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Mitochondria as a Therapeutic Target in Heart Failure
Mitochondria as a Therapeutic Target in Heart Failure

... biogenesis (30,34). Importantly, changes in mtDNA replication machinery represented a very early event detected in hypertrophied hearts that have not yet transitioned to failure (30). The actual trigger for reducing mtDNA replication in a setting of increased workload is unknown, and it would be of ...
ANTICOAGULANT
ANTICOAGULANT

... – Intensity of anticoagulation – Concomitant clinical disorders(liver disease ,thyrotoxicosis and fever ) – Quality of management – Concomitant use of other medications 1. Cimetidine and other enzyme inhibitors increase its action while rifampicin and other enzyme inducers inhibit the action of warf ...
ANGINA PECTORIS TREATMENT
ANGINA PECTORIS TREATMENT

... e.g. captopril, enalopril ACE inhibitors are indicated for patients with coronary artery disease when ejection fraction is less than 40%, hypertension, diabetes mellitus or chronic renal disease ...
Baroreflex modulation of ventricular rhythm in atrial fibrillation
Baroreflex modulation of ventricular rhythm in atrial fibrillation

... through its influence on the atrial myocardium. Prolongation of the functional refractory period ...
Pulmonary arteries
Pulmonary arteries

... around the great vessels and trachea but you may not be able to recognize it in the dissecting room since in adult life it is gradually replaced by fat. Because of the deposition of fat after puberty the pink color of the infant’s thymus changes to yellow. It reaches its largest size just before pub ...
Mitochondria as a Therapeutic Target in Heart Failure
Mitochondria as a Therapeutic Target in Heart Failure

... biogenesis (30,34). Importantly, changes in mtDNA replication machinery represented a very early event detected in hypertrophied hearts that have not yet transitioned to failure (30). The actual trigger for reducing mtDNA replication in a setting of increased workload is unknown, and it would be of ...
World Heart Day - ESL Holiday Lessons
World Heart Day - ESL Holiday Lessons

... heart disease are premature. Most people who suffer heart attacks and strokes could live / life longer if they changed their lifestyle. Fewer people would die from heart complaints if they were more awareness / aware of the main risks. These include smoking, eating an unhealthy / healthy diet and no ...
Stroke volume-to-wall stress ratio as a load
Stroke volume-to-wall stress ratio as a load

... was optimized by giving the lowest dose of ketamine needed to 1) restrain the animal and prevent motion artifact, and 2) maintain the heart rate in the range of 350 – 450 beats/min. Ketamine was chosen based on our laboratory’s previous experience (12–14) and considering that alternative agents had ...
Research - Wiley Online Library
Research - Wiley Online Library

... Introduction For both clinical and non-clinical reasons, various strategies have been employed to improve physical performance through augmenting exercise with nutritional and/or hormonal supplements. The intent of these supplements is to increase muscle mass, endurance and power (Spriet & Gibala, 2 ...
Adult Echocardiography Protocol Patient Position For parasternal
Adult Echocardiography Protocol Patient Position For parasternal

... Adjust color gain until Doppler noise is seen, then decrease the gain down just enough to eliminate the noise. ...
Print - Circulation Research
Print - Circulation Research

... as necessary) and the chests were opened by transsternal thoracotomy in the fourth or fifth interspace. The cervical vagi and stellate ganglia were isolated and prepared for stimulation and the left carotid artery was cannulated for pressure recording and subsequent drug injections. The tip of the c ...
cerebral venous sinus thrombosis - The Association of Physicians of
cerebral venous sinus thrombosis - The Association of Physicians of

... have no valve. Connection exists between venous sinuses and the veins of scalp face and neck. They not only provide alternate route but also a path by which infection can spread to venous sinuses from this area to cause CVT. ...
ACC/AHA guidelines for the management of patients with
ACC/AHA guidelines for the management of patients with

... When citing this document, the American College of Cardiology and the American Heart Association recommend that the following format be used: Bonow RO, Carabello B, de Leon AC Jr, Edmunds LH Jr, Fedderly BJ, Freed MD, Gaasch WH, McKay CR, Nishimura RA, O’Gara PT, O’Rourke RA, Rahimtoola SH. ACC/AHA ...
23 Electrpcardiography evaluation of heart work
23 Electrpcardiography evaluation of heart work

... letters (q, r, s). Duration of ventricular complex is 0,06-0,09 s in the standard leads Wave Q displays spread of excitation through the middle and lower thirds of the interventricular septum. It should not exceed 1/4 of prongs ʼ R amplitude in a healthy person, and its duration – 0,03 sec. But aVR- ...
Case-Based Curriculum in Clinical Electrophysiology
Case-Based Curriculum in Clinical Electrophysiology

... Charge circuit timeout: A sequence of events leading to failure of an implantable cardioverter-defibrillator to deliver therapy. Catanzaro JN, et al.32 Trouble shooting arrhythmia management devices is an important aspect of cardiac electrophysiology. Hilgendorf describe a case of a fall in ICD lead ...
Abnormal multiple pregnancy with septuplets in a
Abnormal multiple pregnancy with septuplets in a

... A major pregnancy complication in human medicine is gestational or pregnancy-induced hypertension (23). In this syndrome maternal arterial blood pressure is increased and uterine blood flow is decreased leading to fetal hypoxia (16). It manifests usually late in pregnancy and causes amongst others m ...
Early and Late Systolic Wall Stress Differentially
Early and Late Systolic Wall Stress Differentially

... forces or forces generated within the wall that oppose fiber shortening, which vary significantly with cavity and wall thickness and can interfere with direct comparisons of myocardial stress at different times during ejection. Representative time-resolved short-axis LV wall thickness and cavity are ...
Carvedilol vs metoprolol succinate wide qrs syndrome
Carvedilol vs metoprolol succinate wide qrs syndrome

... patients with diastolic heart failure vs those with systolic heart failure.Apr 4, 2011 . Heart failure (HF) is a complex clinical syndrome caused by structural or. .. metoprolol succinate (β1 receptor selective blockers), and carvedilol (which. . LVEF of 30% or less, and wide QRS intervals (≥130 ms) ...
Bassett, Kiah - Cardiff Metropolitan University
Bassett, Kiah - Cardiff Metropolitan University

... a redistribution of blood that would cause decreased preload due to a reduction in venous return. Previous studies have also shown a reduction in end- diastolic volume, which could mean that the change in LV function previously observed is due to a change in blood movement/flow rather than a reducti ...
Some Properties of a Cardioactive Substance Isolated From Human
Some Properties of a Cardioactive Substance Isolated From Human

... The onset of the positive inotropic response was rapid, appearing a few seconds after the cardioactive plasma substance was added. The augmented contractions persisted for approximately 15 minutes after which they slowly returned to the control level. The addition of cardioactive plasma substance as ...
1-Anatomy of the Heart
1-Anatomy of the Heart

... • Anterior cusp : lies anteriorly and to right. • Posterior cusp : lies posteriorly and to left. o The atrial surfaces of the cusps are smooth, while ventricular surfaces give attachment to chordae tendinae. ...
ACC/AHA Guidelines for the Management of Patients With Valvular
ACC/AHA Guidelines for the Management of Patients With Valvular

... When citing this document, the American College of Cardiology and the American Heart Association recommend that the following format be used: Bonow RO, Carabello B, de Leon AC Jr, Edmunds LH Jr, Fedderly BJ, Freed MD, Gaasch WH, McKay CR, Nishimura RA, O’Gara PT, O’Rourke RA, Rahimtoola SH. ACC/AHA ...
How to Distinguish Between Innocent and Pathologic Murmurs in
How to Distinguish Between Innocent and Pathologic Murmurs in

... The common clinical features of innocent outflow murmur are as folIows: they m u r in early systole, are generally of short duration and low intensity (nearly always Grade 1 or Grade 2, -ionally Grade 3) are crescendo-decrescendo, are p r l y tmnsrnitted elsewhere to the precordium, and, perhaps mos ...
Youth Committee of the Council on Cardiovascular Disease in the
Youth Committee of the Council on Cardiovascular Disease in the

... without heart disease, have been documented extensively.17–23 The benefits include well-described physiological improve­ ments in skeletal muscle function, vascular health, immune system function, obesity prevention,24 and complex psycho­ logical, cognitive and social function.25 Emerging science al ...
Atrial fibrillation and flutter
Atrial fibrillation and flutter

... Fig. 2 Surface (ECG (top four traces) and intracardiac electrograms from right atrium, (RA) during successful ablation of atrial flutter. Rapid, regular atrial depolarisation is seen to proceed around the right atrium until sinus rhythm is restored by blocking the flutter circuit (see pp. 116–117). ...
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