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Plk4/SAK/ZYG-1 in the regulation of centriole
Plk4/SAK/ZYG-1 in the regulation of centriole

... centrioles during G1/S and the protein levels increase at both centrioles into mitosis [29]. In addition to centriole localization, Plk4/SAK protein levels are regulated and, when aberrant, centriole assembly is either amplified or decreased corresponding to levels of Plk4/SAK [30,31]. Defects resul ...
PHL 419 materials
PHL 419 materials

...  There are two principal patterns of cell death:  Necrosis (occurs after ischemia and chemical injury it is always pathologic).  Apoptosis (occurs when a cell dies through activation of an internally controlled suicide program. It is designed to eliminate unwanted cells during embryogenesis and i ...
Differential roles for the low-affinity phosphate transporters Pho87
Differential roles for the low-affinity phosphate transporters Pho87

... for expression of the so-called STRE (stress-responsive element) genes and the PDS (post-diauxic shift) genes respectively [12–14]. Rim15 acts as a nutritional integrator in yeast, since it is regulated by at least four nutrient-regulated kinases: PKA (protein kinase A) inhibits Rim15 activity [15], ...
earthworm dissection
earthworm dissection

... forming larger vessels. Blood is returned to the aortic arches through the dorsal vessel, which runs along the top of the digestive tract. 3) Identify the dorsal vessel, which runs along the top of the intestine. Follow it forward toward the esophagus. Gently move aside any organs that obscure your ...
CHAPTER 10: NERVOUS SYSTEM I
CHAPTER 10: NERVOUS SYSTEM I

... Sensory receptors (located at the ends of peripheral neurons) detect changes (i.e. are stimulated) occurring in their surroundings; Once stimulated, sensory receptors transmit a sensory impulse to the CNS. A sensory impulse is carried on a sensory neuron. ...
Calcium: a regulation system emerges in plant cells
Calcium: a regulation system emerges in plant cells

... the inhibitory action of anticalmodulin drugs on many of these processes (Hepler & Wayne, 1985). Though inhibition often requires high drug concentrations, which can have nonspecific effects on cell metabolism and the Ca2+-regulatory system (Gilroy, Hughes & Trewavas, 1987). Taken as a whole, althou ...
Detection, Diagnosis, Staging
Detection, Diagnosis, Staging

... changes that can be seen under a microscope. For instance, 2 chromosomes may swap some of their DNA, so that part of one chromosome becomes attached to part of a different chromosome. This change, called a translocation, can usually be seen under a microscope. Other types of chromosome changes are a ...
Cell A.
Cell A.

... phopholipase C to cleave PIP2 forming IP3 and DAG from the cell membrane. IP3 then binds to a ligand-gated ion channel on the ER causing the release of calcium ions, which bind to calmodulin & causes the cytoskeleton to change shape. 8.The binding of a sperm to an egg initiates a G protein pathway t ...
Document
Document

... 2 For this section of the examination you must use an HB pencil and, where necessary, an eraser. 3 Check that the answer sheet you have been given has your name, date of birth, SCN (Scottish Candidate Number) and Centre Name printed on it. Do not change any of these details. 4 If any of ...
Maintenance of Shoot and Floral Meristem Cell
Maintenance of Shoot and Floral Meristem Cell

... forms, suggesting that cell-cell interactions probably dictate the boundaries of the WUS expression domain. WUS-expressing cells in the interior of the shoot meristem signal to their overlying neighbors to specify them as pluripotent stem cells (Brand et al., 2000; Schoof et al., 2000). Loss-of-func ...
Gamete Handling and Fertilization
Gamete Handling and Fertilization

... placed in beakers containing either ASW or LiCl solutions. Fertilization was achieved by diluting 3 drops of sperm in ASW and then by placing 3 drops of that solution in the egg containing beakers, after the eggs had been incubated for 10 min. ...
Progress Report on Reduced-Lignin Alfalfa: Part I, Plant Modifications
Progress Report on Reduced-Lignin Alfalfa: Part I, Plant Modifications

... to the cow. Alfalfa would be a better energy source if more carbohydrates within cells were available. Alfalfa cell walls make up the fiber portion of the plant, and alfalfa DM contains between 30-80% fiber. Fiber content is usually dependent on maturity. However, only about 50% of alfalfa fiber is ...
1 Laccases direct lignification in the discrete secondary cell wall
1 Laccases direct lignification in the discrete secondary cell wall

... membranes (Fig. 3; Supplemental Fig. 4). YFP-tagged ABCG11, which has previously been shown to function as a plasma membrane localized cuticular wax and cutin exporter (Bird et al., 2007), was included as a positive control for plasma membrane localization (Supplemental Fig. 4). Secondary cell wall ...
Biology 2121 Review – Cell Structure and Function (Chapter 3
Biology 2121 Review – Cell Structure and Function (Chapter 3

... Know the factors that affect the rate of diffusion. Know examples of substances that use osmosis, simple diffusion and facilitated diffusion to move into and out of cells Know the following concerning tonicity  Distinguish between an isotonic, hypotonic and hypertonic environment that a cell exists ...
Smooth muscles
Smooth muscles

... the central part of the fiber. Fibers do not branch. They range enormously in size from 20 (in wall of small blood vessels) to 500 (in wall of uterus during pregnancy) micrometers. Smooth muscle fibres lie over one another in a staggered fashion (tapered part of one fibre over thicker part of anothe ...
Chapter_4_Tissue_Power_Point
Chapter_4_Tissue_Power_Point

... Hard (bone), semisolid (fat), or liquid (blood) Histology is the science that deals with the study of tissues. Pathologist specialized in laboratory studies of cells and tissue for diagnoses Copyright 2009, John Wiley & Sons, Inc. ...
Regulation of endothelial and hematopoietic development by the
Regulation of endothelial and hematopoietic development by the

... vasculogenesis, which first occurs in the extraembryonic yolk sac and subsequently in the embryo proper [1]. After primitive vessels have formed, the vascular plexus expands by endothelial sprouting and intussusceptive vessel growth in a process known as angiogenesis. Maturation of the vascular netw ...
File
File

... • Did you provide a diagram of your body system with the major parts or organs labeled? • Did you give descriptions of the functions of each organ? Teamwork • Did you share examples and give descriptions of interactions with other body systems? Fun Facts • Did you provide five facts (or more) about ...
Chapter 12 Cytoskeleton
Chapter 12 Cytoskeleton

... Even small bipolar filaments composed of myosin-II molecules can slide actin filaments over each other, thus mediating local shortening of an actin filament bundle ...
Respiratory System ppt
Respiratory System ppt

... Humans ventilate their lungs by the mechanism of breathing, which involves inspiration and expiration. The volume of air that is taken into the lungs can increase if the need for oxygen increases, such as during exercise. External respiration takes place in the lungs, between the air in the alveoli ...
ch_18 - WordPress.com
ch_18 - WordPress.com

... -The blood comes in direct contact with the tissue cells thus exchanging respiratory gases, food materials and waste products directly between blood and tissue cells. -Blood flows slowly through the open sinuses because of lack of enough blood pressure. -Respiratory pigment, if any, is dissolved in ...
Proteolysis and orientation in Dictyostelium slugs
Proteolysis and orientation in Dictyostelium slugs

... (Received 11 January 1993; revised 25 April 1993; accepted 25 June 1993) ...
Syringolin Reprograms Wheat to Undergo
Syringolin Reprograms Wheat to Undergo

... al., 1999). This interpretation is also supported by the observation, as exemplified in Figure 3I, that epidermal cells at infection sites on syringolin A–treated leaves were unable to undergo plasmolysis and to take up neutral red dye, indicating irreversible membrane damage (Koga et al., 1988; Gör ...
The Evolution of Membranes - University of Guelph Physics
The Evolution of Membranes - University of Guelph Physics

... influence on the mechanical properties of such a composite membrane. The glycocalyx carbohydrate network on the outside surface is generally believed to be responsible for cell–cell recognition and adhesion to other cells. The black objects extending from one side of the lipid bilayer to the other r ...
Unit 2 cardiovascular system 3.44MB 2017-03
Unit 2 cardiovascular system 3.44MB 2017-03

... flows through the kidneys. The waste material then leaves the body in the form of urine. Water and mineral ion content must also be kept constant for our cells to work effectively. Water Control - Our bodies take in water from food and drinks and when we release energy. We lose water in sweat, faece ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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