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A SHORT HISTORY OF BIOINFORMATICS
A SHORT HISTORY OF BIOINFORMATICS

... deCode genetics publishes a paper that described the location of the FET1 gene, which is responsible for familial essential tremor, on chromosome 13 (Nature Genetics). ...
human-genome-project
human-genome-project

... Some interesting findings from the HGP • Chromosome 1 has the most genes (2968), and the Y chromosome has the fewest ...
Rapid Evolution in the Human Genome
Rapid Evolution in the Human Genome

... makes us human. I will describe two different methods we have developed for identifying lineage-specific evolution: a phylogenetic hidden Markov model (phylo-HMM) and a likelihood ratio test (LRT). The phylo-HMM works well for identifying relatively ancient events, while the LRT is much more powerfu ...
Genome Sequences of the Primary Endosymbiont “Candidatus
Genome Sequences of the Primary Endosymbiont “Candidatus

... tabaci is one of the top 100 invasive species worldwide (5). Similar to other obligate bacteria living in sap-sucking insects, “Ca. Portiera aleyrodidarum” is thought to provide essential nutrients to whiteflies (2). B. tabaci is a species complex comprised of 11 highlevel genetic groups that are we ...
Ess | Rebekah Ess Biology Lab November 2, 2012 “Genomic DNA
Ess | Rebekah Ess Biology Lab November 2, 2012 “Genomic DNA

... enough samples of each taxon to find out. One reason thought to have caused diversity is the idea that the forest elephant female herds saw repeated migration of the savanna elephant bulls, displacing the gene pool in every wave; this could also be a cause of mtDNA discrepancy. Rohland et al. hypnot ...
KARYOTYPES & THE HUMAN GENOME
KARYOTYPES & THE HUMAN GENOME

... This project is an ongoing effort to analyze the human genome in order to map genes & determine what causes certain diseases, to give us clues to some of the properties of life and to find information that may be useful in developing drugs & treatments for ...
Color Atlas of Genetics / Thieme Flexibook, 4th Edition
Color Atlas of Genetics / Thieme Flexibook, 4th Edition

... High quality color plates in classic Thieme Flexibook style, illustrating the most complex structures and processes in a clear, understandable way and enabling the reader to form a mental image of the structure and its function. A comprehensive picture of the field of genetics, from its fascinating ...
Origins of Pharmacogenomics
Origins of Pharmacogenomics

... New technologies that arose from the Human genome Project such as DNA microarrays and lab card or “lab-on-a-chip” devices may eventually make it possible to cheaply and quickly prescreen patients for certain polymorphisms before drug therapy is initiated ...
16. Nuclear gene organization
16. Nuclear gene organization

... Satellite DNA: DNA at the centromeres of chromosomes, can be physically separated from the rest of nuclear DNA  alpha-satellite DNA contains binding site for CENP-B, a centromeric protein. Minisatellite DNA: DNA near telomeres  Very useful for DNA fingerprinting  Location on many chromosomes mean ...
BIOL 433 Plant Genetics Term 1, 2005
BIOL 433 Plant Genetics Term 1, 2005

... http://www.nature.com/nmeth/journal/v5/n1/full/nmeth1156.html ...
BIOL 433 Plant Genetics Term 1, 2005
BIOL 433 Plant Genetics Term 1, 2005

... http://www.nature.com/nmeth/journal/v5/n1/full/nmeth1156.html ...
The relationship between genes and traits is often complex
The relationship between genes and traits is often complex

... Next week for our final lecture of the semester, we will look at what DNA can tell us about the origins of Homo sapiens. ...
TE content correlates positively with genome size
TE content correlates positively with genome size

... • cDNA synthesis and insertion of the new copy into chromosomal DNA occurs simultaneously, by TPRT (target-primed reverse transcription) • newly-inserted elements typically have a polyA tail and target-site ...
Amsterdam 2004
Amsterdam 2004

... Endo symbiosis of alpha proteo-bacteria gave rise to mitochondria • Mitochondrial DNA in the mitochondria • Hydrogenosomes shown to be derived from mitochondria • Many proteins active in present-day mitochondria are coded for by proteins of eukaryotic invention, archaeal descent • Many proteins of ...
Mutation or polymorphism?
Mutation or polymorphism?

... making up the bulk of the 3 million variations found in the genome. Unlike the other, rarer kinds of variations, many SNPs occur in genes and in the surrounding regions of the genome that control their expression. The effect of a single SNP on a gene may not be large - perhaps influencing the activi ...
Introduction to Next Generation Sequencing
Introduction to Next Generation Sequencing

... • Number of allowed mis-matches (as function of position) • Number of mapped loci (e.g., 1 = unique read sequence) • Generate Consensus Sequence and identify SNPs • Generate Read Enrichment Profile (e.g., Wald Lab tool) • Develop Null Model and Calculate Significantly Enriched Sites • High level ana ...
Keynote for 2008 Genomics Workshop
Keynote for 2008 Genomics Workshop

... our plans for the panda genome (whole genome assembly using short reads) 50x of paired end data using Solexa average read lengths 40~50 bp ...
Lecture 19 Evolution of Senescence
Lecture 19 Evolution of Senescence

... gene were indeed associated with the ability to attain exceptional old age. The FOXO3A association was considerably stronger in centenarians than in nonagenarians, highlighting the importance of centenarians for genetic longevity research. Our study extended the initial finding observed in Japanese ...
Inheritance of Organelle DNA Sequences in a Citrus–Poncirus
Inheritance of Organelle DNA Sequences in a Citrus–Poncirus

... nuclear genome. Insertions of organelle DNA into the nuclear genome of plants and animals have occurred frequently over the course of evolution (reviewed by Blanchard and Lynch 2000; Blanchard and Schmidt 1995; Henze and Martin 2001; Martin and Herrmann 1998). In the land plants there are many examp ...
The Mitochondria as a Minimal Chassis:
The Mitochondria as a Minimal Chassis:

... cellular components. • allow all cellular functions to proceed in a coordinated manner. • all the components of the system must be present at once. ...
Slide 1
Slide 1

... flank two selectable marker genes is inserted into the chloroplast genome through homologous recombination, thereby transforming the native plastome into a TRANSPLASTOME (a). One of the selectable genes (aadA) is designed for exclusive expression in the chloroplast and incorporation of this marker c ...
The UCSC Human Genome Browser
The UCSC Human Genome Browser

... in Nature, with Celera and other industry papers appearing routinely in Science, until recently. 12. The public consortium insisted that Celera cheated by using the public sequence data in a way that retained a lot of the assembly information, while Venter insisted that if Celera had finished the jo ...
Introduction to Medical Genetics
Introduction to Medical Genetics

... Germline Mosaicism The chance that a disorder due to a new AD mutation could occur more than once in a sibship is very low, and having two occur independently in the same gene in the same family is very unlikely  Given that a child has a defect due to a new AD mutation, the risk of having another ...
Genome fusion occurs during endosymbiosis
Genome fusion occurs during endosymbiosis

... Two symbiotic organisms become endosymbiotic when onespecies is taken inside the cytoplasm of another species, resulting in genome fusion. Genome fusion, by endosymbiosis, between two species, one anArchaea and the other a Bacteria, has been proposed as responsible for the evolution of the first euk ...
slides - QUBES Hub
slides - QUBES Hub

... • 20 class meetings of three hours each • 4-5 weeks for background • 5-6 weeks for project • As of fall 2016, 6 sections per quarter ...
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