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Development of the liver in the chicken embryo
Development of the liver in the chicken embryo

... Specimens for scanning electron microscopy were selected from those being prepared for transmission elecEmbedding in glycol methacrylate tron microscopy. Whole livers were cut into slices and Whole livers were removed from chicken embryos immersed in the primary fixative for 3 hr. The slices which r ...
Chapter 6 - Distribution of Materials
Chapter 6 - Distribution of Materials

... The renal artery branches into smaller arterioles and capillaries which are surrounded by nephrons. These small clusters of blood vessels are called a glomerus. ...
- Wiley Online Library
- Wiley Online Library

... threonine (19%) and serine (10.4%). Together these four aa comprised over 50% of the kustd1438 protein sequence. This type of skewed aa composition is characteristic for structural proteins that form higher-order structures, such as the division ring, the cytoskeleton and the cell wall. The structur ...
Betulinic Acid-induced Programmed Cell Death in
Betulinic Acid-induced Programmed Cell Death in

... revealed that cytotoxic responses can be mediated with other cell types (4 – 8), but a key observation remains the significant antitumor response with human melanoma carried in athymic mice (1) under experimental conditions yielding little or no toxicity. Accordingly, a question of great interest co ...
De novo fatty acid synthesis controls the fate between regulatory T
De novo fatty acid synthesis controls the fate between regulatory T

... for the development of effector T (Teff ) cells of the TH1, TH2 and TH17 lineages4. Hence, in the absence of mTOR, or after treatment with the mTOR-specific inhibitor rapamycin, the development of Teff cells is greatly diminished5. Along the same line, it has recently been shown that hypoxia-inducib ...
Tumor-specific T cells in human Merkel cell carcinomas: a possible
Tumor-specific T cells in human Merkel cell carcinomas: a possible

... itself has induced regression of MCC (Friedlaender et al., 2002; Heath et al., 2008; Muirhead and Ritchie, 2007; Val-Bernal et al., 2011; Wooff et al., 2010). Although 80% of MCCs have genomic integration of MCV and produce viral proteins including small and large T antigens, these tumors are still ...
Early Detection, Diagnosis, and Staging Can Chronic Lymphocytic
Early Detection, Diagnosis, and Staging Can Chronic Lymphocytic

... This test is important in diagnosing CLL. It uses a machine that looks for certain substances on or in cells that help identify what types of cells they are (markers). This test can be used to see if the lymphocytes in a sample of blood contain CLL cells. It can also be used to look for CLL cells in ...
Bellairs pm6.5 - The International Journal of Developmental Biology
Bellairs pm6.5 - The International Journal of Developmental Biology

... Michael Abercrombie (left) in 1970. epithelia, such as the endothelium of early blood vessels, few cells in an embryo are present as a monolayer so that cell-cell relationships tend to be more complex than in simple tissue culture. Even within an epithelium, where each cell is closely in contact wit ...
Sickle Cell Disease in Athletes
Sickle Cell Disease in Athletes

... • Limited evidence supports recommendations – Once the athlete is asymptomatic at rest and has  normal end‐organ function, re‐visit precautions  for safe participation. – If the athlete desires to resume activity, allow a  gradual supervised return to activity as tolerated. ...
Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter
Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

... Although two populations of GC B cells were originally defined based on size, LZ and DZ B cells were found to be indistinguishable in size or movement pattern by multiphoton microscopy (Allen et al., 2007b; Hauser et al., 2007a; Schwickert et al., 2007), and there are no anatomically validated surfa ...
The Respiratory System
The Respiratory System

... • Dyspnea can be caused by: • swelling / inflammation of lining of the airways • production of thick mucus • tightening of muscles around airways ...
Conference title, upper and lower case, bolded, 18 point type
Conference title, upper and lower case, bolded, 18 point type

... Tug-of-War Optical Tweezers to Control Cell Clusters Optical tweezers are excellent tools for trapping and manipulating bacteria and cells. Dr. Z Chen’s lab at COSE has designed what they called “tug-of-war” optical tweezers for assessment of cell-cell adhesion - a key factor in biofilm formation. W ...
The Distribution and Morphology Alterations of Microfilaments and
The Distribution and Morphology Alterations of Microfilaments and

... studies on cytoskeleton mainly focused on animal cells, and there were rarely researches or reports about cytoskeleton morphological alterations and molecular mechanism using plant cells as materials. Recently, with the continuous improvement of research technology in life sciences, the understandin ...
senescent cells
senescent cells

... are compromised. Interfering with pathways that can induce senescence-associated replicative arrest are likely to promote cancer, as occurs when p16INK4a, the retinoblastoma (Rb) protein, or p53 is diminished or inactivated (67, 103). On the other hand, strategies that delay senescent cell accumulat ...
Structure-Function Approach Identifies a COOH
Structure-Function Approach Identifies a COOH

... illustrates a TIM-barrel fold that has previously been predicted for the enzyme (19, 29). In addition, conserved glutamic acid residues critical for heparanase catalysis (Glu225 and Glu343; Fig. 1A, red), as well as heparin/HS binding regions (Lys158-Asp171 and Gln270Lys280; Fig. 1A, cyan and green, ...
Target validation: A door to drug discovery
Target validation: A door to drug discovery

... been researched and largely discovered in academic laboratories, and to a lesser extent in the laboratories of pharmaceutical and biotechnology companies. Basic research into understanding the fundamental, essential processes for signaling within and between cells and their perturbation in condition ...
REVIEW CELL DIVISION FROM A GENETIC PERSPECTIVE
REVIEW CELL DIVISION FROM A GENETIC PERSPECTIVE

... In some cases, however, the execution point for a particular mutant occurs considerably before the mutant cell exhibits any observable defect in its progress through the cell cycle. For example, mutants of S. cerevisiae were found with execution points early in the cell cycle, at about the time of b ...
Standard PDF - Wiley Online Library
Standard PDF - Wiley Online Library

... be grouped into 11 families (Smith et al., 2000). This multiplicity of genes supports the view that autolytic activity is an important cellular function but analysis of gene function is likely to be complicated by functional overlap or redundancy. Interestingly, Bisicchia et al. (2007) discovered th ...
The Respiratory is the first system involved in exercise and is the
The Respiratory is the first system involved in exercise and is the

... named the cardiac muscle. Your hearts muscle fibres are different from others, because the hearts muscle fibres a criss cross pattern and can pump blood better than others. In the heart there are four chambers, they’re called the left ventricle and the left atrium, the right ventricle and the right ...
The Respiratory System
The Respiratory System

... The strength of expiration from the lungs also contributes to loudness. A thin-walled, cartilaginous tube that carries air from the larynx to the lungs and bronchi. Spongy, saclike respiratory organs that remove carbon dioxide from the blood, and replaces it with oxygen. The subdivisions of the trac ...
review cell division from a genetic perspective
review cell division from a genetic perspective

... incubation at the restrictive condition for that mutation, whereas mutants with defects in one of the continuously required functions will arrest at the restrictive temperature with cells at a variety of positions in the cell cycle. Classes of mutants may be distinguished from one another and the ro ...
4 - Rochester Community Schools
4 - Rochester Community Schools

... cells with central nuclei; no striations; cells arranged closely to form sheets. Function: Propels substances or objects (foodstuffs, urine, a baby) along internal passageways; involuntary control. Location: Mostly in the walls of hollow organs. ...
10_2007
10_2007

... themselves run out of analgesics for moderate pain. They can request prescriptions for small amounts of analgesics that are left at the information desk in the lobby of the University Hospital at their convenience Because of this manner with which we manage pain, we also are mindful of our obligatio ...
the circulatory system the heart
the circulatory system the heart

... The right ventricle pumps deoxygenated blood through the semilunar valve into the Pulmonary artery (F) which takes the blood into the lungs where it regains oxygen and becomes bright red in ...
Diapositive 1 - ORBi - Université de Liège
Diapositive 1 - ORBi - Université de Liège

... bases. A repression model suggested that SIP1, by binding to theses 2 sites, is able to close a region of DNA and to impair the binding of an activating factor. KLF4, a Krüppel/Sp1-like family member, is down-regulated in some cancers (colon, oesophagus) but up-regulated in others (breast and pancre ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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