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Bioelectrical Signal Recording
Bioelectrical Signal Recording

... Elaborate on Patch-Clamp Technique, which is the most advanced method today; Observe, in loco, one of its applications; Discuss the the advantages and disadvantages and refer to the future prospectives; Present our analysis on the subject; ...
Bioelectrical Signal Recording
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... Elaborate on Patch-Clamp Technique, which is the most advanced method today; Observe, in loco, one of its applications; Discuss the the advantages and disadvantages and refer to the future prospectives; Present our analysis on the subject; ...
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Microscope Lab
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... All organisms are composed of cells, whether they exist as single cells, colonies of cells, or in multicellular form. Cells are usually very small, and for this reason, a thorough understanding of subcellular structure and function has been possible only through advances in electron microscopy and m ...
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... genetic regulation of organ development and programmed cell death have truly opened new avenues for biological and medical research. We have all begun our lives in a seemingly modest way – as the fertilized egg cell, a tenth of a millimeter in size. From this small cell, the adult human being develo ...
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Transport of Substances Across a Cell Membrane

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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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