Age associated changes in erythrocyte membrane surface charge
... adhesiveness to endothelial cells contributing for the development of various pathologies including diabetes mellitus, atherothrombotic complications (Wautier et al., 1981) and sequestration of circulating erythrocytes by macrophages (Beppu et al., 1995). In normal conditions, the amount of oxy-repa ...
... adhesiveness to endothelial cells contributing for the development of various pathologies including diabetes mellitus, atherothrombotic complications (Wautier et al., 1981) and sequestration of circulating erythrocytes by macrophages (Beppu et al., 1995). In normal conditions, the amount of oxy-repa ...
IL-15 and dermal fibroblasts induce proliferation of natural
... The importance of regulatory T cells (Tregs) in the development of self-tolerance was first demonstrated in mice when thymectomy 2 to 4 days after birth was found to prevent the development of CD4⫹CD25⫹ T cells, resulting in organ-specific autoimmune disease.1-3 Subsequent findings in humans have co ...
... The importance of regulatory T cells (Tregs) in the development of self-tolerance was first demonstrated in mice when thymectomy 2 to 4 days after birth was found to prevent the development of CD4⫹CD25⫹ T cells, resulting in organ-specific autoimmune disease.1-3 Subsequent findings in humans have co ...
Function Antigens but with Altered Cytokine Secretion Cells To
... Simultaneous generation of directly and indirectly activated DCs in vivo To compare the functional properties of dir-mDCs and ind-mDCs generated in vivo within the same mice, we produced mixed bone marrow chimeras where lethally irradiated WT recipients were reconstituted with a 1:1 ratio of Ly5.1 W ...
... Simultaneous generation of directly and indirectly activated DCs in vivo To compare the functional properties of dir-mDCs and ind-mDCs generated in vivo within the same mice, we produced mixed bone marrow chimeras where lethally irradiated WT recipients were reconstituted with a 1:1 ratio of Ly5.1 W ...
Intracellular Redox Compartmentation and ROS
... interactor. The compartment on the right lacks this signaling mechanism. Such specificities could explain differences in ROS sensitivity between different compartments or between the same compartment under different conditions. A simple example based on a thiol-disulfide exchange mechanism is shown, ...
... interactor. The compartment on the right lacks this signaling mechanism. Such specificities could explain differences in ROS sensitivity between different compartments or between the same compartment under different conditions. A simple example based on a thiol-disulfide exchange mechanism is shown, ...
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... silencing of most genes on one of the two X-chromosomes to equalize X-linked gene dosage in female cells with that in XY male cells (Avner and Heard, 2001). Although the exact mechanism for X-linked gene silencing is unknown, XCI requires expression of the long non-coding RNA X inactive-specific tra ...
... silencing of most genes on one of the two X-chromosomes to equalize X-linked gene dosage in female cells with that in XY male cells (Avner and Heard, 2001). Although the exact mechanism for X-linked gene silencing is unknown, XCI requires expression of the long non-coding RNA X inactive-specific tra ...
The 2015 World Health Organization Classification of Tumors of the
... First, to comprehensively list the established and new tumor entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft-tissue tumors of the thymus and mediastinum; second, to highlig ...
... First, to comprehensively list the established and new tumor entities and variants that are described in the new WHO Classification of thymic epithelial tumors, germ cell tumors, lymphomas, dendritic cell and myeloid neoplasms, and soft-tissue tumors of the thymus and mediastinum; second, to highlig ...
Non-equilibration of hydrostatic pressure in blebbing cells Guillaume T. Charras
... combination of local and global effects, as seen with the F-actindisrupting agents cytochalasin D and latrunculin B (Fig. 3a; see also Supplementary Video 7). Within seconds of local drug application, there was a global increase in bleb size (Fig. 3a, t ¼ 75 s). Then, blebbing ceased in the treated ...
... combination of local and global effects, as seen with the F-actindisrupting agents cytochalasin D and latrunculin B (Fig. 3a; see also Supplementary Video 7). Within seconds of local drug application, there was a global increase in bleb size (Fig. 3a, t ¼ 75 s). Then, blebbing ceased in the treated ...
Understanding Hyaluronan-Protein Interactions
... proteins. Stabilin-1 (accession code AJ275213) and CAB61358 (which is the accession code for this incomplete sequence) have very similar domain organizations, and the Link modules of these proteins both show about 50% identity with that of TSG-6. However, it is unclear whether or not these are hyala ...
... proteins. Stabilin-1 (accession code AJ275213) and CAB61358 (which is the accession code for this incomplete sequence) have very similar domain organizations, and the Link modules of these proteins both show about 50% identity with that of TSG-6. However, it is unclear whether or not these are hyala ...
Mitochondria in Lung Biology and Pathology: More than - AJP-Lung
... normally expressed in multiple subcellular compartments including the mitochondrial ...
... normally expressed in multiple subcellular compartments including the mitochondrial ...
Tubular structures involved in movement of cowpea mosaic virus are
... tubular structures appeared to consist of a tubule enclosing virus-like particles, loosely enveloped by plasma membrane (Fig. 6b and c). In many cases the plasma membrane along the tubule was ruptured or even absent. The phenomenon observed in ultrathin sections, whereby two (or even more) tubules w ...
... tubular structures appeared to consist of a tubule enclosing virus-like particles, loosely enveloped by plasma membrane (Fig. 6b and c). In many cases the plasma membrane along the tubule was ruptured or even absent. The phenomenon observed in ultrathin sections, whereby two (or even more) tubules w ...
Mitochondria in lung biology and pathology: more than - AJP-Lung
... chemical antioxidants or the expression of enzymatic antioxidant systems to activate hypoxic responses in a normoxic cell. A third model of mitochondrial oxygen sensing (Fig. 1) arose from initial studies showing that intracellular ROS levels actually increase during hypoxia (13, 26). Parallel studi ...
... chemical antioxidants or the expression of enzymatic antioxidant systems to activate hypoxic responses in a normoxic cell. A third model of mitochondrial oxygen sensing (Fig. 1) arose from initial studies showing that intracellular ROS levels actually increase during hypoxia (13, 26). Parallel studi ...
... critical motif for this signaling in both T cells [17] and B cells [16]. It has been suggested that PD-L1 also mediates an inhibitory signal by ligating B7-1 [20], although with the short cytoplasmic tails characteristic of B7 family members it is not clear how this signal may be mediated. The inhib ...
Syntaxin of Plant Proteins SYP123 and SYP132 Mediate Root Hair
... families, as well as their regulatory proteins (Molendijk et al. 2001, Preuss et al. 2004, Xu and Scheres 2005). Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are essential molecules in membrane trafficking and constitute a large superfamily in eukaryotes (Hong 2005 ...
... families, as well as their regulatory proteins (Molendijk et al. 2001, Preuss et al. 2004, Xu and Scheres 2005). Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are essential molecules in membrane trafficking and constitute a large superfamily in eukaryotes (Hong 2005 ...
Control of organ shape - Development
... Fig. 2. Histological analysis of salivary gland internalization in wild-type (WT) embryos. (A,E,I,M) Transverse sections of WT embryos at stages I, II, III and IV, respectively, of salivary gland internalization. For each transverse section represented in the top row, there are three cross sections ...
... Fig. 2. Histological analysis of salivary gland internalization in wild-type (WT) embryos. (A,E,I,M) Transverse sections of WT embryos at stages I, II, III and IV, respectively, of salivary gland internalization. For each transverse section represented in the top row, there are three cross sections ...
insight on the molecular mechanisms that control the expression of
... The correct perception of nociceptive inputs relies on the proper neuronal connection between specialized receptors in the dorsal root ganglia (DRG) and neurons in the superficial laminas of the dorsal spinal cord. One gene intimately related with the establishment of this circuit is Prrxl1, which e ...
... The correct perception of nociceptive inputs relies on the proper neuronal connection between specialized receptors in the dorsal root ganglia (DRG) and neurons in the superficial laminas of the dorsal spinal cord. One gene intimately related with the establishment of this circuit is Prrxl1, which e ...
Solid-Phase Synthesis, Characterization, and Cellular Activities of
... attachment methods are either not discriminatory in terms of where the ND binds the peptide or protein or are limited in the length and complexity of peptide that can be bound.24–27 Furthermore, characterization of the ND surface after biological molecule attachment is very challenging due to the in ...
... attachment methods are either not discriminatory in terms of where the ND binds the peptide or protein or are limited in the length and complexity of peptide that can be bound.24–27 Furthermore, characterization of the ND surface after biological molecule attachment is very challenging due to the in ...
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... magnification image taken at P6 (Fig. 1C), which shows that the pSmad1/5/8 signal extends across the retina at this age. Throughout this period, there is also pSmad1/5/8 immunofluorescence in the ganglion cells that persists until at least P14 (Fig. 1A; GCL). Western blot analysis of total Smad1/5/8 ...
... magnification image taken at P6 (Fig. 1C), which shows that the pSmad1/5/8 signal extends across the retina at this age. Throughout this period, there is also pSmad1/5/8 immunofluorescence in the ganglion cells that persists until at least P14 (Fig. 1A; GCL). Western blot analysis of total Smad1/5/8 ...
Plant tropisms - Semantic Scholar
... How does the perception of photons of light energy lead to a differential growth response that is potentially based on a hormone gradient? First the photons must be perceived by the plant. Blue light-induced phototropic responses utilize a class of chromoproteins known as the phototropins (Figure 1) ...
... How does the perception of photons of light energy lead to a differential growth response that is potentially based on a hormone gradient? First the photons must be perceived by the plant. Blue light-induced phototropic responses utilize a class of chromoproteins known as the phototropins (Figure 1) ...
Print
... mtDNA but rather are supplied by polyadenylation following RNA processing (152). Protein coding and rRNA genes are interspersed with tRNA genes that are thought to demarcate the cleavage sites of RNA processing. The only substantial noncoding region is the D-loop, named after the triple-stranded str ...
... mtDNA but rather are supplied by polyadenylation following RNA processing (152). Protein coding and rRNA genes are interspersed with tRNA genes that are thought to demarcate the cleavage sites of RNA processing. The only substantial noncoding region is the D-loop, named after the triple-stranded str ...
Manuscript - Spiral - Imperial College London
... The major pilin gene, pilE, was amplified using primers designed for amplification of class I or class II alleles either designed in this study or described previously [31]. These primers hybridize to sequences overlapping the stop and start codons (for class II) or in the regions upstream and downs ...
... The major pilin gene, pilE, was amplified using primers designed for amplification of class I or class II alleles either designed in this study or described previously [31]. These primers hybridize to sequences overlapping the stop and start codons (for class II) or in the regions upstream and downs ...
Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis
... mtDNA but rather are supplied by polyadenylation following RNA processing (152). Protein coding and rRNA genes are interspersed with tRNA genes that are thought to demarcate the cleavage sites of RNA processing. The only substantial noncoding region is the D-loop, named after the triple-stranded str ...
... mtDNA but rather are supplied by polyadenylation following RNA processing (152). Protein coding and rRNA genes are interspersed with tRNA genes that are thought to demarcate the cleavage sites of RNA processing. The only substantial noncoding region is the D-loop, named after the triple-stranded str ...
microcircuitry of bipolar cells in cat retina1
... contacts from the AI1 amacrine cell. Axons of four types of cone bipolar cells terminated in sublamina a of the inner plexiform layer and contacted dendrites of off-p and other ganglion cells. One of these cone bipolar cell types, CBal, made reciprocal chemical contacts with the lobular appendage of ...
... contacts from the AI1 amacrine cell. Axons of four types of cone bipolar cells terminated in sublamina a of the inner plexiform layer and contacted dendrites of off-p and other ganglion cells. One of these cone bipolar cell types, CBal, made reciprocal chemical contacts with the lobular appendage of ...
Effects of intestinal adaptation on insulin binding to villus cell
... site normally present in mammalian cells subserve different functions - for example, stimulation of growth by one class and of cellular metabolic functions by the other. It is also not clear if the differences we observed in binding site characteristics between proximal and more distal small intesti ...
... site normally present in mammalian cells subserve different functions - for example, stimulation of growth by one class and of cellular metabolic functions by the other. It is also not clear if the differences we observed in binding site characteristics between proximal and more distal small intesti ...
Neuroblast migration along the anteroposterior axis of C. elegans is
... transcript levels in staged L1 larvae and during embryonic development (Raj et al., 2008). Using this technique, we were able simultaneously to label and visualize individual transcripts of up to three Wnt genes as bright diffraction-limited fluorescent spots in animals with preserved shape (Fig. 1A ...
... transcript levels in staged L1 larvae and during embryonic development (Raj et al., 2008). Using this technique, we were able simultaneously to label and visualize individual transcripts of up to three Wnt genes as bright diffraction-limited fluorescent spots in animals with preserved shape (Fig. 1A ...
appearance and function of endogenous peroxidase in fetal rat thyroid
... many of them have been identified as cross-sectioned profiles of the rough endoplasmic reticulum . The Golgi apparatus is present and in fortuitous sections its inner few lamellae stain for peroxidase (Fig . 7) . In most cells cytoplasmic ribosomes do not stain for peroxidase, but sometimes in cells ...
... many of them have been identified as cross-sectioned profiles of the rough endoplasmic reticulum . The Golgi apparatus is present and in fortuitous sections its inner few lamellae stain for peroxidase (Fig . 7) . In most cells cytoplasmic ribosomes do not stain for peroxidase, but sometimes in cells ...