Gain of function in the immune system caused by a ryanodine
... RyR1 cDNA from wild-type mice (WT) yields the uncut band of about 376 bp, whereas digestion of the cDNA from heterozygous mice (HET RYR1Y522S) yields two bands of 276 bp and 100 bp plus the uncut 376 bp band from the wild-type allele. (B) The resting [Ca2+] of DCs from HET RYR1Y522S mice is signific ...
... RyR1 cDNA from wild-type mice (WT) yields the uncut band of about 376 bp, whereas digestion of the cDNA from heterozygous mice (HET RYR1Y522S) yields two bands of 276 bp and 100 bp plus the uncut 376 bp band from the wild-type allele. (B) The resting [Ca2+] of DCs from HET RYR1Y522S mice is signific ...
Intrinsically Disordered Proteins as Drug Targets
... and thus challenge the sequence-structure-function paradigm [13-15]. This lack of stable structure, over the entire protein length or in some regions (also named Intrinsically Disordered Regions or IDRs), provides them a structural plasticity which is not achievable by ordered proteins that is essen ...
... and thus challenge the sequence-structure-function paradigm [13-15]. This lack of stable structure, over the entire protein length or in some regions (also named Intrinsically Disordered Regions or IDRs), provides them a structural plasticity which is not achievable by ordered proteins that is essen ...
Mary Ann Thompson Arildsen, M
... E2F family have been shown to be regulated in part by microRNAs. E2F2 is unique among the E2F factors in that it is restricted in expression to lymphoid cells, and in Emyc mice knock out of E2F2 causes increased rapidity of tumor formation. After much patience and persistence, we have found several ...
... E2F family have been shown to be regulated in part by microRNAs. E2F2 is unique among the E2F factors in that it is restricted in expression to lymphoid cells, and in Emyc mice knock out of E2F2 causes increased rapidity of tumor formation. After much patience and persistence, we have found several ...
Positioning the Flagellum at the Center of a Dividing Cell To
... atmospheric oxygen. Once the cells were fixed on a transmission electron microscope (TEM) grid or a light microscope slide, they were stained for observation of their flagella. Microscopy analyses revealed that the individual flagella of cells of strain SS-5 are always positioned at the south pole o ...
... atmospheric oxygen. Once the cells were fixed on a transmission electron microscope (TEM) grid or a light microscope slide, they were stained for observation of their flagella. Microscopy analyses revealed that the individual flagella of cells of strain SS-5 are always positioned at the south pole o ...
Autophagy_Marc
... involves cell degradation of unnecessary or dysfunctional cellular components through the actions of lysosomes . The breakdown of cellular components promotes cellular survival during starvation by maintaining cellular energy levels. Autophagy allows the degradation and recycling of cellular compone ...
... involves cell degradation of unnecessary or dysfunctional cellular components through the actions of lysosomes . The breakdown of cellular components promotes cellular survival during starvation by maintaining cellular energy levels. Autophagy allows the degradation and recycling of cellular compone ...
Engineering amount of cell–cell contact demonstrates biphasic
... proliferation rates in cells contacting multiple neighbors within densely crowded monolayers [1]. This phenomenon, known as contact-dependent inhibition of cell proliferation, has been shown to require VE-cadherin, since cadherin-null cells fail to fully arrest proliferation at confluence [7,11,13–1 ...
... proliferation rates in cells contacting multiple neighbors within densely crowded monolayers [1]. This phenomenon, known as contact-dependent inhibition of cell proliferation, has been shown to require VE-cadherin, since cadherin-null cells fail to fully arrest proliferation at confluence [7,11,13–1 ...
Fungal pathogenicity Wolfgang Knogge
... height similar to the erected lips of the stomatal guard cells [14]. In response to this recognition, all bean rust races as well as many other rust species [15,16] formed appressoria that were morphologically and functionally similar to those formed in vivo. The biochemical mechanism of thigmotropi ...
... height similar to the erected lips of the stomatal guard cells [14]. In response to this recognition, all bean rust races as well as many other rust species [15,16] formed appressoria that were morphologically and functionally similar to those formed in vivo. The biochemical mechanism of thigmotropi ...
Effect of lithium and sodium cations on the
... mainly because phosphoglucomutase, a key enzyme of galactose metabolism, is inhibited [2]. High salt concentrations (0.30.5 M NaCl) inhibit most enzymes because of the perturbation of the hydrophobic-electrostatic balance between the forces maintaining protein structure. Many metabolic reactions an ...
... mainly because phosphoglucomutase, a key enzyme of galactose metabolism, is inhibited [2]. High salt concentrations (0.30.5 M NaCl) inhibit most enzymes because of the perturbation of the hydrophobic-electrostatic balance between the forces maintaining protein structure. Many metabolic reactions an ...
Sequential steps in clathrin-mediated synaptic vesicle endocytosis
... average size is larger and the size variability is increased when compared with that of vesicles in wild-type controls [5,6]. Moreover, microinjection studies in the squid giant synapse [7] have shown that a peptide corresponding to the clathrin assembly domain of AP180 causes a marked depletion of ...
... average size is larger and the size variability is increased when compared with that of vesicles in wild-type controls [5,6]. Moreover, microinjection studies in the squid giant synapse [7] have shown that a peptide corresponding to the clathrin assembly domain of AP180 causes a marked depletion of ...
Exploring Bioinorganic Pattern Formation in Diatoms. A Story of
... * Corresponding author; e-mail [email protected]; fax 39 – 081– ...
... * Corresponding author; e-mail [email protected]; fax 39 – 081– ...
![[PDF]](http://s1.studyres.com/store/data/008788910_1-240df7a72520bf68e9b932d1a6287256-300x300.png)
[PDF]
... MicroRNAs (miRNAs) are 18 –25 nt, single-stranded noncoding RNAs that are generated from endogenous hairpinshaped transcripts. miRNAs can suppress post-transcriptional gene expression by base pairing with their target messenger RNAs (mRNAs) and inducing either translational repression or mRNA degrad ...
... MicroRNAs (miRNAs) are 18 –25 nt, single-stranded noncoding RNAs that are generated from endogenous hairpinshaped transcripts. miRNAs can suppress post-transcriptional gene expression by base pairing with their target messenger RNAs (mRNAs) and inducing either translational repression or mRNA degrad ...
The Plant Cell - Gunawardena Lab
... morphologically altered until late stages of PCD. Genomic DNA is fragmented, but not into internucleosomal units. Other cytoplasmic changes, such as shrinkage and degradation of organelles, occur later. This form of PCD resembles tracheary element differentiation in cytological execution but require ...
... morphologically altered until late stages of PCD. Genomic DNA is fragmented, but not into internucleosomal units. Other cytoplasmic changes, such as shrinkage and degradation of organelles, occur later. This form of PCD resembles tracheary element differentiation in cytological execution but require ...
The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on
... such as DNA, proteins and membrane components has been intensively studied and characterized [1–4]. However, also cellular metabolites and the flux through metabolic pathways are affected. The impact of stress on metabolism and its small-molecule cellular constituents has attracted notable attention ...
... such as DNA, proteins and membrane components has been intensively studied and characterized [1–4]. However, also cellular metabolites and the flux through metabolic pathways are affected. The impact of stress on metabolism and its small-molecule cellular constituents has attracted notable attention ...
The Plant Cell - College of Computer, Mathematical, and Natural
... biochemical and molecular features, regardless of their actual membrane localization (Stevens and Forgac, 1997). Additionally, because ATP is the major energy currency of cells, the activity of V-ATPase is thought to be paramount to that of the V-PPase. Certainly, inorganic phosphate (PPi) is an imp ...
... biochemical and molecular features, regardless of their actual membrane localization (Stevens and Forgac, 1997). Additionally, because ATP is the major energy currency of cells, the activity of V-ATPase is thought to be paramount to that of the V-PPase. Certainly, inorganic phosphate (PPi) is an imp ...
feven tigistu-sahle – metabolism of polyunsaturated fatty
... The application of human bone marrow derived mesenchymal stromal cells (hBMSCs) for regenerative or immunomodulatory therapies, e.g. treatment of the graft-versus-host disease, requires in vitro expansion of the cells. The hBMSCs undergo subtle changes during expansion which may compromise their fun ...
... The application of human bone marrow derived mesenchymal stromal cells (hBMSCs) for regenerative or immunomodulatory therapies, e.g. treatment of the graft-versus-host disease, requires in vitro expansion of the cells. The hBMSCs undergo subtle changes during expansion which may compromise their fun ...
Carbohydrates and Glycobiology
... an amino group. The amino group is nearly always condensed with acetic acid, as in N-acetylglucosamine. This glucosamine derivative is part of many structural polymers, including those of the bacterial cell wall. Bacterial cell walls also contain a derivative of glucosamine called N-acetylmuramic ac ...
... an amino group. The amino group is nearly always condensed with acetic acid, as in N-acetylglucosamine. This glucosamine derivative is part of many structural polymers, including those of the bacterial cell wall. Bacterial cell walls also contain a derivative of glucosamine called N-acetylmuramic ac ...
Glutamine breakdown in rapidly dividing cells: waste or investment?
... and maintained with the participation of the (Naþ,-Kþ)ATPase. This protein pumps three Naþ out of the cell and two Kþ into the cell, against their respective electrochemical gradients at the expense of one molecule of ATP. The (Naþ,Kþ)-ATPase is one of the single major users of cellular energy, resp ...
... and maintained with the participation of the (Naþ,-Kþ)ATPase. This protein pumps three Naþ out of the cell and two Kþ into the cell, against their respective electrochemical gradients at the expense of one molecule of ATP. The (Naþ,Kþ)-ATPase is one of the single major users of cellular energy, resp ...
PDF
... fate maps were readily accepted, and have formed the basis of interpretation of much embryological work since then. This was unfortunate, for they are wrong. It was correct to place the notochordal primordium in the embryonic surface, but the mesoderm lies beneath, in the interior, as stated above. ...
... fate maps were readily accepted, and have formed the basis of interpretation of much embryological work since then. This was unfortunate, for they are wrong. It was correct to place the notochordal primordium in the embryonic surface, but the mesoderm lies beneath, in the interior, as stated above. ...
Genes controlling expression of defense responses in
... [12••]. RPP13-mediated resistance does not require EDS1, PAD4, PBS2, or NDR1, is completely unaffected in an eds1 ndr1 double mutant, and is not blocked by nahG [13•]. RPP7 has not been cloned, but RPP8 and RPP13 are LZ-NBS-LRR proteins that are similar to each other [14,15]. Hence, these genes are ...
... [12••]. RPP13-mediated resistance does not require EDS1, PAD4, PBS2, or NDR1, is completely unaffected in an eds1 ndr1 double mutant, and is not blocked by nahG [13•]. RPP7 has not been cloned, but RPP8 and RPP13 are LZ-NBS-LRR proteins that are similar to each other [14,15]. Hence, these genes are ...
Document
... Oxygen consumption . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Glycolytic rate. . . . . . . . . . . . . . . . . . . . ...
... Oxygen consumption . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Glycolytic rate. . . . . . . . . . . . . . . . . . . . ...
L-Carnosine reduces telomere damage and shortening
... Academic Science (Beijing, China). Cells were grown in DMEM supplemented with 10% fetal bovine serum and 100 U/ml penicillin/ streptomycin sulfate at 37 C with 5% CO2 and 95% air. Serial cultivation was carried out with a split ratio of 1:4 at early and of 1:2 at later passages, respectively. At ea ...
... Academic Science (Beijing, China). Cells were grown in DMEM supplemented with 10% fetal bovine serum and 100 U/ml penicillin/ streptomycin sulfate at 37 C with 5% CO2 and 95% air. Serial cultivation was carried out with a split ratio of 1:4 at early and of 1:2 at later passages, respectively. At ea ...
Poster
... inhibitor, and impedes the spreading of the message by making the cell less likely to be in an excited state, causing the cell to relay a neural signal less frequently. Propofol produces its effects by enhancing the activity of the GABAA receptor. Currently, researchers are trying to pinpoint how pr ...
... inhibitor, and impedes the spreading of the message by making the cell less likely to be in an excited state, causing the cell to relay a neural signal less frequently. Propofol produces its effects by enhancing the activity of the GABAA receptor. Currently, researchers are trying to pinpoint how pr ...
15. THYROID FUNCTION Follicular activity
... The secretory components of the gland are made of quasispherical structures called follicles, which are surrounded by secretory cells. The lumen of the follicles fills with a thick substance called colloid, made out of large proteins containing thyroid hormones. The colloid serves as a reservoir for ...
... The secretory components of the gland are made of quasispherical structures called follicles, which are surrounded by secretory cells. The lumen of the follicles fills with a thick substance called colloid, made out of large proteins containing thyroid hormones. The colloid serves as a reservoir for ...
15. THYROID FUNCTION Follicular activity
... Pathological hypothyroidism could be a congenital problem, or a problem with the iodine transport mechanism; in which case, it is considered primary hypothyroidism (Figs. 15-21, 15-22). Secondary reasons for hypothyroidism are pituitary tumors, damage to the thyroid as a consequence of exposure to r ...
... Pathological hypothyroidism could be a congenital problem, or a problem with the iodine transport mechanism; in which case, it is considered primary hypothyroidism (Figs. 15-21, 15-22). Secondary reasons for hypothyroidism are pituitary tumors, damage to the thyroid as a consequence of exposure to r ...