Chapter 1 - Bioinformatics Research Center
... covariation in gene expression provides information about the regulation of gene expression, and can yield clues to unknown gene function as a result of “guilt by association.” Gene expression is also a powerful tool in the identification of candidate genes for any given process, since a gene must ( ...
... covariation in gene expression provides information about the regulation of gene expression, and can yield clues to unknown gene function as a result of “guilt by association.” Gene expression is also a powerful tool in the identification of candidate genes for any given process, since a gene must ( ...
Topic #2: Should adults seek genome editing as a treatment for their
... The genome in every cell in an individual’s body is essentially identical - with a few notable exceptions: for example, the reproductive cells and the mutations acquired by each cell in a person’s lifetime. With these caveats in mind, in theory, the DNA of virtually any cell can be analyzed to provi ...
... The genome in every cell in an individual’s body is essentially identical - with a few notable exceptions: for example, the reproductive cells and the mutations acquired by each cell in a person’s lifetime. With these caveats in mind, in theory, the DNA of virtually any cell can be analyzed to provi ...
Genome editing and CRISPR Aim - Personal Genetics Education
... The genome in every cell in an individual’s body is essentially identical - with a few notable exceptions: for example, the reproductive cells and the mutations acquired by each cell in a person’s lifetime. With these caveats in mind, in theory, the DNA of virtually any cell can be analyzed to provi ...
... The genome in every cell in an individual’s body is essentially identical - with a few notable exceptions: for example, the reproductive cells and the mutations acquired by each cell in a person’s lifetime. With these caveats in mind, in theory, the DNA of virtually any cell can be analyzed to provi ...
CpG Mutation Rates in the Human Genome Are
... FIG. 2.—Rates of 5mC deamination, based on human SNPs with a known ancestral base, plotted with respect to the GC content of neighboring sequences (the orthologous chimpanzee genomic contig [see Methods]). (A) Black bars show the rate of CpG ! TpG or CpG ! CpA base substitutions per CpG dinucleotide ...
... FIG. 2.—Rates of 5mC deamination, based on human SNPs with a known ancestral base, plotted with respect to the GC content of neighboring sequences (the orthologous chimpanzee genomic contig [see Methods]). (A) Black bars show the rate of CpG ! TpG or CpG ! CpA base substitutions per CpG dinucleotide ...
Control of Chromosome Pairing and Genome Evolution in Disomic
... To study the effect of homologous centromeres with other homoeologous portions in the same chromosome on recombination, two different recombinant chromosome substitution lines were crossed to CS in the presence of Ph1. If Ph1 acts only on centromeres to cause chromosomes with homologous centromeres ...
... To study the effect of homologous centromeres with other homoeologous portions in the same chromosome on recombination, two different recombinant chromosome substitution lines were crossed to CS in the presence of Ph1. If Ph1 acts only on centromeres to cause chromosomes with homologous centromeres ...
S Diagnostic Clinical Genome and Exome Sequencing review article
... influenced by the expected inheritance patterns (e.g., dominant or recessive) and whether other family members with and without similar features are available for phenotyping and genetic testing. In some scenarios, it can be important to test unaffected relatives (Table 3). When a de novo variant is ...
... influenced by the expected inheritance patterns (e.g., dominant or recessive) and whether other family members with and without similar features are available for phenotyping and genetic testing. In some scenarios, it can be important to test unaffected relatives (Table 3). When a de novo variant is ...
Plant LTR-retrotransposons and MITEs: control of
... Arabidopsis thaliana retrotransposons represent only the 4 –8% of the genome, in large genomes like maize they can account for more than 50– 80% of their DNA content (Kumar and Bennetzen, 1999). The copy number of retrotransposons increases with their activity due to their replicative mechanism of t ...
... Arabidopsis thaliana retrotransposons represent only the 4 –8% of the genome, in large genomes like maize they can account for more than 50– 80% of their DNA content (Kumar and Bennetzen, 1999). The copy number of retrotransposons increases with their activity due to their replicative mechanism of t ...
Diagnostic Clinical Genome and Exome Sequencing
... influenced by the expected inheritance patterns (e.g., dominant or recessive) and whether other family members with and without similar features are available for phenotyping and genetic testing. In some scenarios, it can be important to test unaffected relatives (Table 3). When a de novo variant is ...
... influenced by the expected inheritance patterns (e.g., dominant or recessive) and whether other family members with and without similar features are available for phenotyping and genetic testing. In some scenarios, it can be important to test unaffected relatives (Table 3). When a de novo variant is ...
Evolutionary Genomics of Fast Evolving Tunicates
... have undergone a similar, yet less extreme, process of genome compaction, gene density is between three (C. intestinalis) and four (C. savignyi) times lower than O. dioica (see table 1 for details on genome sizes and gene numbers). In turn, in comparison to nontunicate chordates, the difference is c ...
... have undergone a similar, yet less extreme, process of genome compaction, gene density is between three (C. intestinalis) and four (C. savignyi) times lower than O. dioica (see table 1 for details on genome sizes and gene numbers). In turn, in comparison to nontunicate chordates, the difference is c ...
Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial
... Plasmodium falciparum-parasitized enythrocytes increase their utilization of glucose as much as 100 times the rate of uninfected host red cells. This increase reflects the need of the parasites to grow; synthesize RNA, protein, and DNA; and reproduce 12 to 24 new progeny all in a 48-hour period. The ...
... Plasmodium falciparum-parasitized enythrocytes increase their utilization of glucose as much as 100 times the rate of uninfected host red cells. This increase reflects the need of the parasites to grow; synthesize RNA, protein, and DNA; and reproduce 12 to 24 new progeny all in a 48-hour period. The ...
DNA Mismatch Repair and Synonymous Codon Evolution in
... Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855 1059. Mol. Biol. Evol. 11(1):88-98. 1994. ...
... Department of Biological Sciences, Rutgers University, Piscataway, New Jersey 08855 1059. Mol. Biol. Evol. 11(1):88-98. 1994. ...
Time Dependency of Molecular Rate Estimates and Systematic
... five sections, and polymorphic sites were uniformly distributed (P 5 0.05). In the d-loop comparisons, however, there were several regions and isolated sites at which intraspecific polymorphisms appeared in two or more of the species (fig. 2b); a test for uniformity was not conducted because the num ...
... five sections, and polymorphic sites were uniformly distributed (P 5 0.05). In the d-loop comparisons, however, there were several regions and isolated sites at which intraspecific polymorphisms appeared in two or more of the species (fig. 2b); a test for uniformity was not conducted because the num ...
Analysis of Drosophila Species Genome Size and Satellite DNA
... ABSTRACT The size of eukaryotic genomes can vary by several orders of magnitude, yet genome size does not correlate with the number of genes nor with the size or complexity of the organism. Although ‘‘whole’’-genome sequences, such as those now available for 12 Drosophila species, provide informatio ...
... ABSTRACT The size of eukaryotic genomes can vary by several orders of magnitude, yet genome size does not correlate with the number of genes nor with the size or complexity of the organism. Although ‘‘whole’’-genome sequences, such as those now available for 12 Drosophila species, provide informatio ...
- The Boyle Lab
... As the sequencing of healthy and disease genomes becomes more commonplace, detailed annotation provides interpretation for individual variation responsible for normal and disease phenotypes. Current approaches focus on direct changes in protein coding genes, particularly nonsynonymous mutations that ...
... As the sequencing of healthy and disease genomes becomes more commonplace, detailed annotation provides interpretation for individual variation responsible for normal and disease phenotypes. Current approaches focus on direct changes in protein coding genes, particularly nonsynonymous mutations that ...
Pandora - W.W. Norton
... limits the different genes that it will search through. Since every gene is actually scaled between zero and five, Pandora can now focus on certain genes and then only return results that may be rated as three or higher (Glaser et al. 7). None of this information is available to the end user on the ...
... limits the different genes that it will search through. Since every gene is actually scaled between zero and five, Pandora can now focus on certain genes and then only return results that may be rated as three or higher (Glaser et al. 7). None of this information is available to the end user on the ...
repetitive extragenic palindromic sequences in pseudomonas
... gene. Applying the described criteria we detected 32 cases in which the intragenic REP sequences corresponded to genes that did not seemed to be real genes. The presence of REP sequences in a gene also could indicate that the gene is shorter than predicted. To detect if a gene containing a REP seque ...
... gene. Applying the described criteria we detected 32 cases in which the intragenic REP sequences corresponded to genes that did not seemed to be real genes. The presence of REP sequences in a gene also could indicate that the gene is shorter than predicted. To detect if a gene containing a REP seque ...
The Genome of a Mongolian Individual Reveals
... Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]–1227). Although the social cultural impacts of Genghis Khan and the Mongolian population have been well documented, explorations of their genome structure and genetic imprints on o ...
... Mongolians have played a significant role in modern human evolution, especially after the rise of Genghis Khan (1162[?]–1227). Although the social cultural impacts of Genghis Khan and the Mongolian population have been well documented, explorations of their genome structure and genetic imprints on o ...
Homologous and Nonhomologous Rearrangements: Interactions
... The Aevol model was developed in our team to study the evolution of genome structure. It simulates the evolution of a population of N artificial haploid organisms with flexible genomes. Although a description of the model has already been published (see Knibbe et al. (2008) and its supp. mat.), we t ...
... The Aevol model was developed in our team to study the evolution of genome structure. It simulates the evolution of a population of N artificial haploid organisms with flexible genomes. Although a description of the model has already been published (see Knibbe et al. (2008) and its supp. mat.), we t ...
The ARG9 Gene Encodes the Plastid-Resident N
... Moreover, the frequency of codons in the Chlamydomonas plastid genes made it likely that the Arabidopsis cDNA would be translated by the set of plastid tRNAs. Using an existing spectinomycin resistance cassette (aadA) for plastid transformation, we designed an arg9c (c for chloroplast) cassette for ...
... Moreover, the frequency of codons in the Chlamydomonas plastid genes made it likely that the Arabidopsis cDNA would be translated by the set of plastid tRNAs. Using an existing spectinomycin resistance cassette (aadA) for plastid transformation, we designed an arg9c (c for chloroplast) cassette for ...
Interactions of Mitochondrial and Nuclear Genes
... genomics strategy has not been successful. Differences between two cytoplasms often may reflect evolutionary divergence and have no correlation with CMS. What is needed, therefore, is to compare recently diverged CMS and fertile lines. Ideal genetic materials are lines of fertile revertants that hav ...
... genomics strategy has not been successful. Differences between two cytoplasms often may reflect evolutionary divergence and have no correlation with CMS. What is needed, therefore, is to compare recently diverged CMS and fertile lines. Ideal genetic materials are lines of fertile revertants that hav ...
Competition between Transposable Elements
... genes while preserving good growth profiles and protein production (Pósfai et al. 2006). Thus, compared with previous efforts (Chao et al. 1983), E. coli MDS42 is an ideal model system for investigating the early spread of IS elements in a bacterial genome. We investigated the evolution of IS-carry ...
... genes while preserving good growth profiles and protein production (Pósfai et al. 2006). Thus, compared with previous efforts (Chao et al. 1983), E. coli MDS42 is an ideal model system for investigating the early spread of IS elements in a bacterial genome. We investigated the evolution of IS-carry ...
Next-Generation Sequencing applied to aDNA
... The makefile is specified using YAML, a human-readable markup language that is visually similar to Python code. In other words, the structure is defined using indentation. Note that tabs cannot be used when editing this file, always use spaces! A copy of the final makefile (“final_makefile.yaml”) wa ...
... The makefile is specified using YAML, a human-readable markup language that is visually similar to Python code. In other words, the structure is defined using indentation. Note that tabs cannot be used when editing this file, always use spaces! A copy of the final makefile (“final_makefile.yaml”) wa ...