to study the bacterial pathogenesis of OM have several limitations, such as the invasiveness of the experimental proc ...
... Otitis media (OM) is one of the most frequent diseases in childhood, and Streptococcus pneumoniae is among the main causative bacterial agents. Since current experimental models used to study the bacterial pathogenesis of OM have several limitations, such as the invasiveness of the experimental proc ...
Correlation of bacteriological flora of the urethra, glans
... prevent contamination throughout their liv ing area. Despite this, no 2 patients in the study group had identical urinary tract infections at the same time, although similar strains were identified on separate occa sions. ...
... prevent contamination throughout their liv ing area. Despite this, no 2 patients in the study group had identical urinary tract infections at the same time, although similar strains were identified on separate occa sions. ...
Local Activation of Dendritic Cells Leads to Insulitis and
... of CD40 by CD154 (CD40L) can convert an immature and tolerogenic DC to a mature and immunogenic DC. The central role of DCs in the initiation of the immune response suggests that these cells also may play an important role in the initial events leading to type 1 diabetes. One possible mechanism, by ...
... of CD40 by CD154 (CD40L) can convert an immature and tolerogenic DC to a mature and immunogenic DC. The central role of DCs in the initiation of the immune response suggests that these cells also may play an important role in the initial events leading to type 1 diabetes. One possible mechanism, by ...
A role of the adaptive immune system in glucose homeostasis
... immune system in glucose homeostasis is maintaining levels of macrophage-stimulating cytokines and preventing disruption in glucose homeostasis. Additionally, our work indicates that the absence of functional B and T cells does not provide protection against HFD-induced insulin resistance as SCID mi ...
... immune system in glucose homeostasis is maintaining levels of macrophage-stimulating cytokines and preventing disruption in glucose homeostasis. Additionally, our work indicates that the absence of functional B and T cells does not provide protection against HFD-induced insulin resistance as SCID mi ...
- University of East Anglia
... to host gene expression. In their study, they comprehensibly examine these responses with respect to the different GIT compartments, rather than focusing on the small intestine or colon, which the majority of previous studies have done. Variations between the colon, ileum, jejunum and duodenum may c ...
... to host gene expression. In their study, they comprehensibly examine these responses with respect to the different GIT compartments, rather than focusing on the small intestine or colon, which the majority of previous studies have done. Variations between the colon, ileum, jejunum and duodenum may c ...
Flagellated Pathogen Exhibit Impaired CD4 T Cell Responses to a
... (14, 15) and also suggested that TLR5-deficient mice are more resistant to some flagellated pathogens (14), but also more susceptible to others (16). In addition to this well-studied interaction of flagellin with host innate immune responses, flagellin also happens to be a protein Ag that is specifi ...
... (14, 15) and also suggested that TLR5-deficient mice are more resistant to some flagellated pathogens (14), but also more susceptible to others (16). In addition to this well-studied interaction of flagellin with host innate immune responses, flagellin also happens to be a protein Ag that is specifi ...
Mouse ENU Mutagenesis to Understand Immunity to Infection
... introduction of putative mutations in a given gene. In addition, recently developed genomic resources have further facilitated the use of genetically modified mice by the scientific community. These include large libraries of knock-out and conditional knock-out mice produced by international consort ...
... introduction of putative mutations in a given gene. In addition, recently developed genomic resources have further facilitated the use of genetically modified mice by the scientific community. These include large libraries of knock-out and conditional knock-out mice produced by international consort ...
Untitled (English)
... Urinary Tract Infection (UTI) is among the most community infections worldwide. Host factors such as patients age and gender may influence the prevalence of the infection. In this study a total of 186 urine samples from patients )1–79 years( whom attended Azady Teaching Hospital at Kirkuk province, ...
... Urinary Tract Infection (UTI) is among the most community infections worldwide. Host factors such as patients age and gender may influence the prevalence of the infection. In this study a total of 186 urine samples from patients )1–79 years( whom attended Azady Teaching Hospital at Kirkuk province, ...
17-26
... spectrometer (Burker Company, German). The peptide mass fingerprint (PMF) map was used to search for the matched protein based on NCBI-NR Metazoa database with Matrix Science software. ...
... spectrometer (Burker Company, German). The peptide mass fingerprint (PMF) map was used to search for the matched protein based on NCBI-NR Metazoa database with Matrix Science software. ...
Genetic vaccines protect against Sin Nombre hantavirus challenge
... Genetic immunization and virus challenge. We purified plasmid DNA with an endotoxin-free kit (EndoFree, Qiagen), and dissolved DNA to a concentration of 1 mg\ml in 0n9 % NaCl. Five to twelve deer mice were immunized with each construct three times at 4 week intervals, using 50 µg of plasmid into ea ...
... Genetic immunization and virus challenge. We purified plasmid DNA with an endotoxin-free kit (EndoFree, Qiagen), and dissolved DNA to a concentration of 1 mg\ml in 0n9 % NaCl. Five to twelve deer mice were immunized with each construct three times at 4 week intervals, using 50 µg of plasmid into ea ...
Transient expression of human papillomavirus type 16 virus
... L1 monomers readily self-assembled into capsomeres and further into virus like particles (VLPs). Immunological characterization and electron microscopy showed that 89 % of L1 retained VLP structure also in extracts prepared from freeze-dried leaves. Plant expressed L1 in crude extracts was highly im ...
... L1 monomers readily self-assembled into capsomeres and further into virus like particles (VLPs). Immunological characterization and electron microscopy showed that 89 % of L1 retained VLP structure also in extracts prepared from freeze-dried leaves. Plant expressed L1 in crude extracts was highly im ...
Factor-Deficient Mice Colony-Stimulating Granulocyte
... cellular immune responses to type II collagen (CII) (21); it is considered to be restricted to mouse strains bearing the H-2q or H-2r haplotypes and is generally performed in DBA/1 mice (22). We recently reported that GM-CSF, when injected i.p. into DBA/1 mice suboptimally primed to develop CIA, exa ...
... cellular immune responses to type II collagen (CII) (21); it is considered to be restricted to mouse strains bearing the H-2q or H-2r haplotypes and is generally performed in DBA/1 mice (22). We recently reported that GM-CSF, when injected i.p. into DBA/1 mice suboptimally primed to develop CIA, exa ...
Cardiovasc. Res. 81197-205 (2009) - digital
... of T cells and positive and negative selection of thymocytes are normal in CD69-deficient mice ...
... of T cells and positive and negative selection of thymocytes are normal in CD69-deficient mice ...
Icd 10 odor urine
... that Reverses Diabetes Permanently in As Little as 11 Days. Medication ★ Diabetes Untreated ★ :: Diabetes Medication Renal Failure - The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. ★ Diabetes Type 1 No Complications Icd 10 ★ :: Free Medical Bracelets Diabetes - The 3 Ste ...
... that Reverses Diabetes Permanently in As Little as 11 Days. Medication ★ Diabetes Untreated ★ :: Diabetes Medication Renal Failure - The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. ★ Diabetes Type 1 No Complications Icd 10 ★ :: Free Medical Bracelets Diabetes - The 3 Ste ...
Atherosclerosis
... • Immunization with selected ApoB-100 peptides reduces atherosclerosis and favorably modifies plaque phenotype in hypercholesterolemic mice. • Immunization with selected ApoB-100 peptides also reduced AngII induced hypertension and aneurysm formation and mortality due to rupture. • These experimenta ...
... • Immunization with selected ApoB-100 peptides reduces atherosclerosis and favorably modifies plaque phenotype in hypercholesterolemic mice. • Immunization with selected ApoB-100 peptides also reduced AngII induced hypertension and aneurysm formation and mortality due to rupture. • These experimenta ...
Consulta: subjectFacets:"Trypanosomiasis" Registros recuperados
... Abstract During the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an ...
... Abstract During the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an ...
The pathogen-associated iroA gene cluster mediates bacterial
... siderocalin, neutrophil gelatinase-associated lipocalin, 24p3, or uterocalin (3–6). We have shown that Lcn2 is a bacteriostatic protein that is constitutively present in neutrophil granules and can be induced and secreted in response to activation of innate immune receptors such as Toll-like recepto ...
... siderocalin, neutrophil gelatinase-associated lipocalin, 24p3, or uterocalin (3–6). We have shown that Lcn2 is a bacteriostatic protein that is constitutively present in neutrophil granules and can be induced and secreted in response to activation of innate immune receptors such as Toll-like recepto ...
... CD8+ and CD4+ lymphocytes [31]. By 1 month postAdV administration, this immunological attack against AdV-infected fibres resulted in virtually complete elimination of transgene expression in mdx as well as control mouse diaphragms [24, 31]. Furthermore, as shown in figure 3, a major decrease in maxi ...
Mice
... to human rheumatoid arthritis, with synovial pannus formation and bone and cartilage erosions ...
... to human rheumatoid arthritis, with synovial pannus formation and bone and cartilage erosions ...
... Furthermore, vaccinated individuals demonstrate considerable variability in their antibody responses to PA. To explore the relationship between PA structure and antigenicity, we produced Escherichia coli strains expressing full-length PA (PA1-4), domains 2 to 4 (PA2-4), domain 1, (PA1), and domain 4 ...
Minnesota Urolith Center - University of Minnesota College of
... Uroliths composed primarily of calcium phosphate carbonate are uncommon. However, this mineral in small quantities is commonly associated with uroliths composed of struvite because both minerals form as a consequence of urinary tract infection with bacteria (e.g. Staphylococcus sp. & Proteus sp.) th ...
... Uroliths composed primarily of calcium phosphate carbonate are uncommon. However, this mineral in small quantities is commonly associated with uroliths composed of struvite because both minerals form as a consequence of urinary tract infection with bacteria (e.g. Staphylococcus sp. & Proteus sp.) th ...
Major urinary proteins
Major urinary proteins (Mups), also known as α2u-globulins, are a subfamily of proteins found in abundance in the urine and other secretions of many animals. Mups provide a small range of identifying information about the donor animal, when detected by the vomeronasal organ of the receiving animal. They belong to a larger family of proteins known as lipocalins. Mups are encoded by a cluster of genes, located adjacent to each other on a single stretch of DNA, that varies greatly in number between species: from at least 21 functional genes in mice to none in humans. Mup proteins form a characteristic glove shape, encompassing a ligand-binding pocket that accommodates specific small, organic chemicals.Urinary proteins were first reported in rodents in 1932, during studies by Thomas Addis into the cause of proteinuria. They are potent human allergens, and are largely responsible for a number of animal allergies, including to cats, horses and rodents. Their endogenous function within an animal is unknown, but may involve regulating energy expenditure. However, as secreted proteins they play multiple roles in chemical communication between animals, functioning as pheromone transporters and stabilizers in rodents and pigs. Mups can also act as protein pheromones themselves. They have been demonstrated to promote aggression in male mice, and one specific Mup protein found in male mouse urine is sexually attractive to female mice. Mups can also function as signals between different species: mice display an instinctive fear response on the detection of Mups derived from predators such as cats and rats.