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Position Effect Variegation
Position Effect Variegation

... Advanced Molecular and Cellular Biology Bio4751 Spring 2003 Gary A. Bulla, PhD ...
The Role of the Cell Cycle Machinery in
The Role of the Cell Cycle Machinery in

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RNAi Screening Identifies the Armadillo Repeat
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... assembly checkpoint protein, Mad1, and studies with Xenopus extracts have shown that XMAD2 interacts with a Mad1-like protein (R. Chen and K. Hardwick, personal communication). The Mad1 protein has also been shown to be phosphorylated by the protein kinase Mps1, and overexpression of Mps1 causes con ...
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Cell cycle



The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication (replication) that produces two daughter cells. In prokaryotes which lack a cell nucleus, the cell cycle occurs via a process termed binary fission. In cells with a nucleus, as in eukaryotes, the cell cycle can be divided into three periods: interphase, the mitotic (M) phase, and cytokinesis. During interphase, the cell grows, accumulating nutrients needed for mitosis, preparing it for cell division and duplicating its DNA. During the mitotic phase, the cell splits itself into two distinct daughter cells. During the final stage, cytokinesis, the new cell is completely divided. To ensure the proper division of the cell, there are control mechanisms known as cell cycle checkpoints.The cell-division cycle is a vital process by which a single-celled fertilized egg develops into a mature organism, as well as the process by which hair, skin, blood cells, and some internal organs are renewed. After cell division, each of the daughter cells begin the interphase of a new cycle. Although the various stages of interphase are not usually morphologically distinguishable, each phase of the cell cycle has a distinct set of specialized biochemical processes that prepare the cell for initiation of cell division.
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