1: Nervous System II: Anatomy Review
... The neuron conducting the impulse toward the synapse is called the __________________ neuron. The axon terminal contains ___________ ____________ filled with ______________________. An action potential in the axon terminal of the _____________ neuron causes the chemical transmitter, also known as a ...
... The neuron conducting the impulse toward the synapse is called the __________________ neuron. The axon terminal contains ___________ ____________ filled with ______________________. An action potential in the axon terminal of the _____________ neuron causes the chemical transmitter, also known as a ...
Characterizing the O-glycosylation landscape of human plasma
... Dissection of the molecular mechanisms by which O-glycans affect these systems is, however, currently impeded by a lack of knowledge of specific O-glycan sites in vivo. The hemostatic system comprises platelet aggregation, coagulation, and fibrinolysis and is critical for the maintenance of vascular ...
... Dissection of the molecular mechanisms by which O-glycans affect these systems is, however, currently impeded by a lack of knowledge of specific O-glycan sites in vivo. The hemostatic system comprises platelet aggregation, coagulation, and fibrinolysis and is critical for the maintenance of vascular ...
Munc18b is an essential gene in mice whose expression is limiting
... defects in both insulin release from pancreatic islet cells and translocation of glucose transporters to the plasma membrane of adipocytes and skeletal muscle cells [13–15]. Munc18b is expressed in epithelial cells and leucocytes [10,16–20], but Munc18b-knockout mice have not been reported. In epith ...
... defects in both insulin release from pancreatic islet cells and translocation of glucose transporters to the plasma membrane of adipocytes and skeletal muscle cells [13–15]. Munc18b is expressed in epithelial cells and leucocytes [10,16–20], but Munc18b-knockout mice have not been reported. In epith ...
Neurons and the Nervous System
... charge) across its plasma membrane called a membrane potential • The resting potential is the membrane potential of a neuron not sending signals • Changes in membrane potential act as signals, transmitting and processing information • In a resting neuron, the currents of K+ and Na+ are equal and ...
... charge) across its plasma membrane called a membrane potential • The resting potential is the membrane potential of a neuron not sending signals • Changes in membrane potential act as signals, transmitting and processing information • In a resting neuron, the currents of K+ and Na+ are equal and ...
Molecular sieving properties of the cytoplasm of Escherichia coli and
... there are few studies that address the mobility of macromolecules in bacterial cells (Elowitz et al., 1999; Konopka et al., 2006; 2009; Mullineaux et al., 2006; van den Bogaart et al., 2007; Slade et al., 2009a,b; Kumar et al., 2010). For GFP in the cytoplasm of E. coli, the diffusion coefficients a ...
... there are few studies that address the mobility of macromolecules in bacterial cells (Elowitz et al., 1999; Konopka et al., 2006; 2009; Mullineaux et al., 2006; van den Bogaart et al., 2007; Slade et al., 2009a,b; Kumar et al., 2010). For GFP in the cytoplasm of E. coli, the diffusion coefficients a ...
Mechanisms and cellular roles of local protein synthesis in mammalian cells
... to respond to extra-cellular signals may be coordinately regulated through RNPs by initiating the translation of many members of a multiprotein complex at the same time and place [4]. This central role of RNP complexes in spatial control of translation will be illustrated through one well-known mam ...
... to respond to extra-cellular signals may be coordinately regulated through RNPs by initiating the translation of many members of a multiprotein complex at the same time and place [4]. This central role of RNP complexes in spatial control of translation will be illustrated through one well-known mam ...
投影片 1
... GSK3b interaction protein (GSKIP), which binds to GSK3beta. We have defined a 25-aminoacid residues region in the C-terminal of GSKIP that is highly similar to the GSK3beta interaction domain (GID) of Axin. Using an in vitro kinase assay, our results indicate that GSKIP is a good GSK3beta substrate ...
... GSK3b interaction protein (GSKIP), which binds to GSK3beta. We have defined a 25-aminoacid residues region in the C-terminal of GSKIP that is highly similar to the GSK3beta interaction domain (GID) of Axin. Using an in vitro kinase assay, our results indicate that GSKIP is a good GSK3beta substrate ...
Secretion mechanisms of volatile organic compounds in specialized
... The present review focuses on cells secreting volatile odorant compounds. This cell type is found in a wide variety of plants, grouped under the term aromatic plants. Such secreting cells are very diverse in morphology, from highly specialized trichomes to nonspecialized cells, including the secreto ...
... The present review focuses on cells secreting volatile odorant compounds. This cell type is found in a wide variety of plants, grouped under the term aromatic plants. Such secreting cells are very diverse in morphology, from highly specialized trichomes to nonspecialized cells, including the secreto ...
An A/ENTH Domain-Containing Protein Functions
... high amino acid sequence similarity to the ENTH domain. The AP180 domain has also been identified in other proteins that are collectively called the AP180 N-terminal homology (ANTH) domain-containing proteins (Rosenthal et al., 1999; Drake et al., 2000; Mao et al., 2001; Wendland, 2002). Both ENTH an ...
... high amino acid sequence similarity to the ENTH domain. The AP180 domain has also been identified in other proteins that are collectively called the AP180 N-terminal homology (ANTH) domain-containing proteins (Rosenthal et al., 1999; Drake et al., 2000; Mao et al., 2001; Wendland, 2002). Both ENTH an ...
Short- and long-term effects of fatty acids on pancreatic alpha cell
... In alpha cells, fatty acids stimulated glucagon secretion and increased triglyceride accumulation in a time- and concentration-dependent manner. These changes were accompanied by a reduction of alpha cell proliferation and an up-regulation of CPT-1 gene expression. Etomoxir significantly counteracte ...
... In alpha cells, fatty acids stimulated glucagon secretion and increased triglyceride accumulation in a time- and concentration-dependent manner. These changes were accompanied by a reduction of alpha cell proliferation and an up-regulation of CPT-1 gene expression. Etomoxir significantly counteracte ...
Phospholipase C-γ1 is a guanine nucleotide exchange factor for
... of these actions are lipase-independent and involve the SH3 domain of PLC-γ1. Dynamin is a member of the GTPase superfamily that essentially participates in clathrin-mediated endocytosis in cells. Three mammalian isoforms of dynamin have been detected (Liu and Robinson, 1995; Urrutia et al., 1997). ...
... of these actions are lipase-independent and involve the SH3 domain of PLC-γ1. Dynamin is a member of the GTPase superfamily that essentially participates in clathrin-mediated endocytosis in cells. Three mammalian isoforms of dynamin have been detected (Liu and Robinson, 1995; Urrutia et al., 1997). ...
Document
... – Is found in the exoskeleton of arthropods – Can be used as surgical thread – Has a nitrogen group CH2O H ...
... – Is found in the exoskeleton of arthropods – Can be used as surgical thread – Has a nitrogen group CH2O H ...
Is fibroblast growth factor 23 a harbinger of mortality in CKD
... Figure 2: Fibroblast growth factor 23 (FGF23) increases cell size in a dose-dependent manner. Panel A. Representative forwardscatter histograms (FSC-H) of HL-1 cardiomyocytes treated with vehicle or FGF23 (900 pg/ml) for 48 h. Panel B. Summary of forward-scatter (FSC-H) data on cardiomyocytes treate ...
... Figure 2: Fibroblast growth factor 23 (FGF23) increases cell size in a dose-dependent manner. Panel A. Representative forwardscatter histograms (FSC-H) of HL-1 cardiomyocytes treated with vehicle or FGF23 (900 pg/ml) for 48 h. Panel B. Summary of forward-scatter (FSC-H) data on cardiomyocytes treate ...
Understanding Our Environment
... Lysosomes - Membrane-bound digestive vesicles that arise from Golgi apparatus. Contain degrading enzymes. - Break down old organelles and other structures and recycles them Microbodies - Bear enzymes for metabolism Glyoxysome - Convert fat into carbohydrates Peroxisome – Detoxify (those of kid ...
... Lysosomes - Membrane-bound digestive vesicles that arise from Golgi apparatus. Contain degrading enzymes. - Break down old organelles and other structures and recycles them Microbodies - Bear enzymes for metabolism Glyoxysome - Convert fat into carbohydrates Peroxisome – Detoxify (those of kid ...
ADP-ribosyltransferases: plastic tools for inactivating protein and
... bacterial toxins and metabolic regulators. ADPRTs catalyze the transfer of the ADP-ribose moiety from NAD+ onto specific substrates including proteins. ADP-ribosylation usually inactivates the function of the target. ADPRTs have become adapted to function in extra- and intracellular settings. Regula ...
... bacterial toxins and metabolic regulators. ADPRTs catalyze the transfer of the ADP-ribose moiety from NAD+ onto specific substrates including proteins. ADP-ribosylation usually inactivates the function of the target. ADPRTs have become adapted to function in extra- and intracellular settings. Regula ...
Chapter 3 PowerPoint
... The Cytoplasm Membranous Organelles • Mitochondria • 95% of cellular ATP supply • Double membrane structure • Outer membrane very permeable • Inner membrane very impermeable Folded into cristae Filled with matrix Studded with ETS complexes ...
... The Cytoplasm Membranous Organelles • Mitochondria • 95% of cellular ATP supply • Double membrane structure • Outer membrane very permeable • Inner membrane very impermeable Folded into cristae Filled with matrix Studded with ETS complexes ...
Campbell Biology, 10e (Reece) Chapter 6 A Tour of the Cell 1) The
... A) The cytoskeleton of eukaryotes is a static structure most resembling scaffolding used at construction sites. B) Although microtubules are common within a cell, actin filaments are rarely found outside of the nucleus. C) Movement of cilia and flagella is the result of motor proteins causing microt ...
... A) The cytoskeleton of eukaryotes is a static structure most resembling scaffolding used at construction sites. B) Although microtubules are common within a cell, actin filaments are rarely found outside of the nucleus. C) Movement of cilia and flagella is the result of motor proteins causing microt ...
To Be or Not to Be … an Inhibitory Neurotransmitter
... Channel Proteins Unlike transporters, channels form a hydrophilic corridor through a membrane to allow ions to move across a membrane directly; ie. no individual ion binding is necessary in a channel. Channels are usually ion selective: allow movement of 1 or few ions. ...
... Channel Proteins Unlike transporters, channels form a hydrophilic corridor through a membrane to allow ions to move across a membrane directly; ie. no individual ion binding is necessary in a channel. Channels are usually ion selective: allow movement of 1 or few ions. ...
m5zn_14bea598b5b7901
... Forces responsible for protein structure • 1.Hydrogen bond: Between the Hydrogen atom and carbonyl oxygen or amide Nitrogen (strong electro negative atoms) • 2.Disulfide bond: is a covalent bond between the sulfhydryl (-SH) group of two cysteine residues. • 3.Hydrophobic interactions: AA with non p ...
... Forces responsible for protein structure • 1.Hydrogen bond: Between the Hydrogen atom and carbonyl oxygen or amide Nitrogen (strong electro negative atoms) • 2.Disulfide bond: is a covalent bond between the sulfhydryl (-SH) group of two cysteine residues. • 3.Hydrophobic interactions: AA with non p ...
Diapositive 1 - International QSAR Foundation
... CTA provide evidence for several stages in neoplastic progression (long term) accurate and comprehensive recapitulation of the in vivo neoplastic process clarify carcinogenecity in case of ambiguous genotoxicity may be indicative of mode of action of substances ...
... CTA provide evidence for several stages in neoplastic progression (long term) accurate and comprehensive recapitulation of the in vivo neoplastic process clarify carcinogenecity in case of ambiguous genotoxicity may be indicative of mode of action of substances ...
The Par3/Par6/aPKC Complex and Epithelial Cell Polarity
... epithelia Par3 is found at TJ and Par6/aPKC are at more apical apex [24], although this difference of localization is not prominent in 2D cultures [25]. In addition to its role in forming the Par complex, Par3 also has Par6/aPKC-independent functions. Par3 contains a conserved N-terminal domain (NT ...
... epithelia Par3 is found at TJ and Par6/aPKC are at more apical apex [24], although this difference of localization is not prominent in 2D cultures [25]. In addition to its role in forming the Par complex, Par3 also has Par6/aPKC-independent functions. Par3 contains a conserved N-terminal domain (NT ...
Articular Receptors
... muscle spindles: primary (Ia) and secondary (II). Primary endings are typically seen in virtually all intrafusal fibers. Secondary endings are seen in CF and in static BF, but not in dynamic BF. ...
... muscle spindles: primary (Ia) and secondary (II). Primary endings are typically seen in virtually all intrafusal fibers. Secondary endings are seen in CF and in static BF, but not in dynamic BF. ...
The Vacuole - Konner Aldridge Enterprises
... The vacuole is found within plant, animal, fungal, and bacterial cells and they serve a vital purpose in each. They are found in hollowed center regions of the cell, and can be very large in plant cells. The vacuole provides help with intracellular digestion and helps the release and effective use o ...
... The vacuole is found within plant, animal, fungal, and bacterial cells and they serve a vital purpose in each. They are found in hollowed center regions of the cell, and can be very large in plant cells. The vacuole provides help with intracellular digestion and helps the release and effective use o ...
University of Zurich - Institute of Molecular Life Sciences
... at low passage number as described (63). M21 (positive for surface-expressed integrins), M21L cells (negative for -integrins) and M21L4 transfected with -integrin cDNA (24) were obtained from Dr. D. Cheresh (Scripps Research Institute, La Jolla, CA, USA). Human kidney HK-2 cells originally iso ...
... at low passage number as described (63). M21 (positive for surface-expressed integrins), M21L cells (negative for -integrins) and M21L4 transfected with -integrin cDNA (24) were obtained from Dr. D. Cheresh (Scripps Research Institute, La Jolla, CA, USA). Human kidney HK-2 cells originally iso ...
G PROTEIN βγ SUBUNITS
... odorants are detected is only poorly understood. Probably the most remarkable receptor is the visual G protein–linked receptor rhodopsin, which can detect small numbers of photons. The other few hundred receptors specifically bind intercellular messenger molecules such as acetylcholine, glutamate, γ ...
... odorants are detected is only poorly understood. Probably the most remarkable receptor is the visual G protein–linked receptor rhodopsin, which can detect small numbers of photons. The other few hundred receptors specifically bind intercellular messenger molecules such as acetylcholine, glutamate, γ ...
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a specific receptor located on the cell surface or inside the cell. In turn, this receptor triggers a biochemical chain of events inside the cell, creating a response. Depending on the cell, the response alters the cell's metabolism, shape, gene expression, or ability to divide. The signal can be amplified at any step. Thus, one signaling molecule can cause many responses.